http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Comprehensive Review of Current and Upcoming Anti-Obesity Drugs
손장원,김성래 대한당뇨병학회 2020 Diabetes and Metabolism Journal Vol.44 No.6
Obesity is among the leading causes of morbidity and mortality worldwide and its prevalence continues to increase globally. Because obesity is a chronic, complex, and heterogeneous disease influenced by genetic, developmental, biological, and environmental factors, it is necessary to approach obesity with an integrated and comprehensive treatment strategy. As it is difficult to achieve and sustain successful long-term weight loss in most patients with obesity through lifestyle modifications (e.g., diet, exercise, and behavioral therapy), pharmacological approaches to the treatment of obesity should be considered as an adjunct therapy. Currently, four drugs (orlistat, naltrexone extended-release [ER]/bupropion ER, phentermine/topiramate controlled-release, and liraglutide) can be used long-term (>12 weeks) to promote weight loss by suppressing appetite or decreasing fat absorption. Pharmacotherapy for obesity should be conducted according to a proper assessment of the clinical evidence and customized to individual patients considering the characteristics of each drug and comorbidities associated with obesity. In this review, we discuss the mechanisms of action, efficacy, and safety of these available long-term anti-obesity drugs and introduce other potential agents under investigation. Furthermore, we discuss the need for research on personalized obesity medicine.
손장원,장혁재,이진경,정희정,송란영,김영진,Saurabh Datta,허란,신상훈,조인정,심지영,홍그루,정남식 한국심초음파학회 2013 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.21 No.2
Background: Accurate assessment of mitral regurgitation (MR) severity is crucial for clinical decision-making and optimizing patient outcomes. Recent advances in real-time three dimensional (3D) echocardiography provide the option of real-time full volume color Doppler echocardiography (FVCD) measurements. This makes it practical to quantify MR by subtracting aortic stroke volume from the volume of mitral inflow in an automated manner. Methods: Thirty-two patients with more than a moderate degree of MR assessed by transthoracic echocardiography (TTE)were consecutively enrolled during this study. MR volume was measured by 1) two dimensional (2D) Doppler TTE, using the proximal isovelocity surface area (PISA) and the volumetric quantification methods (VM). Then, 2) real time 3D-FVCD was subsequently obtained, and dedicated software was used to quantify the MR volume. MR volume was also measured using 3)phase contrast cardiac magnetic resonance imaging (PC-CMR). In each patient, all these measurements were obtained within the same day. Automated MR quantification was feasible in 30 of 32 patients. Results: The mean regurgitant volume quantified by 2D-PISA, 2D-VM, 3D-FVCD, and PC-CMR was 72.1 ± 27.7, 79.9 ±36.9, 69.9 ± 31.5, and 64.2 ± 30.7 mL, respectively (p = 0.304). There was an excellent correlation between the MR volume measured by PC-CMR and 3D-FVCD (r = 0.85, 95% CI 0.70-0.93, p < 0.001). Compared with PC-CMR, Bland-Altman analysis for 3D-FVCD showed a good agreement (2 standard deviations: 34.3 mL) than did 2D-PISA or 2D-VM (60.0 and 62.8mL, respectively). Conclusion: Automated quantification of MR with 3D-FVCD is feasible and accurate. It is a promising tool for the real-time 3D echocardiographic assessment of patients with MR.
손장원,차동원,Sohn, Jang-Won,Cha, Dong-Won 한국디지털건축·인테리어학회 2005 한국디지털건축인테리어학회 논문집 Vol.5 No.1
In the study results, Incheon region, a classic house was consistently built in spite of having been the barrier which a foreign dwelling flowed into until 1960's. And met me in our dwelling habit and changed and used a house built by the Japanese. That is, the traditional dwelling format worked with a spindle accepting other dwelling culture and can do it. It was a too social change and was able to confirm the fact that it extended a room as necessary or it improved a classic house and used as West back various way whom it got cold, and exchanged it to a kitchen of a cause and effect life.
손장원,박정란,Sohn, Jang-Won,Park, Jung-Lan 한국디지털건축·인테리어학회 2005 한국디지털건축인테리어학회 논문집 Vol.5 No.2
It extended in the opening after simultaneous strong point flag and to Incheon the building where the designer whom the many modem time building comes to build but becomes known was not many so. The research against these people did not become accomplished and not to be the back author research which analyzes the work propensity which is the possibility of doing the possibility of becoming accomplished there was not a basic of architectural design. The research which it sees it led and khu lu thu the road khey keyl the back the depths data, it confronted compared to it secured does not become known during that time the multi architect who and the plan office and and and it searched the result of the back which it puts out well it put to the architects who become known and.
Critical Care Paper Review 2012
손장원 대한결핵및호흡기학회 2012 Tuberculosis and Respiratory Diseases Vol.73 No.1
Care of patients with sepsis has improved over the last decade. However, in the recent two years, there was no significant progress in the development of a new drug for critically ill patients. In January 2011, it was announced that the worldwide phase 3 randomized trial of a novel anti-Toll-like receptor-4 compound, eritoran tetrasodium, had failed to demonstrate an improvement in the mortality of patients with severe sepsis. In October 2011, Xigris (drotrecogin alfa, a recombinant activated protein C) was withdrawn from the market following the failure of its worldwide trial that had attempted to demonstrate improved outcome. These announcements were disappointing. The recent failure of 2 promising drugs to further reduce mortality suggests that new approaches are needed. A study was published showing that sepsis can be associated to a state of immunosuppression and loss of immune function in human. However, the timing, incidence, and nature of the immunosuppression remain poorly characterized, especially in humans. This emphasizes the need for a better understanding of sepsis as well as new therapeutic strategies. Many clinical experiences of the extracorporeal membrane oxygenator (ECMO) treatment for adult acute respiratory distress syndrome (ARDS) patients, which is caused by the H1N1 influenza A virus, were reported. The use of ECMO in severe respiratory failure, particularly in the treatment of adult ARDS, is occurring more commonly.