우리나라 여성의 삶의 질에 관한 연구

강한솔,정수현,황은진,이정주,노승용 서울여자대학교 여성연구소 2011 여성연구논총 Vol.26 No.-

People are getting more interested in their “quality of life” as they achieved certain level of economic development. Governments pay great attention on well-being and happiness of people as well and try to find the best way to improve citizens' quality of life. However, South Korea is still on 27th out of 39 OECD and G20 countries in quality of life index, which means that there are great needs to improve Koreans' quality of life. Moreover, it is expected that Korean women's quality of life might be worse than this in its patriarchal environments. In fact, there are few research regarding Korean women's quality of life and it is unknown what personal and social factors affect Korean women's quality of life and how we can improve it. This research attempts to find out factors related to Korean women's quality of life through the surveys of 536 Korean women. The results show that quality of life is most influenced by factors such as self-fulfillment, socio-economic independence, satisfaction with the residence, and satisfaction with cultural activities. In addition, happiness of Korean womem is greatly affected by various factors such as mental health, interpersonal relationship, self-respect, self-fulfillment, socio-economic independence, satisfaction with the residence, and satisfaction with cultural activities. Among various factors related to quality of life and happiness of Korean women, scores of self-respect, self-fulfillment, and interpersonal relationship are high, while scores regarding income are relatively low. Key words:Quality of Life, Happiness, Maslow

인천 재성형 해성점토의 비배수 전단강도 특성에 대한 연구

유남재,이한솔,전상현 江原大學校 産業技術硏究所 2009 産業技術硏究 Vol.29 No.B

The main purpose of this work is to determine characteristics of undrained shear strength of remolded marine clay at Incheon. Laboratory vane tests with remolded marine clay sampled from west coast at Incheon were performed to investigate the undrained shear strength of them being dumped for reclamation after dredging from the sea bottom. Test results were compared with the predicted values of undrained shear strength proposed by many researchers. It was found that measured results about undrained shear strength with water content was in good agreements with values proposed by Mikasa and Modified Mikasa's empirical formula.

인천 및 부산 재성형 해성점토의 비배수 전단강도 특성에 대한 연구

유남재,이한솔,전상현 江原大學校 産業技術硏究所 2010 産業技術硏究 Vol.30 No.A

This research is to determine characteristics of undrained shear strength of remolded marine clay at Incheon and Busan, representing typical marine clays in Korea. Laboratory vane tests with remolded marine clays sampled from coasts at Incheon and Busan were performed to investigate the undrained shear strength of them. Test results were compared with the predicted values of undrained shear strength proposed by many researchers. It was found that measured results about undrained shear strength with water content was in good agreements with values proposed by Terzaghi empirical formula.

시민참여와 정부신뢰

정수현,강한솔,황은진,이정주,노승용 서울여자대학교 사회과학연구소 2012 사회과학논총 Vol.19 No.-

이 연구는 시민참여와 정부신뢰와의 관계를 분석하는데 그 목적이 있다. 이를 위하여, 이 연구에서는 시민참여를 전통적인 오프라인 시민참여와 디지털 방식인 온라인 시민참여로 그 유형을 분류하고, 오프라인 시민참여와 온라인 시민참여의 경험이 정부신뢰와 어떤 관계가 있는지를 분석하였다. 2차 자료를 활용하여 빈도분석, 교차분석, t-test, 분산분석, 회귀분석 등을 실시한 결과 먼저, 우리나라 시민참여 경험자는 약 22% 정도이며, 오프라인 시민참여 경험자는 약 12%, 온라인 시민참여 경험자는 약 15%, 그리고 온라인과 오프라인 시민참여를 모두 경험한 시민은 약 5% 정도인 것으로 나타났다. 또한, 시민참여와 정부신뢰와는 관계를 분석한 결과 통계적으로 유의미한 관계가 없는 것으로 나타났다. 오히려, t-test 및 분산분석 결과 오프라인 및 온라인 시민참여 경험자에 비하여 무경험자의 정부신뢰 수준이 상대적으로 약간 더 높은 것으로 나타났다. 시민참여의 경험 유무 만으로 정부신뢰를 설명하는데는 한계가 있음을 보여 주는 결과일 뿐만 아니라 시민참여를 제도적으로 보장하는 것에서 나아가서 시민참여가 실질적 효과를 높일 수 있도록 시민참여과정에서 정부와 시민의 보다 적극적인 노력이 필요함을 보여주는 결과라 하겠다. Trust in government adds legitimacy to political system, provides social stability, and helps government to work effectively. In addition it increases cooperation between governments and citizens, and improves effectiveness of government affairs. However, citizens' trust in government has been quite low sine 1990s. In Korea, citizens' trust in government dropped after financial crisis in late 1990s. Various literatures indicated that citizen participation is one of the best ways to increase citizens' trust in governments. Especially as information technology increases, it is expected that citizens acquire information about different policy areas, and actively participate in surveys, discussion, and policy evaluation through internet. This research attempts to prove the relationship between citizen participation and trust in government by comparing online and offline citizen participation. The research utilized 2nd dataset from 'the influence of information on citizens' participation in policy-making.' With various statistical techniques such as frequency analysis, cross tabulation, ANOVA, and regression analysis, the characteristics of offline and online policy participants are examined. The results showed that citizens, who participate in policy-making processes more actively both online and offline, trust in government less. Comparing online and offline participation, online participants distrusted government more than offline participants. Such variables as policy competitiveness, democracy in government, quality of government, and transparency in government have direct influences on trust in government. However, citizen participation is not statistically significant. Key Words:Citizen Participation, Traditional Citizen Pariticipation, Digital Citizen Participation, Trust in Government.

사무직 근로자의 수면의 질 및 직무스트레스와 우울과의 관련성

강미나,강수영,권수정,김현주,배재원,이보연,이예진,임의롬,정다영,조한솔 이화여자대학교 간호과학대학 2013 이화간호학회지 Vol.- No.47

Purpose: The purpose of this study was to understand the degree of depression, sleep quality, job stress and their association among office workers. Method: A self-administered questionnaire was distributed to 147 workers employed in 5 big enterprises, and 5 small and medium enterprises from October 21 to November 21, 2012. The questionnaires included socio-demographic and health-related characteristics, job-related characteristics, sleep quality, job stress (KOSS) and depression (CES-D). Result: Among all subjects, 23.1% was in the depression group (21 points and over in the CES-D score). Depressive level was positively correlated with job stress and quality of sleep. The adjusted odd ratio for the effects of sleep quality and job stress on depression significantly increased in the depression group compared to that of the normal group. Multiple regression analysis revealed that the following factors of influence had combined explanatory powers on depression: BMI, life satisfaction, quality of sleep, and job stress. Conclusion: The study revealed that complicated influences were exerted on the level of depression by variable factors, as well as socio-demographic characteristics, health-related characteristics, quality of sleep, and job stress. Specifically, the level of depression was influenced by the quality of sleep and job stress.

Screening of Genetic Polymorphisms of CYP3A4 and CYP3A5 Genes

Lee, Jin Sol,Cheong, Hyun Sub,Kim, Lyoung Hyo,Kim, Ji On,Seo, Doo Won,Kim, Young Hoon,Chung, Myeon Woo,Han, Soon Young,Shin, Hyoung Doo The Korean Society of Pharmacology 2013 The Korean Journal of Physiology & Pharmacology Vol.17 No.6

Given the CYP3A4 and CYP3A5's impact on the efficacy of drugs, the genetic backgrounds of individuals and populations are regarded as an important factor to be considered in the prescription of personalized medicine. However, genetic studies with Korean population are relatively scarce compared to those with other populations. In this study, we aimed to identify CYP3A4/5 polymorphisms and compare the genotype distributions among five ethnicities. To identify CYP3A4/5 SNPs, we first performed direct sequencing with 288 DNA samples which consisted of 96 Koreans, 48 European-Americans, 48 African-Americans, 48 Han Chinese, and 48 Japanese. The direct sequencing identified 15 novel SNPs, as well as 42 known polymorphisms. We defined the genotype distributions, and compared the allele frequencies among five ethnicities. The results showed that minor allele frequencies of Korean population were similar with those of the Japanese and Han Chinese populations, whereas there were distinct differences from European-Americans or African-Americans. Among the pharmacogenetic markers, frequencies of $CYP3A4^*1B$ (rs2740574) and $CYP3A5^*3C$ (rs776742) in Asian groups were different from those in other populations. In addition, minor allele frequency of $CYP3A4^*18$ (rs28371759) was the highest in Korean population. Additional in silico analysis predicted that two novel non-synonymous SNPs in CYP3A5 (+27256C>T, P389S and +31546T>G, I488S) could alter protein structure. The frequency distributions of the identified polymorphisms in the present study may contribute to the expansion of pharmacogenetic knowledge.

Plant Regeneration from Embryogenic Cell-derived Protoplasts and Differential Gene Expression during This Process in Angelica gigas

Han-Sol Lee,Jong-Eun Han,Suk-Hyun Kwon,So-Young Park 한국원예학회 2022 한국원예학회 학술발표요지 Vol.2022 No.5

Liquid chromatography–tandem mass spectrometry quantification of acetamiprid and thiacloprid residues in butterbur grown under regulated conditions

Lee, Han Sol,Kim, Sung-Woo,Abd El-Aty, A.M.,Chung, Hyung Suk,Kabir, Md. Humayun,Rahman, Md. Musfiqur,Jeong, Ji Hoon,Chang, Byung-Joon,Shin, Ho-Chul,Shim, Jae-Han Elsevier 2017 Journal of chromatography. B, Analytical technolog Vol.1055 No.-

<P><B>Abstract</B></P> <P>An analytical method was developed to quantify the residual levels of the neonicotinoid insecticides, acetamiprid and thiacloprid, in field-incurred butterbur samples using liquid chromatography–tandem mass spectrometry (LC–MS/MS). Samples were extracted with acetonitrile and partitioned with dichloromethane. After partitioning, purification was conducted using a Florisil<SUP>®</SUP> cartridge. Linearity of a matrix-matched calibration curve of the two compounds over a concentration range of 0.004–0.4μg/g was excellent, with determination coefficients (<I>R<SUP>2</SUP> </I>)≥0.9998. The limits of detection (LOD) and quantitation (LOQ) for both acetamiprid and thiacloprid were 0.0006 and 0.002mg/kg, respectively. The average recoveries for acetamiprid and thiacloprid at two spiking levels (0.02 and 0.1mg/kg, <I>i.e.</I>, 10×LOQ and 50×LOQ) were between 78.23 to 82.17%, with relative standard deviations (RSDs)≤7.22%. The method was successfully applied to field-incurred samples treated with a commercial pesticide product, either once (zero or 7 days before harvest) or twice (0 and 7, 7 and 14, or 14 and 21 days before harvest). The highest and lowest residues were obtained for the 7 and 0 days’ treatment and the 21 and 14 days’ treatment, respectively. The developed method is simple and accurate and can be extrapolated to other leafy vegetables.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Acetamiprid and thiacloprid were quantified in butterbur using LC–MS/MS. </LI> <LI> Both analytes were extracted with acetonitrile and purified with Florisil cartridge. </LI> <LI> LL partitioning in combination with SPE effectively removed the interferences during purification. </LI> <LI> The developed method determined both analytes accurately and precisely. </LI> <LI> The residual levels in field-incurred butterbur samples decreased with time and number of treatments. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Mapping of QTL for yield and its related traits in a doubled haploid population of Korean wheat

Han Sol Lee,Chul Soo Park,Ji-Ung Jung,Chon-Sik Kang,Hwayoung Heo 한국식물생명공학회 2014 Plant biotechnology reports Vol.8 No.6

This study was conducted to identify thequantitative trait loci (QTL) associated with grain yield andits related traits by analysis of 122 doubled haploid populationderived from a cross between Korean wheat cultivarscarried different yield potential. DH population was evaluatedin replicated field trials in 2011/2012 and 2012/2013at upland and paddy conditions in Iksan, Korea. Grain yieldand its related traits, including days to heading and maturity,culm and spike length, spike number per m2, kernelnumber per spike, and thousand kernel weight, wereinvestigated. A genetic map was constructed with 140microsatellite marker loci and a total of nine QTLs wereidentified on eight chromosomes for grain yield and itsrelated traits. The three QTLs, Xgpw2206, Xgwm247, andXwmc471, were detected on chromosomes 2A, 3A, and 3B,and explained 10.1–22.8 % of phenotypic variation forgrain yield. Among these QTLs, Xgpw2206 and Xgwm247explained 10.7–37.9 % of phenotypic variation for days toheading and maturity, spike length, spike number per m2,and kernel number per spike. Other six QTLs on chromosomes2D, 4A, 5A, 6A, and 7A accounted for 11.4–39.9 %of phenotypic variation for culm and spike length, spikenumber per m2, and thousand kernel weight. Those threeQTLs for grain yield were applied to validate relationshipbetween genotypes of QTL and 25 Korean wheat cultivars. Korean wheat cultivars carried hha genotypes based on theorder of those three QTLs, showed higher GY (664.4 kg/10a) than genotype bha (494.2 kg/10a). Those three QTLscould be used in marker-assisted selection to improve grainyield and its related traits in Korean wheat breedingprograms.

Expression of beta-catenin and its mechanism of delocalization in intestinal-type early gastric cancer based on mucin expression.

Lee, Soo Han,Kang, Hyun Jeong,Shin, Dong-Hun,Cho, Duk-Yeon,Song, Jin Mi,Lee, Han Cheol,Kim, Gwang Ha,Song, Geun Am,Sol, Mee Young,Kim, Jee Yeon,Choi, Kyung Un,Lee, Chang Hun,Huh, Gi Young,Park, Do You Gutenberg 2009 HISTOLOGY AND HISTOPATHOLOGY Vol.24 No.7

<P>The biological characteristics of intestinal-type early gastric cancers (ICs) differ based on mucin phenotypes. Beta-catenin delocalization is a predictive marker of aggressive biological behavior (submucosal invasion and lymph node metastasis) of ICs. The presumptive causative genetic alterations leading to delocalization of beta-catenin in ICs are still controversial, and there are only a few reports regarding beta-catenin expression in gastric cancer based on mucin phenotypes. Therefore, in the current study, the expression and mechanisms of delocalization of beta-catenin were elucidated on the basis of mucin phenotypes in 109 cases of ICs. There was increased cytoplasmic and nuclear beta-catenin expression (delocalization) in ICs with a predominant intestinal mucin phenotype (ICIP; 46.3% [25/54 cases]) compared to ICs with a predominant gastric mucin phenotype (ICGP; 20% [11/55 cases]). There were no beta-catenin or APC mutations in ICs. APC promoter hypermethylation was present in 49 of 105 (46.7%) cases of ICs. There was a significant relationship between APC promoter hypermethylation and beta-catenin delocalization in ICs, especially in ICIPs. There was no relationship between beta-catenin delocalization and APC gene loss of heterozygosity in ICs. In conclusion, we showed that beta-catenin delocalization was more evident in ICIPs, and APC promoter hypermethylation might play a role in delocalization of beta-catenin, especially in ICIPs.</P>