알지네이트 비드를 이용한 메틸 오렌지의 봉입 및 방출에 미치는 키토산의 영향

변종찬, 이상은. 장우석, 이은주, 최진석, 박정숙 충남대학교 약학대학 의약품개발연구소 2017 藥學論文集 Vol.32 No.-

In this study, methyl orange-loaded alginate beads were prepared and compared to investigate the effect of chitosan on the encapsulation and release of hydrophilic methyl orange in alginate beads. Particle size and encapsulation efficiency of alginated beads were determined. Swelling ratio and disintegration of al-ginate beads were investigated in gastrointestinal environment. Particle size of beads was 1.1-1.5 mm and shape was spherical. Weight of beads was increased depending on the content of chitosan. Content of chitosan affected on the encapsulation of methyl orange. Encapsulation of methyl orange in alginate beads without chitosan was 15%, while encapsulation efficiency was increased with addition of chitosan. Beads were not disintegrated in HCl solution (pH 1.2) within 4 h, with floating and swelling. Swelling ratio of beads was in-creased to 222%. Release of methyl orange from alginate beads without chitosan was up to 70% within 2 h in HCl solution (pH 1.2). When chitosan was added to the alginate beads, release of methyl range from beads was significantly reduced. It is supposed that release of methyl orange from beads is resulted from diffusion and erosion of beads, which is pH-dependent. In condusion, chitosan-alginate beads have potentials to control release of small hydrophilic drugs by the addition of chitosan.

좌측 상하악 구치 후방부에 발생한 다형성 선종의 치험례

우길상,이은진,김상규,김진수,변기정 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.2

Pleomorphic adenoma is a circumscribed tumor characterized microscopically by its pleomorphic or mixed appearance, and its clearly recognizable epithelial tissue intermingled with areas of mucoid, myxoid, or chondroid appearance. Plemorphic adenoma, the most common tumor of the salivary glands, is now generally accepted as epithelial and benign adenoma. The palate is the most common site for minor salivary gland tumor. We experienced a case of pleomorphic adenoma occuring in the left retromolar pad area of unusual location. It is unusually large size so that the patient cannot close his mouth. The tumor occupied his mouth fully so that he has much difficulty in closing his mouth and breathing his breath. The lesion was treated with complete excision and reconstruced with buccal fat pedicle flap immediately on the operation under general anesthesia. Histopathological finding indicated pleomorphic adenoma on the left retromolar pad area.

MicroRNAs as potential indicators of the development and progression of uterine leiomyoma

( Eun Jeong Byeon ),( Myung Shin Kim ),( Hee Jeong Lee ),( Min Jeong Kim ) 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-

Objective: Uterine leiomyoma is the most common benign tumor in women of reproductive age. Although uterine leiomyoma is the most common cause of hysterectomy, its pathogenesis remains unclear, and hence the limited number of treatment options. Therefore, the main objective of this study was to examine the role of miRs in the development and progression of leiomyoma and underscore the need to validate their utility as diagnostic or therapeutic targets. Methods: The study enrolled 19 women who received surgical management for uterine leiomyoma (heavy menstrual bleeding, palpable mass) from May, 2018 to February, 2019 in a university hospital. Clinical data were analyzed through chart review, and the association between miR and cytokine was investigated. All statistical analyses were performed using SPSS Statistics for Windows, Version 20.0. Results: Hierarchical clustering analysis [Euclidean method, complete linkage] was performed using the miR profiles of 10 leiomyomas and 6 samples of myometrium. A total of 89 miRs were expressed differentially between leiomyoma and myometrium (P <0.05) and among them 43 miRs showed FDR <0.05. Compared with the myometrium, the leiomyoma showed that 26 of the 43 miRs were up-regulated and 17 miRs were down-regulated, according to the criteria. Five selected miRs were expressed higher in leiomyoma than in myometrium. We found that TGFBR2 and IGF2BP1 were positively stained in 13 (81%) and 10 (62.5%) leiomyoma tissues; however, neither of them was stained in the adjacent myometrium (S3 Fig). Conclusion: This study demonstrated that miRs played a significant role in the pathogenesis of leiomyoma. Particularly, the five miRs including miR-181a-5p, 127-3p, 28-3p, 30b-5p and let-7c-5p, and their target molecules including TGFBR2 and IGF2BP1, were up-regulated in leiomyoma tissues. Additionally, their expression was associated with leiomyoma size and size effect. These findings are significant in understanding of miRs and their role as a potential indicator of leiomyoma development and disease progression.

Type 2 Myocardial Infarction: Another Hidden Cause of Mortality During the COVID-19 Pandemic

Eun Jeong Cho,Kyeongmin Byeon,Young-Hoon Jeong 대한심장학회 2023 Korean Circulation Journal Vol.53 No.12

Composotion and functional diversity of the vaginal microbiome in recurrent vaginitis

( Byeon Eun Jeong ),( Lee Seungok ),( Kim Myungshin ),( Kim Min Jeong ) 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-

Objective: To evaluate the clinical relationship between the vaginal microbiome and the pathophysiology of recurrent vaginitis (RV), we investigated the microbiome taxonomic profile (MTP) in the vaginal samples of Korean female patients with RV. Methods: Forty women of reproductive age diagnosed with RV were enrolled. The vaginal MTP of patients was analyzed using 16S ribosomal RNA gene sequencing, and the results were compared with that of healthy women (n = 100). Further, the association of the vaginal community state type (CST) with the clinical characteristics was analyzed. Results: The species abundance of MTP was significantly lower in patients with RV than in healthy women (p < 0.05), whereas species evenness and diversity were significantly higher in patients with RV than in healthy individuals (p < 0.05). The proportion of the most common vaginal Lactobacillus spp. was significantly lower in the MTP of patients with RV than healthy women (p < 0.01). The beta diversity distance was also significantly different between patients with RV patients and healthy individuals (p = 0.001). Based on the CST, the MTP of 40 RV samples was categorized as follows: 21 (52.5%) for CST IV, 8 (20.0%) for CST III, 5 (12.5%) for CST I, 2 (5.0%) for CST II, 1 for (2.5%) for CST V, and 3 (7.5%) for mixed CST. Patients with underlying uterine diseases (uterine leiomyoma, adenomyosis, and endometrial polyps; n =17) showed higher species richness and diversity than those without (n = 23; p < 0.05). Conclusion: A low proportion of Lactobacillus spp. was found in patients with RV than in healthy women. The abundance and diversity of bacterial taxa were significantly higher in patients with underlying gynecologic disease than those without. Our study offers an insight into the nature of the vaginal microbiome and proposes that surveying the vaginal microbiome is valuable for detecting and treating gynecologic diseases in the future.

8주간 고유수용성감각 운동프로그램이 태권도 품새 선수들의 등속성 근기능에 미치는 영향

변정은(Byeon, Jeong-Eun),김남수(Kim, Nam-Soo) 한국체육과학회 2019 한국체육과학회지 Vol.28 No.6

The purpose of this study was to examine how the proprioception exercise program affects the isokinetic muscular function of the Taekwondo poomsae players. The participants were 20 Taekwondo poomsae players. All subjects were college students located in Gyeonggi-do. The players were ramdomly assigned to either Taekwondo poomsae training group or Taekwondo poomsae training & proprioception exercise program group. For the study, it was checked the isokinetic muscular function before the study and after 8 weeks. Data were collected by using Two-way ANOVA and the statistically significant levels were set α=.05. The study showed that there were no significant difference in knee joints 60°/sec and 180°/sec of extensor strength for the isokinetic muscular function. But the significant differences were found in knee joints 60°/sec and 180°/sec of the flexor strength, ankle joints 30°/sec and 120°/sec of the plantarflexors strength and dorsiflexors. It was conclude that the proprioception exercise program has a positive effect on improving performance of Taekwondo poomsae players. Continuous developing a variety of exercise programs is needed considering characteristics of Taekwondo poomsae players.

Seasonal Difference of Fruit Quality Attributes in Sweet Pepper Cultivars under Simulated Export System

Si-Eun Byeon,Hnin Phyu Lwin,Jinhee Lee,Theint Thandar Latt,Hyowon Park,Sangyo Jeong,Yeo Eun Yun,Jung-Soo Lee,Jinwook Lee 한국원예학회 2022 한국원예학회 학술발표요지 Vol.2022 No.11

Analysis of Dietary Fiber and Free Sugar Content for Nutritional Information by Variety of Tomato

Suran Byeon,Yusang Jeong,Eunchae Cho,Eun-Jeong Jeong,Yong-Suk Kim 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

Tomatoes are low in calories and contain various nutrients, making them an excellent source of vitamins and minerals. They are consumed through a variety of processing methods, because nutrients are better absorbed when blanched or mashed. In this study, the contents of dietary fiber and free sugar by variety of tomato was analyzed according to raw and blanched. Dietary fiber and free sugar were analyzed according to the Korean Food Code. Total dietary fiber content was detected as 1.68±0.01 g/100 g in CT-R and 2.08±0.05 g/100 g in CT-B. In the blanched samples, the content of insoluble dietary fiber was higher than that of soluble dietary fiber except for DT-B. Among the five tomato varieties, BT-R and BT-B had the lowest total dietary fiber content. In the free sugar analysis, only glucose and fructose were detected in all samples. DT-B had the highest glucose content and was detected as 2.36±0.01 g/100 g. The fructose content was 1.63±0.01 g/100 g in GT-B, which was lower than the average content of the blanched samples. This study will provide consumers with tomato nutrition information.

Pregnancy outcomes following uterine necrosis due to uterine artery embolization: a case report and review of literature

( Kyung Eun Lee ),( Eun Jeong Byeon ),( Min Jeong Kim ) 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-

Postpartum hemorrhage(PPH) is the most important cause of increased maternal morbidity and mortality. In recent years, the uterine artery embolization(UAE) has been implemented as a conservative treatment at many clinical centers. If succeed bleeding control for PPH, the UAE can maintain fertility by preserving the uterus, so it can be a good treatment for women who want to become pregnant in future. The complications of UAE include uterine necrosis, placenta accrete spectrum(PAS), recurrent PPH, infection and amenorrhea. However, UAE has various complications from traumatic vessel injury to focal inflammation. Among these complications, uterine necrosis is one of serious complication about success of future pregnancy. From January 2014 to December 2021, 11 uterine necrosis after UAE due to PPH was confirmed three medical centers by pelvic CT. Three of them subsequently became spontaneously pregnant. When uterine necrosis is confirmed, it is very difficult to decide between surgical treatment and conservative treatment when selecting a treatment method. Although the frequency of uterine necrosis after implementing the UAE is not high, a sufficient explanation for amenorrhea and infertility caused by it should be made. Guidelines for the definition and treatment of partial or total uterine necrosis are not clear, yet. Recently, cases of successful pregnancy after uterine necrosis due to UAE have been reported. In our cases, succeed to pregnant was confirmed in patients who received conservative treatment for uterine necrosis. Since damage to the endometrium and myometrium caused by uterine necrosis is a risk factor that can cause recurrent PPH or PAS, aggressive evaluations for the diagnosis of PAS will be required if pregnancy is successful. In further study, long-term follow up of those who underwent the UAE is needed. Also, additional studies should be conducted in relation to the treatment for identifying PAS occurring in subsequent pregnancies.

만성 기능성 변비 환자에서 동적 MR 배변조영술의 유용성

정은주 ( Jeong Eun Ju ),명승재 ( Myeong Seung Jae ),김아영 ( Kim A Yeong ),하현권 ( Ha Hyeon Gwon ),송혜경 ( Song Hye Gyeong ),장혜숙 ( Jang Hye Sug ),변정식 ( Byeon Jeong Sig ),이진혁 ( Lee Jin Hyeog ),양석균 ( Yang Seog Gyun 대한소화기기능성질환·운동학회 2003 Journal of Neurogastroenterology and Motility (JNM Vol.9 No.2

목적: 배변조영술은 배변시 직장항문의 형태 및 기능적 변화에 대한 많은 정보를 제공하지만, 방사선에 노출되고 골반저 및 주변구조를 직접 볼 수 없다는 단점이 있다. 이를 극복하기 위하여 MR배변조영술이 소개되었으나, 아직까지 임상적 유용성에 대하여 이견이 많은 실정이다. 이에 저자들은 골반저근실조 환자에서 동적 MR 배변조영술의 임상적 유용성과 특징적 MR 소견을 알아보고자 하였다. 대상 및 방법: 서울아산병원 변비클리닉을 방문한 ROME II 기준의 Background/Aims: Barium defecography (BD) provides information about anorectal motion during defecation. However, BD involves radiation exposure and does not visualize the pelvic organs around the anorectum. Magnetic resonance (MR) defecography was introd