과민성 장 증후군의 증상 경감을 위한 비약물적 접근 고찰

최명애,김금순,안경주,채영란,최정안,홍해숙,박미정,이경숙,신기수,정재심 대한기초간호자연과학회 2005 Journal of korean biological nursing science Vol.7 No.2

There have been many trials of clinical efficacy of multicomponent and single component treatments for irritable bowel syndrome(IBS). We reviewed effects of non phamacological treatments in the IBS. Though the efficacy of multi-component approaches was unclear, several results suggest that cognitive behavioral therapy was effective in improving gastrointestinal symptoms of IBS. As a single component, cognitive therapy and relaxation with or without biofeedback could improve the symptoms and psychological health of IBS patients. Yoga, meditation, self-help information and hypnotherapy could be applicable to IBS.

나노부품 초정밀가공기용 마이크로스테이지의 절삭력 예측모델 시뮬레이션

김재열,심재기,곽이구,안재신,한재호,노기웅 한국공작기계학회 2003 한국공작기계학회 춘계학술대회논문집 Vol.2003 No.-

Recently, according to the development of mechatronics industry that was composed of NT, ST, IT, RT and etc, the necessity of nano-parts was increased. Because of the necessity, this research was started for improving work precision of the parts as fixing UPCU (Ultra Precision Cutting Unit) on lathe. So, in this research, we executed the modeling of UPCU (Ultra Precision Cutting Unit) by the application of PZT, the relationship between the displacement of tool in UPCU and the cutting force of it has been in take a triangular position in the case of plane cutting. The modeling of system, that is containing the fine displacement, was performed. Also, we would like to find the optimal cutting condition through the simulation of relationship between the displacement and the cutting force.

일 간호대학의 지역사회 방문간호사업 사례

강윤숙,최양자,고영애,전시자,조갑출,이옥철,주혜경,신기수,안은숙 적십자간호전문대학 2000 적십자간호전문대학논문집 Vol.22 No.-

[PG-0009] Antioxidant activities and phytochemical contents of diverse representative tea germplasm

Gi-An Lee(Gi-An Lee),Nayoung Ro(Nayoung Ro),Do Yoon Hyun(Do Yoon Hyun),Gwang-Yeon Gi(Gwang-Yeon Gi),Kyung Jun Lee(Kyung Jun Lee),Weilan Li(Weilan Li),Eun Ae Yoo(Eun Ae Yoo),SooKyeong Lee(SooKyeong Lee 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-

Variation of seed germiability in diverse rice genetic resources

Gi-An Lee,Young-Ah Jeon,Ho-Sun Lee,Young-Yi Lee,Jung-Sook Sung,Jung-Yoon Yi,Jong-Wook Chung,Myung-Chul Lee,Sok-Young Lee,Yeon-Gyu Kim 한국육종학회 2014 한국육종학회 심포지엄 Vol.2014 No.07

Rice (Oryza sativa L.) is important crop as a staple carbohydrate sources and was regarded as domesticated in Asia region. The seed dormancy is one of the domesticated traits, and this character allows that plants survive in various environment. The degree of dormancy have been targeted for controling in breeding program while weak dormancy cause pre-harvest sprouting contrary to the nonuniform seed germination by strong dormancy. In this study, we surveyed the variation of germiability in diverse rice genetic resources including japonica and indica ecotype. Overall, the degree of seed dormancy of rice germplasm was distinguished into four groups and admixed types; first group(G-1) included accessions revealing high germiability, the accessions of second group(G-2) acquired the high germiability by after-ripening process, third group(G-3)’s accessions showed high germiability after dormancy breaking process and the accessions of last group(G-4) maintained the low germiability in spite of the dormancy breaking process. Among the 51 japonica accessions G-1, G-2, G-3 and G-4 included 15, 15, 11 and 10 accessions, respectively, and among 40 indica accessions, G-1, G-2, G-3 and G-4 groups included 15, 15, 9 and 1 accessions, respectively. Based on these primary test, we plan to detail examine the seed germiability and survey the genetic factors affecting the degree of germiability in representative accessions of each group

Proteomics analysis of salt-induced leaf proteins in two rice germplasms with different salt sensitivity

Lee, Dong-Gi,Woong Park, Kee,Young An, Jae,Geol Sohn, Young,Ki Ha, Jung,Yoon Kim, Hak,Won Bae, Dong,Hee Lee, Kyung,Jun Kang, Nam,Lee, Byung-Hyun,Young Kang, Kyu,Joo Lee, Jeung Canadian Science Publishing 2011 Canadian journal of plant science. Revue canadienn Vol.91 No.2

<P> Lee, D.-G., Park, K. W., An, J. Y., Sohn, Y. G., Ha, J. K., Kim, H. Y., Bae, D. W., Lee, K. H., Kang, N. J., Lee, B.-H., Kang, K.-Y. and Lee, J. J. 2011. Proteomics analysis of salt-induced leaf proteins in two rice germplasms with different salt sensitivity. Can. J. Plant Sci. 91: 337-349. This study was conducted to investigate salt-stress-related physiological responses and proteomics changes in the leaves of two rice (Oryza sativa L.) cultivars. Shoot growth and water content of rice leaves were more severely reduced in Dalseongaengmi-44 than in Dongjin under salt stress. The salt-sensitive Dalseongaengmi-44 exhibited a greater increase in sodium ion accumulation in its leaves than the salt tolerant Dongjin. Comparative analysis of the rice leaf proteins using two-dimensional gel electrophoresis (2-DGE) revealed that a total of 23 proteins were up-regulated under salt stress. Based on matrix-assisted laser desorption ionization-time of flight mass spectrometry and/or electrospray ionization-tandem mass spectrometry analyses, the 23 protein spots were found to represent 16 different proteins. Ten of the identified proteins were previously reported to be salt-responsive proteins, while six, class III peroxidase 29 precursor, beta-1,3-glucanase precursor, OSJNBa0086A10.7 (putative transcription factor), putative chaperon 21 precursor, Rubisco activase small isoform precursor and drought-induced S-like ribonuclease, were novel salt-induced proteins. Under salt stress, fragmentation was increased in several proteins containing the Rubisco large chain. The results of these physiological and proteomics analyses provide useful information that can lead to a better understanding of the molecular basis of salt-stress responses in rice. </P>

Genetic diversity base on agrinomical traits and SSR markers in Korean rice landraces

Kyung Jun Lee,Jong-Ro Lee,Gi-An Lee,Sebastin Raveendar,Kyung-Ho Ma,Sok-Young Lee,Jong-Wook Chung 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07

In order to assess the genetic diversity, phylogenetic relationships and population structure of Korean rice landraces, 76 accessions were estimated using agronomical traits and SSR markers. Among 11 agronomical traits, amylose content (AC) was the trait with the largest variance with values ranged from 4.9 to 28.39 %, while grain length (GL) was the lowest variance ranged from 4.4 to 5.9 cm. In the result of PCA, the first PC with Eigen value of 217.5 explained 60.3% of the total variance. Culm length (CL) was the variable with the largest positive loadings. Growth period (GP) was the positive variances, while AC was the negative variance. The second PC with Eigen value of 80.6 explained an additional 22.4% of the total variance. Growth period (GP) was variable with highest positive loading. Amylose content (AC) was variable with high positive, while CL was the negative variance. The 49 SSR markers produced a total of 473 alleles with an average of 9.6 alleles. The polymorphism information content (PIC) was in the range 0.11 to 0.93. The observed heterozygosity ranged from 0.12 to 0.39, with an average of 0.61. 76 rice accessions showed two subpoplations and three groups based on SSR markers. Group I and Gropu II appertained Pop-2 and Pop-1 subpopulation, respectively. They showed similar agronomical traits. Group III consisted 7 rice accessions predominantly appertained to Pop-1. These results provide insight into the characters of Korean rice landraces and help to improve our knowledge of rice breeding

Evaluation of genetic diversity of red pepper landraces (Capsicum annuum L.) from Bulgaria using SSR markers

Sejong Oh,Jeongran Lee,Gi An Lee,Jae Young Song,Tsvetelina,Lilia,Yeon Gyu Kim,Ju Hee Lee,Myung Chul Lee 한국육종학회 2012 한국육종학회 심포지엄 Vol.2012 No.07

The amount of genetic variability of a species is essential for its survival and adaptation in different environments, and studies of genetic diversity using molecular markers are necessary to understand the genetic structure of a population and to orientate effective strategies of germplasm conservation. The aim of current study was to determine the SSR markers that can be used rapidly and reliably to evaluated the pepper of Bulgaria landraces, and applied the markers to assement of introduce genetic diversity of the pepper germplasm. We used 22 polymorphic microsatellite markers to analysis of genetic diversity within 61 pepper collection of Bulgaria landraces germplasm, all SSR primers pairs produced 80 polymorphic and reproducible amplification fragments. An average value of polymorphic information contents (PIC) were 0.334 with a range of 0.061 to 0.63. The mean values of observed (HO) and expected heterozygosity (HE) were 0.383 and 0.154, respectively, indicating a considerable amount of polymorphism within this collection. A genetic distance-based phylogeny grouped into three distinct groups, which was the landrace, moderate and wilde type, genetic distance (GD) value was 0.540. An average day of flowering time was 53 days with a range of 45 to 60 days. The everage od fruit length and width were 9.38cm with a range 2.1 to 23.6cm, and 3.51cm with a range 0.6 to 8.9cm, respectively. Molecular data were complemented with morphological measurements according to the descriptor list for the pepper collection of Bulgaria landraces germplasm.

MRI-Based Attenuation Correction for PET/MRI Using Multiphase Level-Set Method

An, Hyun Joon,Seo, Seongho,Kang, Hyejin,Choi, Hongyoon,Cheon, Gi Jeong,Kim, Han-Joon,Lee, Dong Soo,Song, In Chan,Kim, Yu Kyeong,Lee, Jae Sung Society of Nuclear Medicine 2016 The Journal of nuclear medicine Vol.57 No.4

<P>Inaccuracy in MR image-based attenuation correction (MR-AC) leads to errors in quantification and the misinterpretation of lesions in brain PET/MRI studies. To resolve this problem, we proposed an improved ultrashort echo time MR-AC method that was based on a multiphase level-set algorithm with main magnetic field (B-0) inhomogeneity correction. We also assessed the feasibility of this level-set-based MR-AC method (MR-AC(level)), compared with CT-AC and MR-AC provided by the manufacturer of the PET/MRI scanner (MR-AC(mMR)). Methods: Ten healthy volunteers and 20 Parkinson disease patients underwent F-18-FDG and F-18-fluorinated-N-3-fluoropropyl-2-beta-carboxymethoxy-3-beta-(4-iodophenyl)nortropane (F-18-FP-CIT) PET scans, respectively, using both PET/MRI and PET/CT scanners. The level-set-based segmentation algorithm automatically delimited air, bone, and soft tissue from the ultrashort echo time MR images. For the comparison, MR-AC maps were coregistered to reference CT. PET sinogram data obtained from PET/CT studies were then reconstructed using the CT-AC, MR-AC(mMR), and MR-AC(level) maps. The accuracies of SUV, SUVr (SUV and its ratio to the cerebellum), and specific-to-nonspecific binding ratios obtained using MR-AC(level) and MR-AC(mMR) were compared with CT-AC using region-of-interest-and voxel-based analyses. Results: There was remarkable improvement in the segmentation of air cavities and bones and the quantitative accuracy of PET measurement using the level set. Although the striatal and cerebellar activities in F-18-FP-CIT PET and frontal activity in F-18-FDG PET were significantly underestimated by the MR-AC(mMR), the MR-AC(level) provided PET images almost equivalent to the CT-AC images. PET quantification error was reduced by a factor of 3 using MR-AC(level) (SUV error < 10% in MR-AC(level) and < 30% in MR-AC(mMR) [version VB18P], and < 5% in MR-AC(level) and < 15% in MR-AC(mMR) [VB20P]). Conclusion: The results of this study indicate that our new multiphase level-set-based MR-AC method improves the quantitative accuracy of brain PET in PET/MRI studies.</P>

Plenary Session 1 : PS-1-5 ; Is HBsAg seroclearance following nucleoside analogue therapy durable in patients with chronic hepatitis B?

( Gi Ae Kim ),( Young Suk Lim ),( Ju Hyun Shim ),( Kang Mo Kim ),( Han Chu Lee ),( Yung Sang Lee ),( Young Hwa Chung ),( Dan Bi Lee ),( Jih Yun An ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

Background: Spontaneous or interferon-induced HBsAg seroclearance is durable in most patients with chronic hepatitis B (CHB). However, little is known about the durability of HBsAg seroclearance following nucleoside analogue (NUC) therapy. Methods: Among 4,578 patients who were treated with either lamivudine (n=1,924) or entecavir (n=2,654) at a tertiary referral hospital in Korea between 2000 and 2010, 121 achieved HBsAg seroclearance. Fifty-eight patients were included in this study after exclusion of 63 patients; acute hepatitis B (n=19), hepatocellular carcinoma (n=8), prior treatment with interferon (n=6), prior immunosuppressive therapy (n=17), liver transplantation (n=6), follow-up loss immediately after HBsAg seroclearance (n=5), and continued NUC therapy (n=2). Results: Mean age of 58 patients were 42 (SD 11) years and 41 (71%) were males. All were assumed to have HBV genotype C. At the initiation of NUC therapy, median levels of ALT and HBV DNA were 153 IU/L (interquartile range [IQR], 48-340 IU/L) and 7.0 log10 copies/mL (IQR, 3.8-8.0 log10 copies/mL), respectively. Twenty-seven (47%) had HBeAg. The median duration of NUC therapy (56 with lamivudine and 2 with entecavir) before HBsAg seroclearance was 42 months (IQR, 24-66 months). During a median follow-up period of 20 months (IQR, 12-32 months), HBsAg reversion occurred in 5 of 58 (8.6%) patients. Three of those 5 patients achieved re-clearance of HBsAg without treatment during further follow-up. The other 2 patients remained HBsAg-positive, but with low titer (<1.0 IU/mL) and undetectable HBV DNA by PCR. Virologic recurrence (detectable HBV DNA by PCR) occurred in 12 of 58 (20.7%) patients. However, all of these patients maintained HBV DNA <10,000 copies/mL. No patient experienced biochemical relapse (ALT flare > x5 ULN). Conclusion: HBsAg seroclearance following NUC therapy is rare but durable in most patients with CHB after treatment discontinuation. Therefore, HBsAg seroclearance would be an ideal treatment endpoint during NUC therapy.