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알코올 금단 발작 환자에서 진전 섬망 예방에 대한 Nimodipine과 Chlordiazepoxide의 효과 비교
정두신,양광익,이보람,방차옥,이태경,성기범,안무영,박형국 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1
Background & objectives : An increase of calcium influx during alcohol withdrawal state may contribute to neuronal hyperexitability, which cause delirium tremens(DT). Some investigators have found calcium channel blockers effects in prevention of DT in experimental animals. Therefore we evaluated the preventive effects of calcium channel blocker(nimodipine) and benzodiazepine(chlordiazepoxide) on the development of DT in alcohol withdrawal seizure(AWS) patients. Method : A total 59 patients with AWS were divided into three groups according to the management nimodipine-treated, chlordiazepoxide-treated, and control(no specific medication) groups. We compared the incidence rates of DT in the three groups. Results : Total incidence rate of DT was 30.5%(18 of 59 patients). There were 6 DTs of 18 patients(33.5%) in nimodipine-treated group, 4 of 21 patients(22.5%) in chlordiazpoxide-treated group, and 8 of 20 patients(44.0%) in control. Conclusion : The control group(44.0%) showed the highest incidence rate of DT. And nimodipine-treated(33.5%) and chlordiazepoxide-treated group(22.5%) were followed. However, this result failed to demonstrated statistically significant differences due to small numbers size.
Cha, Ji-Yun,Jeon, Yong-Deok,Xin, Mingjie,Kim, Do-Kuk,Lee, Hoon-Yeon,Kim, Bo-Ram,Hwang, Sung-Woo,Kim, Dae-Ki,Jin, Jong-Sik,Lee, Young-Mi Informa UK (TaylorFrancis) 2017 Bioscience, Biotechnology, and Biochemistry Vol.81 No.11
<P>The aim of this study is to examine the anti-inflammatory effect of Euphorbia supina (ES) ethanol extract in dextran sulfate sodium (DSS)-induced experimental colitis model. ES was per orally administered at different doses of 4 or 20 mg/kg body weight with 5% DSS in drinking water for 7 days. Twenty mg/kg of ES administration regulated body weight decrease, recovered colon length shortening, and increased disease activity index score and myeloperoxidase level in DSS-induced colitis. Histological features showed that 20 mg/kg of ES administration suppressed edema, mucosal damage, and the loss of crypts induced by DSS. Furthermore, ES suppressed the expressions of COX-2, iNOS, NF-kB, IkBa, pIkBa in colon tissue. These findings demonstrated a possible effect of amelioration of ulcerative colitis and could be clinically applied.</P>
해파리 분말의 상토 첨가물로서의 효과 및 상토의 미생물 군집 변화에 대한 연구
백보람(Bo-Ram Beck),최재호(Jae-Ho Choi),김영록(Young-Rok Kim),차하은(Ha-Eun Cha),도형기(Hyung-Ki Do),황철원(Cher-Won Hwang) 한국토양비료학회 2012 한국토양비료학회지 Vol.45 No.2
해파리 분말을 추가함으로써 나타나는 화분 내의 수분흡착력 및 유지력은 일반 상토보다 월등하고 이는 작물을 관리함에 있어 안정성과 건기 또는 단수로 인한 수분고갈을 예방할 수 있을 것으로 생각된다. 미생물의 경우 DGGE pattern과 염기서열 분석을 통해 확연한 군집변화를 유도하였으며, 식물과 공생관계에서 중요한 Bacteroidetes들의 다양성을 증가시키는 효과를 보았다. 이러한 긍정적인 면이 있지만, 해파리를 분말화하는 공정에 있어서 Potassium alum을 사용 한다는 것이 문제점으로 나타났다. 이 문제를 해결해야만 상품으로써의 가치가 더욱 높아지는데, 이는 해파리가 상토 첨가제로써의 역할도 충분히 할 수 있기 위해서는 phosphate가 inorganic phosphate으로 변환되는 것을 방지해야 하기 때문이다. 요약하자면, 본 실험을 통해 해파리의 잠재적인 자원력 및 고부가 가치화의 가능성은 충분히 나타났다고 생각한다. 이것이 가지는 의미는 식용으로 사용되는 해파리는 제한적이며 독성 해파리들은 거의 사용되지 않기 때문에, 산업적 측면에서 가용성 자원이 늘어난다는 것이다. 또한 환경개선적 측면에서, 독성 해파리률 포함한 해파리들은 여름철 (약 7~8월경)에 해수의 온도 상승과 관련하여 개체수가 급증하여 각 종 어장과 해수욕장에 피해를 주게 된다. 그렇기에 고부가 가치화가 이루어진다면 해파리의 출몰 시기와 이동경로를 예측하여 독성 및 식용불가 해파리들을 사전에 어획함으로써 해양관련 산업에 피해를 줄이고 어민들의 어획종이 늘어남과 동시에 해파리를 이용한 상품을 개발하는 데에 필요한 원자재 확보에도 도움이 될 것이라 생각한다. Recently, the population of toxic and/or unusable jellyfish is increasing during summer along the east coast of Korea, causing massive economical and ecological damage to fisheries, nuclear power plant and marine environment. To solve this problem, this study was carried out using jellyfish as a potential soil additive for horticulture. The jellyfish was solidified and homogenized, then mixed with a commercial bed soil. Allium tuberosum ROTH was planted to control bed soil (BS) and jellyfish powder mixed bed soil groups (Mixed bed soil, MBS), and following parameters were measured during five weeks: water content, electrical conductivity and growth of leaves. At the end of the experiment, bacterial community structures of each pot were analyzed by DGGE. The relative water adsorption of jellyfish powder was about 2.5 times greater compared to its dry weight. The water content of MBS group was significantly higher than BS group 6.5 to 14.2%, and the electric conductivity of MBS group was measured around 2.8 dS/m where BS group was resulted average of 1.8 dS/m. However, the leaves of BS group were grown 30% longer compared to MBS group. DGGE analysis of MBS group was shown in high number of phylum Bacteroidetes and increased diversity of Sphingobacteriia compared to BS group. Jellyfish powder as a soil additive surely will be a good candidate as humectant and microbiota stimulator, although there are several obstacles such as high electrical conductivity and residual alum salt which used for solidification of jellyfish.
연잎과 민들레 추출물에 의한 S. mutans 성장억제 효과
최보람(Chi, Bo-Ram),조다영(Jo, Da-Young),차소영(Cha, So-Young),최민지(Chi, Min-Ji),정혜원(Jeong, Hye-Won),강경희(Kang, Kyung-Hee) 한국산학기술학회 2011 한국산학기술학회논문지 Vol.12 No.12
최근에 연잎과 민들레 추출물의 약리작용에 대한 연구가 활발하게 이루어져 항산화작용, 항알레르기효과, 항 균작용, 항암활성 등에 관한 연구가 보고되고 있다. 이에 본 연구에서는 colony forming unit와 흡광도를 측정하여 연 잎과 민들레 추출물이 S. mutans에 미치는 성장억제효과를 연구하였다. 추출물의 첨가에 따른 S. mutans의 성장억제 율을 측정한 결과, 추출물의 농도가 높아질수록 S. mutans의 성장억제율도 높아지는 결과를 얻었다. 이로써 연잎과 민 들레 추출물은 S. mutans의 성장을 억제하는 항균효과를 가지고 있음을 본 연구에서 확인 할 수 있었다. Results regarding the anti-oxidative, anti-allergic, anti-bacterial and anti-cancer effects of lotus leaf and dandelion have been reported through active research on the medical effects of medicine prepared from crude drugs. This paper aimed to examine the anti-bacterial effect of lotus leaf and dandelion extracts on S. mutans by evaluating the colony forming unit and growth curve. In accordance with the growth inhibition rate of S. mutans according to the addition of lotus leaf and dandelion extracts, the higher the extract concentration was, the higher the growth inhibition rate of S. mutans was. This paper therefore verifies that lotus leaf and dandelion extracts have an effect in inhibiting the growth of S. mutans.
Production of γ-amino Butyric Acid by Lactic Acid Bacteria in Skim Milk
Jin Young Cha(차진영),Young Rok Kim(김영록),Bo Ram Beck(백보람),Ji Hun Park(박지헌),Cher Won Hwang(황철원),Hyung Ki Do(도형기) 한국생명과학회 2018 생명과학회지 Vol.28 No.2
동해안 지역 수산발효식품과 수산물로부터 다양한 종류의 유산균들을 분리하여 감마아미노낙산(GABA) 활성을 위해 분석을 하였다. 박층크로마토그래피(TLC)를 이용하여 GABA를 생성하는 4개의 균주를 확보하였으며, 16S rRNA sequencing 분석 결과를 통해 FSFL0004, FSFL0005, FSFL0036 균주는 Lactobacillus (Lb.) brevis, 그리고 FGL0007은 Lactococcus (Lc.) lactis에 가장 유사한 것으로 확인하였다. Lb. brevis FSFL0004와 FSFL0005는 발효된 아귀로부터 분리되었고, Lb. brevis FSFL0036는 갈치 젓갈로부터 분리되었으며, Lc. lactis FGL0007 균주는 참가자미의 내장으로부터 분리되었다. 고속액체크로마토그래피(HPLC)를 사용한 정량분석결과를 보면, FSFL0004, FSFL0005, FSFL0036과 FGL0007에서 각각 10,754.37 μg/ml, 13,082.79 μg/ml, 12,290.19 μg/ml, 45.07 μg/ml의 GABA가 생성되었다. GABA가 풍부한 낙농제품의 발효 종균으로서 상용화 실험을 위해 1% MSG를 포함한 탈지방우유에 4개의 균주를 각각 접종하였다. TLC 결과를 보면 4개의 균주 모두가 GABA 생성을 보였다. HPLC 분석 결과를 보면, 4균주 중 Lc. lactis FGL0007이 가장 높은 GABA 생성(431.42 μg/ml)을 보였다. 본 연구의 내용은 GABA가 함유된 유제품 개발의 기반이 될 수 있을 것으로 생각한다. Lactic acid bacteria were isolated from a variety of fermented seafoods and sea creatures from the East Sea Rim, Korea and were screened for γ-amino butyric acid-producing (GABA) activity. Through a 16S rRNA sequence analysis, the bacteria of interest, which were GABA-positive on the thin-layer chromatography analysis, were recognized as three isolates of Lactobacillus (Lb.) brevis and one isolate of Lactococcus (Lc.) lactis. Lb. brevis FSFL0004 and FSFL0005 were isolated from fermented anglerfish and Lb. brevis FSFL0036 was derived from salted cutlass fish. The Lc. lactis strain FGL0007 was isolated from the gut of a brown sole flounder. According to HPLC analysis, the GABA contents produced by FSFL0004, FSFL0005, FSFL0036 and FGL0007 were equivalent to 10,754.37 μg/ml, 13,082.79 μg/ml, 12,290.19 μg/ml, and 45.07 μg/ml respectively in 1% monosodium glutamate-supplemented methionyltRNA synthetase (MRS) broth. The four strains were inoculated in skim milk with 1% monosodium glutamate to commercialize the strains as starter cultures for GABA-enriched dairy products, and TLC results displayed the production of γ-amino butyric acid by all four strains in the adaptation media. Lc. lactis FGL0007 demonstrated the greatest GABA production (431.42 μg/ml) by HPLC analysis. The GABA production by lactic acid bacteria strains in the skim milk demonstrated in the present study may be helpful for the production of GABA-enriched dairy products.
Yong-su Cha,Hye-seon Jeon,Chung-hwi Yi,Oh-yun Kwon,Bo-ram Choi 한국전문물리치료학회 2016 한국전문물리치료학회지 Vol.23 No.2
Background: Several studies have discussed diverse exercise methods considered to be useful for the selective contraction of the vastus medialis oblique (VMO) muscle for the treatment of patellofemoral pain syndrome. Some studies have reported that exercise methods, including hip adduction, in closed kinetic chain exercises are more effective in terms of the muscle activation of the VMO and the timing of the muscle’s initial contraction. We focused on isometric contraction during a closed kinetic chain exercise with hip adduction. Objects: The purpose of this study was to examine muscle activation in the VMO and the vastus lateralis (VL) and the onset time difference between their initial contractions via closed kinetic chain isometric quadriceps femoris exercises including hip adduction. Methods: In total, 36 healthy subjects adopted two hip positions during isometric contraction of the quadriceps femoris in a closed kinetic chain exercise (hip neutral and hip adduction position). Statistical analyses were conducted using a paired t-test (α=.05). Results: Isometric contraction of the quadriceps femoris in a closed kinetic chain exercise caused a greater increase in VMO muscle activity in the hip adduction position [52.68±22.21 percentage of maximal voluntary isometric contraction (%MVIC)]than the hip neutral position (43.43±19.85 %MVIC). The onset time difference (VL-VMO) decreased more in the hip adduction position (-82.14±34.2 ㎳) than the hip neutral position (73.94±2.94 ㎳). Conclusion: We recommend this exercise as a clinically useful therapeutic method for patients with patellofemoral pain syndrome due to weakening of the VMO muscle and lateral inclination of the patella.