청각장애초등학생을 위한 음악교육프로그램 개발 연구

이드보라ㆍ남선화ㆍ정미라(Debora LeeㆍNam Sun WhaㆍJeong Mi ra) 한국특수교육학회 2016 특수교육학연구 Vol.50 No.4

韓國人의 위달抗體價 調査報告

鄭泰華,全南昊,尹尙五,柳榮海 國立保健硏究院 1974 국립보건연구원보 Vol.11 No.-

GO-39 : Prognostic significance of treatment-induced pathologic remission and adjuvant chemotherapy after interval cytoreduction following neoadjuvant chemotherapy in epithelial ovarian cancer

( Shin Wha Lee ),( Kyu Rae Kim ),( Dae Yeon Kim ),( Jong Hyeok Kim ),( Young Man Kim ),( Young Tak Kim ),( Joo Hyun Nam1 ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-

목적: The objective of the study was to analyze the prognostic role of pathological response to neoadjuvant chemotherapy (NACT) and adjuvant management in unresectable advanced ovarian cancer (AOC) patients. 방법: We retrospectively evaluated 94 unresectable AOC patients treated with NACT followed by interval debulking surgery (IDS). Pathological response was classified as follows: complete remission (CR) in the absence of residual disease, microscopic (microPR) in the presence of microscopic tumor foci, and macroscopic (macroPR) when macroscopic residual disease was detected. Adjuvant management was classified to two groups: the one was treated with 3 cycles of adjuvant chemotherapy and the other was treated with more than 3 cycles. 결과: No differences were observed in the distribution of baseline clinicopathological characteristics among 3 pathologic groups. Median progression- free survival was 28 months CR, 16 in microPR, and 13 in macroPR (p<0.05). Median overall survival was 52 months in CR, 32 in microPR, and 21 in macroPR (p<0.05). Median PFS was not different between 3ACT and 6ACT, but median OS was significantly longer in 6ACT when the analysis was conducted in platinum-respondors (28 months vs. 34 months). 결론: The pathologic response to NACT is associated with a favorable prognosis. Additionally, the sufficient adjuvant chemotherapy was important. The careful clinical setting is necessary for the patients treated with IDS following NACT

2007년도 덕성여자대학교 신입생의 특성

정형남,정선화,김남재 덕성여자대학 학생생활지도연구소 2007 學生生活硏究 Vol.23 No.-

2007년도 덕성여자대학교 신입생 및 그 가정의 제반특성을 파악하기 위하여 인적 사항, 가정환경, 입학 만족도, 대학생활, 가치관, 자신에 대한 지각, 강의주제 등에 관한 설문조사를 실시하였다. 총 신입생 1281명 중 응답자 1066명의 자료를 분석하여 각 문항 별로 신입생 전체는 물론 각 학부의 응답 빈도 및 비율을 제시하였다. 되풀이 확인된 결과로는 우선, 대다수의 학생들이 수도권지역의 고등학교를 졸업하였으며 중산층 이상의 가정 출신이라는 점이다. 대부분 부모가 모두 생존해 계시고 고졸이상의 학력을 가지고 있다. 두번째, 학생들은 취업에 큰 관심을 가지고 있으며 장래 취업을 준비하기 위해 대학에 진학 했다고 답한 경우가 많았다. 이외에도 대학별 특징 등 중요한 결과들을 논의에서 요약하였다. 그리고 그 결과들이 시사하는 바를 제안하였다. Examined the characteristics of the students who entered Duksung Women's University in 2007. The total number of 1066(out of 1281) undergraduates completed an autobiographical questionnaire which inquires about demographic variables, family environment, satisfaction with the university, expectancies of a campus life, value system, self-concept, and lecture subject. Results show that a majority of the students were graduated from high schools located in Seoul. Both of their parents are alive, in the middle or higher socioeconomic groups and of high educational accomplishment(at the lowest, high school graduates). One of the replicated findings is that students are highly interested in career development. A great proportion of career preparation. The result also indicate that many students have chosen our university solely based on their grades. And many students report that they are satisfied with their choice, which is very encouraging. Other result such as the characteristics unique to each college are also summarized and several suggestions are presented In the discussion section.

2008년도 덕성여자대학교 신입생의 특성

정선화,김남재 덕성여자대학 학생생활지도연구소 2008 學生生活硏究 Vol.24 No.-

Examined the characteristics of the students who entered Duksung Women's University in 2008. The total number of 1054(out of 1445) undergraduates completed an autobiographical questionnaire which inquires about demographic variables, family environment, satisfaction with the university, expectancies of a campus life, value system, self-concept, and lecture subject. Results show that a majority of the students were graduated from high schools located in Seoul. Both of their parents are alive, in the middle or higher socioeconomic groups and of high educational accomplishment(at the lowest, high school graduates). One of the replicated findings is that students are highly interested in career development. A great proportion of career preparation. The result also indicate that many students have chosen our university solely based on their grades. And many students report that they are satisfied with their choice, which is very encouraging. Other result such as the characteristics unique to each college are also summarized and several suggestions are presented in the discussion section.

女性 能力 開發을 위한 女性學課程 設置의 提案

玄永學,鄭世華,李男德,李效再 이화여자대학교 한국문화연구원 1976 韓國文化硏究院 論叢 Vol.28 No.-

For the past 20 years, there has been a substantial increase in the percentage of women going to colleges and universities in Korea: the statistics indicate that the male and female ratio changed from 87.3% to 12.2% in 1952 to 73.9% to 26.1% in 1974. Inspite of the increasing trend, some academic observers recently began to voice their opinions against higher education for women on the basis that Korean women, regardless of their education in an occupation or public life. The following trends partially support this opinion. First, the tendency of female students concentrating their major fields on a limited number of specializations, such as teachers' education, language, arts, nursing and medical technology, is a contrasting phenomenon with male students, who are more or less evenly distributed throughout all the areas of specialization as their major fields. Second, the remarkable increase in female labor participation for the past 10-15 years is largely contributed by women in the agricultural sector and manufacturing industries, as the percentage of women with higher education have shown not as much of an increase in the labor market as that of these with elementary level or less education. Furthermore, the percentage of women in professions and managerial occupations which would require college education for qualification toward has decreased from 2% in 1960 to 1.8% in 1970. Thirdly, a survey of Ewha graduates concerning their attitudes toward women's social role and college education presents revealing results of their conservatism and resignation sex equality and occupational roles. These findings certainly contradict the egalitarian principles of modern higher education and human potentials. However, there are now growing trends among female college students, with the awareness of changing sex roles, of taking seriously their future occupations and other social roles in addition to marriage. They are showing a greater concern for developing their potentials for professions and egalitarian roles for society, realizing the need for overcoming socio-cultural limitations as well as personal inertia. These are signs calling for new directions in women's education in Korea by introducing women studies programs which are designed to liberate women from the culturally conditioned state of self-awareness and the traditional status and role.

Association of <i>miR-149</i> polymorphism with onset age and severity in Charcot–Marie–Tooth disease type 1A

Nam, Soo Hyun,Kanwal, Sumaira,Nam, Da Eun,Lee, Min Hee,Kang, Tae Hoon,Jung, Sung-Chul,Choi, Byung-Ok,Chung, Ki Wha Elsevier 2018 Neuromuscular disorders Vol.28 No.6

<P><B>Abstract</B></P> <P>Charcot–Marie–Tooth disease type 1A (CMT1A) is caused by 1.5-fold increased dosage of the <I>PMP22</I>; however, onset age and severity vary considerably among patients. The exact reason behind these phenotypic heterogeneities has rarely been discovered yet. Because miRNAs are the key regulators of gene expression, we speculated that variants of miRNAs might be the genetic modifiers for CMT1A. This study noticed a common single nucleotide polymorphism (n.86T > C, rs2292832) in the <I>miR-149</I> which was predicted to target several CMT causing genes including <I>PMP22</I>. The rs2292832 was located near the 3′ end of the precursor microRNA of the <I>miR-149</I>. We performed an association study between the rs2292832 polymorphism and clinical phenotypes of CMT1A in subjects consisting of 176 unrelated Korean CMT1A patients and 176 controls. From this study, we observed that rs2292832 was closely associated to the onset age and severity of CMT1A. Particularly, the TC and CC genotypes were significantly associated with late onset and mild symptom. Therefore, we suggest that the rs2292832 variant in the <I>miR-149</I> is a potential candidate as a genetic modifier which affects the phenotypic heterogeneity of CMT1A. This study may provide the first evidence that polymorphism in the <I>miR</I> gene is associated with the CMT1A phenotype.</P> <P><B>Highlights</B></P> <P> <UL> <LI> An association study was conducted between <I>miR-149</I> SNP and severity of CMT1A. </LI> <LI> The rs2292832 SNP was closely associated to the onset age and severity of CMT1A. </LI> <LI> The TC and CC genotypes were associated with late onset and mild symptom. </LI> <LI> The rs2292832 in <I>miR-149</I> was suggested as a potential genetic modifier of CMT1A. </LI> </UL> </P>

Identification of Genetic Causes of Inherited Peripheral Neuropathies by Targeted Gene Panel Sequencing

Nam, Soo Hyun,Hong, Young Bin,Hyun, Young Se,Nam, Da Eun,Kwak, Geon,Hwang, Sun Hee,Choi, Byung-Ok,Chung, Ki Wha Korean Society for Molecular and Cellular Biology 2016 Molecules and cells Vol.39 No.5

Inherited peripheral neuropathies (IPN), which are a group of clinically and genetically heterogeneous peripheral nerve disorders including Charcot-Marie-Tooth disease (CMT), exhibit progressive degeneration of muscles in the extremities and loss of sensory function. Over 70 genes have been reported as genetic causatives and the number is still growing. We prepared a targeted gene panel for IPN diagnosis based on next generation sequencing (NGS). The gene panel was designed to detect mutations in 73 genes reported to be genetic causes of IPN or related peripheral neuropathies, and to detect duplication of the chromosome 17p12 region, the major genetic cause of CMT1A. We applied the gene panel to 115 samples from 63 non-CMT1A families, and isolated 15 pathogenic or likelypathogenic mutations in eight genes from 25 patients (17 families). Of them, eight mutations were unreported variants. Of particular interest, this study revealed several very rare mutations in the SPTLC2, DCTN1, and MARS genes. In addition, the effectiveness of the detection of CMT1A was confirmed by comparing five 17p12-nonduplicated controls and 15 CMT1A cases. In conclusion, we developed a gene panel for one step genetic diagnosis of IPN. It seems that its time- and cost-effectiveness are superior to previous tiered-genetic diagnosis algorithms, and it could be applied as a genetic diagnostic system for inherited peripheral neuropathies.

Thermal Properties and Viscous Flow Behavior of Bulk Amorphous Mg59.7Cu18.5Pd9.6Y12.2 Alloy

Wha-Nam Myung,Hyun-Goo Kim,In-Sun Hwang 한국물리학회 2004 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.44 No.6

Using dierential scanning calorimetry, we observed four exothermic peaks and three distinct melting endothermic peaks from a bulk amorphous Mg59:7Cu18:5Pd9:6Y12:2 alloy cast in an argon atmosphere. The activation energies for crystallization were 123.50, 156.90, 158.90, and 121.70 kJ/mol for the rst, second, third, and fourth peak, respectively, while the thermal stability range of the supercooled liquid was 27 C at a heating rate of 10 C/min. Thermomechanical analysis experiments showed that the eective viscosity of the Mg59:7Cu18:5Pd9:6Y12:2 sample decreased with increasing temperature until a steady-state viscous- ow temperature (Tvs) at which the eective viscosity of the bulk sample showed a minimum. We found that the eective linear expansion coef- cient and the free-volume fraction increased with increasing temperature until Tvs. We conrmed that the relative displacement under a compression stress depended strongly upon the amorphicity of the samples.

Axonal Charcot‐Marie‐Tooth neuropathy concurrent with distal and proximal weakness by translational elongation of the 3′ UTR in <i>NEFH</i>

Nam, Da Eun,Jung, Sung‐,Chul,Yoo, Da Hye,Choi, Sun Seong,Seo, Sung‐,Yum,Kim, Gwang Hoon,Kim, Song Ja,Nam, Soo Hyun,Choi, Byung‐,Ok,Chung, Ki Wha Wiley Periodicals, Inc. 2017 Journal of the peripheral nervous system Vol.22 No.3

<P><B>Abstract</B></P><P>Mutations in the <I>NEFH</I> gene encoding the heavy neurofilament protein are usually associated with neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS). Recently, frameshift variants in <I>NEFH</I> (p.Asp1004Glnfs*58 and p.Pro1008Alafs*56) have been reported to be the underlying cause of axonal Charcot‐Marie‐Tooth disease type 2CC (CMT2CC). The frameshift mutation resulted in a stop loss and translation of a cryptic amyloidogenic element (CAE) encoded by the 3′ untranslated region (UTR). This study also identified a <I>de novo</I> c.3015_3027dup frameshift mutation predicting p.Lys1010Glnfs*57 in <I>NEFH</I> from a CMT2 family with an atypical clinical symptom of prominent proximal weakness. This mutation is located near the previously reported frameshift mutations, suggesting a mutational hotspot. Lower limb magnetic resonance imaging (MRI) revealed marked hyperintense signal changes in the thigh muscles compared with those in the calf muscles. Therefore, this study suggests that the stop loss and translational elongations by the 3′ UTR of the <I>NEFH</I> mutations may be a relatively frequent genetic cause of axonal peripheral neuropathy with the specific characteristics of proximal dominant weakness.</P>