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Xiang Mei Yan,Uy Dong Sohn,Min Jae Joo,Jae Chun Lim,Wan Kyun Whang,Sang Soo Sim,Chaeuk Im,Hak Rim Kim,Seok Yong Lee,In Kyeom Kim 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.9
The mechanism of the protective effect of quercetin-3-O-β-D-glucuronopyranoside (QGC) from the leaves of Rumex aqauticus on indomethacin (IND, a representative NSAID)-induced gastric damage in rats was investigated. Pre-treatment with QGC significantly attenuated INDinduced gastric mucosal injury. An increase in myeloperoxidase (MPO) activity and expression of intercellular adhesion molecule (ICAM)-1 protein and mRNA expression of the pro-inflammatory cytokines tumor necrosis factor-α and interleukin-1β, as well as a decrease in gastric mucus secretion were detected in the gastric mucosa of IND-treated rats. QGC reversed the side effect of IND on MPO activity and mucus production. Furthermore, QGC pre-treatment notably decreased ICAM-1 protein and mRNA expression of the pro-inflammatory cytokines, suggesting that QGC protection from IND-induced damage is associated with increased gastric mucus secretion, inhibition of free radical production by activated neutrophils via ICAM-1, and pro-inflammatory cytokine downregulation.
Inhibitory Effects of $(1R,9S)-{\beta}-Hydrastine$ on Calcium Transport in PC12 Cells
Yin, Shou Yu,Jin, Chun-Mei,Yang, Yoo-Jung,Lim, Sung-Cil,Lee, Chong-Kil,Hwang, Bang-Yeon,Ro, Jai-Seup,Lee, Myung-Koo 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.1
[ $(1R,9S)-{\beta} ]-Hydrastine$ (BHS), at $100{\mu}M$, has been shown to mainly reduce the $K^+-induced$ dopamine release and $Ca^{2+}$ influx by blocking the L-type $Ca^{2+}$ channel and inhibit the caffeine activated store-operated $Ca^{2+}$ channels, but not those activated by thapsigargin, in PC12 cells. In this study, the effects of BHS on $Ca^{2+}$ transport from $Ca^{2+}$ stores in the absence of external $Ca^{2+}$ were investigated in PC12 cells. BHS decreased the basal intracellular $Ca^{2+}$ concentration $([Ca^{2+}]_i)$ in the absence of external $Ca^{2+}$ in PC12 cells. In the absence of external $Ca^{2+}$, pre-treating PC12 cells with $100{\mu}M$ BHS reduced the rapid increase in the $[Ca^{2+}]_i$ elicited by 20mM caffeine, but not that by $1{\mu}M$ thapsigargin. In addition, BHS inhibited the increase in the $[Ca^{2+}]_i$ elicited by restoration of 2mM $CaCl_2$ after the $Ca^{2+}$ stores had been depleted by 20mM caffeine, but not those depleted by $1{\mu}M$ thapsigargin, in the absence of external $Ca^{2+}$. These results suggested that BHS mainly inhibited $Ca^{2+}$ leakage from the $Ca^{2+}$ stores and the caffeine-stimulated release of $Ca^{2+}$ from the caffeine-sensitive $Ca^{2+}$ stores in PC12 cells.
Fan-Qin Meng,Mei-Chun Zhu,G. Charles Clifton,Kingsley U. Ukanwa,James B.P. Lim 국제구조공학회 2021 Steel and Composite Structures, An International J Vol.41 No.1
The steel-reinforced concrete-filled steel tubular column (SRCFT) is a new form of composite columns. Before widely accepted in engineering practice, its fire behaviour shall be fully understood. Four representative circular SRCFT stub columns were built and tested to failure under ISO fire herein. The tests explored the effect of reinforced steel, the internal or external heating condition and load ratios. The experimental results indicated that the inserted section steel significantly improved the fire resistance of circular SRCFT columns. The non-uniform fire condition did not produce a detrimental effect on the fire response of the specimen. The numerical model was developed and validated against the experimental results. Then a parametric study was present to evaluate the effect of load level, eccentricity and heating conditions. A comparison was made to check the accuracy of a widely accepted design method. The comparison indicated the design method was generally 36% conservative for axially loaded condition and 25% un-conservative for eccentrically loaded condition.
Inhibitory Effects of (1R,9S)-β-Hydrastine on Calcium Transport in PC12 Cells
Shou Yu Yin,Chun Mei Jin,Yoo Jung Yang,Sung Cil Lim,이종길,황방연,Jai Seup Ro,이명구 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.1
(1R,9S)-β-Hydrastine (BHS), at 100 μM, has been shown to mainly reduce the K+-induced dopamine release and Ca2+ influx by blocking the L-type Ca2+ channel and inhibit the caffeine activated store-operated Ca2+ channels, but not those activated by thapsigargin, in PC12 cells. In this study, the effects of BHS on Ca2+ transport from Ca2+ stores in the absence of external Ca2+ were investigated in PC12 cells. BHS decreased the basal intracellular Ca2+ concentration ([Ca2+]i) in the absence of external Ca2+ in PC12 cells. In the absence of external Ca2+, pretreating PC12 cells with 100 μM BHS reduced the rapid increase in the [Ca2+]i elicited by 20 mM caffeine, but not that by 1 μM thapsigargin. In addition, BHS inhibited the increase in the [Ca2+]i elicited by restoration of 2 mM CaCl2 after the Ca2+ stores had been depleted by 20 mM caffeine, but not those depleted by 1 μM thapsigargin, in the absence of external Ca2+. These results suggested that BHS mainly inhibited Ca2+ leakage from the Ca2+ stores and the caffeine- stimulated release of Ca2+ from the caffeine-sensitive Ca2+ stores in PC12 cells.
Inhibition of Tyrosine Hydroxylase by (1R,9S)-β-Hydrastine Hydrochloride in PC12 Cells
Shou Yu Yin,Yu Mi Kim,Jae Joon Lee,Chun Mei Jin,Yoo Jung Yang,Kyo Whan Lim,Min Hee Kang,Myung Koo Lee 한국생약학회 2004 Natural Product Sciences Vol.10 No.3
It is reported that (1R,9S)-b-hydrastine hydrochloride (BHSH) decreased the intracellular dopamine content by inhibiting tyrosine hydroxylase (TH) activity in PC12 cells. In this study, the inhibitory mechanisms on TH activity by BHSH in PC12 cells were investigated. BHSH treatment caused a reduction of TH activity and TH mRNA level in a dose-dependent manner. After the treatment of 20 mM BHSH, TH activity and TH mRNA content were reduced at 15 min, reached the minimal levels at 6-24 h, and then recovered gradually to the control level. BHSH at 10-50 mM caused a decrease in the basal intracellular cyclic AMP levels at 10 min in a concentration-dependent manner. In addition, BHSH at 20-100 mM decreased the basal intracellular Ca2+ concentration ([Ca2+]i) immediately in a dose-dependent manner. BHSH also inhibited the 56 mM K+ depolarization-induced elevation in [Ca2+]i, and blocked caffeine-activated store-operated Ca2+ entry in PC12 cells. These data suggest that BHSH inhibits TH activity and TH gene expression, in part, through reducing cyclic AMP content and basal [Ca2+]i in PC12 cells.