White luminescence of Ho3+/Tm3+/Yb3+-codoped CaWO4 synthesized via citrate complex route assisted by microwave irradiation

CHO, Hyun,HWANG, Seok Min,LEE, Jae Bin,KA, Dong Hyun,KIM, Tae Wan,LEE, Bo Seul,LEE, Ji Young,LEE, Jung-Il,RYU, Jeong Ho Elsevier 2014 Transactions of Nonferrous Metals Society of China Vol.24 No.suppl1

FCT 5 : Fractional laser-assisted topical imiquimod 5% cream treatment for recalcitrant common warts in children

( Hyun Chang Ko ),( Jeong Min Kim ),( Hyun Ho Cho1 ),( Won Jeong Kim ),( Je Ho Mun ),( Margaret Song ),( Hoon Soo Kim ),( Byung Soo Kim ),( Moon Bum Kim ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: Conventional destructive modalities for warts like cryotherapy or laser ablation have some limitations that are excruciating pain during procedure, in especially pediatric patients. Imiquimod is a topical immune response modifier that was approved for treating genital and perianal warts. But, thick stratum corneum of common warts may act as a barrier against drug permeation via the skin. Objectives: To evaluate efficacy and safety of above treatment. Methods: Eleven pediatric patients (6 female and 5 male, mean age 12.5 years) were included in this study. The lesions were treated by fractional 2940 nm Er:YAG laser for achieving the penetration of stratum corneum with 1 or 2 weeks intervals. Then, imiquimod 5% cream was self-applied once daily for 5 days a week. Assessment of response and adverse effects was performed every 2 weeks until complete clearance or up to maximum of 48 weeks. Pain during procedure was checked by VAS (0-10). Results: 8 out of 11 (72.7%) patients experienced complete clearance of all warts lesions. Mean duration of total treatment was 29.7 (16-48) weeks. Mean number of fractional laser treatment was 17.5 (8-37) times. No significant adverse effect was observed. VAS score of the pain during fractional laser treatment was 2.4 (1-4), comparing with 6.2 (5-8) during cryotherapy. Conclusion: Fractional ErYAG laser-assisted topical 5% imiquimod cream is an effective and safe treatment option for recalcitrant common warts of the children do not tolerate pain well.

시클러 캡슐(세파클러 250㎎)에 대한 경보세파클러 캡슐의 생물학적동등성

조혜영,강현아,김세미,박찬호,오인준,임동구,문재동,이용복 한국약제학회 2005 Journal of Pharmaceutical Investigation Vol.35 No.1

The purpose of the present study was to evaluate the bioequivalence of two cefaclor capsules, Ceclor (Lilly Korea Co., Ltd.) and Kyongbocefaclor (Kyongbo Pharm. Co., Ltd.), according to the guidelines of the Korea Food and Drug Administration (KFDA). The release of cefaclor from the two cefaclor formulations in vitro was tested using KP VIII Apparatus II method with various dissolution media (pH 1.2. 4.0. 6.8 buffer solution and water). Twenty four healthy male subjects. 22.96±1.52 years in age and 67.03±7.90 kg in body weight, were divided into two groups and a randomized 2x2 cross-over study was employed. After one capsule containing 250 mg of cefaclor was orally administered, blood was taken at pre-determined time intervals and the concentrations of cefaclor in serum were determined using HPLC method with UV detector. The dissolution profiles of two formulations were similar at all dissolution media. In addition. the pharmacokinetic parameters such as AUC_(t), C_(max) and T _(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t). C_(max) and untransformed Tmaa. The results showed that the differences between two formulations based on the reference drug, Ceclor. were -1.90%, 2.68% and -7.60% for AUCt, C_(max) and T_(max), respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log 0.8 to log 1.25 (e.g., log 0.91-log 1.06 and log 0.92-log 1.18 for AU', and C_(max), respectively). Thus. the criteria of the KFDA bioequivalence guideline were satisfied, indicating Kyongbocefaclor capsule was bioequivalent to Ceclor capsule.

우울증 관련 평가도구의 개관

조현주,채정호,전태연 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.2

Objective : Since a lot of assessment tools for depression have been developed and used, it is difficult to choose the proper and optimal instruments for the purpose of their usage, In order to maximize the effectiveness of assessment for depression, this paper reviewed the characteristics and specific features of currently using tools. Method : The domestically and internationally using assessment tools for depression were reviewed and classified by litera-hire search and clinical experience. Results : Methods of assessment, selecting guides and characteristics of assessment tools for depression were presented. Conclusion : This paper would provide helpful guidelines for selecting the assessment tools. We suggest that it is needed to develop the assessment tools for depression that reflects Korean specific culture and custom.

하악골에 발생된 Low grade 골육종:증례보고

조현이,정종철,김호성,최재욱,성대경,서지훈,김성범,이계혁 大韓顎顔面成形再建外科學會 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.1

Osteosarcoma is a primary malignant tumor arising most often in the long bone, but rare in jaw bone. Especially osteogenic sarcoma of the mandible is a rare tumor, comprising less than 0.5% of all head and neck tumors. Osteosarcoma occurs cheifly in young persons, and presenting very survival rates. Histopathologically this tumor can be classified three types, osteoblastic, fibroblastic, chondroblastic and classified from low grade to high grade by anaplasia or mitosis of the tumor cells. Sometimes, the exact diagnosis of osteosarcoma is difficult especially in low grade osteosarcoma, even if clinical or radiographical findings suggest to osteosarcoma. So suspcious to malignant bone tumor in clinical or radiological findings, biopsy should be taked from deep portion and multiple area, and sharing the patient history and radiographs with pathologist will assist in the development of the diagnosis. We report a case of low grade osteosarcoma on the mandible initially difficulty in accurate diagnosis. The patient visited our hospital for routine dental treatment but radiographic findings displayed ill-defined radiolucency with osteoid formation on the mandible. Final diagnosis was difficulty in initial biopsy but subsequent biopsy taked from deep portion presented infiltrative growth and mitosis of the tumor cell in some area with small osteoid bone formation, so we could reach final diagnosis as low grade sarcoma. We treated this patient with bloc resection of the mandible and immediate reconstruction with iliac corticocancellous block.

개 전염성 기관기관지염 치료 증례

조현석,김대희,송근호 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2011 動物醫科學硏究誌 Vol.18 No.1

A 8-year-old male castrated yorkshire terrier dog with a infectious tracheobronchitis was referred to the Veterinary Medical Teaching Hospital of Chungnam National University. Infectious tracheobronchitis was diagnosed by the history, clinical signs, polymerase chain reaction, laboratory examinations (complete blood count, serum chemistry) and the diagnostic imaging. The clinical signs were improved after antibiotics treatment. Doxycycline is effective for Bordetella bronchiseptica as infectious tracheobonchitis in a dog.

Helicobacter pylori와 대장균의 Shuttle Vector 개발

조명제,이우곤,이상룡,김경희,안영숙,김성희,김현주,류복덕,최여정,윤영혜,백승철,전영석,이광호 경상대학교 유전공학연구소 1997 遺傳工學硏究所報 Vol.16 No.-

In this study, a vehicle vector using cryptic plasmids was constructed for gene transfer in Helicobacter pylori. pHP51(3.9 kb) and pHP489(1.2 kb) were selected for constructing vectors from cryptic plasmid of H. pylori isolates in Korea. The HindⅢ-digestedDNA fragment(1.2kb) of pHP489 and 1.6kb DNA fragment of pHP51 were ligated with a kanamycin resistance gene(aph3'-Ⅲ) from C. jejuni to produce the recombinant plasmids pHP489K and pHP51K, respectively. Transformation frequency of pHP51K by electroporation was low. But pHP489K could be effectively transformed into various H. pylori strains. In order to design an intermdiate vehicle vector for gene transfer into H. pylori, pBlueHP489K was prepared by recloning pHP489K DNA into pBluescript and pTZ19R vector. This vector permitted the DNA fragment containing pHP489 sequence, aph3'-Ⅲ, and cloned DNA to be cut and self-ligated in the SacⅠ site after cloning. ureA and ureB gene were inserted into pBlueHP489K, resulting in pBlueHP489K/AB. The DNA fragment containing pHP489, kanamycin resistance gene(aph3'-Ⅲ), and urease structural gene was cut away from pBlueHP489K/AB and self-ligated to generate pBlueHP489K/AB. pBlueHP489K/AB made urease-negative H. pylori strains restore their urease activity. By this experiment, pBlueHP489K was confirmed to be the vehicle system for transferring H. pylori genes.

이중에너지 방사선 흡수계측법을 이용한 성인 남녀의 장골 및 경골의 골밀도에 관한 연구

조용석,김경원,이경호,박현진,서상수,오상엽 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.3

Purpose : The aim of this study was to evaluate the bone mineral density of iliac and tibial bone which are frequently selected as autogenic bone graft donor sites, and to evaluate the efficiency of this method as a guideline for the selection of bone graft donor site. Materials and Methods : In this study 61 male and 70 female volunteers at Chungbuk National University Hospital were involved between Jan. 1998 to Sept. 1999. We measured bone mineral density of the iliac and the tibial bone using dual energy X-ray absorptiometry. We evaluated the data using the SAS system for Windows and bone mineral density of the lumbar was used for control. Results : Age showed the highest correlation in correlation matrix between physical and bone variables. Height and weight showed lower correlation of linear increment. In man, the change of bone density according to age demonstrated linear decrease irrespective of the lumbar, ilium, and tibia. In woman, the change of bone density according to age showed cubic form, which increased in the third and forth decade. So it had a peak bone mass on about 35 year-old, thereafter, the change of bone density slowly decreased until 50 year-old, but it rapidly decreased after 50 year-old and it slowly decreased again after 65 year-old. Both in all subjects and subject with osteoporosis, the change of bone mineral density according to age showed statistically significant decrease in lumbar and tibia, but ilium was irrespective. Conclusion : In patients of aged or with osteoporosis, ilium demonstrated less tendency of decrease in bone mineral density than tibla. So this preliminary study suggested that ilium seemed better donor site for autogenic bone graft than tibia.

Cycloheximide가 Mouse肝臟의 인산염 分解酵素의 活性에 미치는 影響

趙賢熙,鄭鎬三,李圭植 漢陽大學校 環境科學硏究所 1985 環境科學論文集 Vol.6 No.-

Cycloheximide는 Streptomyces griseus에서 추출한 항진균성 항생제로 진균의 성장을 저해하는 물질로 알려져 왔으며 포유동물의 세포에서 ribonucleic acid와 단백질 합성을 저해한다고 생화학적 방법에 의하여 보고되었다. 최근에 이르러 cycloheximide의 투여로 간세포내 소기관인 조면내형질세망 및 Golgi complex의 손상에 의해서 단백질합성이 저해된다고 형태학적으로 연구 보고된 바 있다. 이와같은 cycloheximide의 투여로 간세포가 손상을 입어 단백질합성이 저해될 때 간세포내 인산염분해효소로 분포되어 있는 acid phosphatase와 adenosine triphosphatase 활성을 추구하였다. 실험동물로는 실험실에서 사육한 건강한 ICR계 체중 20∼30gm의 mouse를 사용하였으며 정상대조군과 cycloheximide 투여군으로 구분하고 실험군은 다시 cycloheximide 투여 후 6시간군, 12시간군, 24시산군 및 36시간군으로 나누었고 각군에 10마리씩 배정하였다. Cycloheximide는 mouse의 체중 ㎏당 4㎎ 되게 생리적 식염수에 용해하여 0.1㎖를 복강내에 투여후 6시간, 12시간, 24시간 및 36시간 후에 희생시켜 간장을 적출하고 10% neutral formalin에 고정한 다음 cryostat로 두께 15㎛ 되게 동결절편을 만들어 Gomori법으로 acid phosphatase활성과 Wachstein 및 Meisel법으로 adenosine triphosphatase 활성을 관찰한 결과 다음과 같은 결과를 얻었다. 1. Cycloheximide 투여후 6시간, 12시간군 및 24시간군의 mouse 간소엽에서 중심 정맥부로 부터acid phosphatase 활성이 증가되기 시작하여 36시간군에서는 간소엽 전역에 중등도 이상의 강한 활성이 관찰되었다. 2. Cycloheximide 투여후 24시간군에서 부터 간소엽의 중심 정맥부에 ATPase 활성이 감소되기시작하여 36시간 경과군에서는 간소엽 전역에 음성반응을 나타내었다. 상기와 같은 결과는 cycloheximide 투여로 간장의 acid phosphatase는 간장이 손상을 입을 때 그 활성이 보다 강한 양성반응을 보이고 adenosine triphosphatase는 역으로 활성이 약해진다고 사료된다. It has been knwon that cycloheximide, an antifungal antibiotics extracted from streptomyces griseus, inhibits the growth of fungus. It has been reported by several investigators that this drug inhibits ribouncleic acid activity and protein synthesis of the mammalian cell. Recently, several reporters indicated that the cycloheximide causes the damage of hepatocyte. The observations by electron microscopic, histochemical and histological studies revealed that cycloheximide inhibits the RNA and protein synthesis by the injury of rough endoplasmic reticulum and the desocciation of polysome in hepatocyte. This study attempted, on the activities of acid phosphatase adenosine triphosphatase, phosphatelysis-enzymes distributed in the hepatocytes in the mouse liver. Healthy albino mice(ICR strain) of 20gm±in body weight were used as experimental animals which were divided into the control and cycloheximide treated groups. The animals of the cycloheximide treated groups were administered cycloheximide. (dissolved in physiological saline sol., by intraperitoneal injection in a dose of) 4mg per kg of body weight in a volume of 0.1ml, intraperitoneally. The experimental animals were sacrificed at intervals of 6, 12, 24 and 36 hours after administration of cycloheximide, respectively. The liver specimens were fixed with 10% neutral formalin, the sections of 15㎛ thickness were stained by Gomori, Wachstein and Meisel`s method for the detection of acid phosphatase and adenosine triphosphatase activities. The results were obtained as follows; 1. Acid phosphatase activity was increased in the central zone of liver lobule at the 6 hour and 24 hour period of the cycloheximide treated group, moderately positive activity was showed in the liver lobule at the 36 hour period group. 2. Adenosine triphosphatase activity was decressed in the centrol zone of liver lobule at the 24 hour period of the cycloheximide treated group. Negative reactions were showed in the whole liver lobules at the 36 hour period group. Consequently, it is supposed that cycloheximide caused increase of liver acid phosphatase result from liver damage, while adenosine phosphtase activity of the liver was decreased.

신뢰성방법에 기초한 강교량의 잔존피로 수명 및 피로 위험도 평가

조효남,임종권,최현호 漢陽大學校 工學技術硏究所 1999 工學技術論文集 Vol.8 No.1

본 논문은 잔존피로수명 및 피로파괴 신뢰성해석 절차의 확립을 위해 피로신뢰성방법에 대한 기존 국내외 관련 연구에 대한 심도 깊은 고찰을 수행하였고 실온적인 평가방법을 제시하였다. 따라서 본 연구에서는 Miner 누적손상법칙에 기초한 S-N 피로해석이론 중에서 주로 확률적 S-N 방법과 Ang-Munse's방법에 대한 최근 평가 기술을 집중 고찰하였으며, 이를 실제 성수대교의 붕괴원인 규명에 적용해 봄으로써 그 타당성을 검증하였다. 또한 이를 위해서 성수대교의 붕괴 원인으로 추정되고 있는 핀연결 수직재의 피로응력범위의 보다 정확한 추정을 위하여 shell요소를 사용한 엄밀 국부 FEM해석이 수행되었다. This paper presents practical evaluation methods of the fatigue life and fatigue failure probability for the assessment based on all the available results of various field and labolatory tests. Therefore, both the probabilistic S-N approach and the well known Ang-Munse's fatigue reliability method based on linear damage-accumulation hypothesis, commonly known as Miner's rule, are used and demonstrated in order to verify it's appropriateness. A local FEM analysis using fine meshes shell elements is carried out for the more precise estimation of stress range of the vertical pin-connected hanger whose fatigue fracture triggered the collapse of the bridge.