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( Bog Ja Jeoung ),( Yu Jin Jeong ),( Eun Bin Kim ),( Eun Sol Cho ) 한국체육학회 2015 국제스포츠과학 학술대회 Vol.2015 No.1
Purpose : In previous researches, we learned that exercising promotes physical fitness ,strength and positive change in the physical satisfaction level but reviewing previous researches, there was a limit in our finding as it was based on a singular physical activity or exercise and we could not exactly find out which exercise provided the most physical change and satisfaction level. Therefore, the purpose of this study was to find out effects of physical fitness and satisfaction according to participate in exercise method(circuit strength, weight bearing program and badminton). Method: Twelve college students participated exercise program(circuit strength program : n=4, weight bearing program : n=4 and badminton : n=4) who measured 20m PACER, push-up, grip strength, sit-up and sit-reach and body composition, and satisfaction which ``Sports Participants Satisfaction Questionnaire`` developed by Yoo et al(2010). The questionnaire covered improving physical function (3), improved exercise capacity (3), promote social and psychological benefits (3), two healthy living (2) which consisted of total of 14 questions with 5 multiple choices. With regard to the body satisfaction level survey, we have used the BSQ: Body Shape Questionnaire developed in 1987 by Cooper, Taylor and Fairvurn. Park, Eun-ah and Noh, Young-kyung was edited the BSQ questionnaire for this research. The body satisfaction level survey consisted of four sub-variables and a total of 27 questions. Result: First, there is a high level of increase overall in physical strength measurement results especially in sit-ups, flexibility, push-ups and cardiovascular endurance. However, there was little difference between the groups in terms stamina changes while we could not compare physical strength changes based on the type of exercise. Second, there was a slight decrease in weight, BMI, waist and hip circumference with regard to physical changes. However, the physical changes between groups were small while there was no physical change based on the type of exercise. In addition, the was no changes in the level of satisfaction based on after and before exercising while there was only slight difference exercise groups. Third, overall satisfaction level showed significant increase among the exercise groups while the health exercise showed the highest level of satisfaction followed by badminton and circuit training. In terms of exercise satisfaction level by category, physical function improvement and improved exercise capacity showed the highest level of increase and there was little difference in the exercise satisfaction level based on the exercise type. Fourth, if we look at the satisfaction level for physical strength change, satisfaction level was high for strength and agility category but showed no changes between exercise groups. Conclusion: This research is the study of the satisfaction level and changes in physical and physical strength based on three different exercises for different exercise groups. Based on the results of the study, exercising regularly helps increase the overall physical level in all exercise groups and the satisfaction level gradually increases. However, there was little difference between the exercise groups and this research was unable to verify the difference based on the exercise groups. Since the research was limited to 12 participants, a follow-up research should be conducted based on an extended level of participants.
Generation of Soluble Human Tumor Necrosis Factor-α Receptor 1-Fc Transgenic Pig
Cho, Bumrae,Koo, Ok Jae,Hwang, Jong-Ik,Kim, Hwajung,Lee, Eun Mi,Hurh, Sunghoon,Park, Sol Ji,Ro, Han,Yang, Jaeseok,Surh, Charles D.,d’Apice, Anthony J.,Lee, Byeong Chun,Ahn, Curie Lippincott Williams Wilkins, Inc. 2011 Transplantation Vol.92 No.2
BACKGROUND.: Acute humoral xenograft rejection (AHXR) is an important barrier to xenograft survival. Human tumor necrosis factor-α (hTNF-α) is one of the essential mediators of AHXR and induces activation of porcine endothelial cells (PECs), resulting in upregulation of major histocompatibility complex molecules, adhesion molecules, and proinflammatory chemokines. We investigated whether introduction of a soluble human tumor necrosis factor receptor I-Fc (shTNFRI-Fc) fusion gene can suppress activation of PECs and, more importantly, produced shTNFRI-Fc transgenic pigs. METHODS.: The shTNFRI-Fc gene expression vector was constructed and inserted into PECs. The inhibitory effects of shTNFRI-Fc were tested by luciferase assay, reverse-transcriptase polymerase chain reaction, and flow cytometry. A shTNFRI-Fc transgenic pig was generated by somatic cell nuclear transfer. The expression of shTNFRI-Fc in the transgenic pig was evaluated by PCR, western blot, enzyme-linked immunosorbent assay, and immunohistochemistry. The inhibitory effects of shTNFRI-Fc in the serum obtained from the transgenic pig were also tested. RESULTS.: In comparison with control green fluorescent protein, shTNFRI-Fc protein showed much stronger inhibitory effects on NF-&kgr;B activation in the HEK293-NF-&kgr;B-luciferase reporting cell line, expression of chemokines and adhesion molecules in PECs, and TNF-α-mediated cytotoxicity. We successfully generated shTNFRI-Fc transgenic pig. Sera obtained from the transgenic pig inhibited induction of chemokines, and E-selectin in PECs stimulated with Human TNF-α. CONCLUSIONS.: We have generated transgenic pigs producing shTNFRI-Fc protein that can inhibit TNF-α-mediated activation of PECs. Because TNF-α is an important mediator of xenograft rejection, the use of xenografts that can produce shTNFRI-Fc proteins de novo could be an effective approach in overcoming a considerable component of the xenograft rejection process, especially AHXR.
Ha, Eun-Sol,Baek, In-hwan,Cho, Wonkyung,Hwang, Sung-Joo,Kim, Min-Soo Pharmaceutical Society of Japan 2014 Chemical & pharmaceutical bulletin Vol. No.
<P>The aim of the present study was to investigate the effect of Soluplus? on the solubility of atorvastatin calcium and to develop a solid dispersion formulation that can improve the oral bioavailability of atorvastatin calcium. We demonstrated that Soluplus? increases the aqueous solubility of atorvastatin calcium. Several solid dispersion formulations of atorvastatin calcium with Soluplus? were prepared at various drug?:?carrier ratios by spray drying. Physicochemical analysis demonstrated that atorvastatin calcium is amorphous in each solid dispersion, and the 2?:?8 drug?:?carrier ratio provided the highest degree of sustained atorvastatin supersaturation. Pharmacokinetic analysis in rats revealed that the 2?:?8 dispersion significantly improved the oral bioavailability of atorvastatin. This study demonstrates that spray-dried Soluplus? solid dispersions can be an effective method for achieving higher atorvastatin plasma levels.</P>