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Jaemin Kim(Jaemin Kim),Hyoung Seok Kim(Hyoung Seok Kim),Su Jin Yoo(Su Jin Yoo),Moon Jung Choi(Moon Jung Choi),Youngju Lew(Youngju Lew),Jong Woo Kim(Jong Woo Kim),Han Joo Cho(Han Joo Cho) 대한안과학회 2022 Korean Journal of Ophthalmology Vol.36 No.5
Purpose: To determine the efficacy of immediate pars plana vitrectomy as the primary treatment for acute endophthalmitis in patients with a visual acuity (VA) of hand motion (HM) or better. Methods: A total of 149 patients who were referred to a single center for acute endophthalmitis after cataract surgery over the 13-year study period were retrospectively analyzed. Only patients presenting with a VA of at least HM were included. Patients were initially treated with either primary vitrectomy or intravitreal antibiotic injection alone, and their visual outcomes and reintervention rates after initial treatment were compared. Results: There was no significant difference in the proportion of good (final VA ≥20 / 40) and poor (VA ≤ counting finger) visual outcomes between the groups. However, subgroup analysis of patients with a VA of HM (92 eyes) showed that the incidence of reintervention (14 of 72 eyes [19.4%] vs. 9 of 20 eyes [45.0%]) and poor visual outcomes (10 of 72 eyes [13.9%] vs. 8 of 20 eyes [40.0%]) were lower after prompt vitrectomy than after intravitreal antibiotic injection alone (p = 0.019 and p = 0.022, respectively). For those with a VA of at least counting finger, no significant difference was observed between the groups. Conclusions: For patients with endophthalmitis presenting with a VA of HM, performing a prompt vitrectomy reduced the incidence of reintervention and poor visual outcomes than the administration of intravitreal antibiotics alone. Our results suggest that primary vitrectomy for patients with endophthalmitis presenting with a VA of HM could be more beneficial than intravitreal antibiotic injection alone.
Through-Silicon Via Capacitance–Voltage Hysteresis Modeling for 2.5-D and 3-D IC
Kim, Dong-Hyun,Kim, Youngwoo,Cho, Jonghyun,Bae, Bumhee,Park, Junyong,Lee, Hyunsuk,Lim, Jaemin,Kim, Jonghoon J.,Piersanti, Stefano,de Paulis, Francesco,Orlandi, Antonio,Kim, Joungho IEEE 2017 IEEE transactions on components, packaging, and ma Vol.7 No.6
<P>We propose, for the first time, an explicit semiconductor physics-based through-silicon via (TSV) capacitance-voltage (CV) model. The effect of TSV CV hysteresis is demonstrated in the model, and the TSV capacitance is modeled with respect to dc bias voltage and the dimension of the TSV. The proposed model is verified by comparison to the measurement results. The effect of hysteresis in the model correlates well with the measurement results. This model can be utilized in a circuit level simulation to expand the possible application of the model to, but not limited to, hierarchical power distribution network impedance analysis, RC delay analysis, input-output power consumption analysis, and crosstalk and eye diagram simulation in any 3-D-IC systems using TSVs.</P>
Kim, Jonghoon J.,Heegon Kim,Jung, Daniel H.,Sumin Choi,Jaemin Lim,Youngwoo Kim,Junyong Park,Hyesoo Kim,Dongho Ha,Bae, Michael,Joungho Kim IEEE 2017 IEEE transactions on electromagnetic compatibility Vol.59 No.4
<P>As the data rate of Low Power Double Data Rate 4 (LPDDR4) memory now exceeds 3.2 Gb/s, it is becoming more difficult to meet the target specifications. While testing has become of utmost importance, it is not viable to have a direct access to the signal pins in a package on package configuration due to the densely located array of solder balls; instead, a test interposer with an excellent electrical performance needs to be adopted to provide test access. In this paper, we first propose a novel test interposer scheme for testing LPDDR4 memory packages. For accurate testing without significant influence on the intrinsic signal path, the proposed test interposer is designed considering a number of signal integrity issues such as intersymbol interference, jitter, impedance matching, and crosstalk. Furthermore, by adopting silicone rubber sheet in place of soldering, the proposed test interposer enhances reusability of the packages with a fast setup time. Moreover, a reconstruction method is proposed that can reconstruct the voltage at application processor using the waveform captured on the test interposer, instead of probing at the ball gray array directly. Through a series of simulations and measurements, we experimentally verified the proposed test interposer. The proposed test interposer scheme can be widely adopted for testing of high-performance packages with its high accuracy and practicality.</P>
Kim, Sun Hong,Seo, Hyunseon,Kang, Jiheong,Hong, Jaeyoung,Seong, Duhwan,Kim, Han-Jin,Kim, Jaemin,Mun, Jaewan,Youn, Inchan,Kim, Jinseok,Kim, Yu-Chan,Seok, Hyun-Kwang,Lee, Changhee,Tok, Jeffrey B.-H.,Bao American Chemical Society 2019 ACS NANO Vol.13 No.6
<P>Both self-healable conductors and stretchable conductors have been previously reported. However, it is still difficult to simultaneously achieve high stretchability, high conductivity, and self-healability. Here, we observed an intriguing phenomenon, termed ?electrical self-boosting?, which enables reconstructing of electrically percolative pathways in an ultrastretchable and self-healable nanocomposite conductor (over 1700% strain). The autonomously reconstructed percolative pathways were directly verified by using microcomputed tomography and <I>in situ</I> scanning electron microscopy. The encapsulated nanocomposite conductor shows exceptional conductivity (average value: 2578 S cm<SUP>?1</SUP>; highest value: 3086 S cm<SUP>?1</SUP>) at 3500% tensile strain by virtue of efficient strain energy dissipation of the self-healing polymer and self-alignment and rearrangement of silver flakes surrounded by spontaneously formed silver nanoparticles and their self-assembly in the strained self-healing polymer matrix. In addition, the conductor maintains high conductivity and stretchability even after recovered from a complete cut. Besides, a design of double-layered conductor enabled by the self-bonding assembly allowed a conducting interface to be located on the neutral mechanical plane, showing extremely durable operations in a cyclic stretching test. Finally, we successfully demonstrated that electromyogram signals can be monitored by our self-healable interconnects. Such information was transmitted to a prosthetic robot to control various hand motions for robust interactive human-robot interfaces.</P> [FIG OMISSION]</BR>
JaeMin Kim,KyungYeol Bae,HeeJu Kang,SungWan Kim,IlSeon Shin,YoungJoon Hong,JuHan Kim,HeeYoung Shin,YoungKeun Ahn,JongKeun Kim,MyungHo Jeong,JinSang Yoon 대한신경정신의학회 2014 PSYCHIATRY INVESTIGATION Vol.11 No.1
Depression is common after acute coronary syndrome (ACS), adversely affecting cardiac course and prognosis. There have been only a few evidence-based treatment options for depression in ACS. Accordingly, we planned the Korean Depression in ACS (K-DEPACS) study, which investigated depressive disorders in patients with ACS using a naturalistic prospective design, and the Escitalopram for DEPACS (EsDEPACS) trial, which assessed the efficacy and safety of escitalopram for treating major or minor depression in patients with ACS. Participants in the K-DEPACS study were consecutively recruited from patients with ACS who were recently hospitalized at Chonnam National University Hospital, Gwangju, South Korea. Diagnoses were confirmed by coronary angiography from 2005. Data on depressive and cardiovascular characteristics were obtained at 2 weeks, 3 months, 12 months, and every 6 months thereafter following the index ACS admission. The K-DEPACS participants who met the DSM-IV criteria for major or minor depressive disorder were randomly assigned to groups in the 24-week, double-blind, placebo-controlled EsDEPACS trial beginning in 2007. The outcome of treatments for depressive and other psychiatric symptoms, issues related to safety, including general adversity, and cardiovascular factors were assessed. The K-DEPACS study can significantly contribute to research on the complex relationships between depression and ACS. The results of the EsDEPACS trial provide an additional treatment option for clinicians treating these patients.
Lee, Jaemin,Kang, Tae Heung,Yoo, Wonbeak,Choi, Hyunji,Jo, Seongyea,Kong, Kyungsu,Lee, Sang-Rae,Kim, Sun-Uk,Kim, Ji-Su,Cho, Duck,Kim, Janghwan,Kim, Jeong-Yoon,Kwon, Eun-Soo,Kim, Seokho AMERICAN ASSOCIATION FOR CANCER RESEARCH 2019 CANCER IMMUNOLOGY RESEARCH Vol.7 No.2
<P>The homing of natural killer (NK) cells is often inhibited by pancreatic cancer tumors. A mesothelin-directed antibody conjugated to a cleavable NK cell—recruiting chemokine increased NK-cell infiltration of PDAC tumors, reduced tumor burden, and improved survival.</P><P>Natural killer (NK) cells are primary immune cells that target cancer cells and can be used as a therapeutic agent against pancreatic cancer. Despite the usefulness of NK cells, NK-cell therapy is limited by tumor cell inhibition of NK-cell homing to tumor sites, thereby preventing a sustained antitumor immune response. One approach to successful cancer immunotherapy is to increase trafficking of NK cells to tumor tissues. Here, we developed an antibody-based NK-cell–homing protein, named NK-cell–recruiting protein-conjugated antibody (NRP-body). The effect of NRP-body on infiltration of NK cells into primary and metastatic pancreatic cancer was evaluated <I>in vitro</I> and in murine pancreatic ductal adenocarcinoma models. The NRP-body increased NK-cell infiltration of tumors along a CXCL16 gradient (CXCL16 is cleaved from the NRP-body by furin expressed on the surface of pancreatic cancer cells). CXCL16 induced NK-cell infiltration by activating RhoA via the ERK signaling cascade. Administration of the NRP-body to pancreatic cancer model mice increased tumor tissue infiltration of transferred NK cells and reduced the tumor burden compared with that in controls. Overall survival of NRP-body–treated mice (even the metastasis models) was higher than that of mice receiving NK cells alone. In conclusion, increasing NK-cell infiltration into tumor tissues improved response to this cancer immunotherapy. The combination of an NRP-body with NK-cell therapy might be useful for treating pancreatic cancer.</P>