설편평세포암에서 CD44, MMP-2, MMP-9, TIMP-1의 발현

이상화,표성운,김영실,최목균 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.4

Adhesion molecules and proteinases play an important role in the invasion and metastasis of a malignant tumor. However, there have not been many studies on tongue squamous cell carcinoma at Saint Mary's Hospital and Kangnam Saint Mary's Hospital, the Catholic University of Korea, between 1994 and 2000, and had not received chemo-or radiotherapy. The expression of the adhesion molecules CD44H, proteinases MMP-2 and MMP-9, and TIMP-1, which controls MMP activity, was analyzed by immunohistochemistry. In addition their association with the tumor size, lymph node metastasis, clinical stage, and cell differentiation was evaluated. Increased MMP-2 expression was significantly correlated with lymph node metastasis and clinical stage. However, it did not correlate with tumor size or cell differentiation. CD44H, MMP-9 and TIMP-1 expression were not significantly related to tumor size, lymph node metastasis, clincial stage and cell differentiation. The results suggest that MMP-2 is a possible immunohistochemical prognostic factor in tongue squamous cell carcinoma. Futher reasearches will be needed to investigate the additional tumor prognostic factors and their mechanisms.

액시드 캅셀(니자티딘 150 mg)에 대한 넥스 캅셀의 생물학적 동등성

김지만,이상봉,전성실,신영희 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.1

The purpose of the present study was to evaluate the bioequivalence of two nizatidine capsules, Axid (Lilly Korea Pharm. Co., Ltd.) and Nex (Bi-nex Pharm. Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The nizatidine release from the two nizatidine capsules in vitro was tested using KP Apparatus method with various dissolution media (pH 1.2, 4.0, 6.8 buffer solutions and water). The dissolution profiles of two nizatidine capsules were very similar at all dissolution media. Twenty four normal male volunters were divided into two groups with a randomized 22 cross-over study. After two capsules (300 ㎎ nizatidine) were orally administrated, blood as taken and the concentrations of nizatidine in serum were determined using HPLC with UV detector. The pharmacokinetic parameters such as AUC_(t), C_(max) T_(max) were determined. The result showed that the differences in AUC_(t), C_(max) and T_(max) between two nizatidine capsules absed on the Axid were-6.16%, -8.26% and -1.82%, respectively. There were no sequence effects between two capsules in these parameter. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25)(e.g., log(0.91) ∼log(0.97) and log(0.85)∼log(0.99) for AUC_(t) and C_(max), respectively), indicating that Nex capsule is bioequivalent to Axid capsule.

Effects of Reed (Phragmites communis) on Growth Performance, Carcass Characteristics, and Meat Quality in Hanwoo Steers

Sang Min Lee(이상민),Sun Sik Chang(장선식),Ki Yong Chung(정기영),Hyeong Cheol Kim(김형철),Sun Ho Choi(최순호),Ha Yeon Jeong(정하연),Boh Suk Yang(양보석),Sung Sill Lee(이성실),Young Moo Cho(조영무) 한국생명과학회 2012 생명과학회지 Vol.22 No.10

본 연구는 한우 거세우의 비육시 급여 조사료의 종류가 발육 및 도체특성에 미치는 영향을 구명하고자 수행하였다. 한우 거세우 21두를 3처리(건초, 갈대 및 갈대+볏짚), 처리당 7두씩 완전 임의 배치하였다. 시험결과 개시체 중 및 종료체중은 처리구별(대조, T1 및 T2)로 각각 125.5, 128.3 및 128.3 kg과 697.4, 614.6 및 706.7 kg으로 나타났다. 일당증체량은 대조구(0.70 kg/d)와 T2 처리구(0.71 kg/d)가 T1 처리구(0.60 kg/d)보다 향상된 경향을 나타났지만 유의적인 차이는 없었다. 건물섭취량은 유의적인 차이는 없었지만 T1 처리구가 다른 처리구에 비해 비교적 낮았다. 육량특성에서 도체중은 대조구와 T2처리구간에는 차이가 없었지만, T2처리구는T1 처리구에 비해 높았다(p<0.05). 등지방두께와 등심단면적은 대조구와 T2처리구가 T1처리구 보다 높았고, 육량등급(A:B:C, %)은 T1 처리구(43:57:0)가 다른 처리구(대조구 0:71:29, T2 29:42:29)에 비해 높았다. 육질특성에서는 지방색과 조직감은 처리구 간 유의적인 차이가 없었다. 그러나 육색과 성숙도는 T2 처리구에 비해 T1 처리구가 유의적으로 높았다 (p<0.05). 근내지방도 및 육질1등급이상 출현율은 T1처리구에 비해 대조구와 T2처리구가 높았다. 본 연구의 결과를 종합해 볼 때 거세한우 비육시 조사료로서 갈대와 볏짚을 혼합급여할 때 발육, 사료 이용성 및 도체 성적이 향상되어 갈대가 한우의 조사료원으로서 활용가치가 있는 것으로 판단되었다. This study investigated the effects of diet of different forages on growth performance and carcass characteristics of Hanwoo steers. Twenty-one Hanwoo steers were randomly allocated to three groups (fed hay, reed, and reed with rice straw) of seven steers each. Initial and final body weights of control, T1, and T2 groups were 125.5, 128.3, 128.3 kg and 697.4, 614.6, 706.7 kg, respectively. Average daily gain tended to increase in controls (0.70 kg/d) and the T2 group (0.71 kg/d) but not as much in the T1 group (0.60 kg/d); however, there was no significant difference. DMI was not significantly different among the treatment groups, but T1 was relatively lower than the other groups. For the yield traits, carcass weight was not significantly different between controls and the T2 group but was greater in the T2 group compared to the T1 group (p<0.05). Back fat thickness and rib eye area were higher in controls and T2 compared to T1; yield grade (A:B:C, %) was greater in T1 (43:57:0) compared to the other groups (control 0:71:29; T2 29:42:29). For the quality traits, fat color and texture were not significantly different among groups. However, meat color and maturity were significantly greater in T1 compared to T2 (p<0.05). Marbling score and appearance rate of over 1st meat quality grade were greater in the control and T2 groups compared to the T1 group. Based on the results, growth performance, feed utilization, and carcass traits appeared to improve when roughage containing rice straw plus reed was offered. Therefore, reed is worth considering as a roughage source for fattening Hanwoo steers.

Laboratory detection of Lyme borreliosis and these serological characteristics

Sang Hee Park,Kyu Jam Hwang,Joo Hyun Kim,A Ram Ki,Soo Kyoung Shim,Young Sill Choi,Mi Yeoun Park 대한인수공통전염병학회 2008 창립총회 및 학술대회 초록집 Vol.2008 No.1

Effects of Methylcellulose on Cellulolytic Bacteria Attachment and Rice Straw Degradation in the In vitro Rumen Fermentation

Sung, Ha Guyn,Kim, Min Ji,Upadhaya, Santi Devi,Ha, Jong K.,Lee, Sung Sill Asian Australasian Association of Animal Productio 2013 Animal Bioscience Vol.26 No.9

An in vitro experiment was conducted to evaluate the effect of methylcellulose on the attachment of major cellulolytic bacteria on rice straw and its digestibility. Rice straw was incubated with ruminal mixture with or without 0.1% methylcellulose (MC). The attachment of F. succinogenes, R. flavefaciens and R. albus populations on rice straw was measured using real-time PCR with specific primer sets. Methylcellulose at the level of 0.1% decreased the attachment of all three major cellulolytic bacteria. In particular, MC treatment reduced (p<0.05) attachment of F. succinogenes on rice straw after 10 min of incubation while a significant reduction (p<0.05) in attachment was not observed until 4 h incubation in the case of R. flavefaciens and R. albus. This result indicated F. succinogenes responded to MC more sensitively and earlier than R. flavefaciens and R. albus. Dry matter digestibility of rice straw was subsequently inhibited by 0.1% MC, and there was a significant difference between control and MC treatment (p<0.05). Incubated cultures containing MC had higher pH and lower gas production than controls. Current data clearly indicated that the attachment of F. succinogenes, R. flavefaciens and R. albus on rice straw was inhibited by MC, which apparently reduced rice straw digestion.

오징어 부산물의 급여가 한우암소 산육 및 도체특성에 미치는 영향

Sang Min Lee(이상민),Sun Sik Jang(장선식),Seok Dong Lee(이석동),Seong Koo Hong(홍성구),Sung Sill Lee(이성실),Jae Seok Woo(우제석) 한국생명과학회 2012 생명과학회지 Vol.22 No.1

본 연구는 한우 암소의 산육 및 도체특성에 있어 오징어 부산물의 급여 효과를 알아보기 위해 수행되었다. 한우 16두(나이 7세, 체중484.1±63.6 ㎏)를 대조구 및 처리구(오징어 부산물 첨가), 등 2그룹(각각 8두)으로 완전임의 배치하였다. 사료급여는 두 그룹 모두 자유채식토록 하여 150일간 시험을 수행하였다. 일당증체량은 처리구가대조구 보다 유의적으로 높았다(p<0.05). 시험기간 내 사료섭취량 및 사료요구율은 처리구가 대조구 보다 유의적으로 낮았다(p<0.05). 육량특성에 있어서, 등지방두께, 등심단면적 및 육량지수는 두 처리구간 비슷한 경향을 나타내었고, 도체중은 처리구가 363.4 ㎏ 대조구 353.1 ㎏으로 처리구간 유의적 차이는 없었다. 육질특성에서는 육색, 지방색, 조직감 및 성숙도는 두 그룹간 유의적 차이가 없었다. 그러나 근내지방도 및 육질 1등급 이상 출현율은 대조구 보다 처리구가 높았다. 그러므로 본 연구의 결과 오징어부산물의 급여는 한우 암소의 산육 및 도체특성을 향상시키는 것으로 생각된다. This study was conducted to evaluate the effect of feeding squid by-products on the growth performance and carcass characteristics of Hanwoo cows. Sixteen Hanwoo cows, aged 7 years and weighing 484.1±63.6 ㎏, were randomly allocated to 2 feeding groups (8 animals per group): control and treatment (fed squid by-products). Both groups were fed ad libitum for 150d. Average daily gain was significantly higher in the treatment group than in the control group (p<0.05). During the experimental period, DMI and feed conversion ratios were significantly lower in the treatment group than in the control group (p<0.05). The results of yield traits, back fat thickness, rib eye area, and yield index were similar between the two groups. Carcass weights were 363.4 ㎏ and 353.1 ㎏ for treatment and control, respectively, but these differences were not statistically significant. Quality traits such as meat color, fat color, texture, and maturity were also not significantly different between the two groups. However, marbling score and rate of appearance of high quality grade (1??, 1?, and 1) were higher in the treatment group than in the control group. These results suggest that feeding squid by-products may improve the growth performance and carcass characteristics of Hanwoo cows.

Expression of E-Cadherin and β-Catenin in Relation To Clinicopathologic Features in Oral Squamous Cell Carcinoma

( Sung Woon Pyo ),( Kwang Bae Lee ),( Young Sill Kim ),( Sang Hwa Lee ) 대한악안면성형재건외과학회 2006 Maxillofacial Plastic Reconstructive Surgery Vol.28 No.S1

구강으로 돌출한 선천성 두개내 기형종 -1 부검례-

김영실,이교영,강창석,심상민,김선무 대한병리학회 1990 Journal of Pathology and Translational Medicine Vol.24 No.3

Brucella Endocarditis with Splenic Abscess: A Report of the First Case Diagnosed in Korea

Sang Hyun Park,Young Sill Choi,Yu Jeong Choi,Soung Hoon Cho,윤희정 연세대학교의과대학 2009 Yonsei medical journal Vol.50 No.1

Human brucellosis has a broad spectrum of clinical manifestations, which includes endocarditis, a focal complication that is uncommon yet responsible for the majority of associated deaths. The most successful treatment outcomes of Brucella endocarditis have been reported with usage of both antimicrobial agents and surgery. However, there are few reports on the treatment of Brucella endocarditis using antibiotics only. We report the first case in Korea of Brucella endocarditis with aortic valve vegetations and an accompanying splenic abscess, which were treated successfully with antibiotic therapy alone.

텔레매틱스 데이터 교환을 위한 마크업 언어의 설계 및 구현

박성은(Sung Eun Park),장은실(Eun Sill Jang),이용규(Yong Kyu Lee) 한국전자거래학회 2008 한국전자거래학회지 Vol.13 No.2

최근 텔레매틱스 서비스가 활성화되고 있지만, 이기종 단말기 및 플랫폼에서 사용할 수 있도록 데이터 양식이 표준화되지 않아서 데이터의 공유가 제약되며, 단말기와 서버 간의 데이터 통신 시 데이터 항목을 변경할 경우 서버 및 단말기 프로그램의 수정이 불가피하다. 이러한 문제를 해결하기 위하여 본 논문에서는 텔레매틱스 데이터 표준화를 위한 방안으로 XML 기반의 tele-XML 표준안을 정의하고, tele-XML를 구성하는 각 프레임워크와 관련 스키마를 설계한다. 또한 tele-XML 문서의 처리를 통하여 표준화된 데이터를 얻을 수 있도록 관련 API 라이브러리와 모듈을 구현함으로써 기존의 텔레매틱스 서비스를 개선할 수 있도록 한다. Telematics services are being widely used recently. However, data sharing is restricted because data representations among telematics severs and terminals are not yet standardized. Moreover, changes of some data items can cause the modification of telematics software. To resolve the problem, we define an XML-based markup language, called tele-XML, for the standard representation of telematics data, and design a framework and related schema for the tele-XML. We also implement API libraries and program modules for the processing of tele-XML documents. By using the proposed representation and processing scheme, the previous problem can be resolved.