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유비쿼터스 환경에서 다양한 개인화 서비스에 적용하기 위한 사용자 모델링의 일반화 방법론
이주연(Juyeon Lee),이성진(Seongjin Lee),이수원(Soowon Lee) 한국정보과학회 2006 한국정보과학회 학술발표논문집 Vol.33 No.2B
최근 연구가 활발히 진행되고 있는 ‘유비쿼터스’라는 새로운 패러다임은 기존보다 더욱 많은 컴퓨팅 자원을 이용하여 사용자의 편의를 지원하는 것을 그 목표로 하고 있다. 유비쿼터스 컴퓨팅 환경에서 사용자를 지원하기 위한 대표적인 예로 개인화 서비스를 들 수 있으며, 개인화 서비스는 사용자에 대한 모델링이 필수 요소가 된다. 개개인의 행동 패턴 혹은 선호도 정보로 구성된 사용자 모델은 다양한 개인화 서비스의 원활한 지원을 위해 지금까지 유용하게 사용되고 있지만, 기존의 사용자 모델은 각 서비스가 개발될 때, 그 서비스에 적합한 형태로 매번 설계되어야 하는 문제점을 지닌다. 본 논문에서는 이러한 문제점을 해결하고자, 사용자 모델을 구성하는 정보들을 분석하여, 모델 설계에 필요한 일반화된 입력 패턴들을 도출하고, 도출된 패턴들을 바탕으로 더욱 쉽고 빠르게 사용자 모델을 생성할 수 있는 방법을 제안한다.
이주희(Lee, JuHee),이태화(Lee, Taewha),이현경(Lee, Hyunkyeong),김상희(Kim, Sanghee),배주연(Bae, Juyeon),한지희(Han, Jeehee),이경은(Lee, Kyongeun) 한국간호교육학회 2015 한국간호교육학회지 Vol.21 No.4
Purpose: The purpose of this study was to develop an integrated nursing practicum education matrix based on the learning outcomes of each stage. Methods: In this Delphi technique study, 10 experts, consisting of six professors and four nurses, participated in the development of the matrix. The first step was an in-depth review for the composition of the questionnaire and the second step was the Delphi technique. The Delphi survey was conducted two times in order to complete the components of the matrix. The survey data was analyzed for statistical averages and standard deviations to decide the order of priority. Results: According to each stage (i.e. fundamental stage, competent stage, and proficient stage), the matrix was composed of education contents, methods, evaluation methods, and curriculum outcomes. Conclusion: The integrated nursing practicum education matrix of Y University was completed. The developed matrix will result in a reduction in the gap between nursing education and clinical practice and an improvement in nursing competency.
( Subeen Lee ),( Juyeon Kang ),( Hyun Jung Lee ),( Yoon Hee Lee ),( Gun Oh Chong ),( Dae Gy Hong ),( Yoon Soon Lee ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-
Objective: We evaluated the clinical significance of clinical factors and hematological parameters as prognostic factors in patients with locally advanced cervical cancer (LACC) who received definitive concurrent chemoradiotherapy (CCRT). Methods: We retrospectively analyzed 125 patients with LACC (FIGO stage IIB to IIIB) who received definitive CCRT. Clinical factors and hematological parameters, including neutrophil-to-lymphocyte ratio (NLR) were assessed pre- and post-CCRT. Neutrophil-to-lymphocyte ratio (NLR) was calculated by dividing absolute neutrophil counts by absolute lymphocyte counts. Tumor size was determined by measuring the largest tumor diameter in MRI or CT images. Univariate and multivariate analysis for disease-free survival (DFS) and overall survival (OS) were performed using clinical factors and hematological parameters. Results: Disease recurred in 46 (36.8%) patients, and 24 patients (19.2%) died. On multivariate analysis, tumor size, paraaortic lymph node metastasis, post-treatment NLR, NLR (pre-treatment NLR/post-treatment NLR) and PLR (platelet-to-lymphocyte ratio) (pretreatment PLR /posttreatment PLR) were significant prognostic factors for DFS. Among them, only post-treatment NLR and tumor size were a significant prognostic factor for OS (p<0.001). Combination of tumor size and post-treatment NLR were significant prognostic factor for DFS and OS. Patients with large tumor size and elevated post-treatment elevated NLR were shown poor prognosis. Conclusion: Combination of tumor size and post-treatment NLR may serve as a prognostic indicator in patients with LACC who received definitive CCRT.
Lee, Juyeon,Bahk, Jinwook,Kim, Ikhan,Kim, Yeon-Yong,Yun, Sung-Cheol,Kang, Hee-Yeon,Lee, Jeehye,Park, Jong Heon,Shin, Soon-Ae,Khang, Young-Ho Elsevier 2018 Journal of stroke and cerebrovascular diseases Vol.27 No.3
<P><B>Background</B></P> <P>Little is known about within-country variation in morbidity and mortality of cerebrovascular diseases (CVDs). Geographic differences in CVD morbidity and mortality have yet to be properly examined. This study examined geographic variation in morbidity and mortality of CVD, neighborhood factors for CVD morbidity and mortality, and the association between CVD morbidity and mortality across the 245 local districts in Korea during 2011-2015.</P> <P><B>Methods</B></P> <P>District-level health care utilization and mortality data were obtained to estimate age-standardized CVD morbidity and mortality. The bivariate Pearson correlation was used to examine the linear relationship between district-level CVD morbidity and mortality Z-scores. Simple linear regression and multivariate analyses were conducted to investigate the associations of area characteristics with CVD morbidity, mortality, and discrepancies between morbidity and mortality.</P> <P><B>Results</B></P> <P>Substantial variation was found in CVD morbidity and mortality across the country, with 1074.9 excess CVD inpatients and 73.8 excess CVD deaths per 100,000 between the districts with the lowest and highest CVD morbidity and mortality, respectively. Higher rates of CVD admissions and deaths were clustered in the noncapital regions. A moderate geographic correlation between CVD morbidity and mortality was found (Pearson correlation coefficient = .62 for both genders). Neighborhood level indicators for socioeconomic disadvantages, undersupply of health care resources, and unhealthy behaviors were positively associated with CVD morbidity and mortality and the relative standing of CVD mortality vis-à-vis morbidity.</P> <P><B>Conclusions</B></P> <P>Policy actions targeting life-course socioeconomic conditions, equitable distribution of health care resources, and behavioral risk factors may help reduce geographic differences in CVD morbidity and mortality in Korea.</P>
mySyntenyPortal: an application package to construct websites for synteny block analysis
Lee, Jongin,Lee, Daehwan,Sim, Mikang,Kwon, Daehong,Kim, Juyeon,Ko, Younhee,Kim, Jaebum BioMed Central 2018 BMC bioinformatics Vol.19 No.-
<P><B>Background</B></P><P>Advances in sequencing technologies have facilitated large-scale comparative genomics based on whole genome sequencing. Constructing and investigating conserved genomic regions among multiple species (called synteny blocks) are essential in the comparative genomics. However, they require significant amounts of computational resources and time in addition to bioinformatics skills. Many web interfaces have been developed to make such tasks easier. However, these web interfaces cannot be customized for users who want to use their own set of genome sequences or definition of synteny blocks.</P><P><B>Results</B></P><P>To resolve this limitation, we present mySyntenyPortal, a stand-alone application package to construct websites for synteny block analyses by using users’ own genome data. mySyntenyPortal provides both command line and web-based interfaces to build and manage websites for large-scale comparative genomic analyses. The websites can be also easily published and accessed by other users. To demonstrate the usability of mySyntenyPortal, we present an example study for building websites to compare genomes of three mammalian species (human, mouse, and cow) and show how they can be easily utilized to identify potential genes affected by genome rearrangements.</P><P><B>Conclusions</B></P><P>mySyntenyPortal will contribute for extended comparative genomic analyses based on large-scale whole genome sequences by providing unique functionality to support the easy creation of interactive websites for synteny block analyses from user’s own genome data.</P>
The Peroxisomal Localization of Hsd17b4 Is Regulated by Its Interaction with Phosphatidylserine
Lee, Sang-Ah,Lee, Juyeon,Kim, Kwanhyeong,Moon, Hyunji,Min, Chanhyuk,Moon, Byeongjin,Kim, Deokhwan,Yang, Susumin,Park, Hyunjin,Lee, Gwangrog,Park, Raekil,Park, Daeho Korean Society for Molecular and Cellular Biology 2021 Molecules and cells Vol.44 No.4
Phosphatidylserine (PS), a negatively charged phospholipid exclusively located in the inner leaflet of the plasma membrane, is involved in various cellular processes such as blood coagulation, myoblast fusion, mammalian fertilization, and clearance of apoptotic cells. Proteins that specifically interact with PS must be identified to comprehensively understand the cellular processes involving PS. However, only a limited number of proteins are known to associate with PS. To identify PS-associating proteins, we performed a pulldown assay using streptavidin-coated magnetic beads on which biotin-linked PS was immobilized. Using this approach, we identified Hsd17b4, a peroxisomal protein, as a PS-associating protein. Hsd17b4 strongly associated with PS, but not with phosphatidylcholine or sphingomyelin, and the Scp-2-like domain of Hsd17b4 was responsible for this association. The association was disrupted by PS in liposomes, but not by free PS or the components of PS. In addition, translocation of PS to the outer leaflet of the plasma membrane enriched Hsd17b4 in peroxisomes. Collectively, this study suggests an unexpected role of PS as a regulator of the subcellular localization of Hsd17b4.
Lee, Seungyeon,Park, Sungbin,Lee, Hyunkyung,Jeong, Dawoon,Ham, Juyeon,Choi, Eun Ha,Kim, Sun Jung Elsevier 2018 FREE RADICAL BIOLOGY AND MEDICINE Vol.126 No.-
<P><B>Abstract</B></P> <P>Cold atmospheric plasma (CAP) has gained attention for use in cancer treatment owing to its ability to preferentially induce cancer cell death; however, the involved molecular mechanism remains to be elucidated. Herein, an epigenetic effect of CAP on cancer cells was examined by performing a genome-wide ChIP-seq for H3K4me3 in MCF-7 breast cancer cell line. Consequently, 899 genes showed significantly changed methylation level at H3K4 with constructing “Cellular Compromise, DNA Replication, Recombination, Repair, and Cell Cycle” as the top network. Comparisons with expression array data revealed a coincidence between histone modification and gene expression for 18 genes, and the association was confirmed by ChIP-PCR and qRT-PCR for selected genes. The expression of the affected genes, such as <I>HSCB</I> and <I>PRPS1,</I> was recovered when a histone demethylase JARID1A was inhibited. Furthermore, JARID1A was induced by CAP via the reactive oxygen species signaling. The two genes are known as oncogenes and show a higher expression in breast cancer tissue, and this was supported by the decreased colony formation ability of MCF-7 cells when the cells were treated with siRNAs against each gene. Taken together, these data indicate that CAP inhibits cancer cell proliferation by modulating the methylation level of H3K4 corresponding to oncogenes.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Cold atmospheric plasma induced genome-wide alteration of H3K4me3 in the MCF-7. </LI> <LI> The H3K4me3 of HSCB and PRPS1 was increased by cold atmospheric plasma. </LI> <LI> Inhibition of a histone demethylase (JARID1A) recovered expression of HSCB and PRPS1. </LI> <LI> Cold atmospheric plasma inhibits cancer cell proliferation by modulating H3K4me3. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>