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Fu, Yan Yan,Kang, Kyung Ja,Ahn, Jung Myung,Kim, Hae-Ryoung,Na, Ki Young,Chae, Dong-Wan,Kim, Suhnggwon,Chin, Ho Jun Tohoku University Medical Press 2010 The Tohoku journal of experimental medicine Vol.222 No.4
<P>Oxidative stress is an important pathogenic factor in diabetes. Bilirubin may serve a cytoprotective function as an anti-oxidant. The Gunn rat lacks the enzyme uridine-diphosphate glucuronosyltransferase that is responsible for conjugation of bilirubin, exhibiting elevation of plasma bilirubin. We examined the effect of hyperbilirubinemia on the pancreatic damage caused by streptozotocin (STZ) in the Gunn rat. Male Wistar rats and male Gunn rats were treated with STZ (WS and GS groups, respectively) or vehicle (WC and GC groups, respectively). All 5 rats in the WS group developed diabetes, defined as fasting blood glucose 300 mg/dL or more, at 3 days, whereas only 2 of the 5 GS rats became diabetic at 7 days after STZ injection. Without insulin supplement at 7 days after STZ injection, the WS group displayed higher levels of fasting blood glucose (510.3 ± 50.3 vs. 236.4 ± 42.5 mg/dL, <I>p</I> = 0.003) and HbA1c (5.0 ± 0.1 vs. 3.9 ± 0.1, <I>p</I> = 0.001), compared to those of GS group. In Wistar rats, STZ induced apoptosis of the pancreatic islet cells, accompanied with activation of NADPH oxidase and increased production of reactive oxygen species and nitric oxide, but not in Gunn rats. Moreover, in a rat insulinoma cell line (RIN-m5F), pre-treatment with bilirubin (0.1 mg/dL) decreased cell death and apoptosis caused by STZ, and also reduced H<SUB>2</SUB>O<SUB>2</SUB> production. Considering the protective effect of hyperbilirubinemia against STZ-induced injury, we postulate that bilirubin could be a potential therapeutic modality for oxidative stress of pancreas islets.</P>
Fu-Yan Zhuge,CONG-WANG ZHANG,CHANG-CHUN ZENG,Han-Ping Liu 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2015 NANO Vol.10 No.7
Gold nanoparticles (Au NPs) have promising applications in the fields of drug delivery and photothermal therapy. 5-hydroxydecanoate (5-HD) is a kind of highly selective mitochondrial ATP sensitive potassium (mitoKATP) channel blocker. In this research, firstly, 5-HD was studied whether it could induce human lung adenocarcinomas (A549) cells apoptosis; secondly, PEGylated gold nanoparticles loaded with 5-HD (Au NPs-PEG-5-HD) were prepared to develop a new chemotherapy and photothermal therapy in one system under the irradiation of green light-emitting diode (LED). Subsequently, in vitro cytotoxicity test was analyzed by cell counting kit-8 (CCK-8), the change of mitochondrial membrane potential (Δψm) was determined by immunofluorescence microscopy with R-123 fluorescence, and cell apoptosis and necrosis rate were detected by flow cytometry. The results of CCK8 revealed that the inhibition rates of A549 cells were all greatly increased when cells were treated with free 5-HD, free 5-HD +LED irradiation, Au NPs-PEG-5-HD and Au NPs-PEG-5-HD+LED irradiation, and Au NPs-PEG-5-HD had enhanced cell-killing effect compared with 5-HD, furthermore, the Au NPs-PEG-5-HD and LED irradiation played a very great synergy effect. The immunofluorescence microscopy data also exhibited a reduction of Δψm correspondingly. Flow cytometric analysis showed that the apoptosis rate of cells that were incubated with free 5-HD, 5-HD+LED irradiation, Au NPsPEG-5-HD or Au NPs–PEG–5-HD+LED irradiation significantly increased to about 9.2%, 10.7%, 18.3% or 12.4% and the percentage of necrosis cells increased to around 8.8%, 9.7%, 48.0% or 69.8%, respectively. In a word, all the results indicated that the 5-HD had shown the ability to induce A549 cells apoptosis as a chemotherapy agent, and its ability would be improved when 5-HD is loaded on PEGylated Au NPs, as well as Au NPs-PEG-5-HD exhibited significantly enhanced photothermal effects for treatment of lung adenocarcinomas.
Developmental endothelial locus-1 prevents development of peritoneal adhesions in mice
Fu, Yan,Tsauo, Jiaywei,Sun, Yucheng,Wang, Zhe,Kim, Kun Yung,Lee, Seung-Hwan,Kim, Dong-Young,Jing, Feifeng,Lim, Dahae,Song, Ho-Young,Hyun, Hoon,Choi, Eun Young Elsevier 2018 Biochemical and biophysical research communication Vol.500 No.3
<P><B>Abstract</B></P> <P>Postoperative peritoneal adhesions, fibrous bands formed in the peritoneal cavity following surgery, represent a common, challenging and costly problem faced by surgeons and patients, for which effective therapeutic options are lacking. Since aberrant inflammation is one of the key mechanisms underlying peritoneal adhesion formation, here we set out to study the role of developmental endothelial locus-1 (Del-1), which has been recently identified as an endogenous inhibitor of inflammation, in the formation of postoperative peritoneal adhesions using a mouse model of peritoneal adhesions induced by ischemic buttons. Del-1-deficient mice had a higher incidence of adhesions, and their adhesions had higher quality and tenacity scores. Del-1 deficiency also led to enhanced inflammation mediators and collagen production. Finally, Del-1 supplementation decreased the incidence and severity of postoperative peritoneal adhesions. Taken together, these results indicate a protective role for Del-1 in postoperative peritoneal adhesion formation.</P>
Almost Disturbance Decoupling for a Class of Inherently Nonlinear Systems
Yan-Ming Fu,Guang-Ren Duan,Ai-Guo Wu 제어·로봇·시스템학회 2009 International Journal of Control, Automation, and Vol.7 No.2
The problem of almost disturbance decoupling (ADD) for a class of inherently nonlinear systems is considered. The controlled systems are beyond triangular form and possess uncontrollable linearization. The performance of ADD is characterized in terms of L2-L2p gain. By using the tool of adding a power integrator, under a set of growth conditions a smooth sate feedback controller is explicitly constructed to attenuate the influence of the disturbance on the output with an arbitrary degree.
Yan-Fu Lin,Jiann-Rong Chen,Jo-Ming Tseng,Shu-Yu S. Wang,Chi-Min Shu 한국화학공학회 2008 Korean Journal of Chemical Engineering Vol.25 No.3
Methyl ethyl ketone peroxide (MEKPO) is an unstable material that is classified as an explosive substance. We evaluated MEKPO 10 mass% under mixing with three inorganic acids (6 N HNO3, 6 N H3PO4, and 6 N H2SO4) by adiabatic system of vent sizing package 2 (VSP2). Results from evaluation and testing indicated that these three inorganic acids could increase the degree of hazard while combined with pure MEKPO. Therefore, information on the hazards and phenomena of runaway reaction should be provided in order to lessen the degree of hazard.
Yan-Ming Fu,Yang Lu,Mao-Rui Zhang 제어·로봇·시스템학회 2017 International Journal of Control, Automation, and Vol.15 No.5
This paper deals with the model reference tracking control problem of continuous-time periodic linearsystems when the actuator occurs jumping fault. The main contribution is to formulate the parametric designalgorithm for the systems by utilizing the parametric solution of the generalized Sylvester matrix equations. Theexistence condition of the controller is deduced based on the Lyapunov stability theory. The controller consistsof the additive contribution of two terms: a feedback term and a feedforward term. The feedback term is thefeedback control law which can stabilize the system with finite expected cost. The feedforward term is the completeparametric feedforward tracking compensator. The simulation for flying around mission is carried out about twospacecrafts in elliptical orbit. The simulation results show the effectiveness of the proposed approach.
Gastric Cancer Stem Cells: Mechanisms and Therapeutic Approaches
Yan Fu,Peizhun Du,Jing Zhao,Cheng’en Hu,Yunyun Qin,Guangjian Huang 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.10
Gastric cancer (GC) is the third leading cause of cancer-related deaths worldwide. GC stem-like cells (GCSCs), with unlimitedself-renewal, differentiation, and tumor-regenerating capacities, contribute significantly to the refractory features of GC and havegained increasing attention for their role in GC drug resistance, relapse, and metastasis. Therapies targeting GCSCs seem to beone of the most promising methods to improve the outcomes of GC patients. Extensive investigations have attempted to outlinethe regulatory mechanisms in GCSCs and to develop GCSCs-targeting therapies with which to diminish GC drug resistance, metastasisand relapse. To the best of our knowledge, there is a lack of reviews summarizing these studies. In this review, we systematicallyrecapitulated findings regarding the regulatory mechanisms of GCSCs, as well as therapies that target GCSCs, hoping tosupport the development of prognostic biomarkers and GCSCs-targeting anticancer therapies in GC.