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정상 한국인에서 연령증가에 따른 혈장 Dehydroepiandrosteronesulfate ( DHEA-S ) 농도 및 DHEA - S / cortisol 비의 변화
박성우,유형준,임성희,최문기,유재명,박민숙,이권엽,박철수,김철홍,김현규,김두만,박규용 대한내분비학회 1997 Endocrinology and metabolism Vol.12 No.2
Backgroud: DHEA-S is the most abundant steroid hormone in circulation, and primarily secreted from the adrenal cortex, but its physiological role is little known. One of the characteristic features of DHEA-S is progressive decrement of plasma DHEA-S level with advancing age, in contrast, plasma levels of other adrenal hormones are not chaging or littie decreasing. To grasp the trends of plasma DHEA-S level and DHEA-S/cortisol ratio by age in healthy Korean, we measured the plasma DHEA-S levels and DHEA-S/cortisol ratios in healthy Korean. Methods: Healthy Korean(men: 99, women: 102, age range: 15-97 year old)were studied. Subjects were not taking drugs(such as glucocorticoid or androgenic medication) or cigarettes known to modify the plasma level of DHEA-S and cortisol, and had no evidence of hepatic, renal disease or hyperlipidemia as determined by serum lipid, bilirubin, SGOT, SGPT, BUN, creatinine. Data were analyzed by 10-year age group for men and women: i.e, 10-19, 20-29, 30-39, 40- 49, 50-59, 60-69, 70-79, 80-89 and 90 year or more. Plasma DHEA-S levels were measured by using a commercially available RIA kit with 125I labeled-DHEA-SO4(Coat-A Count DHEA-SO4), and for the measurement of plasma cortisol levels, commercial Gamma Coat TM[125I] Cortisol Radioimmunassay Kit was used. Results:. 1) In both men and women, plasma DHEA-S level showed high interindividual variation within the same age group. 2) There were individual sex differences in plasma levels of DHEA-S, in all age groups, plasma DHEA-S levels were significantly higher values for men than for women. 3) Maximum plasma DHEA-S levels(men; 237+-3.35 ug/dL, women; 108+-17.5 ug/dL) were at third decade in both men and women. 4) Both men and women showed the continuous decline in plasma DHEA-S level with age. These age-related decline was more prominent in men than in women(men; y= -3.152 * +292.6, r2= 0.8459, P$lt;0.05, women; y= -1.417 * +143.3, r2 = 0.7278, P$lt; 0.05). 5) As an index of aging, there was no stastical difference between DHEA-S and DHEA- S/cortisol ratio. Conclusion: In healthy Korean, there were high interindividual variation of plasrna DHEA-S levels. In both men and women plasma DHEA-S level was peak at third decade, and from when it declined progressively with age. These results suggest that although the reliability of single plasma DHEA-S measurement are limited, the decline of DHEA-S with advancing age might be a specific marker of endocrinologic hormonal milieu(aging index). Also, concerning to individual adrenal secreting capacity, we measured DHEA-S/cortisol ratio. But we did not found that plasma DHEA-S/cortisol ratio is superior to the plasma DHEA-S level as an aging index. (J Kor Soc Endocrinol 12:245-254, 1997)
Case Report : Hepatoid Carcinoma of the Pancreas Combined with Neuroendocrine Carcinoma
( Ji Ye Jung ),( Yoon Jae Kim ),( Hee Man Kim ),( Hong Jeoung Kim ),( Seung Woo Park ),( Si Young Song ),( Jae Bock Chung ),( Chang Moo Kang ),( Joo Yeon Pyo ),( Woo Ick Yang ),( Seung Min Bang ) The Editorial Office of Gut and Liver 2010 Gut and Liver Vol.4 No.1
Hepatoid carcinoma is a primary extrahepatic carcinoma whose morphology, immunohistochemistry, and behavior are similar to those of hepatocellular carcinoma. The most common sites of extrahepatic carcinoma are the stomach and ovary, but nine cases of hepatocellular differentiation of the pancreas have been reported in the literature. We report another case of hepatoid carcinoma of the pancreas that was associated with the development of a pancreatic endocrine carcinoma in a 46-year-old man. Serum alpha-fetoprotein (AFP) was elevated to 262.49 IU/mL and radiological examinations revealed a mass measuring 7.5 cm in diameter in the head of the pancreas. He underwent a conventional Whipple operation, and light microscopy showed adenocarcinoma that was immunopositive for AFP, hepatocyte antigen, cytokeratin, chromogranin, synaptophysin, and alpha-1 antichymotrypsin. Although hepatoid differentiation was not shown unequivocally histologically, other immunohistochemistry findings supported the diagnosis of hepatoid carcinoma combined with neuroendocrine carcinoma. The patient was healthy and had no evidence of recurrence at 4 months after the surgery. This report describes why hepatoid carcinoma should be considered as a differential diagnosis of a pancreatic mass, especially when serum AFP is elevated. (Gut Liver 2010;4:98-102)
全權雨,江崎次夫,吳在萬 江源大學校 森林科學硏究所 1996 Journal of Forest Science Vol.12 No.-
우리나라에서는 농업분야의 경쟁력 강화를 위한 일환으로 임도사업이 전국적으로 실시되고 있으나 임도개설에 따른 土砂流出 및 水質惡化 등의 환경문제가 대두되고 있다. 따라서 임도사업의 역사가 길고 자연환경 등이 우리나라와 유사한 일본에 있어서 임도분야의 연구방향, 임도개설유역의 환경영향평가 방법, 環境親和型 林道施工 및 연구방법에 대한 자료를 정리하였으므로 앞으로의 合理的인 流域管理와 親環境的 林道事業에 유용하게 사용될 것으로 생각된다. In our country, nation-wide forest road works are being carried out as one of the efforts to bolster the international competitiveness of agriculture, however such environmental problems as sediment discharge and water quality degradation accompany such efforts more often than not. Hence, in this research report. we compile and analyze the Japanese sources dealing with the 「research direction of the forest road construction」, 「environmental impact assessment upon the watershed of the forest road construction」 , 「environmentally-sound forest road construction and its research method」 in consideration of the fact that natural environment of Japan is similar to that of our country and Japanese forest road works has a long history. We hope that this report be useful to the reasonable watershed management and the environmentally-sound forest road works.
이만재,박치영,곽재정,유보열,기장도,박찬국,김만우,김정용 조선대학교 1995 The Medical Journal of Chosun University Vol.20 No.1
Tuberculosis of duodenum is so rare and is usually secondary to pulmonary or intestinal tuberculosis . It is difficult to diagnose duodenal tuberculosis in clinical and radiologic findings due to its non-specific symptoms and inconsistent lesion. The diagnosis was made on the basis of the histological study of the endoscopic biopsy and resected surgical specimen. so we report a case of tuberculosis of duodenal bulb and of ascending colon with, the brief review of the literatures.
β-Carotene과 알코올을 섭취한 쥐의 혈액 성분변화의 상관관계
고재웅,조만희,이상한,우기민,염윤기,김창세 순천향의학연구소 2000 Journal of Soonchunhyang Medical Science Vol.6 No.2
The study was carried out to investigate the effects of dietary carotenids and β-carotene on the hematological changes caused by alcohol administration into the rats. The results were analyzed using several statistical methods; SPSS computer program for measuring the mean values and standard deviations, one way ANOVA for the test of significance, Duncan method for post HOC multiple comparison, and Pearson method for measuring the correlation coefficient. The following are the conclusion from those statistical analysis. 1. ALB and TB were shown to have the most significant correlation among the blood compositions f개m the basic dietary groups. 2. BUN and CHO were shown to have the most positive correlation among those from the carrot-fed groups. 3. CA and AG were shown positively correlated, and CHO and IP negatively correlated, respectively among those from the cheese-fed groups. 4. AP was shown positively correlated among those from the alcohol-administrated groups. 5. CHO, CA and BUN were shown positively correlated, and CA was negatively correlated among those from the β-Carotene -fed groups. 6. TB and TP were not affected by the correlations between the blood composition from all the experimental groups.
Rhizopus delemar IAM 6254가 生産하는 生澱粉 分解酵素의 特性
정만재,우정숙,임계숙,조대선 충북대학교 농업과학기술연구소 1991 農業科學硏究 Vol.9 No.2
The optimum cultural temperature and the optimum cultural time for the enzyme production on wheat bran medium were 30℃ and 72 hrs, respectively. The addition of diammonium hydrogen phosphate, ammonium chloride and ammonium sulfate on wheat bran medium, respectively, increased slightly the enzyme production. The enzyme was purified by ammonium sulfate fractionation, DEAE-cellulose and CM-cellulose column chromatography. The specific activity of the purified enyzme was 177.5U/mg. protein and the yield of enzyme activity was 10.3% . The purified enzyme showed a single band on polyacrylamide disc gel electrophoresis and its molecular weight was estimated to be 59,000 by SDS polyacrylamide disc gel electrophoresis. The isoelectric point for the purified enzyme was pH 5.4. The optimum temperature and optimum pH were 55℃ and pH 5.0, respectively The purified enzyme was identified as glucoamylase and showed a high hydrolysis rate on various raw starches such as corn, rice and sweet potato.
全槿雨,吳在萬 江原大學校 林科大學 森林科學硏究所 1991 Journal of Forest Science Vol.7 No.-
This study was conducted to find out the suitable gradient and length of the slope from the landslide of banking slope and cutting slope caused by rainfall. The survey was carried out on forest road built in 1986. And the period of survey was from June, 1989 to August, 1989 after dividing the forest road into A and B. The survey plots consisted of the 12 banking slopes and 6 cutting slopes. The results obtained from the study were summarized as follows; 1. The rate of landslide appeared 75% in A forest road, 50% in B forest road, and then the average 67% in A and B forest road. But the value of landslide showed considerably low. 2. Because of landslide chiefly occuring on banking slope of 36˚∼38˚ and on cutting slope of 42˚∼ 43˚, it is suitable to decide the banking slope and cutting slope below each 36˚and 40˚. 3. Landslide was the same on banking slopes through the length of slope. The best suitable length of slope is below 4m in cutting slope.