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Toshio Suzuki,Ryota Akagi,Fumio Nanba,Shizuka Saito,Toshinari Maruo,Toshiya Toda,Yoko Yamashita,Hitoshi Ashida 한국식품영양과학회 2024 Journal of medicinal food Vol.27 No.2
Black soybean seed coat extract (BE) contains multiple bioactive polyphenols, including flavan-3-ols andanthocyanins. BE improves endothelial function; however, it is unclear whether BE protects endothelial cells from senescence. In this study, we examined the effects of BE on endothelial cell senescence and vascular function in healthy individuals. High concentrations of glucose were used to induce senescence in bovine aortic endothelial cells incubated with BE. Senescence, vascular function, and oxidative stress markers were measured. Incubation with BE remarkably inhibitedsenescence-associated b-galactosidase and lactate dehydrogenase activities and dose dependently reduced intracellular reactiveoxygen species levels in bovine aortic endothelial cells. BE treatment increased the levels of endothelial nitric oxidesynthase (eNOS) mRNA and endothelial nitric oxide (NO) metabolites and increased the mRNA expression of klotho, a geneassociated with an antiaging phenotype. To examine the effects of BE in humans, we conducted a clinical study using the secondderivative of the fingertip photoplethysmogram to investigate vascular function and aging in 24 healthy volunteers. The participantsconsumed BE supplements (100mg/day) or a placebo for 2 weeks. When compared with the placebo group, the BE groupshowed considerably improved vascular function, NO metabolite levels, and oxidative stress. These results suggest that BEsupplementation improves endothelial function, possibly through antioxidant activity and NO production, and may consequentlyreduce the cardiovascular risk associated with aging. BE supplementation may be an effective and safe approach to reduce the riskof atherosclerosis and cardiovascular disease; however, additional studies investigating chronic vascular inflammation are needed.
Precision Medicine Approaches to Prevent Gastric Cancer
( Juntaro Matsuzaki ),( Hitoshi Tsugawa ),( Hidekazu Suzuki ) 대한간학회 2021 Gut and Liver Vol.15 No.1
Gastric cancer remains one of the most common causes of cancer-related death worldwide, although the incidence is declining gradually. The primary risk factor for gastric cancer is Helicobacter pylori infection. The Kyoto global consensus report recommends eradication of H. pylori in all infected patients. However, because it is difficult to stratify the risk of carcinogenesis among patients with a history of H. pylori infection, annual endoscopic surveillance is performed for everyone after eradication. This review summarizes the current approaches used to screen for novel molecules that could assist in the diagnosis of gastric cancer and reduce mortality. Most well-studied molecules are tissue protein biomarkers expressed by the gastric epithelium and associated with metaplasia-dysplasia-carcinoma sequences. Other strategies focus on the origin of cancer stem cell-related markers, such as CD44, and immune reaction-related markers, such as matrix metallopeptidases. Noninvasive methods such as blood-based approaches are more attractive. Serum pepsinogen levels predict the severity of gastric mucosal atrophy before H. pylori eradication, whereas plasma ghrelin levels are associated with atrophy even after eradication. Cell-free DNAs and RNAs are attractive tools for the early detection of cancer. These ideas could lead to the development of more personalized strategies for cancer prevention based on cuttingedge technologies. (Gut Liver 2021;15:3-12)
Mitsuo Nunome,Hitoshi Suzuki,Kazuo Moriwaki 한국동물분류학회 2013 Animal Systematics, Evolution and Diversity Vol.29 No.4
In Japan, the wild house mouse Mus musculus consists of two lineages, one from Southeast Asia (Mus musculus castaneus; CAS) and one from northern Eurasia (Mus musculus musculus; MUS). However, the exact origins of the parental lineages are unclear. A recent work using mitochondrial sequences revealed that Japanese CAS and MUS are closely related to haplotypes from South China and the Korean Peninsula, respectively. Recent phylogeographic analyses using nuclear gene sequences have also confirmed a close relationship between Japan and Korea in the MUS component. However, the Japanese CAS components in the nuclear genome are likely to be unique and to differ from those of other CAS territories, including South China. Although the origins are still unresolved, these results allow us to conclude that two areas of the continent, South China and the Korean Peninsula, are the primary source areas of Japanese wild mice and suggest pre-historical introductions associated with certain historical agricultural developments in East Asia.
Nunome, Mitsuo,Suzuki, Hitoshi,Moriwaki, Kazuo The Korean Society of Systematic Zoology 2013 Animal Systematics, Evolution and Diversity Vol.29 No.4
In Japan, the wild house mouse Mus musculus consists of two lineages, one from Southeast Asia (Mus musculus castaneus; CAS) and one from northern Eurasia (Mus musculus musculus; MUS). However, the exact origins of the parental lineages are unclear. A recent work using mitochondrial sequences revealed that Japanese CAS and MUS are closely related to haplotypes from South China and the Korean Peninsula, respectively. Recent phylogeographic analyses using nuclear gene sequences have also confirmed a close relationship between Japan and Korea in the MUS component. However, the Japanese CAS components in the nuclear genome are likely to be unique and to differ from those of other CAS territories, including South China. Although the origins are still unresolved, these results allow us to conclude that two areas of the continent, South China and the Korean Peninsula, are the primary source areas of Japanese wild mice and suggest pre-historical introductions associated with certain historical agricultural developments in East Asia.
Inhibition of plasminogen activator inhibitor-1 attenuates against intestinal fibrosis in mice
( Jin Imai ),( Takashi Yahata ),( Hitoshi Ichikawa ),( Abd Aziz Ibrahim ),( Masaki Yazawa ),( Hideaki Sumiyoshi ),( Yutaka Inagaki ),( Masashi Matsushima ),( Takayoshi Suzuki ),( Tetsuya Mine ),( Kiyo 대한장연구학회 2020 Intestinal Research Vol.18 No.2
Background/Aims: Intestinal fibrosis is a major complication of Crohn’s disease (CD). The profibrotic protein transforming growth factor-β (TGF-β) has been considered to be critical for the induction of the fibrotic program. TGF-β has the ability to induce not only the expression of extracellular matrix (ECM) including collagen, but also the production of plasminogen activator inhibitor-1 (PAI-1) that prevents enzymatic degradation of the ECM during the onset of fibrotic diseases. However, the significance of PAI-1 in the developing intestinal fibrosis has not been fully understood. In the present study, we examined the actual expression of PAI-1 in fibrotic legion of intestinal inflammation and its correlation with the abnormal ECM deposition. Methods: Chronic intestinal inflammation was induced in BALB/c mice using 8 repeated intrarectal injections of 2,4,6-trinitrobenzene sulfonic acid (TNBS). TM5275, a PAI-1 inhibitor, was orally administered as a carboxymethyl cellulose suspension each day for 2 weeks after the sixth TNBS injection. Results: Using a publicly available dataset (accession number, GSE75214) and TNBS-treated mice, we observed increases in PAI-1 transcripts at active fibrotic lesions in both patients with CD and mice with chronic intestinal inflammation. Oral administration of TM5275 immediately after the onset of intestinal fibrosis upregulated MMP-9 (matrix metalloproteinase 9) and decreased collagen accumulation, resulting in attenuation of the fibrogenesis in TNBS-treated mice. Conclusions: PAI-1-mediated fibrinolytic system facilitates collagen degradation suppression. Hence, PAI-1 inhibitor could be applied as an anti-fibrotic drug in CD treatment. (Intest Res 2020;18:219-228)
Radioprotection Effects and the Anti-Cancer Effects of the Species (Miroku-Tea)
Gu, Yeun-Hwa,Suzuki, Ikukatu,Hasegawa, Takeo,Hayashi, Ikuo,Hitoshi, Tawaraya,Ahn, Kyoo-Seok INSTITUTE OF ORIENTAL MEDICINE KYUNG-HEE UNIVERSIT 2001 JOURNAL OF ORIENTAL MEDICINE Vol.6 No.1
In recent years the effectiveness of species (Miroku-Tea) as an anti-cancer, anti0biotic effect and anti-virus effect has become more widely known. Furthermore the beneficial effects of species (Miroku-Tea) leaves have also been studied. In this study, we investigated measurement of blood cells, the NK cell activity, the radio-protective and anti-cancer effects of species (Miroku-Tea) extract. The leucocytes and the lymphocyte were transietnly increased after injection of species (Miroku-Tea). Anti-tumor effect was occurred after the injuection of species (Miroku-Tea). NK cells activity increased 2 times after the injection of species (Miroku-Tea) compared with the control group. Radiation protection occurred from the inhibition of body weight loss and also a prolonged the surviving fraction after the injection of species (Miroku-Tea).
(Yeun hwa Gu),(Hasegawa Takeo),(Suzuki Ikukatsu),(Hayashi Ikuo),(Kyoo Seok Ahn),(Tawaraya Hitoshi) 경희대학교 한의학연구소 2000 JOURNAL OF ORIENTAL MEDICINE Vol.5 No.1
In this study abundant malformations of ICR mice in the organogenesis stages were observed and the radioprotection effect of Macro-Glucan(β-1-3glucan) was shown. This research examined the radioprotection effect of Macro-Glucan(β-1-3glucan) and its terato
Literature Review on Recent Magnetocardiography and Impedance-MagnetocardiographyTechnologies
Y. Seki,A. Tsukamoto,K. Tsukada,Hitoshi Horigome,Miki Yokokawa,Yoshihide Chiba,Kimio Tanaka,A. Kandori,T. Miyashita,K. Ogata,D. Suzuki,K. Saito,K. Yokosawa,Satsuki Yamada,Shigeyuki Watanabe,Iwao Yamag 한국초전도학회 2006 Progress in superconductivity Vol.8 No.1