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김병천,김정일 안성산업대학교 1996 論文集 Vol.28 No.-
We propose a fast fractal image coding algorithm to shorten long time to take on fractal image encoding. For its performance evaluation, the algorithm compares with other traditional fractal coding methods. In the traditional fractal image coding methods, an original image is contracted by a factor in order to make the corresponding image to be compared with. Then, the whole area of the contracted image is searched in order to find the fixed point of contractive transformation of the original image corresponding to the contracted image. It needs a lot of searching time on encoding. However, the proposed algorithm considerably reduces encoding time by using scaling method and limited search area method. On comparison of the proposed algorithm with Jacquin's method, the proposed algorithm is at least 180times as fast as that Jacquin's method on encoding time with a little degradation of the decoded image quality and a little increase of the compression rate. Therefore, it is found that the proposed algorithm largely improves the performance in the aspect of encoding time when compared with other fractal image coding methods.
B형 만성 활동성 간염 환자에서 Prednisolone 단기이탈 및 Alpha Interferon 병합요법의 효과
이종선,김병호,성자원,허승식,이기천,정현용,이헌영,김영건 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.2
To evaluate the safety and efficacy of Pd withdrawal followed by recombinant alpha- Interferon 2b therapy. Nine patients were given a single daily subcutaneous injection of ^α-Interferon at a dose of 3 x 10 exp(6) units/day for first weeks and thrice weekly for next 15 weeks (maintenance) after pd tappered over 6 weeks. To evaluate the efficacy of therapy, we measured serum aminotransferase activities monthly during and after therapy, and also measured serm HBsAg, HBeAg and DNA probe before and after therapy. To evaluate the safety of therapy, all patients checked peripheral blood WBC, Hemoglobin, Platelet, BUN and Creatinine. The results were as follows : 1. In control group, the normalization of s-AST & ALT level, negative seroconversion of DNA probe & HBeAg were observed in 1/12(8%) & 7/10(17%), 0/10(0%) & 0/12(0%) at 6 months later, and maintained response in 1/11(9%) & 1/11(9%), 2/9(22%) & 2/11(18%) until 1 years later. 2. In treatment group, Serum AST and ALT returned to normal in 8/9 & 8/9 cases (89%) after 1 montns Tx. (mean serum AST : 33±8, ALT : 34±12 IU/ml) and maintained to normal response in 5/9(56%) & 6/9 cases(67%)after 6 months Tx. (mean s-AST : 55±43, ALT : 66±84 IU/ml), 3/9(33%) & 4/9 cases(44%) after 1 years Tx. It was statistically significant reponse except s-AST of after 1 years Tx. 3. In treatment group, s- HBeAg returned to normal in 3/9 cases(33%) after 1 months Tx., and maintained to normal response in 1/7 & 1/4 cases among follow up patients in after 6 & 12 months Tx. Serm DNA probe level were observed significantly negative seroconversion in 8/9 cases(89%) after 1 months Tx. (p<0.003), and maintained to negative response in 2/6 & 1/3 cases after 6 & 12 months Tx. 4. Serum AST, ALT, HBeAg and DNA probe were not significantly correlated with therapeutic response in relation to histologic diagnosis. 5. Fever and myalgia were noted in 9(100%) & 6(67%) cases. Headache, mild hair loss, anorexia, nausea, facial flushing & diarrhea were noted in few cases. Peripheral WBC(3cases) & platelet counts(3cases) were decreased transiently. This study shows that Pd withdrawal followed by recombinant alpha Interferon 2b therapy may be safe and effective in decrease the level of s-DNA probe, transaminase activity, loss of HBeAg and less adverse effect of clinical and hematologic examinations in patients with CAH type B. But it was necessary for study with large number of patients, more prolonged follow up duration and more strict control study.
Inhibition of Cytochrome P -450 by safrole in Rat Liver Microsomes
Tae Cheon Jeong,Jeong Woo Park,Suck Young Choe,Jih Hyun Kim,Byung Sam Kim,Kyu Hwan Yang 생화학분자생물학회 1993 BMB Reports Vol.26 No.2
Inhibition kinetics of cytochrome P-450 (P-450)-dependent monooxgenases by an environmental carcinogen safrole (1-allyl-3,4-methylenedioxybenzene) was studied in rat liver microsomes. The activities of P-450ⅠA1-specific ethoxyresorufin O-deethylase (EROD), P-450ⅡB-specific pentoxyresorufin O-dealkylase (PROD), and P-450ⅡE1-specific p-nitrophenol hydroxylase (PNPH) were inhibited dose-dependently when safrole was added into the reaction mixtures from 50 to 400 μM. Meanwhile, the P-450ⅢA1-specific erythromycin N-demethylase (ERDM) was not inhibited at all by safrole up to 400 μM. The inhibition pattern studies for each reaction in Dixon and Cornish-Bowden plots showed three distinct kinetics; mixed inhibition for EROD, uncompetitive for PROD, and noncompetitive for PNPH. The K_i` values of safrole for EROD and PNPH were 95.4 and 215.1μM respectively. The K_i` values of safrole for PROD was 9.48 μM. These results suggest that safrole inhibits microsomal P-450 isozyme-specific monooxygenases with distinct mechanisms and safrole could be used as an useful inhibitor to study P-450-mediated monooxygenase reactions.
Mee Yeon Hong,Heon Cheon Jeong,Dong Young Kim,Hyung Wook Jeong,Ki-Gyoung Kim,Yeon Soo Han,Byung Rae Jin,Iksoo Kim 한국응용곤충학회 2008 한국응용곤충학회 학술대회논문집 Vol.2008 No.05
We determined the complete mitochondrial genome (mitogenome) of the jewel beetle, Chrysochroa fulgidissima (Coleoptera: Buprestidae) from two overlapping fragments and subsequent sub fragments. The 15,592-bp long C. fulgidissima mitogenome contains gene arrangement and content identical to the most common arrangement found in insects. Most individual C. fulgidissima mitochondrial (mt) genes were well within the range found in the respective genes of other insects. The 875-bp A+T-rich region is shortest among the coleopteran mitogenomes sequenced in their entirety. The region is interesting in that it contains several stem-and-loop structures and tRNA-like structure found in the A+T-rich regions of other insect mitogenomes. As seen in other insect motogenomes the start codon of C. fulgidissima COI gene also is unusual because no typical start codon is available. Three of the 13 protein-coding genes have incomplete termination codon T or TA. All tRNA formed stable stem-and-loop structure, except for tRNASer(AGN), the DHU arm of which formed a simple loop as seen in many other metazoan mt tRNASer(AGN).
우울장애 환자에서 Bipolar Spectrum Diagnostic Scale의 선별결과에 따른 생활사건 경험 및 주관적 스트레스 인지 비교
천용준(Yong Jun Cheon),강태욱(Tae Uk Kang),문은수(Eunsoo Moon),박제민(Je Min Park),이병대(Byung Dae Lee),이영민(Young Min Lee),정희정(Hee Jeong Jeong),이강윤(Kang Youn Lee),최윤미(Yoonmi Choi),정봉주(Jeong Bong Joo) 대한생물치료정신의학회 2016 생물치료정신의학 Vol.22 No.1
Objectives:There are some evidences that patients with bipolar depression experience more stressful life events than patients with unipolar depression do. However, there is lack of evidence that bipolarity in depressive patients is associated with more frequent and severe stressful life events. The current study is aimed to compare life events and perceived stress according to the Bipolar Spectrum Diagnostic Scale(BSDS) results in depressive patients. Methods:A total of 102 patients who have experienced major depressive episodes were recruited. Two groups with or without positive screening of Bipolar Spectrum Diagnostic Scale(BSDS) were divided. Stress-related factors were measured by the Life Experiences Survey(LES) and Perceived Stress Scale(PSS). Results:Patients with depressive disorders who screened positive on the BSDS showed more life events(p=.006) and higher impact of life events(p=.005) checked on the LES, and higher score on the PSS negative perception subscale(p=.010) than those who screened negative on the BSDS did. After the adjustment of Beck Depression Inventory(BDI), depressive patients with BSDS(+) experienced more life events(p=.019) and higher impact of life events(p=.029) than those with BSDS(-). However, the difference of PSS negative perception subscale between two groups disappeared after adjusting the effects of depressive symptoms. Conclusion:These results suggest that depressive patients with positive screening of BSDS may response to life events in negative ways and feel more stressful. The positive screening of BSDS in depressive patients can affect their trajectories of depression. Further, large scale and prospective studies are needed to clarify these relationships between bipolar spectrum disorder and stress.
Man Il Kim,Iksoo Kim,Heon Cheon Jeong,Byung Rae Jin 한국응용곤충학회 2008 한국응용곤충학회 학술대회논문집 Vol.2008 No.10
The 15,389-bp long complete mitochondrial genome (mitogenome) of the redspotted apollo butterfly, Parnassius bremeri (Lepidoptera: Papilionidae) was determined. This genome has a gene arrangement identical to those of all other sequenced lepidopteran insects, but differs from the most common type, as the result of the movement of tRNAMet to a position 5’-upstream of tRNAIle. No typical start codon of the P. bremeri COI gene is available. Instead, a tetranucleotide, TTAG, which is found at the beginning context of all sequenced lepidopteran insects was tentatively designated as the start codon for P. bremeri COI gene. All protein-coding genes (PCGs), but COII (T) have complete termination codon TAA or TAG. One of the most unusual feature of the P. bremeri mitochondrial genome is the presence of two tRNA-like structures, such as the tRNATrp-like sequence and tRNALeu (UUR)-like sequence with proper anticodon and clover-leaf structures in the 514-bp long A+T-rich region. Furthermore, the A+T-rich region possesses three sequences that have the potential to form stem-and-loop structures, flanked by the conserved sequences, "TA(A)TA" at the 5’ end and "G(A)nT’ at the 3’ end. After more genomic and phylogenetic analyses are performed, further detailed information will be available.
Somatostatin 투여로 임상적 호전을 보인 악성인슐린종 1 예
정창호,권용준,한승수,김종호,이병두,김광희,문병천,전배완 대한내과학회 1991 대한내과학회지 Vol.41 No.2
A 61 year-old woman with symptomatic, malignant insulinoma was hospitalized with random blood glucose levels of 16-48 mg/dl and corresponding serum insulin levels of 35~54 μIU/ml. Physical examination showed a slightly enlarged liver, which was palpable 1 finger breadth below the right costal margin. Abdominal CT and selective celiac angiogram revealed hypervascular pancreatic mass with metastases to the liver and spleen. Ultrasono-guided aspiration biopsy cytology of the pancreas and excisional biopsy of tumor thrombus on the gastrocolic omentum revealed islet cell adenoma. Treatment was begun with subcutaneous injection of 50㎍ of SMS 201-995 every 8 hours. The hypoglycemic symptom was well controlled by doses of 200~250㎍ t.i.d and blood glucose levels also improved, There were no significant side effects except for diarrhea which was easily controlled by conservative treatment. The potential value of this new drug in management of malignant insulinoma was illustrated by this case over a short period, but the long-term effects on the serum glucose and insulin levels in our patient remain to be determined.