Evaluation of Scopolamine Patch Pharmacotherapy for Motion Sickness in S. Korean

Sung Cil Lim,Myung Koo Lee,Chong Kil Lee,Bo Reum Lee 한국응용약물학회 2008 Biomolecules & Therapeutics(구 응용약물학회지) Vol.16 No.2

Developing of the Manual for INR Management by Patient Self-Testing INR monitor for Warfarin taking Patients in S. Korea(초록)

( Sung Cil Lim ),( Myung Koo Lee ),( Chong Kil Lee ) 한국응용약물학회 2008 학술대회 Vol.2008 No.1

Chitin from Cuttlebone Activates Inflammatory Cells to Enhance the Cell Migration

Lim, Sung Cil,Lee, Ki-Man,Kang, Tae Jin The Korean Society of Applied Pharmacology 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.4

Our previous report showed that the extract from cuttlebone (CB) had wound healing effect in burned lesion of rat and the extract was identified as chitin by HPLS analysis. We herein investigated the morphology in CB extract using scanning electron microscope (SEM). Chitin was used as a control. There is no difference in morphology between CB extract and chitin. We also assessed the role of CB extract on the production of inflammatory mediators using murine macrophages and the migration of inflammatory cells. The extract induced the production of nitric oxide (NO) in macrophages. While the extract of CB itself stimulated macrophages to increase the expression of pro-inflammatory cytokines such as tumor necrosis factor (TNF)-${\alpha}$, interleukin (IL)-$1{\beta}$, and IL-6, CB extract suppressed the production of those cytokines by LPS. CB extract also induced the production of mouse IL-8 which is related to the cell migration, and treatment with CB enhanced fibroblast migration and invasion. Therefore, our results suggest that CB activates inflammatory cells to enhance the cell migration.

Interrelation between Expression of ADAM 10 and MMP 9 and Synthesis of Peroxynitrite in Doxorubicin Induced Cardiomyopathy

( Sung Cil Lim ) 한국응용약물학회 2013 Biomolecules & Therapeutics(구 응용약물학회지) Vol.21 No.5

Doxorubicin is still main drug in chemotherapy with limitation of use due to adverse drug reaction. Increased oxidative stress and alteration of nitric oxide control have been involved in cardiotoxicity of doxorubicin (DOX). A Disintegrin And Metalloproteinase (ADAMs) are transmembrane ectoproteases to regulate cell-cell and cell-matrix interactions, but role in cardiac disease is unclear. The aim of this study was to determine whether DOX activates peroxynitrite and ADAM 10 and thus ADAM and matrix metalloproteinase (MMP) induce cardiac remodeling in DOX-induced cardiomyopathy. Adult male Sprague-Dawley rats were subjected to cardiomyopathy by DOX (6 times of 2.5 mg/kg DOX over 2-weeks), and were randomized as four groups. Then followed by 3, 5, 7, and 14 days after cessation of DOX injection. DOX-injected animals signifi cantly decreased left ventricular fractional shortening compared with control by M-mode echocardiography. The expressions of cardiac nitrotyrosine by immunohistochemistry were signifi cant increased, and persisted for 2 weeks following the last injection. The expression of eNOS was increased by 1.9 times (p<0.05), and iNOS was marked increased in DOX-heart compared with control (p<0.001). Compared to control rats, cardiac ADAM10- and MMP 9- protein expressions increased by 20 times, and active/total MMP 9 proteolytic activity showed increase tendency at day 14 after cessation of DOX injection (n=10, each group). DOX-treated H9C2 cell showed increased ADAM10 protein expression with dose-dependency (p<0.01) and morphometric changes showed the increase of ventricular interstitial, nonvascular collagen deposition. These data suggest that activation of cardiac peroxynitrite with increased iNOS expression and ADAM 10-dependent MMP 9 expression may be a molecular mechanism that contributes to left ventricular remodeling in DOXinduced cardiomyopathy.

Review on the Clinical Pharmacy Education in the U.S.A.

Sung Cil Lim 대한약학회 2008 大韓藥學會 總會 및 學術大會 Vol.2008 No.1

오메가-3 지방산이 함유된 헤어에센스 제조 및 육모 및 탈모 방지에 미치는 평가

김상엽, 임성실 충북대학교 약품자원개발연구소 2010 약학논문집 Vol.25 No.-

본문참조

한국인 제2형 당뇨병 환자에 대한 디펩티딜 펩티다제 4 억제제 중 Sitagliptin과 Vildagliptin의 약물 사용 평가

이옥상(Ok Sang Lee),임성실(Sung Cil Lim),박현정(Hyun Jung Park) 大韓藥學會 2012 약학회지 Vol.56 No.2

Type 2 Diabetes Mellitus (T2DM) is characterized by high blood glucose in the context of insulin resistance and relative insulin deficiency. Diabetes is often initially managed by increasing exercise and dietary odification. As the condition progresses, medications may be needed such as oral sulfonylurea or others. Recently, dipeptidyl peptidase 4 (DPP-4) Inhibitor is new drug which can control blood glucose by increasing the active levels of incretin hormone in the body. However, researches have been carried out for mostly Caucasian and Japanese, not for Koreans at all. Therefore, this study was to evaluate the efficacy and safety of DPP-4 inhibitor (Sitagliptin, Vildagliptin) in patients with T2DM in Koreans. This study was carried out retrospectively with reviewing of medical records from the 141 patients who received sitagliptin or vildagliptin over 24 week periods from January 2009, to December 2009. Information including demographics, concomitant medication, disease duration, and exercise was evaluated. HbA1c, random blood glucose, post prandial 2 hour glucose, blood pressure, AST, ALT, serum creatinine, total cholesterol, triglyceride levels were also collected at baseline and endpoint (at 24 weeks). In each post-treatment group, HbA1c, random blood glucose and post prandial 2 hour glucose levels were decreased significantly from baseline in the sitagliptin group (-0.82%, -28.76 mg/dl, -46.65 mg/dl) and vildagliptin group(-1.22%, -27.96 mg/dl, -67.2 mg/dl). Greater HbA1c mean reductions from baseline to 24 weeks were seen in patients with higher baseline values (>7.0%), with shorter disease durations (≤1 year) compared with those with lower baseline values (1 year) in both sitagliptin and vildagliptin groups. The incidences of hypoglycemia, headache and upper respiratory infection were 0%, 8.7%, 5.8% in sitagliptin group and 2.8%, 8.3%, 6.9% in vildagliptin group. In conclusion, our results showed DPP-4 inhibitor provided similar efficacy compared with sulfonylurea after 24 weeks of treatment and were safer than sulfonylurea in hypoglycemia for Korean T2DM. Also vildagliptin was associated with significant improvement in HbA1c reduction in Korean patient with subgroup (body mass index

Evaluation of Factors affecting Therapeutic Differences of Antihypertensive Drugs of Korean Patients.

이옥상, 임성칠 충북대학교 약품자원개발연구소 2012 약학논문집 Vol.27 No.-

Background: Hypertension should be controlled well because of its complications related to cardiovascular diseases and hypertensive patients are treated by both pharmacotherapy and lifestyle modification. Though, it is difficult for patients to maintain normal blood pressure evenly due to a variety of response to antihypertensive drug. In order too study which factors may cause therapeuic differences of antihypertensive agents, we evaluated blood pressure, monitoring parameter in western medicine, among patients taking Angiotensin Ⅱ Receptor Blocker or Calcium Channel blocker commonly used in Korea. Methods: From April 2006 to June 2012, we retrospectively studied hypertensive patients in Kyunghee University Hospital at Gangdong. We collected information regarding sex, age, sasang consitution classification, antihypertensive drugs (Angiotensin Ⅱreceptor blocker; ARB, Calcium channel blocker; CCB, ARB+CCB), blood pressure by reviewing electronic medical record. Patients not having blood pressure (base of follow-up) or changing to other classes of antihypertensive drugs during follow-up were excluded. Statistical analysis was used by SPSS (Ver.12.0) and Microsoft Excel 2007. P values less than 0.05 were statistically significant. Results: We selected total 573 patients. CCB was the most used in all groups. Baseline BP was higher in respectively So-yang, femlae and over 65 years groups. BP reduction in 1 month after staring medication between female and male was Female (ARB: -12.9/-3.7, CCB: -10.9/-5.0, ARB+CCB: -19.7/-7.3), Male (ARB: -9.5/-1.6, CCB: -13.5/-6.2, ARB+CCB: -16.2/-7.8) (Drug (P ≤ 0.05/ P ≤0.05), Sex (P >0.05/ P>0.05)). Reduction in blood pressure between under 65 years and over 65 was under 65 years (ARB: -10.5/-5.0, CCB: -10.8/-5.7, ARB+CCB: -12.1/4.9), over 65 years (ARB: (-10.5/-1.3, CCB: -12.5/-4.3, ARB+CCB: -23.3/-8.9) (Drug (P≤0.05/ P>0.05), Age (P>0.05/ P>0.05)). Conclusion: According to our study results, differences of reduction in blood pressure were caused by age, gender, However, further larger scale or prospective studies are required in order to confirm these results.

한국인 시각 장애우 환자의 복약지도 증진을 위한 점자용 보조라벨 개발의 필요성과 개발방법 제시

임성실,이명구,이종길,이보름,Lim, Sung-Cil,Lee, Myung-Koo,Lee, Chong-Kil,Lee, Bo-Reum 대한약학회 2008 약학회지 Vol.52 No.3

All pharmacists must provide the drug consultation whenever dispense drugs to patients by the Korean Pharmacy Law. Drug consultation is very important procedure for increasing pharmacotherapy. Because it maximizes the therapeutic effects or/and minimizes adverse drug reaction during the drug therapy. However, it is not easy to do because of the dynamic and hectic pharmacy environment. Especially, if someone has a disabling body function, they required more time and efforts to perform consultation by pharmacist. Currently several auxiliary labels for helping drug consultation are using in pharmacy practice but not for disabling patients. Therefore we developed the total 53 auxiliary labels with size of 0.7 cm (width) and 1 cm (length) by Braillewriter letters for blind patients. This research has been performed for total 12 months (Mar. 15ts, 2007$\sim$Feb. 25th, 2008) and the developing methods are consisted of 4 steps: 1) selection of essential informations, 2) simplification of information, 3) changing for Braillewriter letters, 4) application and revising by blindness patients. Also the labels are consisted of 12 for adverse reactions and precautions, 8 for directions, 2 for storages, 9 for duration, 9 for dosage forms, and 12 for common names. After developed those labels, we revised those labels by discussion with 2 blind people. In conclusion, the new auxiliary labels for blind patients can increase therapeutic effects and decrease risks from pharmacotherapy besides decreasing of pharmacist's work load in the future.

Comparative Evaluation for the Use of Oral Ibuprofen and Intravenous Indomethacin in Korean Infants with Patent Ductus

Mi Jeong Heo,Sung Cil LIM,Ok Sang Lee 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.9

Ductus arteriosus is a normal connecting blood vessel between the pulmonary artery and aorta in the fetus. However, if the ductus arteriosus is not closed and maintained as the open state even after 72 h of the birth, this is called a patent ductus arteriosus (PDA). Intravenous indomethacin is the conventional treatment for PDA in immature infants, but remains controversial in mature infants. The purpose of this study was to compare intravenous indomethacin and oral ibuprofen with regard to efficacy and safety for treatment of PDA. 78 neonates treated for PDA were included and classified into immature (n = 49) and mature (n = 29) groups. Ductal closure occurred in immature infants treated with indomethacin (74.1%) and ibuprofen (90.9%). Ductal closure occurred in mature infants treated with indomethacin (66.7%) and ibuprofen (92.9%). Platelet counts were increased in immature infants treated with ibuprofen (p = 0.027). Hyponatremia occurred in immature infants treated with ibuprofen (p = 0.002) and in both groups of mature infants (p = 0.001 for both groups). Serum creatinine values were lowered in mature infants treated with ibuprofen (p = 0.032). Bleeding occurred in 5 immature infants treated with indomethacin. Administration of furosemide for urine output was more frequent in the mature groups than in the immature group. In conclusion, oral ibuprofen was as effective as intravenous indomethacin in the immature groups and more effective in the mature groups. Adverse effects of oral ibuprofen were less severe than intravenous indomethacin.