Multiple myeloma 환자에서 Bortezomib치료 후 발생한 마비성 장폐색증 1례

김준영,이원식,손창학,박성길,진한영,박석주,조영완,정은욱,강명주,박정하,주영돈 인제대학교 2006 仁濟醫學 Vol.27 No.-

Bortezomib is the first clinically available proteasome inhibitor that is clinically effective in the treatment of multiple myeloma. A proteasome inhibitor acts through multiple mechanisms to arrest tumor growth, tumor spread, and angiogenesis. The main adverse effects of bortezomib are gastrointestinal symptoms, cytopenia, fatigue, and peripheral neuropathy. To date, severe paralytic ileus has not been reported as a toxic effect of bortezomib treatment in multiple myeloma. Bortezomib is a novel agent that has only been used clinically for 30 months, so a need exists to further evaluate its toxicity. We report a case of grade Ⅲ (NCI CTCAE v3.0) or grade Ⅳ(SWOG toxicity criteria) paralytic ileus in a 65-year-old man with relapsed multiple myeloma who underwent one cycle of single-agent bortezomib treatment scheduled in a 21-day cycle (1.3 mg/㎥ as a single i.v. bolus on days 1, 4, 8, and 11).

비강 및 비인두에 발생한 도립유두종과 편평상피암종의 p53단백 및 세포증식능에 관한 연구

한주호,윤기중,이재규,신대균,박근호,조향정,문형배 圓光大學校 醫科學硏究所 1996 圓光醫科學 Vol.12 No.2

The inverted papilloma and squamous cell carcinoma are common neoplasia in the sinonasal cavity and nasopharynx, but the incidence of these tumors are very low and the study on the oncogenesis or biological activity of the tumor cells are not well known. This study was designed to evaluate the oncogenic roles of the p53 gene and the proliferative activity of the tumor cells in the inflammatory polyp, inverted papilloma and squamous cell carcinoma. The experiment was carried by the immunohistochemical stains about the p53 protein, PCNA and Ki-67, histochemical stain about the AgNORs. and flow cytometric analysis about the DNA ploidy using the formalin fixed paraffin embedded tissues. The frequency of the expression of p53 protein was 0%(0/16 cases) in the inflammatory polyps, 18.8% (3/16 cases) in the inverted papillomas, and 87.5%(14/16 cases) in the squamous cell carcinomas. The labelling index(%) of the PCNA and Ki-67 was 5.3% and 3.3% in the inflammatoy polyps, 29.6% and 25.2% in the inverted papillomas, and 51.9% and 36.8% in the squamous cell carcinoma. The expression of the PCNA and Ki-67 was distributed in the periphery of the tumor islands of the inverted papilloma and was distributed in the both of center and periphery of the tumor islands of the squamous cell carcinoma. The number of nuclear AgNORs was increased in the order of inflammatory polyps (0.96), inverted papillomas(1.34) and squamous cell carcinoma(2.09). The frequency of the DNA aneuploidy was 0%(0/16 cases) in the inflammatory polyps, 18.8%(3/16 cases) in the inverted papillomas. and 12.5%(2/16 cases) in the squamous cell carcinomas. Above results indicates that the changes of the p53 gene and proliferative activity of the tumor cells are involved on the oncogenesis and the biological activity of the inverted papilloma or squamous cell carcinoma in the nasopharynx and sinonasa cavity.

肝吸蟲症 濃厚流行地(金海市)에 있어서의 疫學的 推移에 관한 硏究

朴洙培,朱炅煥,林漢鍾 고려대학교 의과대학 1984 고려대 의대 잡지 Vol.21 No.1

In order to observe the epidemiological changes of clonorchiasis in the high endemic area in Korea, the stool examinations were carried out in Bulam-dong, Kimhae City. A total of 423 stool specimens collected from the inhabitants of this area were examined both by cellophane thick smear method and Stoll’s egg dilution counting technique. The result of this survey was compared to the data obtained in 1973 by the quantitative analysis applying the regression equations, the simple and two-stage catalytic curves. The metacercarial density of Pseudorasbora parva and the tendency of familial aggregation of this area were also compared with those of 1973. In addition to this study informal interview were conducted to investigate the KAP (knowledge, attitude and practice) of the raw fish eating habit of the ingabitants in this area. The results are as follows: 1. Overall prevalence rate of clonorchiasis was reduced from 68.3% to 45.6% in a period of 10 years. 2. In 1973, both sexes in all age groups showed almost parallel high infection rates. However in 1983, the rate for males was slightly higher than that for females and a marked reduction in the prevalence was encountered in the youngest age group. 3. The mean E.P.G. count of Clonorchis sinensis infection in the surveyed area was 10,846 in 1973. But the mean E.P.G. count was decreased to 4,858 in 1983. The degree of intensity of Clonorchis sinensis infection determined by E.P.G. count was evenly distributed in geavy, very heavy, light and moderate infections in 1973 whereas an E.P.G. of over 10,000 was seen only in 14.0% of examinee in 1973. 4. The two-stage catalytic model was applied to this study and the calculation led to the equation y=1.042(e^(-0.003t)-e^(-0.074t)); a>b in 1973, and y-1.130(e^(-0.003t)-e^(-0.026t); a>b in 1983. 5. The intensity of endemicity was compared with the regression equations calculated from cumulative percentages of E.P.G. counts. The regression equations were y=2.75+1.46 log^(χ)(Cs. D_(50) 64.76) in 1973 compared to y=3.27+1.59 log^(χ)(Cs. D_(50) 12.25) in 1983. 6. In high endemic area such as Kimhae City the tendency of familial aggregation was recognized not in 1973 but in the present study. 7. Metacercarial infestation rate of P.parva did not change but metacercarial density was decreased from 1,312.4 ea/fish to 1,233.4 ea/fish in 1972 and 1973 to 160.8 ea/fish in 1983. 8. The KAP(knowledge, attitude and practice) of raw-fish eating habit of inhabitants were mentioned.

전자 상거래에서 인터넷 쇼핑몰의 비즈니스 평가 모델

박용진,한주윤,정봉주 한국경영과학회 2000 經營 科學 Vol.17 No.3

This paper proposes an evaluation model for internet shopping mall business by defining its characteristics and evaluation criteria. We analyzed the characteristics of internet shopping mall business environments and classified the business into four major categories. We derived the evaluation criteria which can evaluate all categories comprehensively. The proposed criteria are cost, netizen, technology, transaction, and marketing, each of which gives a significant Impact on the business profitability. Based on these criteria, a quantitative evaluation method was developed. We also proposed a penta-classification scheme which can be used to identify the overall characteristic shape of each internet shopping mall business site. An actual application of our evaluation model was illustrated in order to show that our proposed model may be used in the real business sites.

교류전해에칭용 에틸렌글리콜의 알루미늄박판의 부식억제 효과

박성민, 양정진, 김홍일, 김한주, 김성한, 신진식, 박수길 충북대학교 건설기술연구소 2008 충북대학교 건설기술연구소 논문집 Vol.27 No.1

In this study, additions of aluminium foil eching characteristics were compared with sulfuric acid for capacitor. sulfuric acid and ethylene glycol is used as addition, characteristics of funtional group from addition were guessed by comparing of aluminium foil eching characteristics. When sulfuric acid was added in HCI etching solution, corrosion of aluminum metal was inhibited by the chemical adsorption of sulfate ion, when ethylen glycol was added in HCI etching solution, corrosion inhibited by the chemical adsorption of OH­^ion.

가야산 국립공원일대의 식생 및 식물상 연구 : 단지봉 지역을 중심으로 Especially on the Danji-bong Area

박광우,권영한,최경,오승환,김동갑,김주환 한국환경생물학회 2005 환경생물 : 환경생물학회지 Vol.23 No.1

본 조사지역인 가야산국립공원은 지리학적으로는 북위 35?5′00″~35?9′30″, 동경 128?2′30″~128?09′30″에 위치하고, 행적구역상으로는 경상남도의 합천군과 거창군, 경상북도의 성주군, 고령군에 걸쳐 있으며, 총면적은 57.81 km꼬?이른다. 가야산은 우리나라 기후지역상 온대남부에 위치하고, 식물구계학적으로는 남부아구에, 식생구계학상으로는 냉온대에 속하는 것으로 알려져 있다. 또한, 전체면적의 약 82.5%가 해발 600m 이상이며, 1,000m이상이 약 10.3%에 해당된다. 가야산의 해인사-극락골-토신골 지역은 잘 보존된 소나무림이 우점하고 있고, 부분적으로 노각나무가 산생하는 것이 관찰되었으며, 해인사-진대밭골-두리봉 지역은 계곡에는 소나무와 졸참나무가 고지대에는 신갈나무 등이 부분적으로 군락을 형성하고 있었다. 또한 남산제일봉과 북사면은 각각 등산로와 임도가 형성되어 있어 소나무와 졸참나무, 신갈나무 등이 혼재된 양상을 나타내었고, 백운동계곡 주변은 다른 사면과 달리 식생의 발달정도가 소나무와 관목위주로 매우 단순했다. 특기할만한 점은 상왕봉 주변에서 흰참꽃, 설앵초, 네귀쓴풀, 백리향, 솔나리, 구름송이풀 등의 희귀 또는 고산성 식물들이 분포하는 것이 확인되었다. 가야산국립공원지역에 분포하는 양치식물 이상의 관속식물을 대상으로 조사한 결과 91과 268속 373종 1아종 75변종 12품종 4잡종으로 총 465분류군이 조사 확인되었으며, 이는 우리나라 관속식물 4,071 분류군의 11.4%에 해당되었다. 한국특산식물은 11과 15속 15분류군으로 조사지역내 분포하는 465분류군중 약 3.2%이며. 식물구계학적 특정식물은 17과 21속 25분류군으로 이는 가야산 소산식물 465분류군의 5.4%이었고, 조사지역에 분포하는 귀화식물은 5과 7속 7분류군으로 우리 나라전체 귀화식물종 177종류의 4%이다. 또한 가야산 단지봉(1,028.5m)에서 새로 발견된 산간습지 (forested wetland)와 자란초 자생 군락지에 대해 식생 및 층위별 종조성을 토대로 현존 식생 구조를 분석하였다. This study aims to investigate the flora of Mt. Gaya National Park, especially focused on the forested wetland vegetation of Danji-bong area. The flora of Mt. Gaya was investigated from April in 2003 to October in 2004. Vascular plants of this area consist of total 465 taxa, 4 hybrids, 12 forma, 75 varieties, 1 subspecies, 373 species, 268 genera, 91 families. It corresponds to 11.4% of totally 4,071 taxa appeared in Korea. Korean endemic plants were composed 11 families, 15 genera, 14 species, 1 variety and totaling 15 taxa. And also actual vegetation structures were analyzed the newly founded forested wetland and natural population Ajuga spectabilis on the Danji- bong area using the vegetation and the species composition by tree layer.

인터넷 서비스 유형분석 모델 개발에 관한 연구

박주석,박진휘,이한규 한국경영과학회 2001 한국경영과학회 학술대회논문집 Vol.- No.1(2)

Electronic Commerce grows rapidly in the past few years. Also, the power of EC doesn't become weak in the future. The increase of EC market scale provides powerful foundation to the Internet development. Unlike other technology, Internet has several distinctive character. First, As Internet spreads fast to the public, it became the usable technology to them in a short time. Second, Comparing to other technology, the work with using Internet isn't difficult to public so the basis of technology prepared in a short period. Third, Internet applicates all the industry and economic so, it makes economic foundation for making synergy during a short period. These Internet characters influence to EC growing speed which is basement of Internet growth. Due to Digital revolution giving much more influence than last Industrial Revolution, E-Business such as e-Management, B2B, B2C became the survival strategies for enterprise's management efficiency. Owing to emergence of technology like ultrahigh speed data communication, Broadband communication, wireless Internet, Internet TV, IS95C(2.5GB), 3G and activation of internet business, products and service through Internet become realized. Because of this, Supply of products and service through Internet are on the increase. But demand of voice communication become saturated, so increase of profit and sale through it reach the limit. Communication demand for products and service is a growing tendency. Consequently, research about vision and business strategies of Internet service for promoting the business founded on internet required.

腦囊尾蟲症의 化學的療法에 관한 臨床的 硏究

朴昌潤,朱炅煥,林漢鍾 고려대학교 의과대학 1982 고려대 의대 잡지 Vol.19 No.3

The purpose of this study was to evaluate the therapeutic effect of praziquantel (Embay8440, Biltricide®) on human cerebral cysticercosis. The praziquantel is a broad spectrum anthelmintic agent and has a high activity against cestodes and trematodes. Before and after the treatment with oral administration of the praziquantel the changes in structure of Cysticercus cellulosae biopsied in subcutaneous tissue were studied by scanning and transmission electron microscope, and cerebral cysticercosis by computerized tomographic scanning. The results were as follows : 1. The findings of the observations on subcutaneous Cysticercus biopsied after treatment were compared with those of before treatment. At the early stage of the treatment, small vacuoles were scattered along the basement layer in the tegumental syncytium of the scolex and neck regions. In the scanning electron microscopic observation, marked surface changes were present in the neck region with many bleb-like structures formed by the bursting of the large vacuoles in the tegumental syncytium. In the specimens biopsied at 2 or 5 weeks after treatment, the degenerations and necrosis of the tegumental syncytium were seen in all part of cysticercus. 2. The scanning electron microscopic findings of Cysticercus cellulosae obtained from the 4th ventricle of the cerebral cysticercosis patients by the surgical operation were identical with those of subcutaneous tissues. 3. In 12 cases of cerebral cysticercosis treated with prziquantel in dosage of 3×25 ㎎/㎏ for 3 or 4 consecutive days, there were no cessations of the convulsive seizures during the 6 months follow up. Among them 9 cases were given again with the same doses of the drug for 4 or 7 days. In 7 of 9 cases, no more convulsive seizure was experienced over one or two years after the second treatment. At the same time the lesions of the brain C.T. scanning were disappeared, decreased in size or calcified. In the other 3 cerebral cysticercosis cases, the complete cure was also obtained after the oral medication of praziquantel with the doses of 3×25 ㎎/㎏ for 7 consecutive days. 4. In the treatment of cerebral cysticercosis with praziquantel, it was found that the combined oral medication of dexamethasone during the course of treatment was effective on preventing and minimizing the side effects.

실험계획법을 이용한 능동형 미소혼합기의 근사최적화

박재용,이원구,유진식,김용대,한석영,맹주성 한국공작기계학회 2008 한국공작기계학회 춘계학술대회논문집 Vol.2008 No.-

An active micro-mixer, which was composed of an oscillating micro-stirrer in the microchannel to provide rapid, effective mixing at high flow rates was analyzed. The effects of molecular diffusion and disturbance by the stirrer were considered with regard to two types of mixer models: the simple straight microchannel and microchannel with an oscillating stirrer. Two types of mixer models were studied by analyzing mixing behaviors such as their interactionafter the stirrer. The mixing was calculated by Lattice Boltzmann methods using the D2Q9 model, In this study, the time-averaged mixing index formula was used to estimate the mixing performance of time-dependent flow. The mixing indices of the two models were compared. From the results, it was found that the mixer with an oscillating stirrer was much more enhanced and stabilized. Therefore, an approximate optimization of an active micro-mixer with an oscillating stirrer was performed using Kriging method with OLHD(Optima1 Latin Hypercube Design) in order to obtain a optimum solution. The design parameters were established as the frequency, the length and the angle of the stirrer, and the optimal values were determined to be 1.0346, 0.66D and ±45°, respectively. It was found that the mixing index of the optimal design increased by 88.72% compared with that of the original design.

白地어음 制度에 관한 考察

朴菜均,尹柱漢 朝鮮大學校 法政大學 1997 法政大論文集 Vol.4 No.-

백지어음은 그 자체로서는 어음은 아니나 그 후에 백지어음 행위자(보통 백지어음 발행인)의 의사에 따라 소지인이 백지를 보충하면 어음으로서 완성되어 어음상 권리를 표창하게 되며 백지어음 행위자는 그 기록에 따라 책임을 진다. 이같이 백지어음에 있어서는 백지로 되어 있는 조건을 보충하면 어음상의 권리가 발생하나 이 어음상의 권리는 요건보충에 의하여 돌연히 발생하는 것이 아니고 보충이전에 보충을 정지조건으로 하는 어음상의 권리가 백지어음에 표창되어 보충이란 정지조건을 성취하면 어음은 어음상의 권리 즉 어음지급청구권을 표창하게 된다. 따라서 백지어음은 요건이 보충되기 전이라도 보충권과 함께 이러한 조건부권리를 표창하며 이 권리는 백지어음의 양도에 의하여 보충권과 함께 전전유통한다고 보겠다. 이상에서 논술한바와 같이 백지어음제도에 관한 의의, 경제적기능, 요건, 성질, 효력, 보충권등에 대해서 문제점을 보아왔거니와 학설, 판례, 실행으로서 사회에서 통용되고 있으며 명문화되지 않는 어음행위등에 대해서 타법규와의 준용등 혼란을 예상하여 볼 때 백지어음제도의 법제화도 고려해 볼 필요가 있다고 본다.