위암환자의 복강내에 투여한 Mitomycin C-Carbon Particle의 Mitomycin 용출에 관한 연구

노승무,조영훈,정경수,오정연,김진향,양준묵,강대영,송규상,조준식,최선웅,이진호,민병무,김용백,김창식,박근성,인현빈,정현용,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherpy seems a logical choice for cancer chemotherapy. The Mitomycin C(MMC) adsorbed by the activated charcoal particles(CH) is relatively released when the drug concentration surrounding the carbon particles becomes low in the peritoneum of the peritoneal cavity. For the intraperitoneal chemotherapy on the advanced gastric adenocarcnoma, mitomycin C adsorbed on activated carbon particles was administered in the peritoneal cavity just before abdominal wall closure. The closed drainage tubes were inserted in the peritoneal cavity and clamped for tuo hours after completion of operation. MMC concentrations were serially measured in peritoneal fluid, plasma and urine at 2hour, 48 hour, 72 hour and 168 hour following its administration in order to study the efficacy of the MMC-CH as a drug delivery system. There were minimal toxicities in born marrow, liver, and gastrointestinal system after intraperitoneal MMC-CH administration. The data of this study suggested that MMC-CH may have a somewhat more beneficial effect than surgery alone when administered in optimal dose and schedules, but the MMC concentration of the peritoneal fluid was not sufficient to eradicate remnant cancer cells, and effective duration of maintenance was only below 24 hours in the peritoneal fluid and plasma.

Rat의 복강에 삽입한 Fluorouracil-Polyglycolic acid 제형의 Fluorouracil 용출에 관한 연구

노승무,정경수,오정연,김진향,양준묵,강대영,송규상,최정목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1

A common form of relapse in adenocarcinoma of the stomach is intraperitoneal dissemination, in fact, among gastric adenocarcinoma patients who have undergone surgery intended to cure, approximately 50% of the patients develope initial recurrence in the peritoneal cavity regardless of the anatomic site of the primary tumor within the stomach. The efficacy of systemic postoperative chemotherapy to prevent peritoneal recurrence of gastrric adcnocarcinoma is not satisfactory. There is still a great need for improved therapeutic strategies on the disseminated microscopic disease and small miliary nodules remaining on the peritoneal surface or lymphatics after operation. The authers have made fluorouracil-polyglycolic acid composite disks(Fu-PGA disks) with fluorouracil and biodegradable polymer: polyglycolic acid for more effective intraperitoneal chemotherapy. We inserted the Fu-PGA disk(s) in the peritoneal cavity of rat and pharmacokinetic study was performed to measure fluorouracil concentration in the peritoneal fluid, plasma, liver, kidney and heart tissue at 24 hour, 72 hour and 168 hour after insertion of Fu-PGA disk(s). Myelosuppressive action of this composite also was determined following its administration. The data of this study suggested that Fu-PGA composite will be a new device releasing drugs in a controlled manner and having targetability to peritoneum, and this device will be improving the efficacy of intraperitoneal chemotherapy for gastric adenocarcinoma.

Rat의 복강에 삽입한 Filorouracil-Polyglycolic acid제형의 Fluorouracil용출에 관한 연구

노승무,정경수,오정연,김진향,양준묵,강대영,송규상,최정목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

A common form of relapse in adenocarcinoma of the stomach is intraperitioneal dissemination, in fact, among gastric adenocarcinoma patients who have undergone surgery intended to cure, approximately 50% of the patients develope initial recurrence in the peritoneal cavity regardless of the anatomic site of the primary tumor within the stomach. The efficacy of systemic postoperative chemotherapy to prevent peritoneal recurrence of gastrric adenocarcinoma is not satisfactory. There is still a great need for improved therapeutic strategies on the disseminated microscopic disease and small miliary nodules remaining on the peritoneal surface or lymphatics after operation. The authers have made fluorouracil-polyglycolic acid composite disks(Fu-PGA disks) with fluorouracil and biodegradable polymer: polyglycolic acid for more effective intraperitoneal chemotherapy. We inserted the Fu-PGA disk(s) in the peritoneal cavity of rat and pharmacokinetic study was performed to measure fluorouracil concentration in the peritoneal fluid, plasma, liver, kidney and heart tissue at 24 hour, 72 hour and 168 hour after insertion of Fu-PGA disk(s). Myelosuppressive action of this composite also was determined following its administration. The data of this study suggested that Fu-PGA composite will be a new device releasing drugs in a controlled manner and having targetability to peritoneum, and this device will be improving the efficacy of intraperitoneal chemotherapy for gastric adenocarcinoma.

임산부에서 발병한 신낭종 감염 1예

노현진 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

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V₂O-B₂O₃-PbO 유리의 전자 상자성 공명연구

노태호,전인,박영민,강재필,김성재,박현진,송승기 명지대학교 자연과학연구소 1996 자연과학논문집 Vol.14 No.-

V₂O??-B₂O₃-PbO 유리의 VO??에 관한 전자 상자성 (EPR) 스펙트럼으 연구하였으며, vanadium이온의 스핀해밀토니안 상수들을 구하였다. 유리시료안의 V₂O??양을 증가시킴에 따라 g??과 g??값은 증가하였으나 A??과 A??값은 감소하였다. 이는 V₂O??수가 증가하면 동일 평면상의 vanadium과 oxygen배위간 결합의 공유성이 증가함을 의미한다. 유리내의 vanadium 4가이온은 정방형 일그러진 8면체를 한 vanadyl착물로 존재한다. Electron Paranmagnetic Resonance(EPR) SPECTRA OF (VO)?? in V₂O??-B₂O₃-PbO glasses have been studied and spin hamiltonian paramenters of vanadium ion have been calculated. It is found that the value of g??and g?? increases while the value of A?? and A?? decreases with an increase of V₂O?? content in the glass samples, showing that the covalency in the in-plane vanadium -oxygen ligand bonds increase with increasing the concentration of V₂O??. The tetravalent vanadium ions exist as vanadyl complexes with tetragonally distorted octahedral sites in the glasses.

웹 기반 건설 하도급 대금지불 프로세스 모델

노준오,이현종,구교진,현창택 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1

The purpose of this study is to improve the subcontract payment process in domestic Construction industry. This study researches the previous documents and payment processes of construction company so that improves subcontract payment process. Recently, subcontract increase with time in domestic construction industry. But many subcontract companies have difficulty in financing problems because of unreasonable practice. Requesting a payment, contractor and subcontractor make out a payment so their time and effort necessarily were spent. Therefore unnecessary things are removed in subcontract payment process so that settle a reasonable subcontract payment process.

위전절제시 단순공장간치술의 임상적 의의

노승무,배진선,정현용,이병석,조준식,신경숙,송규상,이태용 충남대학교 암연구소 2003 암연구소 업적집 Vol.3 No.-

Purpose: The aim of this study was to evaluate the short-term outcome of a jejunal interposition, by comparing it with a conventional Roux-en-Y gastrojejunostomy, after a total gastrectomy. Materials and Methods: For 28 patients (20 men and 8 women) with a gastric adenocarcinoma, who underwent an isoperistaltic simple jejunal interposition, weight, hemoglobin, hematocrit, serum protein and albumin, and cholesterol levels were checked before the operation and at 1 year and 2 years after the surgery. Also, endoscopy was performed to confirm reflux esophagitis. In this study, the data were collected between January 1993 and July 1999 at Chungnam National University Hospital, and the results were compared with those of the Roux-en-Y procedure. Results: The body weights at 1 year and 2 years after the surgery had returned to 86.0% and 87.6% of the recent original body weight in the jejunal interposition (Jl) group and to 90.8%, 87.0%, respectively in the Roux-en-Y (RY) group. The levels of hemoglobin (g/dl) were 13.3, 12.5, and 11.9 in the Jl group, and 13.8, 12.6, and 12.1 in the RY group at the time of the operation and at 1 year, and 2 years after the surgery, respectively. The total serum protein (g/dl) levels were 7.1, 7.2, and 7.5 in the Jl group and 7.1, 7.0, and 7.2 in the RY gropu at the time of the operation and at 1 year and 2 years after the surgery, respectively. The serum albumin (g/dl) levels were 4.2, 4.1, and 4.2 in the Jl group and 4.2, 4.2, and 4.2 in the RY group at the time of the operation and at 1 year, and 2 years after the surgery, respectively. The total serum cholesterol (mg/dl) levels were 186.5, 174, and 164 in the Jl group and 213.7, 171.1, and 141.0 in the RY group at the time of the operation and at 1 year and 2 years after the surgery, respectively. The endoscopic finding showed that reflux esophagitis occurred in 7.1% of the patients in the Jl group and in 3.5% in the RY group. Conclusion: We think that from the view point of quality of life, a jejunal interposition, as well as a Roux-en-Y procedure, is a useful reconstruction methods for a total gastrectomy. (J Korean Gastric Cancer Assoc 2001;1:210-214)

위전절제시 단순공장간치술의 임상적 의의

노승무,배진선,정현용,이병석,조준식,신경숙,송규상,이태용 충남대학교 암공동연구소 2003 암공동연구소 업적집 Vol.3 No.

Purpose: The aim of this study was to evaluate the short-term outcome of a jejunal interposition, by comparing it with a conventional Roux-en-Y gastrojejunostomy, after a total gastrectomy. Materials and Methods: For 28 patients (20 men and 8 women) with a gastric adenocarcinoma, who underwent an isoperistaltic simple jejunal interposition, weight, hemoglobin, hematocrit, serum protein and albumin, and cholesterol levels were checked before the operation and at 1 year and 2 years after the surgery. Also, endoscopy was performed to confirm reflux esophagitis. In this study, the data were collected between January 1993 and July 1999 at Chungnam National University Hospital, and the results were compared with those of the Roux-en-Y procedure. Results: The body weights at 1 year and 2 years after the surgery had returned to 86.0% and 87.6% of the recent original body weight in the jejunal interposition (Jl) group and to 90.8%, 87.0%, respectively in the Roux-en-Y (RY) group. The levels of hemoglobin (g/dl) were 13.3, 12.5, and 11.9 in the Jl group, and 13.8, 12.6, and 12.1 in the RY group at the time of the operation and at 1 year, and 2 years after the surgery, respectively. The total serum protein (g/dl) levels were 7.1, 7.2, and 7.5 in the Jl group and 7.1, 7.0, and 7.2 in the RY gropu at the time of the operation and at 1 year and 2 years after the surgery, respectively. The serum albumin (g/dl) levels were 4.2, 4.1, and 4.2 in the Jl group and 4.2, 4.2, and 4.2 in the RY group at the time of the operation and at 1 year, and 2 years after the surgery, respectively. The total serum cholesterol (mg/dl) levels were 186.5, 174, and 164 in the Jl group and 213.7, 171.1, and 141.0 in the RY group at the time of the operation and at 1 year and 2 years after the surgery, respectively. The endoscopic finding showed that reflux esophagitis occurred in 7.1% of the patients in the Jl group and in 3.5% in the RY group. Conclusion: We think that from the view point of quality of life, a jejunal interposition, as well as a Roux-en-Y procedure, is a useful reconstruction methods for a total gastrectomy. (J Korean Gastric Cancer Assoc 2001;1:210-214)

공황장애 환자의 성격요인과 방어기제의 특성에 관한 연구

심진현,백상빈,신영철,오강섭,노경선,이시형 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

연구목적: 본 연구는 공황장애 환자들을 대상으로 성격요인과 방어기제 검사를 실시하였으며 우울 및 사회기능 정도를 측정하여 상관관계를 알아보았다. 방 법: 1997년 9월부터 1998년 8월까지 환자들중 공황장애로 진단된 35명을 대상으로 성격요인검사(Sixteen Personality Questionnaire 한국판) 및 방어기제검사(이화방어기제검사)를 시행하여 스텐점수(1-10)화 하였고, 우울증척도(Beck Depressive Inventory 한국판) 및 사회기능장애척도(Sheehan Disability 한국판)를 시행하였다. 결 과: 1) 개별항목 (1) 성격요인과 방어기제의 척도별 평균점수에서 정상보다 높거나(8점이상) 낮은(3점이하) 척도는 없었다. (2) 성격요인중 불안감이 높았고 자아강도, 신중성, 사변성은 낮은 점수를 보였다. (3) 방어기제중 신체화, 행동화의 점수가 높았고 유우머, 억제, 이타주의, 회피, 합리화는 낮은 점수를 보였다. (4) BDI의 평균점수는 18.25±9.97이었다. (5) SDS의 평균점수는 업무항목 4.88±3.11. 사회활동/오락활동항목 4.57±2.92였다. 2) 상관관계 (1) 성별간 비교에서 성격요인은 사변성, 죄책감을 방어기제는 허세, 부정, 수동공격, 투사를 남성 이 높게 보였다(p<0.05). (2) 연령증가는 성격요인중 낮은지능과 방어기제는 예견, 해리와 상관을 허세와 역상관을 보였다(p<0.05). (3) BDI 점수는 성격요인중 지능도, 자아강도, 도덕성, 죄책감, 통제력, 불안감등과 방어기 제중 해리, 신체화등과 유의미한 상관관계를 나타냈다(p<0.05). (4) 사회기능장애척도의 업무항목은 성격요인중 죄책감, 진보성, 불안감, 도덕성과 방어기제의 신 체화, 투사등과 유의미한 상관이 있었고, 사회/오락활동항목은 성격요인의 죄책감, 불안감과 방어기제중 허세, 투사 등과 유의미한 상관관계가 있는 것으로 나타났다(p<0.05). 3) BDI와 사회기능장애척도의 업무항목간에는 유의미한 상관관계가 있는 것으로 나타났다(p<0.05). 결 론: 공황장애 환자는 성격요인검사상 불안감이 높고 자아강도, 신중성, 사변성은 낮게 나타 났으며, 신체화 등의 신경증적 방어기제를 주로 사용하는 반면 유우머, 억제, 이타주의, 회피, 합리화의 방어기제는 적게 사용하는 것으로 나타났다. 증상의 강도와 관련이 있는 우울증상은 업무활동에 영향을 미쳐 이와 관련된 중등도의 사회기능의 장애를 초래하고 있는 것으로 보인다. Objectives : The purpose of this study was to evaluate the characteristics of personality factor and defense mechanism and relationship with depression and disability. Methods : Study subjects consisted of 35 panic disorder patients diagnosed with the criteria of DSM-Ⅳ. Data were collected through Sixteen Personality Factor Questionnaire, Ehwa Diagnostic Test of Defense Mechanism, Beck Depression Inventory and Sheehan Disability Scale. Statistics employed for the analyses were Pearson correlation and independent sample t-test. Results : In personality factors and defense mechanisms, there were no definitely abnormal range of scores. But, among personality factors, tension/anxiety factor scored high and unstableness/stableness, shyness/boldness and praxernia/atunia were in low range of score. In defense mechanism, somatization and acting-out scored high and humor, suppression, altruism, avoidance and rationalization scored low. The mean BDI score was 18.25±9.97. The mean score of SDS were 4.88±3.11 in work category and 4.57±2.92 in social/leasure category. Male patients were significantly correlated with guit-proneness and atuia in personality factor and passive-aggressiveness, projection, denial and show-off in defense mechanism, compared with female patients(p<0.05). The patients` age was correlated with low intelligence in persolity factor and dissociation and anticipation in defense mechanism. It was negatively correlated with show-off(p<0.05). The BDI score was correlated with low intelligence, superego, unstableness, self-conflict, high superego and atunia in personality factor and dissociation and somatization in defense mechanism(p<0.05). There was a significant relationship between BDI score and SDS work category(p<0.05). Conclusions: Panic disorder patients show high score of tension/anxiety factor and they frequently use neurotic defense style like somatization. The depressive symptom, which depends on symptom severity, appears to have influence on work category and to cause social disability.

과학 수행 평가 문항의 선정 및 제작을 위한 평가 준거의 개발

김은진,박현주,강호감,노석구 한국과학교육학회 2003 한국과학교육학회지 Vol.23 No.1

본 연구에서는 과학교육에서 수행평가의 올바른 사용과 정착을 위하여 과학 수행평가문항의 선정과 제작을 위한 평가준거를 개발하였다. 이를 위하여 과학과 평가목표 및 수행평가에 대한 이론적 논의를 통해 평가준거의 대범주로 평가 목표의 충실도(Fidelity), 수행평가의 특징과 구성 요소에 대한 만족도(Satisfaction), 문항의 내용 타당도(Content Validity), 학습자에 대한 내용의 적합도 및 공정성(Suitability & Fairness), 문항의 신뢰도와 객관도(Reliability & Objectivity), 사용상의 편의성 및 실용성(Usability)의 6가지 범주를 개발하였고, 각 대범주별 하위항목을 선정하여, 총 25개의 하위 항목을 가진 평가준거표를 개발하였다. 그리고 개발된 평가준거표의 타당도는 과학교육 연구자 5명의 안면타당도로 보았고, 신뢰도는 3가지 종류의 과학 수행평가문항을 과학교육 전문가 2명과 초등예비교사 6명이 평가하교, 그 결과를 Kendall계수를 통한 평가자간 합치도로 검증하였다. 그 결과 합치도는 통계적으로 유의한 수준으로 나타났다. 이상의 과정을 통하여 최종적인 평가준거표를 완성하여 제시하였다. We have developed of a criterion that would help to select and develop performance assessments in science education. There are six categories of a criterion: Fidelity, satisfaction, content validity, fairness & suitability, reliability & objectivity, and usability. There are the total of 25 sub-categories under the six categories. Five science educators evaluated the validity of the criterion. For reliability of the criterion, Kendall's tau-b was used. Eight science educators and elementary teachers evaluated three performance assessment tasks for the correspondence of the criterion. This study also discuss the implications of this criterions as well.