The Age-related Microstructural Changes of the Cortical Gray and White Matter Ratios on T2-, FLAIR and T1- weighted MR Images

최순섭,김휘영,이기남,하동호,강명진,이진화,윤성국 대한자기공명의과학회 2011 Investigative Magnetic Resonance Imaging Vol.15 No.1

Purpose : The purpose of this study was to investigate the microstructural changes according to aging on the thickness and signal intensity (SI) of the cortical gray matter (GM) and white matter (WM) on the T2-, fluid-attenuated inversion recovery (FLAIR)and T1- weighted MR images in normal subjects. Materials and Methods : The 10, 20, 30, 40, 50, 60, 70, 80 and 90 year age groups of men and women (each 10 individuals) who underwent routine brain MRI, including the T2-, FLAIR and T1- weighted images, were selected for this study. We measured the thickness and the SI of the cortical GM and WM at the postcentral gyrus, which has an even thickness at the level of centrum semiovale, on the axial scans and we calculated the mean values of the thickness ratio of the gray/white matter (TRGW)and the signal intensity ratio of the gray/white matter (SRGW), and we compared the ratios of each age group. Results : On the T2-weighted images, the TRGWs were 0.81 and 0.79 at the age of 10and they were 0.73 and 0.71 at the age of 90 in the men and women, respectively. So,the GM thickness was decreased more than the WM thickness was with aging. On the FLAIR images, the TRGWs were 1.09 and 1.00 at the age of 10 and they were 1.11 and 0.95 at the age of 70 in the men and women, respectively. On the T1-weighted images, the TRGWs were 0.66 and 0.80 at the age of 10, and the ratio was changed to 0.90 and 0.78 at the age of 90 in the men and women, respectively. On the T2-weighted image, the SRGWs were 1.53 and 1.43 at the age of 10, and they were 1.23 and 1.27 at the age of 90 in the men and women, respectively. On the FLAIR images, the SRGWs were 1.23 and 1.25 at the age of 10 and they were 1.06and 1.05 at the age of 90 in the men and women, respectively. On the T1-weighted images, the SRGWs were 0.86 and 0.85 at the age of 10, and they were 0.90 and 0.87at the age of 90 in the men and women, respectively. Conclusion : We suggest that the age-related microstructural changes of the thickness and the SI of the cortical GM and WM on the T2-, FLAIR and T1- weighted images are unique, and so this knowledge will be helpful to differentiate neurodegenerative disease from normal aging of the brain. 목적: 정상인의 나이에 따른 뇌피질의 회질과 백질의 T2 강조, FLAIR, T1 강조 영상에서의 두께와 신호강도의 미세구조 변화 양상을 알고자 한다. 대상 및 방법: 남녀 각각 10 명씩의 10세, 20세, 30세, 40세, 50세, 60세, 70세, 80세, 90세 군의 T2, FLAIR, T1강조 MR영상을 이용하였다. 뇌의 난형중심 부위의 축상영상에서 일정한 두께를 보이는 후중심뇌회 부위에서 피질의회질과 백질의 두께와 신호강도를 측정하여, 각 군의 평균값을 구하여 나이 증가에 따른 회질/백질 두께 비와 회질/백질의 신호강도 비의 변화 양상을 비교 관찰하였다. 결과: T2 강조영상에서 회질/백질 두께 비는 남녀 각각 10세에는 0.81과 0.79, 90세에는 0.73과 0.71로써 회질이백질의 두께보다 더 감소하였으며, 회질/백질 신호 비는 10세에는 1.53과 1.43, 90세에는 1.23과 1.27로써 남녀 각각 20%와 11% 감소하였다. FLAIR 영상에서 회질/백질 두께 비는 남녀 각각 10세에는 1.09와 1.00, 70세에는1.11과 0.95였으며, 회질/백질 신호 비는 10세에는 1.23과 1.25, 90세에는 1.06과 1.05로써 남녀 각각 14%와16% 감소하였다. T1 강조영상에서 회질/백질 두께 비는 남녀 각각 10세에는 0.66과 0.80이었고, 90세에는 0.90과0.78로 변화하였으며, 회질/백질 신호 비는 10세에는 0.86과 0.85, 90세에는 0.90과 0.87로써 남녀 각각 5%와2% 증가하였다. 결론: T2, FLAIR, T1 강조영상에서 뇌피질의 회질과 백질의 나이증가에 따른 두께와 미세신호강도의 변화 양상은 특징적이며, 이 양상을 이해하는 것은 뇌의 정상 노화와 퇴행성 질환을 구별하는데 도움을 줄 것으로 생각된다.

자기공명영상에서의 퇴행성척추판단 변화와 추간판염의 감별진단

최순섭 대한영상의학회 1994 대한영상의학회지 Vol.30 No.6

요독증 가토에서 Gd-DTPA에 의한 혈뇌장벽 및 뇌조직 손상

최순섭 대한영상의학회 1996 대한영상의학회지 Vol.35 No.6

Purpose : An experimental study was carried out to evaluate the morphological changes in the blood brainbarrier and neighbouring brain tissue caused by Gd-DTPA in uremia-induced rabbits. Materials and Methods :Bilateral renal arteries and veins of ten rabbits were ligated. Gd-DTPA(0.2 mmol/kg) was intravenously injectedinto seven rabbits immediately after ligation. After MRI, they were sacrificed 2 or 3 days after ligation in orderto observe light and electron microscopic changes in the blood brain barrier and brain tissue. Results : MRIfindings were normal, except for enhancement of the superior and inferior sagittal sinuses on T1 weighted imagesin uremia-induced rabbits injected with Gd-DTPA. On light microscopic examination, these rabbits showedperivascular edema and glial fibrillary acidic protein expression ; electron microscopic examination showedseparation of tight junctions of endothelial cells, duplication/rarefaction of basal lamina, increased lysosomesof neurons with neuronal death, demyelination of myelin, and extravasation of red blood cells. Uremia-inducedrabbits injected with Gd-DTPA showed more severe changes than those without Gd-DTPA injection. Conclusion :Injuries to the blood brain barrier and neighbouring brain tissue were aggravated by Gd-DTPA administration inuremia-induced rabbits. These findings appear to be associated with the neurotoxicity of Gd-DTPA.

갑상선결절의 고해상능 초음파검사 소견

최순섭 대한영상의학회 1985 대한영상의학회지 Vol.21 No.4

Ultrasonography, it's excellent ability of differentiating cystic from solid lesion and depicting detailed architecture, proved itself useful in the diagnosis of thyroid pathologies. Advanced high resolution equipments made hdden small lesion detected and finer structure clearly seen. They seemed to throw light on the histological diagriosis of thyroid diseases, especially differentiation of benignancy and malignancy. Author reviewed pictures of high-resolution ultrasonography of thyroid disease (24 cases) and correlated them with proven pathological findings. The results were as follows: 1. Multiplicity of lesion favors benignancy (4 cases). 2. Well defined margin favors benignancy (14/17), while ill defined margin favors malignancy (3/4), and lesion of no margin favors thyroiditis (3/3). 3. Surrounding halo favors benignancy (7 cases). 4. Hypoechogenicity were found in most of malignancy and thyroiditis. Cystic components in solid nodule were common findings in benign and ma ignant lesions. Calcification was not found in malignancy.

부비동의 CT 및 MRI

최순섭 釜算慶南耳鼻咽喉科學會 1993 임상이비인후과 Vol.4 No.2

백내장의 초음파소견

최순섭 대한영상의학회 1985 대한영상의학회지 Vol.21 No.5

Examining the eye with high resolution ultrasonography, authors encountered 34 cases(41 eyeballs) of cataract and found out its characteristic ultrasonographic findings, though cataract is easily recognized by physician on inspection. Ultrasonographic findings of cataract were as follows; 1. Thickening of lens dut to edema. 2. Demonstration of lens echo in whole circumference. 3. Multiple internal lens echo.

나이와 뇌실질부피 변화 및 혈관이상에 따른 총뇌혈류량 변화: 이차원 위상대조 자기공명영상을 이용한 연구

최순섭,Liu Haiying,신태범,윤성국,오종영,이영일 대한자기공명의과학회 2004 Investigative Magnetic Resonance Imaging Vol.8 No.1

대후두공을 기준으로 한 뇌교와 소뇌편도의 정상위치 : 자기 공명영상을 이용한 계측

최순섭,이영일,정덕환 동아대학교의과대학 1992 동아의대학술지 Vol.4 No.1

타자의 영역을 점유한 시선이 형성하는 경계 감각에 관한 연구 ( A Study on the Creation of Sense of the Threshold by the Gazes that Occupy the Realm of The Others )

최순섭,김광현 대한건축학회 2002 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.22 No.2

중요 혈액 구성성분이 혈액 CT 번호에 미치는 영향 : 실험적 연구

최순섭 대한영상의학회 1992 대한영상의학회지 Vol.28 No.4

The study was undertaken to evaluate the effect of major blood components on the CT number. The CT numbers according to the various levels of hematocrit, total protein and cholesterol were checked and analyzed by the dilution of pack cell, plasma and 184 complete blood cell count samples under same scanning conditions. In case of normal protein and cholesterol level (33 samples), the CT number was increased about 5.5 hounsfield unit according to 10% increase of hematocrit level: and In case of normal hematocrit and cholesterol level(39 samples), the CT number was increased about 3.5 hounsfield unit according to 1gm% increase of protein level. CT number changes were not predictable according to the changes of cholesterol level(34 samples). From these results, we concluded that major blood component should be considered in the CT number analysis of tissue.