Negative Regulation of Hypoxic Responses via Induced Reptin Methylation

Jason S. Lee,김윤호,김익수,김보규,최희준,이지민,신희재,김정화,김지영,서상범,이호,Olivier Binda,Or Gozani,Gregg L. Semenza,김민형,김근일,황대희,백성희 Sookmyung Women's University Research Institute of 2010 여성과 건강 Vol.6 No.1

Negative Regulation of Hypoxic Responses via Induced Reptin Methylation

Jason S. Lee,김윤호,김익수,김보규,최희준,이지민,신희재,김정화,김지영,서상범,이호,Olivier Binda,Or Gozani,Gregg L. Semenza,김민형,김근일,황대희,백성희 Sookmyung Women's University Research Institute of 2010 여성과 건강 Vol.6 No.1

정상인에서 베타3-아드레날린 수용체 유전자의 변이가 복부 비만도 및 지질대사에 미치는 영향

김영선,윤석기,김철희,서교일,김학선,김극배,변동원,유명희 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.1

The β₃-adrenergic receptor is expressed in visceral adipose tissue in humans and is thought to contribute to the regulation of the resting metabolic rate and lipolysis. We studied the influence of a mutation in the β₃ -adrenergic receptor gene(Trp64Arg) on body fat distribution, central obesity, lipid metabolism in 65 healthy young male adults. One out of 65 subjects were homozygous (Arg/Arg) for the trp64Arg mutation, 17 subjects were heterozygous (Trp/Arg), and 47 lacked the mutation(Trp/Trp). The body weight, height, body mass index, waist-to-hip ratio were similar between the subjects with- and without the mutation. Total body fat, abdominal fat amount, body fat distribution, serum total- and HDL-cholesterol, triglyceride, glucose, and insulin concentrations were also not different according to the presence or absence of the mutation. These results suggested that Trp64Arg mutation in β₃-adrenergic receptor gene is not a major contributing factor for central obesity or change in lipid metabolism in Korean young adults.

청소년의 인터넷 중독 정도에 따른 정신과적 공존질환 및 행동 양상에 관한 연구

이준영(June-Young Lee),박이진(E-Jin Park),조근호(Keun-Ho Joe),채숙희(Suk-Hi Chai),김성벽(Sung-Byuk Kim),이창욱(Chang-Uk Lee),김대진(Dai-Jin Kim) 한국중독정신의학회 2010 중독정신의학 Vol.14 No.1

Objectives:This study aimed to clarify the differences in psychiatric comorbidities and, behavioral patterns correlating with the severity of Internet addiction in adolescents. Methods:We assessed 321 adolescents recruited from an Internet rescue school, psychiatric outpatients, and 4 schools in Seoul and Gyeonggido. We divided them into a non-addicted group, a potential-risk group, and a high-risk group according to Young’s Internet Addiction Test (IAT). We evaluated their psychiatric comorbidities and behavioral patterns via psychiatric clinical interview, the Children’s Depression Inventory (CDI), the State-Trait Anxiety Inventory (STAI), and a self-report questionnaire about behavioral pat-terns. Results:There were significant differences in CDI and STAI scores among the 3 groups. The IAT, CDI, and STAI scores correlated positively with each other. There were differences in psychiatric comorbidity distributions between the potential-risk and high-risk groups, but only “other mood disorder” showed a significant difference. There were also significant differences in behavioral patterns among the 3 groups. Conclusion:This study suggests that there are psychiatric comorbidity and behavioral pat-tern differences according to Internet addiction severity in adolescents. We expect further studies will reveal more profound understandings of these relationships.

원발성 유방암에서 Sodium Iodide Symporter의 발현과 ^(99m)Tc-MIBI 유방스캔의 관계

석주원,김성장,곽희숙,이창훈,김인주,김용기,배영태,김동수 대한핵의학회 2002 핵의학 분자영상 Vol.36 No.6

목적: hNIS는 갑상선 조직 외에 다른 조직들에서도 발현된다고 알려져 있다. 유방암 세포는 그런 조직들 중에 하나이며, 그에 의한 유방암의 방사성옥소치료의 가능성이 제시되고 있다. 본 연구에서는 유방암 조직에서 hNIS의 발현정도를 알아보고, ^99mTc-MIBI 유방스캔과 hNIS의 발현 정도와의 관계를 조사하여 보았다. 대상 및 방법: 본 연구에서는 유방암으로 수술을 시행했던 56명의 환자를 대상으로 하였다. hNIS의 발현은 면역조직화학염색에 의해서 평가되었으며, 그 결과를 ^99mTc-MIBI 유방스캔의 판정 결과와 비교하였다. 결과: 전체 56명의 환자에서 hNIS의 발현율은 41.1%였다. 병리학적 진단에 의해 침윤성관상피암종이었던 49명에서의 발현율은 42.9%, 관상피내암종이었던 7명에서의 발현율은 28.6%였다. ^99mTc-MIBI 유방스캔에서 국소섭취 소견이 관찰되었던 41명에서의 hNIS의 발현율은 31.7%였다. 비정상적인 섭취 소견이 관찰되지 않았던 15명의 환자에서의 hNIS의 발현율이 의미있게 높게 관찰되었다(66.7%, p>0.05). 결론: 유방암 환자에서의 hNIS의 발현율은 그다지 높지 않았다. ^99mTc-MIBI 유방스캔에서 섭취증가 소견이 없을 때 hNIS의 발현율이 더 높았다. Purpose: Human Na^+/I- symporter (hNIS) is known to be expressed in many tissues other than thyroid gland. The breast cancer cells are one of them and the possibility of radioiodine therapy in treatment of the breast cancer may be suggested. We investigated the expression rate of hNIS and the relationship between the expression of hNIS and the finding of 99mTc-MIBI scintimammography in the breast cancer. Materials and Methods: Surgically proved 56 patients with breast cancer were the subjects of this study. The expression of hNIS were evaluated by immunohistochemistry and the results were compared to the findings of 99mTc-MIBI scintimammography. Results: Overall expression rate of hNIS was 41.1% in 56 patients. According to the pathologic diagnosis, it was 42.9% in 49 patients with invasive ductal carcinoma and 28.6% in the 7 patients with ductal carcinoma in situ. The expression rate of hNIS in the 41 cases with a focal increased uptake at he breast lesion on 99mTc-MIBI scintimammogram was 31.7%. That in the 15 cases without any abnormal uptake on the scan was significantly higher(66.7%, p<0.05). Conclusion: The expression rate of hNIS in the patients with breast cancer was not so high. The rate was higher in the patients with no increased uptake at the breast lesion on 99mTc-MIBI scintimammography. (Korean J Nucl Med 2002;36;325-32)

항갑상선제로 치료한 그레이브스병 환자의 관해예측인자

남일송,윤여일,김선규,김용현,이주영,목지오,윤석기,김철희,김영선,변동원,서교일,유명희 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background: Most cases of Graves' disease have been treated by antithyroid drugs in Korea. The major drawbacks of antithyroid drugs are the relative high rate of relapse and the inconvinience of long term therapy. Measurement of TBII and TRH stimulation test have been considered as the most reliable tests predicting relapse, but the predictive power is not high enough to use in clinical situation. This study was performed to find good prognostic indicators in Graves' disease patients after the discontinuation of antithyroid drug therapy. Subjects and methods : We restrospectively evaluated 96 patients with Graves' disease who showed normal TRH test at the end of antithyroid drug therapy and were followed for more than one year. Serum T3, T4, T3/T4 ratio, TBII, Anti-TPO Ab and TGAb levels were measured at the time of diagnosis and at the end of therapy. Two to three months after withdrawal of antithyroid medication, serum TSH and free T3 responses to TRH were examined. These parameters were compared between the relapse group and the remission group. Results : Among the 96 patients, 22 patients(22.9%) relapsed(Group Ⅱ) and 74 patients(77.1%) remained in remmision(Group Ⅰ). No significant difference was observed between the relapse and the remission group in clinical parameters, serum T3, T4, TSH, T3/T4 ratio, TBⅡ and Anti-TPO Ab determined before and after treatment. Serum TSH and free T3 levels measured after TRH stimulation were also similar in both groups. Serum TGAb levels determined at the end of treatment were significantly higher in the remission group(p<0.05). Relapse following the discontinuation of therapy occured within 24 months in 72.7% of the relapsed cases. After 24 months, relapse rate was reduced significantly. Conclusion : These results suggest that high serum TGAb levels could be a favorable prognostic indicator for the long term remission of Graves' disease treated with antithyroid drugs, and may suggest that Hashimoto's thyroiditis is combined with Graves' disease in those patients.

寶城江댐 流域의 植生

金順熙,鄭泳喆,金琮鴻 순천대학교 기초과학연구소 1993 基礎科學硏究誌 Vol.4 No.-

The vegetation, which is based on vascular plants, in the vicinity of the Po^sung-gang dam was investigated phytosociologically over 13 times on 57 points from November, 1991 to July, 1993. Species composition, live form, and community structure of the flora, species diversity, and similarity index were determined, and the profile diagram of plant community and actual vegetation map were constructed. Vascular plant flora in the surveyed area was 34 orders, 92 families, 247 genera, 340 species, 1 subspecies, 44 varieties and 2 forma, in total 387 kinds. The composition of life form was classified into Ch-D_1-R_5-e type. Vegetation was classified into coniferous forest and deciduous broad-leaved forest. Coniferous forests were composed of the communities of Pinus densiflora and P. thunbergii as the natural forest, and P. rigida community, Chamaecyparis obtusa community and other 15 mixed forest communities as artificial forest. Deciduous broad-leaved forests were extensively composed of natural forest such as Quercus acutissima community and Q. aliena community, and artificial forest such as Alnus japonica community, C. crenata community and Robinia pseudo-acacia community, and other 6 mixed forest communities. The communities of Camellia japonica and Miscanthus sinensis var. purpurascens were observed on a small scale in the surveyed area. Species diversity index was 1.105, in coniferous forest and 1.118 in deciduous broad-leaved forest. Similarity index between the two communities was 0.555, which means those communities are remarkably different from each other in species composition. Pterophyta quantity(Pte-Q), which is 0.68, was lower than that of national average, 1.68, while urbanization index measured as 2.37 was higher than that of national average, 9.9. The vegetation of vascular plants in Po^sung-gang Dam was coincided with that of the southern area of the Korearn peninsula, in distribution types of family or genus. It was to be noted that a natural community of Scirpus radicans which is generally believed to be distributed in northern area was found in this surveyed area.

國産化 콘크리트 膨脹劑 開發에 관한 硏究

金熙鍾,朴文浩,金勇熙 동아대학교 공과대학 부설 한국자원개발연구소 1980 硏究報告 Vol.4 No.2

Expansive agent, that is widely put into use in U.S., U.S.S.R., Japan and other developed countries, has not been made in our country yet. In this article, new expansion agent is attempted by using limestone, alunite and anthracite ashes in order to put into our actual use, and the compressive and tensile strength and the expansion rate of two kinds of concrete, made with Japanese Agent Type A and our developmental expansive agent, were comparised through a lot of tests. According to our test results, when the same amount of agent was admixed in concrete the compressive and tensile strength of our new expansion agent was much higher than that of Japanese and also σ_(28) was increased by 4% as to that of normal Concrete. In case of the expansion rate, if was proportioned to the admixing amount and the most suitable mixing amount in the structual construction was 1%.

개 분획채취 동결정액의 생존성과 인공수정에 의한 임신율에 관한 연구

김영희,김상근 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

This study was carried out to investigate the general characteristics such as volume, sperm concentration, sperm motility, sperm abnormality on whole semen, removed seminal plasma by removed seminal plasma with saline and tris buffer semen and fractional semen of dogs, and the effect of temperature and preservation time and cryoproservation on motility of whole and removed seminal plasma with salin and tris buffer semen. Multiple ejaculates were collected from small dogs by the digital manipulation of penis. The volume per ejaculate semen, sperm of concentration and motility and abnormal sperm rate of lst fractional semen were 0.65±0.09ml, 4.52±0.35×10^(6)cells/ml, 15,64±3.85% and 5.50±0.62%. Also, 2nd fractional semen were 1.25±0.20ml, 3.35±0.48×10^(6)cells/ml, 96.25±4.65% and 4.24-0.46%. And 3rd fractional semen were 1.45±0.21ml, 3.85±0.52×10^(6)cells/ml, 92.82±4.24% and 4.66±0.58%, respectively. The sperm of concentration and motility and abnormal sperm rates of whole, removed seminal plasma with saline and tris buffer semen were 5.45±0.82×10^(6) cells/ml. 95.55±4.65%, 4.58-0.45% and 4.82±0.36×10^(6)cells/ml, 90.10± 3.42%, 6.48±0.68% and 4.55±0.45×10^(6)ce11s/ml, 93.25±3.85%, 4.82±0.58%, respectively. The motility of whole, removed seminal plasma with saline and tris buffer semen were higher at 4℃ than at 38℃. When preservation temperature was at 4℃, survival rates of removed seminal plasma with saline and tris buffer sperm were 97.54%~6.25% at 1~72 hrs, 97.40%~5.62% at 1~100 hrs, respectively. The survival rates of slow and rapid frozen 2nd fraction, removed seminal plasma with salin and tris buffer semen were 67.3±4.45%, 88.8±4.46% and 46.4±3.84%, 74.4±4.20%, respectively. Survival rates was significantly higher in frozen removed seminal plasma with saline and tris buffer semen than that in control group (8.5±2.12%).

폐결핵 초치료 환자들의 치료 결과에 영향을 주는 요인

김경순,조영하,전진호,조은희,은충기 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.3

Objectives : To figure out the factors related to the failure of primary pulmonary tuberculosis(Tb) treatment and to enhance the efficiency of the treatment. Methods and Materials : The subjects were 137 Tb patients composed of the two groups; 44 failure cases and 93 success cases who admitted in National Masan Tuberculosis Hospital during 2001. The failure means no improvement with the standard short term regimen of INH and RFP. Patients' informations were gathered through medical records and face-to-face interview survey, and, the data were analyzed with SPSS(ver 10.0). Results : Mean age of the subjects were 47.6 years. Most cases were diagnosed at clinics or hospitals at first, due to the symptoms. No difference in smoking and alcohol habits between the two groups. The cases who got the informations about the whole process of treatment, and following regular regimens were more in the success group. The proportion of multi-drug resistance to the regular primary Tb regimen was higher in the failure group 8 cases out of 25 detectable failure cases. 0 case among 46 successful cases. And the four regular regimen(INH, RFP, EMB, PZA) was popular type of the resistance. In chest X-ray, multiply involved lesion(≥ two lobes), atelectasis and pleurisy were more frequent in the failure group. Conclusion : The major factors that enhance the efficiency of Tb treatment were the informations and compliance. Enough explanation about the whole process would be essential during Tb treatment, and, in case of MDR-Tb, susceptible regimen and surgical therapy should be considered.