부분적 무치증을 동반한 법랑질 형성부전 환자의 치험례

윤형석,김용기 大韓小兒齒科學會 1992 大韓小兒齒科學會誌 Vol.19 No.2

Enamel hypoplasia may be defined as an incomplete formation of the organic enamel matrix of teeth can be derived from a variety of local and systemic factors. A 9-year-old female patient with a chief complaint of abnormal crown shape with partial anodontia came to the clinic for complete rehabilitation. Family history revealed the presence of notched central incisors in her brother and VDRL was performed to rule out congenital syphilis which responded positively in this case. Functional orthodontic appliance were delivered to increase vertical dimension and hypoplastic teeth were restored either stainless steel crown or composite resin restoration. Congenital missing and extracted areas were recovered by delivering upper and lower removable acrylic partial dentures.

HPLC-MS/MS를 이용하여 혈장 중 레보티인정의 정량분석

채석,오형근,이상선,김형기,손동렬,염윤기,맹주양,권준택 순천향의학연구소 2008 Journal of Soonchunhyang Medical Science Vol.14 No.2

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Midazolam의 백서 기관평활근 이완효과와 Flumazenil의 길항작용

윤석화,신용섭,손수창,이원형,김혜자,최세진 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2

Midazolam have been used widely as adjuvants in both regional and general anesthesia and in high risk patients in the intensive care unit. In the present study we evaluated the effect of midazolam and antagonistic effect of flumazenil on isolated rat tracheal preparations mounted for recording isometric contractile force. Trachea smooth muscle were contracted with acetylcholine (10^-5M, Ach) and potassium chloride (40mM KC1). Midazolam 5x10 exp (-6)M and 5x10 exp (-5)M produced dose-dependent relaxation and flumazenil (3.2 x 10 exp (-7)M), central antagonist of benzodiazepine, pretreatment had no significant change midazolaminduced relaxation. Midazolam probably did not relax airway smooth muscle by activatong central benzodiazepine receptors, as flumazenil did not block the concentration-related relaxation of midazolam. Our study suggests that flumazenil may be used satety for asthmatic patients who have been with midazolam, as flumazenil did not antagonize airway relaxation elicited by midazolam.

Glutaraldehyde의 농도 및 pH에 따른 항균효과 및 결체조직에 미치는 자극에 관한 비교연구

윤형석,김용기 大韓小兒齒科學會 1993 大韓小兒齒科學會誌 Vol.20 No.1

The purpose of this study was to compare the antmicrobial and irritational effects of various glutaraldehyde groups under defferent concentrations along with pH levels on two species of microorganisma,S.aureus and S. sanguis, and dorsal connective tissue of 16 Sprague Dawley rats. The results can be summarized as follows: 1.The intensity of antimicrobial effects on two tested species increased as the concentration of glutaraldehyed got higher. 2.Buffered groups demonstrated stronger antimicrobial effects over unbufferde groups under all tested concentrations and showed statistically significant differences(<0.05) except 10% S. sanguis group. 3.The results of connective tissue reaction study showed the general increased in severity of tissue irritation and in the diffusion of fixed tissue layer. 4.No apparent histological differences could be found in the degree of tissue irritation between buffered and unbuffered glutaraldehyde groups. 5.The overall picture of histological ovservation demonstrated the decrease of inflammatory response with time and no notably different findings bwtween experimental groups were indicated after 4 weeks of test periods.

정맥내 통증자가조절법을 이용한 Nalbuphine-Ketorolac과 Butorphanol-Ketorolac의 술후 진통효과 비교

윤석화,이원형,손수창,신용섭,김윤희,양신영 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

This study aimed to compare analgegic efficacy, satisfaction score and side effect of nalbuphine-ketorolac and butorphanol-ketorolac by using intravenous patient controlled analgesia(IV-PCA) for postoperative anlgesia following a gastrectomy for stomach cancer. Ninety patients who had undergone gastrectomy for stomach cancer under general anesthesia were randomly divided into two groups. Each group recieived nalbuphine 50mg with ketorolac 150mg(Group 1, n=45) and butorphanol 5mg with ketorolac 150mg(Group 2, n=45) by using IV-PCA during postoperative 48hrs. Assessments for pain with numerical rating scale(NRS), and side effects were evaluated at 2hr, 6hr, 12hr, 24hr, 36hr and 48hr after the operation. There were no significant difference in NRS for pain during rest, but Group 2 requested significantly greater amount of supplementary diclofenac during first 24 hours. Side effects were higher Group 1 in pruritus, nausea and vomiting and Group 2 in sedation, nausea and vomiting. This study suggests that adding ketorolac with intravenous nalbuphine or butrophanol in using an intravenous PCA can decrease analgesics requirement and improve analgesic property without the major morbidity like respiratory depression, but needs for the careful observation and treatment on the side effects like nausea. vomiting, pruritis and sedation...

6상 여자방식을 이용한 7상 BLDC 전동기 구동시스템

전윤석,이용균,목형수 건국대학교 산업기술연구원 2003 건국기술연구논문지 Vol.28 No.-

3-Phase BLDC Motor, which is generally used, has limited usage in high speed, due to pulsation torque occurring commutation and variable speed. To solve this problem, it is necessary to increase invariable, pole number or the number of slots. Currently, due to rapid growth of semiconductor technology and trend toward smaller and cheaper production of switching device, Multi-Phase BLDC Motor for high speed and high output power is being actively pursued to produce. In this paper 7-Phase BLDC Motor drive system and controller are designed and 7-Phase modulation method with 6-Phase conduction is studied for ideal operation of controller.

한국인에서의 CYP2C19 돌연변이 유전자형의 다형성에 관한 연구

채석,채상우,양동규,김형기,권준택,염윤기 순천향의학연구소 2000 Journal of Soonchunhyang Medical Science Vol.6 No.2

The S-mephenytoin 4'-hydroxylase (CYP2C19) metabolizes a number of clinically used drugs and shows a marked interethnic difference in the incidence of the poor metabolizer (PM). Recent studies have found a third (CYP2C19*4) and forth (CYP2C19*5) mutations in Caucasians. In the present study, we genotyped 536 healthy unrelated Koreans for functionally defective alleles, CYP2C19*2, CYP2C19*3, CYP2C19*4, and CYP2C19*5. Detection of the normal (CYP2C19*1) and defective alleles was performed by polymerase chain reaction/restriction enzyme analysis. The genomic DNA was isolated from peripheral blood. The allelic frequencies of the wild-type (CYP2C19*1) and CYP2C19*2 were 72.6% and 27.4%, and the wild-type (CYP2C19*1) and CYP2C19*3 were 85.1% and 14.9%, respectively. For each CYP2C19*2 and CYP2C19*3 the observed number of three genotypes were similar to those calculated in accordance with the Hardy-Weinberg equation. The frequencies of homozygotes for CYP2C19*2, CYP2C19*3 and compound heterozygotes were 9.7%, 2.8% and 4.2%, respectively. The mutants of CYP2C19 were identified in 36 subjects (16.7%). The mutated CYP2C19*4 and CYP2C19*5 alleles were not detected in this study. These results suggest that frequency of mutants of CYP2C19 in Koreans resembled the Orientals rather than Caucasians, and we founded the racial variability of the frequencies of the CYP2C19*4 and CYP2C19*5 alleles in the Orientals.

Urapidil, Labetalol의 투여가 기관내 삽관시 심혈관계에 미치는 영향

신용섭,윤석화,손수창,이원형,이정은,황원재,김만수,김영주,김혜자,최세진 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

We have examined the comparative efficacy of small doses of intravenous urapidil and labetalol in blunting hemodynamic response to endotracheal intubation and surgical incision in 30 patients without cardiovascular diseases. After intravenous urapidil 0.2 mg/kg or labetalol 0.2 mg/kg anesthesia was induced with thiopental 5mg/kg. Endotracheal intubation was facilitated by vecuronium 0.15 mg/kg with priming principle and anesthesia was maintained with enflurane and nitrous oxide in oxygen. Systolic, diastolic and mean arterial pressure and heart rate were measured before administration of the drugs, 5 minute after administration, just prior to endotracheal intubation and 1, 3, 5, 10 minute after intubatin. Also the peak blood pressures and heart rate within 10 minutes after surgical incision were measured. Endotracheal intubation and surgical stimulation were associated with significant increases in blood pressures and heart rate in both urapidil and labetalol group. Comparison of the changes in systolic, diastolic, and mean artrial pressures and heart rate between urapidil and labetalol group showed no significant difference except peak systolic pressure after surgical incision. It is concluded that the pressor response to endotracheal intubation and surgical stimulation are not influenced significantly by urapidil 0.2 mg/kg or labetalol 0.2 mg/kg. However, urapidil and labetalol preloading may be similarly effective in the blunting of the increases in blood pressures with larger doses of the durgs during anesthetic induction.

장루 보유자의 생활 만족도 조사

서현석,이석환,고영관,오수명,윤충,주흥재,이기형 대한대장항문학회 1998 Annals of Coloproctolgy Vol.14 No.3

비만을 동반한 위암 환자에서 두 병을 같이 수술 치료한 경험(증례)

최경현,윤기영,문형환,신연명,서경원,안수미,송윤미,석정희,정경연,이은하 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.3

Obesity is growing problem in Korea. We had a case of bariatric surgery during gastric cancer operation. Patient was 29 year old Korean lady with early gastric cancer located in the lesser curvature side of the middle 1/3 of the stomach. Her body weight was 89 kg, height 163 cm, and thus body mass index was 33.5 kg/m2. Preoperative blood pressure was 130/90 mmHg, hemoglobin 12.9 g/dL, total lymphocyte count 3,280/mL, serum albumin 4.3 g/dL, CEA 1.1 ng/mL, CA 19-9 9.1 ng/mL, and alpha fetoprotein 2 ng/mL. Another associated disease was right thyroid follicular neoplasm. The chest X-ray was normal. After IM injection of 2,500 units of heparin 30 minutes before the induction of general anesthesia, she received curative subtotal gastrectomy and Roux en Y gastrojejunostomy when a malabsorption loop of 120 cm jejunum was incorporated between the Treitz ligament and the end to side jejuno-jejunostmy site at May 29th 2006. Her postoperative course was uneventful except a minor wound seroma and the elevations of serum amylase(up to 4 folds) and lipase(up to 2 folds). She lost her body weight 9 kg in 5th, 21 kg in 7th, and 27 kg in 10th postoperative months to became 61.5 kg. On follow up exams in July 2008, she gained 4 kg to overcome her weakness and fatigue. From the above result, the incorporation of a malabsorption loop during reconstruction phase of gastric cancer operation was a good option for obese gastric cancer patients especially in cases of early gastric cancer.