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Double-gate thin film transistor with suspended-gate applicable to tactile force sensor
Nguyen An Hoang-Thuy,Nguyen Manh-Cuong,조성용,응웬안위,김혜원,Seok Yeongcheol,윤지연,최리노 나노기술연구협의회 2020 Nano Convergence Vol.7 No.31
This paper presents a straightforward, low-cost, and effective integration process for the fabrication of membrane gate thin film transistors (TFTs) with an air gap. The membrane gate TFT with an air gap can be used as the highly sensitive tactile force sensor. The suspended membrane gate with an air gap as the insulator layer is formed by multiple photolithography steps and photoresist sacrificial layers. The viscosity of the photoresist and the spin speed was used to modify the thickness of the air gap during the coating process. The tactile force was measured by monitoring the drain current of the TFT as the force changed the thickness of the air gap. The sensitivity of the devices was enhanced by an optimal gate size and low Young’s modulus of the gate material. This simple process has the potential for the production of small, versatile, and highly sensitive sensors.
Whole Genome-Based Phylogenetic Analysis of Bacterial Two-Component Systems
Thuy Vu An Nguyen,홍순호 한국생물공학회 2008 Biotechnology and Bioprocess Engineering Vol.13 No.3
To adapt to their environment, bacterial strains have developed various environmental signal sensing systems or two-component systems. To evaluate the evolutionary relationship of two-component systems, 246 two-component system genes from KEGG were analyzed. Phylogenetic tree structure indicated that most two-component systems are strain specific. Most of two-component system genes have co-evolved, and some two-component system pairs have evolved via recruitment model. By two-component system gene content analysis, new aspect of cellular metabolism evolution was provided.
Thuy-An Nguyen,이상화 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.48 No.-
Au nanostructures electrodeposited on amine-terminated indium tin oxide (ITO) glass as surfaceenhancedRaman scattering (SERS) substrates. The number of electrodeposition cycles (one cycle consistsof a nucleation potential of 0.7 V for 2 s and a growth potential of0.3 V for 1000 s) were optimized. Among as-prepared substrates (1–10 cycles), Au nanostructures formed by three cycles yielded thehighest Raman signals of probe molecules, owing to their rough surface morphology with multiple inter-space nanogaps. The Au nanostructure exhibited the very low detection limits of 10 10M for crystal violetand 10 9M for dopamine, as an ultrasensitive SERS substrate
Bulky carbon layer inlaid with nanoscale Fe2O3 as an excellent lithium-storage anode material
Thuy-An Nguyen,이상화 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.68 No.-
Bulky carbon layer uniformly distributed with nanoscale Fe2O3 was prepared via a direct carbonation of Fe3+–polyacrylonitrile complexes at 700 °C under N2 flow. The iron oxide carbon composites exhibited an excellent cycling performance for lithium storage with a reversible capacity of ∼810 mAh g−1 after 250 cycles at a current rate of 100 mA g−1. The enhancement was mainly attributed to dual functions of bulky carbon layer which facilitated the lithium-ion diffusion and accommodated the volume changes of active Fe2O3 during charge/discharge process. Our novel chemical strategy is quite effective for scalable fabrication of high capacity lithium-storage materials.
Thuy Vu An Nguyen,홍순호 한국생물공학회 2009 Biotechnology and Bioprocess Engineering Vol.14 No.2
In this study, two-component system (TCS) gene profile and metabolic network gene profile based phylogenetic trees were constructed and compared to each other to evaluate the evolutionary relationship between the bacterial sensing system and metabolism. The gene profiles of the these systems suggested that bacteria employed different evolutionary strategies to optimize the two-component system and metabolic network. In addition, comparative analysis revealed that the TCS based tree showed better family grouping than the metabolic network based tree, which indicated that the TCS and metabolic network have been modified îá~ self-evolution and recruitment methods, respectively In this study, two-component system (TCS) gene profile and metabolic network gene profile based phylogenetic trees were constructed and compared to each other to evaluate the evolutionary relationship between the bacterial sensing system and metabolism. The gene profiles of the these systems suggested that bacteria employed different evolutionary strategies to optimize the two-component system and metabolic network. In addition, comparative analysis revealed that the TCS based tree showed better family grouping than the metabolic network based tree, which indicated that the TCS and metabolic network have been modified îá~ self-evolution and recruitment methods, respectively
An Sunho,Vo Tam Thuy Lu,Son Taekwon,Choi Hoon,Kim Jinyoung,Lee Juyeon,Kim Byung Hoon,Choe Misun,Ha Eunyoung,Surh Young-Joon,Kim Kyu-Won,Seo Ji Hae 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Human sterile α motif and HD domain-containing protein 1 (SAMHD1) has deoxyribonucleoside triphosphohydrolase (dNTPase) activity that allows it to defend against human immunodeficiency virus type I (HIV-1) infections and regulate the cell cycle. Although SAMHD1 mutations have been identified in various cancer types, their role in cancer is unclear. Here, we aimed to investigate the oncogenic role of SAMHD1 in human clear cell renal cell carcinoma (ccRCC), particularly as a core molecule promoting cancer cell migration. We found that SAMHD1 participated in endocytosis and lamellipodia formation. Mechanistically, SAMHD1 contributed to the formation of the endosomal complex by binding to cortactin. Thereafter, SAMHD1-stimulated endosomal focal adhesion kinase (FAK) signaling activated Rac1, which promoted lamellipodia formation on the plasma membrane and enhanced the motility of ccRCC cells. Finally, we observed a strong correlation between SAMHD1 expression and the activation of FAK and cortactin in tumor tissues obtained from patients with ccRCC. In brief, these findings reveal that SAMHD1 is an oncogene that plays a pivotal role in ccRCC cell migration through the endosomal FAK-Rac1 signaling pathway.