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손지연 ( Ji Youn Sohn ),이경애 ( Kyung Ae Lee ),홍윤경 ( Yun Kyung Hong ),류완희 ( Wan Hee Yoo ) 대한류마티스학회 2009 대한류마티스학회지 Vol.16 No.4
Thromobotic thrombocytopenic purpura (TTP) is a multisystem disorder that`s characterized by consumptive thrombocytopenia, microangiopathic hemolytic anemia, and neurologic symptoms. TTP is associated with many diseases and several therapeutic drugs. We report here on the first Korean case of a patient with rheumatoid arthritis (RA) and who developed TTP that was associated with trimethoprim-sulfamethoxazole (TMP-SMX) in Korea. She recovered from the TTP following daily sessions of therapeutic plasma exchange (TPE) with fresh plasma replacement and glucocorticoid therapy. Awareness of the possible development of TTP in patient with RA and who is being treated with TMP-SMX is important for making the early diagnosis and administering proper treatment.
손지연 ( Ji Youn Sohn ),김소리 ( So Ri Kim ),박성주 ( Seoung Ju Park ),이흥범 ( Heung Bum Lee ),이용철 ( Yong Chul Lee ),이양근 ( Yang Keun Rhee ) 대한결핵 및 호흡기학회 2009 Tuberculosis and Respiratory Diseases Vol.67 No.6
Background: A combination of salmeterol and fluticasone propionate (SFC) and tiotropium bromide (TIO) is commonly prescribed for COPD patients but there is little data on their effectiveness, particularly in COPD patients with bronchial hyperresponsiveness. This study compared the spirometric improvement based on the change in FEV1, FEV1/FVC, and IC as well as the clinical outcomes of the therapeutic strategies with SFC and TIO versus the individual components in patients with severe COPD and bronchial hyperresponsiveness. Methods: This study examined the spirometric data and clinical outcomes of 214 patients with COPD and hyperresponsiveness, who were divided into three groups according to the therapeutic regimen (TIO only, SFC only, and a triple therapy regimen). Results: All regimen groups showed early improvement in the FEV1 and IC (at 3- and 6 months after treatment). However, long-term beneficial effects were observed only in the SFC group (at 24 months after treatment). However, these beneficial effects decreased after a 36-month follow up. In all spirometric results, the 12-, 24-, and 36-months data showed a similar degree of improvement in the three groups. The triple therapy group showed higher St. George`s Respiratory Questionnaire scores and lower acute exacerbations and hospitalization. Conclusion: SFC can be a more important component in the pharmacological treatment of severe COPD patients with hyperresponsiveness than TIO, particularly in the spirometric and clinical outcomes.
Sohn, Hee-Sook,Nam, Ji-hyun,Cha, Youn-Soo The Korean Nutrition Society 2004 Nutritional Sciences Vol.7 No.2
The objective of this study was to examine diet-induced changes in the expression of UCP2 mRNA in the liver and UCP3 mRNA in the skeletal muscle of mice fed a high-sucrose or high-fat diet. Male ICR mice, aged 4 weeks, were divided into three dietary groups and fed control (N) or modified AIN-76 high-sucrose (US) or high-fat (HF) diets for 12 weeks. The serum total cholesterol (TC) and LDL-cholesterol concentrations of the HF group were significantly higher than those of the N and HS groups. The hepatic TC and triglyceride contents of the HS and HF groups were also significantly higher than those of the N group. The HS diet group had higher serum leptin and insulin levels compared to those of the HF group. Hepatic UCP2 mRNA expression was significantly higher in the HS group than in the N group, but the level in the HF group did not differ from that of the N group. Muscular UCP3 mRNA level was significantly higher in the HF group and especially in the HS group than in N the group. We observed that two gene (UCP2, 3) levels exhibited a similar tendency. These results suggest that UCPs mRNA levels and energy expenditure may be altered or controlled by various dietary patterns. Further research is needed to elucidate the effects of diet on the regulation of many obesity-related genes.
이지은,손장원,이규형,박윤선,김국현,최재원,은종렬,장병익,김태년 영남대학교 의과대학 2006 Yeungnam University Journal of Medicine Vol.23 No.1
Behcet's disease has rarely been reported in association with malignant diseases. In most cases the autoimmune nature of the disease itself of immunosuppressive drug use has been blamed for malignant transformation. Solid tumors in addition to lymphoid and hematological malignancies are also seen during the course of Behcet's disease. We present here a case of colon cancer in a 40-year-old man with Behcet's disease. A near total colectomy was performed and postoperative chemotherapy and radiotherapy was administered to treat visceral peritoneal invasion. Recurrent evidence was not found. We present the clinical details of this rare case of colon cancer with Behcet's disease.
무용수의 신체질량지수에 따른 체력과 웰니스에 관한 연구
손보람(Sohn, Bo-Ram),조정호(Cho, Jung-Ho),신말연(Shin, Mal-Ryun),이지현(Lee, Ji-Hyun),정재현(Jung, Jae-Hyun),김선민(Kim, Sun-Min),김수연(Kim, Soo-Youn) 한국체육과학회 2016 한국체육과학회지 Vol.25 No.3
The purpose of this study was to provide the dancers’ basic guideline based on their wellness life. The study conducted with purposive sampling targeting, a total of 101 dancers who study dancing in school or participated in dancing career. Study called TestWell and Wingate were used, which are based on physical fitness with anaerobic power, cardiorespiratory endurance, flexibility, and body composition (BMI) measured by In-body 720. The study is carried out with one-way analysis of variance (ANOVA) for analysis and Fisher’s Least Significant Difference (LSD) test was used as post-hoc, with significant level of 0.5. According to the study, significant differences were found in cellular water (both intra and extra), muscle weight, lean body mass, and physical dimensions based on Body Mass Index (BMI). The study indicates that the way dancers perceive wellness makes a great contribution to their physical dimension, it is considered that dancers need wellness-based systematic care (or approach) to avoid dancer’s health deterioration.
난소의 악성 혼합 뮬러리안 종양의 소장 및 대장 재발 1예
이지은 ( Ji Eun Lee ),손장원 ( Jang Won Sohn ),문희정 ( Hee Jung Moon ),이상훈 ( Sang Hoon Lee ),박윤선 ( Youn Sun Park ),최재원 ( Jae Won Choi ),김국현 ( Kook Hyun Kim ),은종렬 ( Jong Ryul Eun ),장병익 ( Byung Ik Jang ),김태년 ( 대한장연구학회 2006 Intestinal Research Vol.4 No.1
Malignant mixed mullerian tumor (MMMT) is rare tumor of the ovary, representing less than 1% of all ovarian malignancies. MMMT is an uncommon tumor containing epithelial and mesenchymal components. Most of all were heterologous type and 80% occur in postmenopausal women. It is a aggressive and rapidly progressive tumor. MMMT is highly malignant and the prognosis is poor because of frequent metastasis and recurrance. The survival rate is very low in spite of surgery, chemotherapy and radiotherapy. The optimal treatment is still controversial. We experienced one recur case of malignant mixed mullerian tumor of the ovary in intestine and report with brief review of literature. (Intestinal Research 2006;4:53-56)
The relationship between body mass index and inflammatory markers in college females
Lee, Ji-Hyun(이지현),Cho, Jung-Ho(조정호),Shin, Mal-Ryun(신말연),Jung, Jae-Hyun(정재현),Kim, Sun-Min(김선민),Jung, In-Woo(정인우),Kim, Soo-Youn(김수연),Sohn, Bo-Ram(손보람) 한국체육과학회 2015 한국체육과학회지 Vol.24 No.1
The purpose of this study is to analyze the relationship between BMI and inflammatory marker, to find whether BMI can reflect inflammatory marker, and to define the usefulness of BMI as obesity evaluation index for female college students. 110 female college students participated to this study and their height, weight, and body composition were measured. and CRP, TNF-α, IL-6 were analysed as inflammatory marker through blood sampling. Some questionnaire of Heyward’s life style survey are used to survey habit of physical activities for variants for statistical analysis. Pearson’s simple correlation analysis, partial correlation analysis and simple regression analysis were used to examine the relation of BMI and inflammatory makers. The result of this study shows that there is significant relationship between BMI and CRP and partial correlation analysis in which age and habit of physical activities are controlled shows that BMI and CRP are also significantly related. It could be suggested that BMI can be used as index for obesity related inflammatory marker partially.
위장관 ; 이물질 섭취에 의한 식도 천공의 발생률과 임상 양상
김지은 ( Ji Eun Kim ),유승목 ( Seung Mok Ryoo ),김윤정 ( Youn Jung Kim ),이종승 ( Jong Seung Lee ),안신 ( Shin Ahn ),서동우 ( Dong Woo Seo ),손창환 ( Chang Hwan Sohn ),류정민 ( Jeong Min Ryu ),김원영 ( Won Young Kim ) 대한소화기학회 2015 대한소화기학회지 Vol.66 No.5
목적: 식도 천공은 드물지만 치명적인 질환이다. 하지만 이물질 섭취에 의해 발생한 식도 천공의 발생률과 임상 양상에 대한 연구는 국내에서는 미비한 상태이다. 이 연구는 식도 내이물질로 응급의료센터에 내원하였던 성인 환자들을 대상으로 식도 천공의 발생률과 임상 양상, 치료 결과를 알아보기 위한 것이다. 대상 및 방법: 2000년 1월부터 2008년 7월까지 단일 응급의 료센터에 이물질을 섭취하여 내원한 1,009명의 환자 중에서 식도 이물이 확인된 196명의 환자를 대상으로 연구를 시행하였고, 그 중에서 식도 천공이 발생한 18명의 전자의료기록을 후향적으로 분석하였다. 결과: 식도 이물의 발생률은 19.4% (196/1,009)였고, 식도 천공의 발생률은 1.8% (18/1,009)였다. 식도 천공이 발생한 환자들에서 가장 흔한 이물질은 생선가시(72.2%)였고, 천공이 발생한 환자의 66.7%에서 흉통을 호소하였다. 식도 천공이 발생한 환자 18명 중 8명이 중환자실에서 입원 치료를 받았으나, 사망한 환자는 없었다. 결론: 이물질 섭취에 의한 식도 천공의 발생률은 1.8%로 높지 않았으나, 식도 내 이물질이 있을 때 식도 천공의 발생률은 9.2%까지 상승하였다. 흉통은 식도 이물이 있는 환자에서 식도 천공을 시사하는 불길한 징후일 수 있다. 그러나 적절한 수술적 처치 혹은 보존적 처치를 받은 경우 대부분 좋은 임상 경과를 보였다. Background/Aims: Esophageal perforation is a rare but often a life-threatening condition. However, the incidence and clinical features of esophageal perforation caused by ingested foreign body are unknown. This study investigated the incidence of esophageal perforation caused by ingested foreign body and evaluated the clinical features and outcome of patients with esophageal perforation. Methods: Among a total of 196 adult patients with confirmed esophageal foreign body and complained of at least one of the related symptoms at the emergency department between January 2000 and July 2008, 18 patients with esophageal perforation due to esophageal foreign body ingestion were included in the study. Data were collected by retrospectively reviewing the electric medical records. Results: The incidence of esophageal foreign body and esophageal perforation in adults was 19.4% (196/1,009) and 1.8% (18/1,009), respectively. Chest pain was the most common symptom and fishbone was the most common foreign body causing esophageal perforation. Mediastinitis or mediastinal abscess occurred in 13 patients (13/18, 72.2%). About half (8/18) of the patients were admitted to the intensive care unit but there was no in-hospital mortality. Conclusions: The incidence of esophageal perforation in patients with foreign body ingestion was low but it increased up to 9.2% in patients with esophageal foreign body. However, prognosis was favorable with timely proper treatment. Chest pain can be an ominous sign indicating the presence of esophageal perforation in patients with esophageal foreign body. (Korean J Gastroenterol 2015;66:255-260)