안내염과 대장암이 동반된 재발성 간농양

전승정,김태헌,류민선,오다연,송명은,이신아,류재인,김혜인,문일환,유권 이화여자대학교 의과학연구소 2011 EMJ (Ewha medical journal) Vol.34 No.2

The causes of pyogenic liver abscess has been known as biliary tract disease or intrabadominal infection but the large proportions of the patients has no apparent underlying disorders. Recently colonic mucosal lesions were reported in patients with cryptogenic liver abscess and it has been suggested that colonic mucosal break may play a role in developing liver abscess in otherwise healthy patients. We experienced a patient of severe recurrent liver abscess complicated with endophthalmitis only 3 months after successful treatment of initial cryptogenic liver abscess and a polypoid colon cancer was discovered by chance. It seems prudent to proceed colonoscopic examination in patients with cryptogenic liver abscess especially when it is recurrent.

Poster Session : PS 0881 ; Lower GI Tract : Alcoholic Liver Disease is Associated with the Increased Risk of Advanced Colonic Neoplasm

( Da Yeon Oh ),( Seong Joon Koh ),( Hwi Young Kim ),( Won Kim ),( Yong Jin Jung ),( Ji Won Kim ),( Byeong Gwan Kim ),( Kook Lae Lee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: The aim of this study is to investigate whether alcoholic liver disease (ALD) is associated with the increased risk of advanced colonic neoplasm in patients with ALD. Methods: We analyzed 118 consecutive patients with ALD who performed colonoscopy between January 2000 and December 2013. For each case, age- (±5 years) and sex- matched controls were identified from patients with non-alcoholic fatty liver disease (NAFLD) and healthy controls. Clinical characteristics were reviewed through medical records, colonoscopic finding, pathologic finding, images. Results: The prevalence of colorectal cancer was 6 (5.1%) in ALD patients, 5 (2.5%) in NAFLD patients, 0 (0.0%) healthy control (P =0.007). In addition, the prevalence of advanced colonic adenoma was 18(15.3%) in ALD patients, 17(8.6%) in NAFLD, in 6 (2.8%) healthy control (P<0.001). A case-control study showed that odds for detecting a colorectal advanced neoplasm among ALD patients without decompensated liver cirrhosis were approximately 10.1 times greater than in healthy controls [OR,10.095; 95% Confidential interval(CI), 3.638-28.014; P<0.001) ]. There was no significant difference in the prevalence of colorectal cancer (P=0.428) and advanced colonic adenoma (P=0.876) according to the presence of decompensated liver cirrhosis (LC) in ALD patients. Age is an independent risk factor for detecting advanced colonic neoplasm in patients with ALD [OR, 1.091; 95% CI, 1.025-1.162; P= 0.007]. Conclusions: The yield for detecting advanced neoplasm was significantly higher in patients with ALD than in healthy control. Screening for colorectal neoplasm using colonoscopy is warranted in ALD patients without decompensated LC.

Does Diabetes Mellitus Influence Standardized Uptake Values of Fluorodeoxyglucose Positron Emission Tomography in Colorectal Cancer?

( Da Yeon Oh ),( Ji Won Kim ),( Seong Joon Koh ),( Mingoo Kim ),( Ji Hoon Park ),( Su Yeon Cho ),( Byeong Gwan Kim ),( Kook Lae Lee ),( Jong Pil Im ) 대한장연구학회 2014 Intestinal Research Vol.12 No.2

Background/Aims: Hyperglycemia is associated with decreased 2-18[F]fluoro-2-deoxy-D-glucose (FDG) uptake by tumorsassessed by positron emission tomography (PET). In this retrospective study we investigated a comparison of standardizeduptake values (SUVs) in patients with primary colorectal cancers who either had diabetes mellitus (DM) or were otherwisehealthy. Methods: The medical records of 397 patients who were diagnosed with colorectal cancer and underwent PETCTbetween January 2006 and December 2012 were analyzed. Eighty patients with DM and 317 patients without DM wereincluded. Clinical characteristics were reviewed and maximal standardized uptake values (SUVmax) were calculated in the primarycolorectal lesions. Results: There was no significant difference between tumor SUVmax in DM patients (10.60±5.78) andthose without DM (10.92±5.44). In addition, no significant difference was detected between tumor SUVmax in DM patients withglycated hemoglobin (HbA1c) levels <8% (10.34±5.17) and those with HbA1c levels ≥8% (10.61±7.27). The maximum size ofthe primary colorectal tumor was associated with SUVmax in a linear regression analysis. Conclusion: The results of this studyshowed that DM did not influence FDG uptake values in colorectal cancer patients regardless of glucose levels. (Intest Res2014;12:146-152)

Editorial : Cross-Regulation of Innate and Adaptive Immunity: A New Perspective for the Pathogenesis of Inflammatory Bowel Disease

( Da Yeon Oh ),( Seong Joon Koh ) The Editorial Office of Gut and Liver 2015 Gut and Liver Vol.9 No.3

Non-Word Repetition and Sentence Repetition Performance in 2–3 Years Old Late Talkers and Normal Children

오다연(Da Yeon Oh),임동선(Dongsun Yim) 한국언어청각임상학회 2013 Communication Sciences and Disorders Vol.18 No.3

배경 및 목적: 본 연구는 2-3세 말 늦은 아동과 정상 아동을 대상으로 비단어따라말하기와 문장 따라말하기 수행 능력 및 다양한 변인들 간의 관련성을 살펴보고자 하였다. 방법: 2-3세 말 늦은 아동과 정상 아동 각각 20명씩, 총 40명으로 하였다. 말 늦은 아동과 정상 아동의 비단어따라말하기 수행 능력과 문장 따라말하기 수행 능력 알아보기 위해 이원혼합분산분석(two-way mixed ANOVA)를 실시하였고, 각 집단에서 비단어따라말하기, 문장 따라말하기와 다양한 변인들(생활연령, 수용어휘력검사 점수, 자음정확도)과 상관관계를 알아보기 위해 Pearson 적률상관계수를 구하여 측정하였다. 결과: 첫째, 비단어따라말하기는 두 집단 간 통계적으로 유의하지 않았지만 두 집단 모두 음절길이가 길어질수록 수행률이 저조하여 통계적으로 유의한 차이를 보였다. 문장 따라말하기는 두 집단 간 통계적으로 유의한 차이를 보였으며, 두 집단 내 구문적 난이도에 따라 통계적으로 유의한 차이를 보였다. 다양한 변인들 중 정상 아동의 경우 생활연령과 문장 따라말하기 능력이 비단어따라말하기 수행과 유의한 상관을 보였으며, 말 늦은 아동의 경우에는 자음정확도와 문장 따라말하기 능력이 비단어따라말하기 수행과 유의한 상관을 보였다. 논의 및 결론: 본 연구를 통하여 문장 따라말하기에서만 말 늦은 아동을 선별할 수 있어, 비단어따라말하기보다 문장 따라말하기가 더 민감하게 말 늦은 아동을 선별할 수 있는 선별 검사도구임을 확인할 수 있었다. Objectives: The purposes of this study were to compare the non-word repetition and sentence repetition performance in late talkers compared to normal children, and to investigate the correlation among non-word repetition, sentence repetition and various other factors. Methods: A total of 40 children composed of 20 late talkers aged from 2 to 3 years old and 20 normal children participated in this study. Results: The results were as follows: a 2-way mixed ANOVA result at each syllable length showed that there was no significant difference on the non-word repetition performance between late talkers and normal children. However both group exhibited a word length effect: as the length of non-words increased, children's performance (percent accuracy of repeating non-words) decreased. On the sentence repetition task, normal children significantly outperformed late talkers. Correlation analysis showed that the non-word repetition performance was significantly correlated with chronological age and sentence repetition performance in normal children. However, in late talkers the non-word repetition performance was significantly correlated with the percent of correct consonant on a standardized articulation test and sentence repetition performance. Conclusion: These results suggest that the sentence repetition performance may be more reliable than the non-word repetition task for accurately identifying late talkers.

크론병의 드문 합병증: 급성 간문맥고혈압으로 발현한 간문맥 및 상장간막정맥 혈전증

오다연 ( Da Yeon Oh ),정혜경 ( Hye Kyung Jung ),권경주 ( Kyoung Joo Kwon ),류재인 ( Jae In Ryu ),손명은 ( Myung Eun Song ),유권 ( Kwon Yoo ),문일환 ( Il Hwan Moon ) 대한내과학회 2013 대한내과학회지 Vol.84 No.5

염증성 장질환의 전신 합병증 중 혈전색전증은 흔하지 않은 합병증이나 일단 발생하면 혈관합병증뿐 아니라 염증성 장질환을 악화시켜 사망률이 높은 것으로 알려져 있다. 궤양성 대장염에서 혈전색전증은 국내에서도 몇몇 증례가 보고되었으나 크론병에서 과응고성으로 인한 혈관 합병증의 사례는 극히 드물다. 저자들은 42세 일란성 남자 쌍둥이 형제에서 크론병이 발병하여 관해 상태를 유지하던 중 형에게 복수와 말초부종이 발생하여 혈액응고 장애와 동반된 간문맥 및 상장간맥 혈전증이 진단되어 조기에 항응고제 치료를 하고 호전된 증례를 경험하여, 기존의 국내에 보고되었던 문헌과 함께 보고한다. Thromboembolic events are rare among systemic complications of inflammatory bowel disease; however, they are a significant cause of mortality when they occur. Several reports have considered thromboembolic events in patients with ulcerative colitis presenting with venous or arterial thromboembolism, such as cerebral thrombosis, deep vein thrombosis, pulmonary thromboembo-lism, portal vein thrombosis, or mesenteric vein thrombosis. However, increased coagulability related to Crohn`s disease is extremely rare compared with that of ulcerative colitis. We report a case of a 42-year-old man with complicated portal hypertension that occurred due to extensive portal vein and mesenteric vein thrombosis. He had a monozygotic twin brother who was also in re-mission with Crohn`s disease. The patient showed protein C and protein S deficiencies; however, he recovered with early anti-coagulation therapy. (Korean J Med 2013;84:713-717)

제주지역 청소년소비자의 용돈관리행동에 관한 연구

오다연 ( Oh Da-yeon ),김정숙 ( Kim Jeong-sook ) 한국금융소비자학회 2017 금융소비자연구 Vol.7 No.1

이 연구는 청소년소비자의 용돈관리행동에 영향을 미치는 요인들의 상대적 영향력과 인과적 효과를 분석하기 위하여, 제주지역 1~3학년 중학생 616명을 대상으로 설문조사를 실시하였으며, 분석결과는 다음과 같다. 첫째, 청소년소비자의 용돈관리행동은 용돈통장을 가지고 있는 청소년소비자가, 가계소득이 많을수록, 용돈 만족도가 높을수록, 부모·대중매체·학교와의 소비자사회화 수준이 높을수록, 용돈관리태도와 용돈관리기능이 높을수록 용돈관리행동을 잘하고 있었다. 둘째, 청소년소비자의 용돈관리행동에 가장 큰 인과적 영향을 미치는 요인은 용돈관리기능이였으며, 간접적으로 가장 큰 영향을 미치는 요인은 자아존중감이였다. 또한, 성별, 용돈통장 유무, 부모·대중매체·학교와의 소비자사회화는 용돈관리행동에 직접적인 영향뿐만 아니라, 용돈관리태도와 용돈관리기능을 통하여 간접적으로도 유의한 영향을 미치고 있었으며, 가계소득, 용돈관리 교육 필요성 인식, 자아존중감은 용돈관리행동에 직접적으로는 유의한 영향을 미치지 않았으나, 소비자사회화 작용인, 용돈관리태도와 용돈관리기능을 통하여 간접적으로는 유의한 영향을 미치고 있었다. 이상의 결과를 통해, 부모, 대중매체, 학교 등 소비자사회화 작용인과 용돈관리태도와 용돈관리기능은 청소년소비자의 용돈관리행동에 매개요인으로 작용하고 있음을 알 수 있다. This study intends to analyze the relative influence and causal effects of the factors that affects allowance management behavior in teenage consumers by surveying middle school students in Jeju region. The study’s results will provide reference material for identifying the spending patterns of teenage consumers in Jeju region and help develop a consumer education program to promote better allowance management behavior in teenage consumers. The data were collected from 616 7th to 9th grade students in middle schools across the Jeju region. For the analysis of the data, techniques such as frequency and percentage, t-test, ANOVA, multiple-range test by Sheffe, and a path analysis using the SPSS 18.0 program were utilized. The main findings of this study are as follows. First, the allowance management behavior of teenage consumers was better where teenage consumers had bank accounts, where the household income was higher than average, where the level of satisfaction with the allowance amount was high, where the level of consumer socialization with parents and school was high, and where a sound allowance management attitude and skill was present. Second, the factor that had the most causal effect on allowance management behavior was the skill in managing allowance, while self-esteem had the biggest indirect effect. In addition, gender, the presence of a bank account, and consumer socialization with parents, mass media and school had not only a direct impact on allowance management behavior but also had an indirect but significant impact through their effect on allowance management attitude and skill. Although household income, the awareness of the need for education of allowance management, and self-esteem did not have a direct significant impact on the allowance management behaviors of teenage consumers, these factors had an indirect significant impact on behavior through allowance management attitude and skill, which are consumer socialization factors. Such results showed that consumer socialization with parents, mass media and school and allowance management attitude and skill are all mediating factors in the allowance management behavior of teenage consumers.

완전분해와 전분해 방법에 의한 영산강,섬진강수계 퇴적물의 중금속농도 상관관계

오다연(Da Yeon Oh),최경균(Kyoung Kyoon Choi),허인애(In Ae Huh),황인성(In Seong Hwang),김영훈(Young Hoon Kim),허진(Jin Hur),신현상(Hyun Sang Shin),오정은(Jeong Eun Oh),신원식(Won Sik Shin),박정훈(Jeong Hun Park) 大韓環境工學會 2011 대한환경공학회지 Vol.33 No.1

본 연구에서는 완전분해와 전분해 전처리 방법에 따른 중금속 농도 사이에 대한 상관관계를 알아보고자 하였다. 영산강·섬진강 수계 하천 및 호소에서 총 43점의 퇴적물 시료를 채취하여, 두 방법으로 전처리하고 5성분의 금속(Cd, Cr, Ni, Pb, Zn)을 분석하였다. 전체적인 중금속의 평균농도는 Zn>Cr>Pb>Ni>Cd 순으로 나타났으며, 전분해 값은 완전분해 값의 35.0% (Cd), 53.8% (Cr), 66.2% (Ni), 64.4% (Pb), 76.4% (Zn)로 완전분해시 중금속 농도가 높게 나타났다. 호소의 중금속 농도가 하천의 농도보다 높게 나타났다. 완전분해와 전분해 농도 사이의 상관관계식을 구하였으며, 강한 상관관계를 가지는 것을 나타난 Zn 및 Ni의 경우 완전분해 농도가 증가할 경우 왕수에 의한 용출농도도 같이 증가하는 것으로 나타났다. 나머지 중금속들에서도 두 분해법에 의한 퇴적물의 중금속농도 사이에 보통이상의 선형상관관계가 있는 것으로 나타났다. 본 연구결과는 퇴적물의 불균질성으로 인해 제한적으로 응용될 수 있을 것으로 판단된다. In this study, the correlations of concentrations in sediment heavy metals between two pretreatment methods, total digestion and aqua regia digestion, have been investigated. Total 43 samples had been collected from streams and lakes in Yeongsan and Seomjin watersheds. They were decomposed in two pretreatment methods and five metal components (Cd, Cr, Ni, Pb, Zn) were analyzed. Overall average concentrations of heavy metals were Zn>Cr>Pb>Ni>Cd in the order. The concentrations of aqua regia digestion were 35.0% (Cd), 53.8% (Cr), 66.2% (Ni), 64.4% (Pb) and 76.4% (Zn) of the concentrations of total digestion and heavy metal concentrations of total digestion were higher. Heavy metal concentrations in sediments from lakes were higher than those from streams. The correlation equations between the concentrations of total digestion and aqua regia digestion were obtained. The concentrations of Zn and Ni, which showed strong linear correlations, increased in aqua regia digestion as the concentration in total digestion increased. The linear correlation coefficients between two digestion methods for most analyzed metals were above the average correlation. However, these results can be applied with limitations due to heterogeneity of sediments.

정상 성인 호흡기능에 대한 들숨 근 강화훈련과 날숨 근 강화 훈련의 효과 비교

이연섭 ( Yeon Seop Lee ),오민영 ( Min Yeong Oh ),박주연 ( Ju Yeon Park ),이대희 ( Dae Hui Lee ),이예진 ( Ye Jin Lee ),정다혜 ( Da Hye Jeong ),홍지연 ( Ji Yeon Hong ),홍하연 ( Ha Yeon Hong ),김현수(교신저자) ( Hyeon Su Kim ) 대한통합의학회 2016 대한통합의학회지 Vol.4 No.1

Purpose : The purpose of this study was to examine the Compare the effects of inspiratory muscle strengthening training and expiratory muscle strengthening training of normal adult respiratory function. Method : In this study, we want to compare the effect of inspiratory muscle strengthening training(n=8) and expiratory muscle strengthening training(n=8) to target the normal adult 16 people. expiratory muscle strengthening training, was 25 minutes of training on the basis of the breathing image program that has been pre-recorded. inspiratory muscle strengthening training, use the power-breathe plus on the measured resistance value, was carried out for 25 minutes. Using the spirometer in order to examine the ability to breathe, FVC, FEV1, FEV1 / FVC, MVV was measured. Result : The results showd that in the breath muscle strengthening training FVC, FEV1, MVV increased statistically significantly. The inspiration muscle strength training FVC, FEV1, MVV was a statistically significant increase, FEV1/FVC decreased. There was no statistically significant difference between. Conclusion : In conclusion, both methods give the result of increasing the effective respiratory function. Inspiratory muscle strengthening training, the function of the lung is very limited to be used when and by us effectively and expiratory muscle strengthening training to increase the capacity of the lung is an effective way that will increase the volume.

Differentiation of highbush blueberry (Vaccinium corymbosum L.) fruit cultivars by GC-MS-based metabolic profiling

Kim, Da Yeon,Kim, So-Hyun,Ahn, Hye Min,Lim, Sa Rang,Oh, Junsang,Choi, Seulgi,Lee, Hong-Jin,Auh, Joong-Hyuck,Choi, Hyung-Kyoon The Korean Society for Applied Biological Chemistr 2015 Applied Biological Chemistry (Appl Biol Chem) Vol.58 No.1

Highbush blueberries (Vaccinium corymbosum L.) are cultivated worldwide for their fruit with unique taste and potential health benefits. Blueray, Bluecrop, and Spartan are prominent among the various blueberry cultivars. We performed gas chromatography-mass spectrometry (GC-MS)-based metabolic profiling to differentiate the fruits of these three cultivars, and built an optimal partial least squares-discriminant analysis (PLS-DA) model to separate them. Amino acids, fatty acids, organic acids, phenolic compounds, and sugars were identified in the fruits. The optimized PLS-DA model for different cultivars of the fruits was obtained by selecting variables based on a variable importance in the projection (VIP) cut-off value of 1.0. Caffeic acid, aspartic acid, acetic acid, threonolactone, inositol, xylose, glucoside, linolenic acid, mannose, altrose, glycine alanine, and valine were found to be relevant and contributing compounds for differentiating cultivars. In addition, a hierarchical cluster analyses dendrogram pattern was correlated with the PLS-DA. This study suggested that GC-MS-based metabolic profiling coupled with multivariate statistical analysis could be used to differentiate the fruits of three major highbush blueberry cultivars.