흉부외상 환자에서 응급 전산화 단층촬영의 효용성에 관한 분석

우건화,김원율,김경환,김홍용,이기재 大韓應急醫學會 1999 대한응급의학회지 Vol.10 No.1

Background. Trauma is the third leading cause of death, irrespective of age, and the leading cause of death in persons under 40 years of age. Computed tomography(CT) is an effective technique in the initial emergent evaluation of the abdomen and head following blunt trauma. Most chest injuries are not seen on conventional chest radiography, or may be underestimated. But routine use of CT in the initial emergent evaluation of chest trauma is controversial. CT, however, has been shown to be useful in the diagnosis of unsuspected chest injuries and in directing therapeutic interventions. This review discusses the efficacy of emergent CT in patients with blunt trauma on the chest. Methods. To evaluate the efficacy of CT of the thorax, a retrospective study comparing early thoracic CT scanning with initial chest roentgenogram(CXR) was carried out on 121 patients with blunt trauma on the chest. The interval between CXR and CT was less than 1 hour. Results. Among 121 patients, 42 patients had normal initial chest roentgenogram in whom 19 patients showed normal CT findings, Sensitivities of diagnosing pneumothorax and pleural effusion by CXR were low (49.3% and 45.1% respectively), whereas 65.7%(44/67) of patients had thoracostomy only by CXR. Conclusion. Although sometimes abused in patients with chest trauma, CT of the thorax is an effective method of detecting thoracic injuries and provides accurate information regarding their pattern and extent in the initial emergent diagnosis.

(-)-Epigallocathechin-3-gallate, an AMPK activator, decreases ovariectomy-induced bone loss by suppression of bone resorption.

Lee, Seung Hun,Kim, Beom-Jun,Choi, Hyung Jin,Cho, Sun Wook,Shin, Chan Soo,Park, Sook-Young,Lee, Young-Sun,Lee, Sun-Young,Kim, Hong-Hee,Kim, Ghi Su,Koh, Jung-Min Springer Verlag 2012 Calcified tissue international Vol.90 No.5

<P>Previously, we showed that AMP-activated protein kinase (AMPK) negatively regulates receptor activator of nuclear factor-κB ligand-induced osteoclast formation in vitro. The present study investigated the effect of (-)-epigallocathechin-3-gallate (EGCG), an AMPK activator, on ovariectomy (OVX)-induced bone loss in mice. Female mice subjected to OVX were administered EGCG for 8?weeks. We measured total-body bone mineral density (BMD) before and after the operation at an interval of 4?weeks. We performed micro-computed tomography (micro-CT) of the tibia and bone histomorphometric examination of the femur. Western blot analysis was additionally performed, to detect levels of the phosphorylated and total forms of AMPK-α in calvarial extracts. EGCG prevented OVX-induced body weight gain. The OVX control did not show a significant increase in BMD values at baseline and after treatment, unlike the sham control. EGCG attenuated OVX-induced bone loss. Micro-CT experiments revealed that EGCG induced a significant increase in trabecular bone volume and trabecular number and a decrease in trabecular spacing compared to the OVX control. Histomorphometric analyses further showed that EGCG suppressed osteoclast surface and number. Phosphorylated AMPK expression was significantly elevated in bone following EGCG treatment. Our findings collectively indicate that EGCG decreases OVX-induced bone loss via inhibition of osteoclasts.</P>

만성골수성백혈병에서의 동종골수이식 : 국내 경험의 후향적 분석 Retrospective Analysis of Korean Experience

이규형,이제환,이정신,김상희,김우건,김춘추,이종욱,김병국,박선양,이홍기,윤성수,김효철,남동기,한지숙,민유홍,현명수,황태주,정익주,박영석,이정애 대한조혈모세포이식학회 1998 대한조혈모세포이식학회지 Vol.3 No.2

연구방법: 국내에서 시행된 만성골수백혈병의 치료를 위한 가족간 동종골수이식의 임상적 특징을 후향적으로 분석하였다. 9개의 병원에서 1986년 9월부터 1997년 6월까지 시행한 137예의 가족간 동종골수이식을 보고하였다. 결과: 전체 환자 중 62%인 85예가 남자였고 연령은 15세에서 50세까지 분포하였다(중앙치 30세). 95예(71%)의 환자는 이식 당시 만성골수성백혈병 만성기의 상태였고 38예(28%)는 가속기 또는 모세포성발증기의 상태였다. 70예(51%)의 환자는 이식전처치로 busulfan+cyclophosphamide (BuCy) 치료를 받았고 42예(31%)의 환자는 cyclophosphamide+전신방사선 조사(Cy-TBI)를 받았다. 환자에게 이식된 단핵구의 수는 0.06-9.5×10^(8)/kg(중앙치 1.2×10^*/kg)였다. 1 예를 제외한 모든 환자에서 이식 후 8-100일(중앙치 17일)에 중성구 500/㎕ 이상의 착상이 관찰되었다. 급성 및 만성이식편대숙주질환은 각각 46%와 43%의 환자에서 관찰되었다. 중앙추적기간 20개월(범위 3-135개월) 경과 후 137예의 환자 중 52예의 환자가 사망하였다. 사망 원인은 감염(27%), 백혈병의 지속 또는 재발(23%), 이식편대숙주질환(21%), 치료독성(15%), 그리고 이식편거부(8%) 등이었다. 환자들의 event-free survival에 영향을 주는 인자로는 이식전 병의 상태(p<0.001)와 환자의 혈청 HBsAg 양성여부(p=0.012)가 중요하였다. Overall survival에 영향을 주는 인자도 이식전 병의 상태와 환자 혈청 HBsAg 양성여부로 나타났다. 결론: 본 연구에서 국내 만성골수성백혈병에 대한 동종골수이식술은 그 시행 예가 급격히 증가하고 있음을 보여주었다. 환자들의 임상 특성과 생존 성적은 외국의 성적과 유사하였다. B형 간염 감염환자의 경우 예후가 유의하게 불량하였고, 이는 추후의 임상연구에서 확인이 필요한 소견으로 사료된다. Background and Methods: Clinical features of allogeneic bone marrow transplantation (BMT) performed for patients with chronic myelocytic leukemia (CML) in Korea were analyzed retrospectively. Nine hospitals reported a total of 137 cases of allogeneic BMT performed between September, 1986 and June, 1997. Results: There were 85 male (62%) and 52 female patients with median age of 30 years (range 15-50). Ninety five patients (71%) were in chronic phase and 38 patients (28 %) were in accelerated/blastic phase of the disease. Seventy patients (51%) received busulfan-cyclophosphamide (BuCy) regimen for preparation and 42 patients (31%) received cyclophosphamide-total body irradiation (Cy-TBI) regimen. The median mononuclear cell dose given to patients was 1.2×10^(8)/kg (range, 0.06-9.5×10^(8)/kg). All but one patient achieved absolute neutrophil count of 500/μl after median 17 days after BMT (range, 8-100 days). Acute and chronic graft-versus-host disease (GVHD) were reported in 61/133 (46%) and in 57/134 (43%) patients, respectively. The median follow-up time of survivors was 20 months (range, 3-135 months). There were 52 deaths (38%). The causes of death were infection (14 patients, 27%), recurrent/persistent disease (12 patients, 23%), GVHD (11 patients, 21%), regimen related toxicity (8 patients, 15%), graft rejection/failure (4 patients, 8%), and unknown (3 patients, 6%). The factors influencing event free survival of the patients were disease status before BMT (p<0.001, by log-rank test) and serum hepatitis B surface antigen status (p=0.012). Longer duration of disease before BMT showed poorer outcome but the difference did not reach statistical significance. The factors affecting overall survival of the patients were disease status before BMT (p=0.009) and hepatitis B surface antigen status (p=0.036). The donor hepatitis B antigen status did not influence event free survival or overall survival of the patients. Conclusion: Clinical features and survival patterns of patients with CML treated with allogeneic BMT in Korea were similar to historical data from other countries. Further data analyses are warranted for the role of hepatitis B virus infection influencing the outcome of allogeneic BMT for CML.

Sexuality and Quality of Life after Hematopoietic Stem Cell Transplantation

(Hong Ghi Lee),(Eun Young Park),(Hyun Mee Kim),(Ki Hyun Kim),(Won Seog Kim),(Sung Soo Yoon),(Won Ki Kang),(Keun Chil Park),(Chan Hyung Park) 대한내과학회 2002 The Korean Journal of Internal Medicine Vol.17 No.1

N/A Background : The quality of sexuali1y is significantly affected by physical changes following hematopoietic stem cell transplantation (HSCT) and the dissatisfied and/or dysfunctional sexuality may cause deterioration in the quality of life (QOL). Methods : With two models of questionnaires, we interviewed thirty-eight patients who remained in the disease-free status after HSCT and had sex partners, to assess: 1) the changes in sexuality, 2) QOL in physical, psychological, social and spiritual domains and 3) the correlation between sexuality and QOL. Results : The common physical changes that may affect sexuality in women were secondary amenorrhea (69.2%), loss of sexual interest (53.8%), diminished vaginal secretion (50%), menopausal syndrome (34.6%), dyspareunia (30.8%) and failure to orgasm (23.1%), while men complained of impotence (41.7%) and difficulty in ejaculation (16.7%). For sexuality, satisfaction of sexual activity, attainment of orgasm and frequency of intercourse decreased significantly after HSCT as compared with the pre-transplant levels. A score measuring QOL after HSCT marked 5.91 on a full score of 10; social domain ranked the lowest (5.01) while physical domain the highest (6.70). Among the items of sexuality, only sexual desire was significantly correlated with QOL; satisfaction, orgasm and frequency were not significantly correlated with QOL. Conclusion : Although sexuality is affected by the physical changes following HSCT, we should not overlook the psychological and social effects on the sexuality of post-transplant patients. Therefore, educational and counseling programs are very important to restore and improve their sexuality.

제49차 대한내과학회 추계학술대회초록집 : 심포지움 ; 급성 백혈병 : 급성 백혈병의 FAB 분류 및 면역표현형

이홍기 ( Hong Ghi Lee ) 대한내과학회 1997 대한내과학회지 Vol.53 No.-

제49차 대한내과학회 추계학술대회초록집 : 심포지움 ; 급성 백혈병 : 급성 백혈병의 FAB 분류 및 면역표현형

이홍기 ( Hong Ghi Lee ) 대한내과학회 1997 대한내과학회지 Vol.53 No.2S

심포지움 : Interleukin-2(IL-2)의 임상응용

이홍기 ( Hong Ghi Lee ) 대한내과학회 1999 대한내과학회 추계학술대회 Vol.57 No.-

동종 골수이식 후 재발한 백혈병에서 공여자 백혈구 주입 : 이식편대백혈병효과에 관한 다기관 임상연구

이석,박선양,김병국,이홍기,박찬형,남동기,김효철,이경희,현명수,오도연,김영철,이순남,성주명 大韓血液學會 1999 大韓血液學會誌 Vol.34 No.2

혈액암 환자의 암피로 대처에 대한 태도

이홍기(Lee, Hong-ghi),홍연표(Hong, Yeon-pyo),윤은자(Yeun, Eun-Ja) 한국웰니스학회 2017 한국웰니스학회지 Vol.12 No.1

의학과 하이테크놀로지에 의한 의료기술의 발전으로 혈액암 환자의 생존률이 빠르게 증가하고 있으나 치료과정 중에 발생하는 암피로는 대부분의 환자에게 심각한 증상으로 발현되어 암환자의 삶의 질에 지대한 영향을 미치고 있다. 피로는 객관화하여 평가할 수 없는 개인의 주관적 증상이다. 이에 Q 방법론을 이용하여 혈액암 환자 자신의 관점을 통해 암피로 대처에 대한 주관적 판단의 가치와 구조를 발견해내는 접근이 필요한 시점이다. Q방법론을 이용하여 혈액암 환자의 암피로 대처에 대한 태도 유형과 그 특성을 파악하기 위함이다. 연구방법: 암피로와 관련된 문헌고찰과 상급종합병원 환자 8명을 대상으로 비구조화된 심층면담을 실시하여 총 37개의 Q 표본을 선정하였다. 편의표집한 혈액암 환자 29명을 대상으로 Q분류를 하였고 자료분석은 PC-QUANL프로그램을 사용하였다. 혈액암 환자의 암피로 대처에 대한 태도는 2개 유형으로 추출되었으며 각각 ‘활동적 전환 대처형’, ‘예방적 보존대처형’으로 명명하였다. 본 연구의 결과는 암피로 대처 현상을 혈액암 환자의 관점에서 이해하고 접근하도록 하는 근거를 제시해 줄 것이다. 또한 혈액암 환자의 암피로 대처를 위해 유형별 특성에 기초한 맞춤형 증상관리 방안을 모색하여 적용함으로써 혈액암 환자의 삶의 질 향상에도 기여할 것이다. The development of medical technology by medical and high technology is rapidly increasing the survival rate of hematologic cancer patients. Cancer fatigue occurs in over half of patients. Therefore, it is necessary to use the Q methodology to find out the value and structure of subjective judgment about the cancer fatigue coping through the hematologic cancer patient"s own viewpoint. The purpose of this study was to investigate the attitudes toward cancer fatigue and its characteristics in patients with hematologic cancer using Q methodology. Method: A total of 37 Q samples were selected by conducting unstructured in-depth interviews with 8 patients in two university hospitals and literature review. 29 patients with hematologic cancer were divided into Q sorting, and data were analyzed using the PC-QUANL program. Two factors of attitudes toward cancer fatigue were extracted from patients with hematologic cancer, and they were named "active conversion coping" and "preventive conservation coping", respectively. These findings will provide a basis for understanding the treatment of cancer fatigue in patients with hematologic cancer from the perspective of patients with hematologic cancer. Futhmore, these findings are expected to be useful in seeking care strategies to reduce fatigue and increasing quality of life in patients with hematologic cancer.

Resveratrol alters microRNA expression profiles in A549 human non-small cell lung cancer cells

Bae, Seunghee,Lee, Eun-Mee,Cha, Hwa Jun,Kim, Karam,Yoon, Yeongmin,Lee, Hyunjin,Kim, Jongran,Kim, Yu-Jeong,Lee, Hong Ghi,Jeung, Hoi-Kyung,Min, Yoo Hong,An, Sungkwan Springer-Verlag 2011 Molecules and cells Vol.32 No.3