[논문]斜角을 고려한 곡선 Box Girder교의 거동에 관한 연구

박성진,이승훈,진치섭 釜山大學校生産技術硏究所 2003 生産技術硏究所論文集 Vol.62 No.-

일반적으로 국도상의 교량은 기존도로의 확장이나 주변지형의 영향 등을 많이 받기 때문에 기하학적 형상이 직선교보다 사교나 곡선교인 경우가 많다. 예를 들어, 고속도로 인터체인지 및 도심지 내의 입체교량 둥에서 교통의 흐름을 원활히 하기 위해서 곡선 교량이 본격적으로 설계 · 시공되고 있다. 또한 구조물의 현장조건에 따라서 사각(skew angles) 이 있는 곡선교의 시공이 불가피하게 되었다. 본 연구에서는 절판구조물로 구성된 단면형태를 가진 곡선교에서 사각의 크기 및 곡률변화에 따른 구조물의 거시적인 거동을 유한요소 범용 프로그램인 SAP2000을 사용하여 비교 · 분석하였다.

Ciprofloxacin의 동물유래 병원세균에 대한 시험관내 항균효과시험

장경수,장치훈,김일택,박승춘,윤효인,전무형 충남대학교 수의과대학 동물의과학연구소 1996 動物醫科學硏究誌 Vol.4 No.-

In this study the antimicrobial spectrum and sensitivity of ciprofloxacin(CFX) against the major pathogenic bacteria isolated from the diseased poultry, pig, cattle in Korea were evaluated in comparison with morfloxacin(NFX), enrofloxacin(EFX), nalidixic acid(NA), gentamicin(GM), tetracycline(TC), erythromycin(EM), streptomycin(SM) and penicillin(PC). Increasing by paper disk diffusion test for total of 439 isolates from poultry, pig and cattle, CFX showed remarkably higher sensitivity(>83%) as compared with other drugs. When three quinolones such as CFX, NFX and NA were compared for the inhibition activity against 4 major pathogens, CFX induced significantly larger diameter of inhibition zone through all of the tested concentration than NFX and NA. As MICs of all drugs for 11 bacterial species isolated from poultry were measured, the MIC range of CFX was 0.125 - 40 ㎍/㎖ in Gram positives, ≤ 0.005 - 2.5 ㎍/㎖ in Gram negatives and 0.08 - 1.25 ㎍/㎖ with 12 isolates of Mycoplasma. MIC_50 and MIC_90 of CFX in these cases revealed consistently lower as compared with those of NFX, GM and PC. When the MICs of the drugs were tested with 11 bacterial species from the diseased pigs, MIC range of CFX was 0.05 - 3.5 ㎍/㎖ in Gram positives, ≤ 0.005 - 0.8 ㎍/㎖ with Gram negatives and 0.5 - 9.0 ㎍/㎖ with 11 isolates of Mycoplasma. MIC_50 and MIC_90 of CFX and NFX were remarkably lower than those of GM and PC. As MICs of CFX, NFX, GM and PC for 10 bacterial species isolated from cattle were tested, the MIC range of CFX was found 0.01 - 4.0 ㎍/㎖ in Gram positives, and ≤ 0.005 - 0.2 ㎍/㎖ in Gram negative bacteria. The MIC_50 and MIC_90 of CFX in cases of cattle appeared remarkably lower than those of the other drugs. CFX, as compared with the other drugs, showed invariably lower MIC_50 and MIC_90 in both of GRam positives and negatives. As MICs of CFX, NFX and PC for 12 reference bacteria were examined, MIC of CFX was 0.03 - 0.25 ㎍/㎖ that was much lower drug concentration than those of NFX(0.25 - 1.0 ㎍/㎖) and PC(0.5 - 16.0㎍/㎖).

절수에 의한 Mongolian Gerbil 장기중량변화에 관한 분석연구

김무강,이기훈,이강이,송치원,이경열,권효정,박미선,정승혁,이행연,김명철 충남대학교 수의과대학 동물의과학연구소 2000 動物醫科學硏究誌 Vol.8 No.-

In this study, authors measured the each organ weight of the long term water deprived Mongolian gerbil, after then we calculated the mean, standard deviation, variance coefficient of the real measured organ weight and induced the organ weight change quantity, rate of quantity, deviation between measured and theological organ weight, deviation rate, sum of deviation rate, organ weight change rate, rate of organ weight by the mathematical formula. The results obtained as follow 1. The weight of the brains, lung, and testis were abruptly decreased after water deprived until the 5th day, after then slowly decreased until the 20th day. 2. The weight of the heart was decreased gradually from the first day until the 20th day. 3. The weight of the liver was abruptly decreased until the 10th day, after then the more slowly decreased until the 20th day. 4. The weight of the thymus, spleen, kidney, and pancreas were abruptly decreased until the 15th day, after then increased slowly until 20th day but the weight of the kidney was abruptly increased from the 10th day. 5. The organ weight change rate and the rate of the each day organ weight were very diversified.

톨루엔 디이소시아네이트 폭로 근로자들의 생물학적 모니터링

안연순,노재훈,김치년,박윤정,정상혁 大韓産業醫學會 1995 대한직업환경의학회지 Vol.7 No.2

Toluene diisocyanate(TDI) is widely used in the production of flexible polyurethane foams, as well as in the formulation of polyurethane paints and coatings. The commercial material is generally a mixture of 2,4- and 2, 6-TDI, the predominant mix being 80% 2,4 and 20% 2,6-TDI. The 2,4-isomer is considerably more reactive than the 2,6-TDI at ambient temperatures due to steric factors involving the positions of the isocyanate groups relative to the ring methyl group. Because of this difference in the reactivities of the isomers, it seemed probable that there might be an increase in the amount of 2,6-TDI offgased relative to the 2,4-isomer. Therefore a relative enrichment of the 2,6-TDI has been found in industrial atmospheres. Toluene diamines, which are metabolites of TDI, in urine have a linear relation with exposure to TDI, so that urianry TDA could be used as a biological index of the exposure to TDI. This study was conducted to investigate the distribution of TDI isomer in industrial atmospheres and to propose proper biological monitoring methods by identifying the relationships between the environmental TDI exposure and concentration of TDA in urine. Concentrations of 2, 4-TDI and 2, 6-TDI in air were 4.38㎍/㎥ and 25.43㎍/㎥, respectively. The Threshold Limited Value of 40㎍/㎥ was exceeded for the 2, 6-TDI in about 46.8%(22 samples) of the samples, while the 2, 4-TDI was not at all exceeded. The ratio between 2, 4-TDI and 2, 6-TDI varied in air samples in the range of 2.4%:97.6%-51.0%:49.0%. There was an enrichment of 2, 6-TDI in air relative to the 2, 4-TDI. Concentrations of 2, 4-TDA and 2, 6-TDA in urine were 1.31㎍/g creatinine and 4.16㎍/g creatinine, respectively. The ratio between 2, 4-TDA and 2, 6-TDA varied in urine samples in the range of 1.4%:98.6%-99.9%:0.1%. There was an enrichment of 2, 6-TDA in urine relative to the 2, 4-TDA. No relation between the concerations of TDA isomer in urine and concerations of TDI isomer in air was found. Above results of this study, workers were more exposed to the 2, 6-TDI relative to the 2, 4-TDI in industrial atmospheres. Therefore, the establishment of TLV for 2, 6-TDI should be considered. Also, the further studies on biological monitorigs of workers exposed to TDI should be continued.

Plasminogen Activator Inhibitor-1: Potential Inflammatory Marker in Late-life Depression

Seung-Hoon Lee(Seung-Hoon Lee),Cheolmin Shin(Cheolmin Shin),Young-Hoon Ko(Young-Hoon Ko),Moon-Soo Lee(Moon-Soo Lee),Moon Ho Park(Moon Ho Park),Chi-Un Pae(Chi-Un Pae),Ho-Kyoung Yoon(Ho-Kyoung Yoon),Cha 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1

Objective: Although several previous studies have examined the association between late-life depression and blood adipokine levels, a marker of chronic inflammation, no studies have comprehensively considered the effects of metabolic syndrome, which is known to affect blood adipokine levels. This study examined blood adipokine levels in geriatric depression after adjusting for the effects of metabolic syndrome. Methods: Participants were selected from the Ansan Geriatric Study (depression group [n = 76] and control group [n = 76]). Blood concentrations of four adipokines (adiponectin, resistin, neutrophil-gelatinase-associated lipocalin [NGAL], and plasminogen activator inhibitor-1 [PAI-1]) were measured using immunoassays. The effects of blood adipokine concentration on the diagnosis of depression were analyzed using multivariate logistic regression to adjust for the effects of metabolic syndrome and potential confounding factors. Results: When the effects of metabolic syndrome and potential confounding factors were adjusted, only PAI-1 could explain the diagnosis of depression among all the adipokines. The depression group showed a lower blood PAI-1 level than the control group. Adiponectin, resistin, and NGAL could not explain the diagnosis of depression when the effects of metabolic syndrome and potential confounding factors were adjusted. Conclusion: This study suggests the possibility that the blood PAI-1 levels in clinically pathological late-life depression may show contrasting results to those with subclinical depressive symptoms. Additionally, considering that most previous studies have been conducted with pre-geriatric populations, the study suggests the possibility that geriatric depression may show inflammatory changes with patterns that are different from those of depression in the pre-geriatric population.

Relationship between Use of Rehabilitation Resources and ICU Readmission and ER Visits in ICU Survivors: the Korean ICU National Data Study 2008-2015

Yun Hee Park,고령은,강단비,JinKyeong Park,Kyeongman Jeon,Jeong Hoon Yang,Chi-Min Park,Joongbum Cho,Young Sook Park,Hyejung Park,조주희,Eliseo Guallar,서지영,Chi Ryang Chung 대한의학회 2020 Journal of Korean medical science Vol.35 No.15

Background: Despite the increasing importance of rehabilitation for critically ill patients, there is little information regarding how rehabilitation therapy is utilized in clinical practice. Our objectives were to evaluate the implementation rate of rehabilitation therapy in the intensive care unit (ICU) survivors and to investigate the effects of rehabilitation therapy on outcomes. Methods: A retrospective nationwide cohort study with including > 18 years of ages admitted to ICU between January 2008 and May 2015 (n = 1,465,776). The analyzed outcomes were readmission to ICU readmission and emergency room (ER) visit. Results: During the study period, 249,918 (17.1%) patients received rehabilitation therapy. The percentage of patients receiving any rehabilitation therapy increased annually from 14% in 2008 to 20% in 2014, and the percentages for each type of therapy also increased over time. The most common type of rehabilitation was physical therapy (91.9%), followed by neuromuscular electrical stimulation (29.6%), occupational (28.6%), respiratory, (11.6%) and swallowing (10.3%) therapies. After adjusting for confounding variables, the risk of 30- day ICU readmission was lower in patients who received rehabilitation therapy than in those who did not (P < 0.001; hazard ratio [HR], 0.70; 95% confidence interval [CI], 0.65–0.75). And, the risk of 30-day ER visit was also lower in patients who received rehabilitation therapy (P < 0.001; HR, 0.83; 95% CI, 0.77–0.88). Conclusion: In this nationwide cohort study in Korea, only 17% of all ICU patients received rehabilitation therapy. However, rehabilitation is associated with a significant reduction in the risk of 30-day ICU readmission and ER visit.

Modified Sulfonated Poly(arylene ether sulfone) Membranes Prepared via a Radiation Grafting Method for Fuel Cell Application

Chi Hoon Park,Dong Won Shin,Young Moo Lee,Phil Hyun Kang,Young Chang Nho 한국고분자학회 2009 Macromolecular Research Vol.17 No.11

Curcumin Derivatives Inhibit the Formation of Jun-Fos-DNA Complex Independently of their Conserved Cysteine Residues

Park, Chi-Hoon,Lee, Ju-Hyung,Yang, Chul-Hak Korean Society for Biochemistry and Molecular Biol 2005 Journal of biochemistry and molecular biology Vol.38 No.4

Curcumin, a major active component of turmeric, has been identified as an inhibitor of the transcriptional activity of activator protein-1 (AP-1). Recently, it was also found that curcumin and synthetic curcumin derivatives can inhibit the binding of Jun-Fos, which are the members of the AP-1 family, to DNA. However, the mechanism of this inhibition by curcumin and its derivatives was not disclosed. Since the binding of Jun-Fos dimer to DNA can be modulated by redox control involving conserved cysteine residues, we studied whether curcumin and its derivatives inhibit Jun-Fos DNA binding activity via these residues. However, the inhibitory mechanism of curcumin and its derivatives, unlike that of other Jun-Fos inhibitors, was found to be independent of these conserved cysteine residues. In addition, we investigated whether curcumin derivatives can inhibit AP-1 transcriptional activity in vivo using a luciferase assay. We found that, among the curcumin derivatives examined, only inhibitors shown to inhibit the binding of Jun-Fos to DNA by Electrophoretic Mobility Shift Assay (EMSA) inhibited AP-1 transcriptional activity in vivo. Moreover, RT-PCR revealed that curcumin derivatives, like curcumin, downregulated c-jun mRNA in JB6 cells. These results suggest that the suppression of the formation of DNA-Jun-Fos complex is the main cause of reduced AP-1 transcriptional activity by curcuminoids, and that EMSA is a suitable tool for identifying inhibitors of transcriptional activation.

Poster Session 2 : Cellular signal transduction and oncogenes ; New synthetic and known curcuminoids inhibit the formation of Fos-Jun-AP-1 DNA complex

( Chi Hoon Park ),( Eun Ryeong Hahm ),( Ju Hyung Lee ),( Chul Hak Yang ) 한국생화학분자생물학회 (구 한국생화학회) 2000 추계학술대회집 Vol.2000 No.-

Selection Problems in terms of Coefficients of Vairiation

Park, Chi-Hoon,Jeon, Jong-Woo,Kim, Woo-Chul The Korean Statistical Society 1982 Journal of the Korean Statistical Society Vol.11 No.1

Selection procedures are proposed for selecting the 'best' industrial process with the smallest fraction defective. For normally distributed industrial processes, this is equivalent to selecting in terms of coefficients of variation. For the case of known vairances, selection procedures by Bechhofer (1954), and Bechhofer and Turnball (1978) are appropriate. We treat this problem for the case of uknown variances with or without reference to a standard. The large sample solutions of design constants are tabulated and the performance of these approximate solutions are investigated.