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한종현,이우진,조성균,이미정,정미란,전정우,김운영,박성혜 동아시아식생활학회 2003 동아시아식생활학회지 Vol.13 No.4
This study was performed to investigate the effects of peking-duck extracts added with medicinal herbs(DJ) on the intoxication of heavy metals (Hg, Pb, Cd, As) in rats. Sprague-Dawley rats weighing 150±15g, were randomly assigned to 5 groups: basal diet only in normal control group(NCG); basal diet and heavy metals without DJ injection in heavy metal control group(HMC); basal diet, heavy metals and DJ(3㎎/㎖) injection in heavy metal low duck juice group(HMLD), basal diet, heavy metals and DJ(30㎎/㎖) injection in heavy metal middle duck juice group(HMMlD); basal diet, heavy metal and DJ(300㎎/㎖) injection in heavy metal high duck juice group(HMHD). Hg and As was injected by 50ppm and Cd and Pb by 25ppm for 17days. Also DJ oral feeding was conducted for 28days. The result of this study were as follows: Food intake and body weight gain in heavy metal administered groups were lower than those of NCG. Liver, kidney and testis weights were not significantly different among 5 groups. GOT, GPT and BUN activities were significantly reduced in DJ treated groups as compared to HMC. DJ showed the suppressing effect on the accumulation of Hg, Pb and Cd in serum, liver and kidney. Fecal Hg and Cd excretions increased with DJ feeding. The results suggested that DJ may have some protective effects on Hg, Cd and Pb intoxication by reducing the accumulation m tissues and increasing excretion. This study also showed the effective way of using duck-extract and its application to the oriental medicine.
전숙,김영희,박지영,고관표,박철영,김덕윤,우정택,김성운,김진우,김영설,고석환 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.2
낭종성 부갑상선 선종과 심한 골병변을 동반한 부갑상선 기능항진증은 매우 드문 질환으로서, 저자들은 양측 고관절의 통증을 초기 주소로 내원한 환자에서 고칼슘혈증과 부갑상선 호르몬 증가, 골병변의 방사선적 소견을 통해 부갑상선 기능항진증을 진단하고, 경부 초음파와 컴퓨터 단층 촬영, 부갑상선 스캔검사 및 수술중 부갑상선 낭종액 검사 등을 통해 기능성 부갑상선 낭종의 한 종류인 낭종성 부갑상선 선종을 진단하고 수술적 제거를 통하여 정상화된 1예를 경험하였다. A cystic parathyroid adenoma is rare. A case of primary hyperparathyroidism, with the cystic formation of a parathyroid adenoma and a severe bony lesion, is reported. A 52-year-old male was admitted due to pain in both hips and for evaluation of hypercalcemia. The plasma level of the intact parathyroid hormone (iPTH) was elevated to 1424 pg/mL. Ultrasonography and the computed tomography revealed a parathyroid cyst on the left thyroid lower pole. Parathyroid scintigraphy detected a parathyroid adenoma. A radiograph showed a subperiosteal bone resorption on the phalanges, and a brown tumor (osteitis fibrosa cystica) on the femur shaft was noted. A surgical excision of the parathyroid adenoma was performed. The PTH level in the cystic fluid was increased. A histological examination confirmed a cystic parathyroid adenoma. The PTH level was normalized after the operation (J Kor SOC Endocrinol 18:214-220, 2003).
셀룰라 오토마타를 이용한 김해시의 도시성장모형에 관한 연구 : 1987~2001년을 중심으로
이성호,윤정미,서경천,남광우,박상철 한국지리정보학회 2004 한국지리정보학회지 Vol.7 No.3
본 논문은 향후 도시의 물리적 성장형태를 예측하고자 하는 일련의 연구로서 김해의 과거 도시 성장과정을 분석함으로써 김해지역에 적합한 셀룰라 오토마타의 네이버후드 및 전이규칙을 결정하는 것을 목적으로 한다. 동적모델과 시간에 따른 변화를 다룰 수 있는 셀룰라 오토마타를 도입하여 1987년부터 2001년까지 김해지역의 도시성장을 분석하였으며, 다양한 네이버후드와 전이규칙의 시뮬레이션을 통해 김해지역에 적합한 네이버후드와 전이규칙을 정립하였다. 결론으로 김해지역은 네이버후드의 행렬이 작을수록, 또한 동일한 거리를 가진 circle 형태보다 정사각형의 네이버후드가 적합하였고, 도시성장속도를 조절하는 α값이 작을수록, 그리고 전환가능성 (Q_(ij))이 클수록 적합한 것으로 나타났다. The purpose of this study is to decide an appropriate neighborhood and a transition rule of cellular automata by analyzing the past growth process of urban areas in Gimhae. With cellular automata which can manage the change based on the dynamic model and time, this study analyzes the urban growth of Gimhae from 1987 to 2001. Also, through the simulation of different types for neighborhood and transition rules, we can find the appropriate neighborhood and the transition rule for Gimhae. In conclusion, the forecast of physical urban growth pattern is more accurate under conditions when the number of matrixes for the neighborhood is small, the shape of the neighborhood is rectangular, "α" value, which control the pace of urban growth, is low and the transition possibility (P_(ij))_is high.
Effect of Silk Fibroin Hydrolysate on the Apoptosis of MCF-7 human Breast Cancer Cells
Chon, Jeong-Woo,Jo, Yoo-Young,Lee, Kwang-Gill,Lee, Heui-Sam,Yeo, Joo-Hong,Kweon, HaeYong Korean Society of Sericultural Science 2013 International Journal of Industrial Entomology Vol.27 No.2
Breast cancer is one of the most common cancers among women worldwide. Recently anticancer agents have been developed using natural substances. To evaluate the anticancer effect of hydrolysates of silk fibroin (HSF), we investigated the effect of HSF on cell viability and apoptosis of a breast cancer cell line, MCF-7, induced through the mitochondrial pathway. The result showed that HSF decreased cell viability in MCF-7 cells in a dose- and time-dependent manner, resulting in an increase in the sub-G1 phase cell population. HSF increased the level of the pro-apoptotic Bax protein and decreased the levels of the anti-apoptotic Bcl-2 protein. In addition, HSF induced apoptosis in MCF-7 cells through a mitochondria-dependent pathway by increasing levels of cytochtome c, and cleavage of PARP. Taken together, these findings suggest that HSF inhibits the proliferation of MCF-7 breast cancer cells through a mitochondria and caspase dependent apoptotic pathway.
Effect of Silk Fibroin Hydrolysate on the Apoptosis of MCF-7 human Breast Cancer Cells
( Jeong Woo Chon ),( Yoo Young Jo ),( Kwang Gill Lee ),( Heui Sam Lee ),( Joo Hong Yeo ),( Haeyong Kweon ) 한국잠사학회 2013 International Journal of Industrial Entomology Vol.27 No.2
Breast cancer is one of the most common cancers among women worldwide. Recently anticancer agents have been developed using natural substances. To evaluate the anticancer effect of hydrolysates of silk fibroin (HSF), we investigated the effect of HSF on cell viability and apoptosis of a breast cancer cell line, MCF-7, induced through the mitochondrial pathway. The result showed that HSF decreased cell viability in MCF-7 cells in a dose- and time-dependent manner, resulting in an increase in the sub-G1 phase cell population. HSF increased the level of the pro-apoptotic Bax protein and decreased the levels of the anti-apoptotic Bcl-2 protein. In addition, HSF induced apoptosis in MCF-7 cells through a mitochondria-dependent pathway by increasing levels of cytochtome c, and cleavage of PARP. Taken together, these findings suggest that HSF inhibits the proliferation of MCF-7 breast cancer cells through a mitochondria and caspase dependent apoptotic pathway.
Anti-adipogenic Effect of Hydrolysate Silk Fibroin in 3T3-L1 Cells
Chon, Jeong-Woo,Lee, Kwang-Gill,Park, Yoo-Kyoung,Park, Kyung-Ho,Yeo, Joo-Hong Korean Society of Sericultural Science 2010 International Journal of Industrial Entomology Vol.21 No.2
Hydrolysate silk fibroin (HSF) is a fibrous protein composed of parallel $\beta$-structures and is made from pure silk elements including 18 amino acids, with glycine, alanine, and serine comprising of over 80% of the amino acids. Numerous studies have documented a range of effects of HSF, including moisturizing, antioxidant activity, nervous system disorders, and many more. We investigated whether HSF has anti-obesity effects in vitro. The effects of HSF inhibition on lipid accumulation and acceleration of lipid degradation in 3T3-L1 cells were studied. Treatment of 3T3-L1 cells with HSF caused significant inhibition of cell viability, an increase in glycerol release, and a decreased in adipocyte differentiation. Moreover HSF stimulated downregulated of adipogenic enzyme expressions (PPAR${\gamma}$ and C/EBP${\alpha}$) and up-regulated of fatty oxidation enzyme expressions (CPT-1 and UCP-2). Based on these results, hydrolysate silk fibroin can be suggested as a potential therapeutic substance as part of a prevention or treatment strategy for obesity.
Anti-adipogenic Effect of Hydrolysate Silk Fibroin in 3T3-L1 Cells
Jeong-Woo Chon,Kwang-Gill Lee,Yoo-Kyoung Park,Kyungho Park,Joo-Hong Yeo 한국잠사학회 2010 International Journal of Industrial Entomology Vol.21 No.2
Hydrolysate silk fibroin (HSF) is a fibrous protein composed of parallel β-structures and is made from pure silk elements including 18 amino acids, with glycine,alanine, and serine comprising of over 80% of the amino acids. Numerous studies have documented a range of effects of HSF, including moisturizing, antioxidant activity, nervous system disorders, and many more. We investigated whether HSF has anti-obesity effects in vitro. The effects of HSF inhibition on lipid accumulation and acceleration of lipid degradation in 3T3-L1 cells were studied. Treatment of 3T3-L1 cells with HSF caused significant inhibition of cell viability,an increase in glycerol release, and a decreased in adipocyte differentiation. Moreover HSF stimulated downregulated of adipogenic enzyme expressions (PPARγand C/EBPα) and up-regulated of fatty oxidation enzyme expressions (CPT-1 and UCP-2). Based on these results, hydrolysate silk fibroin can be suggested as a potential therapeutic substance as part of a prevention or treatment strategy for obesity.
누에생실샘 미세분말을 이용한 베이비파우더 소재 개발에 대한 연구
전정우 ( Jeong Woo Chon ),권해용 ( Hae Yong Kweon ),조유영 ( You Young Jo ),류강선 ( Kang Sun Ryu ),이광길 ( Kwang Gill Lee ),여주홍 ( Joo Hong Yeo ),강필돈 ( Pil Don Kang ),남성희 ( Sung Hee Nam ),박광영 ( Kwang Young Park ),김 한국잠사학회 2012 한국잠사곤충학회지 Vol.50 No.1
In this study, silk gland powder of silkworm were investigated to see the possibility for baby powder cosmetics materials. To test possibility as a baby powder cosmetics, total content rate of amino acids, DPPH free radical scavenging assay, MTT assay, and clinical trial were done. According to the result of the analysis of the amino acids of silk gland powder, serin (26.77%) content was the highest and asparatic acid (15.47%), and glycine (9.62%) were followed. DPPH free radical scavenging activity of silk gland powder was lower than vitamin C by 82.3% and 97%, respectively, which is relatively good. Moisture effect were increased in silk gland powder compared to control cosmetics by 50%. Also, silk gland powder was classified as a practically non-irritating material based on the score 0.05 of primary irritation index. Thus, these results suggest that silk gland powder of silkworm may have beneficial properties as a material for baby powder cosmetics.