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Fluoxetine and Sertraline Attenuate Postischemic Brain Injury in Mice
Shin, Tae-Kyeong,Kang, Mi-Sun,Lee, Ho-Youn,Seo, Moo-Sang,Kim, Si-Geun,Kim, Chi-Dae,Lee, Won-Suk The Korean Society of Pharmacology 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.3
This study aimed to investigate whether selective serotonin reuptake inhibitors (SSRIs) attenuate brain injury and facilitate recovery following photothrombotic cortical ischemia in mice. Male ICR mice were anesthetized and systemically administered Rose Bengal. Permanent focal ischemia was induced in the medial frontal and somatosensory cortices by irradiating the skull with cold light laser. The animals were treated with fluoxetine or sertraline once a day for 14 d starting 1 h after ischemic insult. Treatment with fluoxetine and sertraline significantly reduced the infarct size. The Evans blue extravasation indices of the fluoxetine- and sertraline-treated groups were significantly lower than that of the vehicle group. Treatment with fluoxetine and sertraline shifted the lower limit of the mean arterial blood pressure for cerebral blood flow autoregulation toward normal, and significantly increased the expression of heme oxygenase-1 (HO-1) and hypoxia-inducible factor-1 ${\alpha}$ (HIF-1 ${\alpha}$) proteins in the ischemic region. These results suggest that SSRIs, such as fluoxetine and sertraline, facilitate recovery following photothrombotic cortical ischemia via enhancement of HO-1 and HIF-1 ${\alpha}$ proteins expression, thereby providing a benefit in therapy of cerebral ischemia.
Fluoxetine and Sertraline Attenuate Postischemic Brain Injury in Mice
Tae Kyeong Shin,Mi Sun Kang,Ho Youn Lee,Moo Sang Seo,Si Geun Kim,Chi Dae Kim,Won Suk Lee 대한생리학회-대한약리학회 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.3
This study aimed to investigate whether selective serotonin reuptake inhibitors (SSRIs) attenuate brain injury and facilitate recovery following photothrombotic cortical ischemia in mice. Male ICR mice were anesthetized and systemically administered Rose Bengal. Permanent focal ischemia was induced in the medial frontal and somatosensory cortices by irradiating the skull with cold light laser. The animals were treated with fluoxetine or sertraline once a day for 14 d starting 1 h after ischemic insult. Treatment with fluoxetine and sertraline significantly reduced the infarct size. The Evans blue extravasation indices of the fluoxetine- and sertraline-treated groups were significantly lower than that of the vehicle group. Treatment with fluoxetine and sertraline shifted the lower limit of the mean arterial blood pressure for cerebral blood flow autoregulation toward normal, and significantly increased the expression of heme oxygenase-1 (HO-1) and hypoxia-inducible factor-1Ձ (HIF-1Ձ) proteins in the ischemic region. These results suggest that SSRIs, such as fluoxetine and sertraline, facilitate recovery following photothrombotic cortical ischemia via enhancement of HO-1 and HIF-1Ձ proteins expression, thereby providing a benefit in therapy of cerebral ischemia.
Induction of heme oxygenase-1 protects against podocyte apoptosis under diabetic conditions
Lee, Sang Choel,Han, Seung Hyeok,Li, Jin Ji,Lee, Sun Ha,Jung, Dong-Sub,Kwak, Seung-Jae,Kim, Seung Hye,Kim, Dong Ki,Yoo, Tae-Hyun,Kim, Jin Hyun,Chang, Se-Ho,Han, Dae Suk,Kang, Shin-Wook International Society of Nephrology 2009 Kidney international Vol.76 No.8
Heme oxygenase-1 (HO-1) is an anti-oxidant enzyme normally upregulated in response to oxidant injury. Here we determined the role of HO-1 in podocyte apoptosis in glomeruli of streptozotocin-treated rats and in immortalized mouse podocytes cultured in media containing normal or high glucose. HO-1 expression, its activity, the ratio of Bax/Bcl-2 protein, and active caspase-3 fragments were all significantly higher in isolated glomeruli of diabetic rats and in high glucose–treated podocytes. These increases were inhibited by zinc protoporphyrin treatment of the rats or by HO-1 siRNA treatment of the podocytes in culture. The number of apoptotic cells was also significantly increased in the glomeruli of diabetic rats and in high glucose–treated podocytes. Inhibition of HO-1 accentuated the increase in apoptotic cells both in vivo and in vitro. Our findings suggest that HO-1 expression protects against podocyte apoptosis under diabetic conditions.
신윤호,안정업,김대희,최수경 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(구조계)
The purpose of this study is to establish an evaluation method of fracture of light-weight framed walls by human impact load. In this paper, part (I), we analyzed human impact load applied to framed walls. At first, we made original measuring equipment of impact load, and carried out the experiment on human impact load in various action. After the experiment, we extracted the essential characteristics. And grasped the property of human impact load systematically based on the relation between maximum load and load velocity.
수생식물을 이용한 수질정화 SYSTEM 개발에 관한 연구
신대윤,홍완해,왕승호 조선대학교 환경공해연구소 1999 環境公害硏究 Vol.15 No.2
This study focused on the removal of COD, SS, T-N and T-P of home wastewater in batch and continuous culture reactors using parsley. And the amounts of nitrogen and phosphorus in the tissues of parsley were also detected. The results are as follow ; 1. Parsley has achieved 42% COD removal rate, 55% SS, 10% T-P and 41% T-N for 48 hours retention time. Residual concentration was COD 6.1㎎/ℓ, SS ll㎎/ℓ, T-P 1.112㎎/ℓ and T-N 4.9㎎/ℓ respectively. 2. Nitrogen and phosphorous content, accumulated in the tissues of parsley are 40.4% and 9.2% respectively in batch reactor with 48 hours SRT. They are presenting increasing rate 37.6% of nitrogen and 9% of phosphorous, compared with their influent sample, contending 2.8% of nitrogen and 0.19% of phosphorous. 3. Continuous reactor has achieved 42% COD removal rate, 62% SS, 10% T-N, and 46% T-P, Effluent COD concentration was 5.8㎎/ℓ, SS 8.13㎎/ℓ, T-P 0.84㎎/ℓ and T-N 4.09㎎/ℓ.
신종익,이정한,송한범,강대언,오상훈,차승렬,이용재,김상대,이원호 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)
This study investigates the performance of the reinforced concrete frame with the steel plate slit damper. The test was carried out to investigate the structural behavior between the reinforced concrete bare frame and the reinforced concrete frame with the steel plate slit damper. The test results showed that the energy absorption capacity of the damped-frame was several times larger than that of the bare frame. For the damage by the input energy is concentrated on the steel plate slit damper, the ductilities of the former structure were increased and the damaged frame can be reused after exchange the steel plate slit damper.
이원호,윤현도,강대언,송한범,태경훈,박완신 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)
Ductile coupled flexural wall is the primary seismic load resisting system of buildings. In these systems, connections are generally headed stud bolt connection. The purpose of experimental study is to evaluate the seismic behavior of these connection under cyclic loading. A comprehensive experimental test involving 4 specimens has been performed and this program is used to study the effect of value of moment and edge distance. Through experimental test, the seismic behavior of typical headed stud bolt connections was established.
鄭大琪,宋昊埈,辛民敎 대한본초학회 1997 大韓本草學會誌 Vol.12 No.1
This study was investigated the inhibitory activity of Semen Mirabilis (SM) (Nyctaginaceae) on type 1 immediate hypersensitivity of the anaphylactic type. 1 used a mouse model of passive cutaneous anaphylaxis, an IgE-mediated, mast cell-dependent reaction. Administered orally at 250, 500 ㎎/㎏ body weight 1 h before the challenge, SM was potently inhibited PCA in mouses in which disodium cromoglycate showed poor inhibitory activity. SM inhibited compound 48/80-induced anaphylaxis 94.21% with a dose of 0.5g/㎏ body weight at 1 h before or 5 and 10 min after injection of compound 48/80. SM (0.03-2.0 ㎎/㎖) also exhibited the dose-dependent inhibitory effect on compound 48/80-induced histamine release from rat peritoneal mast cells. Moreover, it was clearly demonstrated that SM and disodium cromoglycate disodium cromoglycate potently inhibited such type I allergic reactions as anaphylactic shocks, suggesting that these drugs, at least in part, share the same mechanism of action. It is suggested that SM may exert a stronger inhibition on the mast cell degranulation process. When I examined the effect of SM on the release of IgE in mouse spleen whole cells and human mycloma U266B1, the release of IgE is inhibited by Mirabilis jalapa L. These results suggest the possibility that the inhibition of allergic reaction by SM is regulated by histamine and IgE.