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안영진,이승호,강신정,황방연,박웅양,안병태,노재섭,이경순 영남대학교 약품개발연구소 1996 영남대학교 약품개발연구소 연구업적집 Vol.6 No.-
A chemical examination of the phenolic compounds in the leaves of Sapium japonicum (Euphorbiaceae) has led to the isolation of eleven phenolic compounds. containing five hydrolysable tannins and six flavonoids. On the basis of chemical and spectroscopic evidences, the structures of these compounds were confirmed to be galic acid(1), 5-O-caffeoyl quinic acid(2), 1-O-galloyl-3, 6-(R)-HHDP-β-n-glucose(coriiagin)(3), 1-O-galloyl-2.4-(R)-DHHDP-βn-glucose (furosin)(4), 1-O-galloyl-2.4-(R)-DHHDP-3.6-(R)-HHDP-β-m-glucose(geraniin)(5), astragalin(6), trifolin(7), afzelin(8), quercetin(9), isoquercitrin(10) and rutin(11). Among them geraniin was the main component.
Acetophenones from the Roots of Cynanchum wilfordii H_(EMSLEY)
Ro, Jai Seup,Kim, Young Ho,Hwang, Bang Yeon,Lee, Kyong Soon,Lee, Jung Joon 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-
Two acetophenones, cynandione A (1) and cynanchone A (2), were isolated from the roots of Cynanchum wilfordii. Their structures were identified by comparison n of their physicochemical and spectral data with reported values.
한국산 복수초성분의 Na<sup>+</sup>, K<sup>+</sup>-ATPase활성에 대한 연구
노재섭(Jai Seup Ro),이경순(Kyong Soon Lee),박웅양(Woong Yang Park),오갑진(Kap Jin Oh),안병태(Beung Tae Ahn),어경춘(Kyong Chun Eo),정도래(Do Rae Jeong),Toshio Nambara(Toshio Nambara) 한국생약학회 1990 생약학회지 Vol.21 No.2
Four known cardiotonic steroids were isolated from roots of Adonis amurensis Regel et Radde and identified as digitoxigenin, cymarin, K-strophanthin and convallatoxin by chromatography on Amberlite XAD-2 zesin and silica gel, highperformance liquid chromatography and gel chromatography on Sephadex LH-20. In order to clarify the structure-activity relationship, thirteen related compounds of digi toxigenin were tested for the inhibitiory activities for Na^+, K^+-adenosine triphosphatase from guinea pig heart. The inhibitory activities of related compounds of digitoxigenin were dependent upon the dicarboxylic acid and amino acid components. The compound having both the arginine and suberic acid moiety showed the higher inhibitory activity. The sulfate and glucuronide of digitoxigenin exhibited much less potency than the parent genin.
조팝나무속 식물의 성분연구 (Ⅰ) : 조팝나무 뿌리의 Sterol 에 대하여
노재섭(Jai-Seup Ro) 한국생약학회 1982 생약학회지 Vol.13 No.1
Spiraea prunifolia Sieb. et. Zucc. var. simpliciflora Nakai (Rosaceae) is distributed in Korea, and used as a folk medicine for antipyretic, antimalarial and emetic. Sterols were obtained from the methanolic extract of the root of above plant. The composition of sterols are campesterol and β-sitosterol which has been determined by gaschromatographic analysis.
Monoamine Oxidase Inhibitory Components from Cayratia japonica
Xiang Hua Han,Jai Seup Ro,홍성수,Ji Sang Hwang,이명구,황방연 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.1
Seven flavonoids were isolated from the whole plants and fruits of Cayratia japonica through the activity-guided isolation of a methanol extract using a monoamine oxidase (MAO) inhibition assay as a monitor. The chemical structures of the isolates were assigned as apigenin-7- O-β-D-glucuronopyranoside (1), apigenin (2), luteolin (3), luteolin-7-O-β-D-glucopyranoside (4), (+)-dihydroquercetin (taxifolin) (5), (+)-dihydrokaempferol (aromadendrin) (6) and quercetin (7). Among the isolated compounds, flavones such as apigenin (2) and luteolin (3), as well as the flavonol, quercetin (7) showed potent inhibitory effects against the MAO activity with IC50 values of 6.5, 22.6, and 31.6 μM, respectively. However, the flavone glycosides, apigenin-7-O-β- D-glucuronopyranoside (1) and luteolin-7-O-β-D-glucopyranoside (4), showed mild MAO inhibition (IC50 values: 81.7 and 118.6 μM, respectively). The flavanonol derivatives, taxifolin (5) and aromadendrin (6), also showed weak inhibition (IC50 values: 154.7 and 153.1 μM, respectively). Furthermore, quercetin (7) had a more potent inhibitory effect on MAO-A (IC50 value: 2.8 μM) than MAO-B (IC50 value: 90.0 μM). Apigenin (2) and luteolin (3) also preferentially inhibited MAO-A (IC50 values: 1.7 and 4.9 μM, respectively) compared with MAO-B (IC50 values: 12.8 and 59.7 μM, respectively).