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설편평세포암에서 CD44, MMP-2, MMP-9, TIMP-1의 발현
이상화,표성운,김영실,최목균 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.4
Adhesion molecules and proteinases play an important role in the invasion and metastasis of a malignant tumor. However, there have not been many studies on tongue squamous cell carcinoma at Saint Mary's Hospital and Kangnam Saint Mary's Hospital, the Catholic University of Korea, between 1994 and 2000, and had not received chemo-or radiotherapy. The expression of the adhesion molecules CD44H, proteinases MMP-2 and MMP-9, and TIMP-1, which controls MMP activity, was analyzed by immunohistochemistry. In addition their association with the tumor size, lymph node metastasis, clinical stage, and cell differentiation was evaluated. Increased MMP-2 expression was significantly correlated with lymph node metastasis and clinical stage. However, it did not correlate with tumor size or cell differentiation. CD44H, MMP-9 and TIMP-1 expression were not significantly related to tumor size, lymph node metastasis, clincial stage and cell differentiation. The results suggest that MMP-2 is a possible immunohistochemical prognostic factor in tongue squamous cell carcinoma. Futher reasearches will be needed to investigate the additional tumor prognostic factors and their mechanisms.
전숙,김영희,박지영,고관표,박철영,김덕윤,우정택,김성운,김진우,김영설,고석환 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.2
낭종성 부갑상선 선종과 심한 골병변을 동반한 부갑상선 기능항진증은 매우 드문 질환으로서, 저자들은 양측 고관절의 통증을 초기 주소로 내원한 환자에서 고칼슘혈증과 부갑상선 호르몬 증가, 골병변의 방사선적 소견을 통해 부갑상선 기능항진증을 진단하고, 경부 초음파와 컴퓨터 단층 촬영, 부갑상선 스캔검사 및 수술중 부갑상선 낭종액 검사 등을 통해 기능성 부갑상선 낭종의 한 종류인 낭종성 부갑상선 선종을 진단하고 수술적 제거를 통하여 정상화된 1예를 경험하였다. A cystic parathyroid adenoma is rare. A case of primary hyperparathyroidism, with the cystic formation of a parathyroid adenoma and a severe bony lesion, is reported. A 52-year-old male was admitted due to pain in both hips and for evaluation of hypercalcemia. The plasma level of the intact parathyroid hormone (iPTH) was elevated to 1424 pg/mL. Ultrasonography and the computed tomography revealed a parathyroid cyst on the left thyroid lower pole. Parathyroid scintigraphy detected a parathyroid adenoma. A radiograph showed a subperiosteal bone resorption on the phalanges, and a brown tumor (osteitis fibrosa cystica) on the femur shaft was noted. A surgical excision of the parathyroid adenoma was performed. The PTH level in the cystic fluid was increased. A histological examination confirmed a cystic parathyroid adenoma. The PTH level was normalized after the operation (J Kor SOC Endocrinol 18:214-220, 2003).
협부지방에서 성체 줄기세포의 분리와 골모 세포로의 분화
표성운(Sung-Woon Pyo),박장우(Jang-Woo Park),이일규(Il-Kyu Lee),김창현(Chang-Hyen Kim) 대한구강악안면외과학회 2006 대한구강악안면외과학회지 Vol.32 No.6
For the repairing of bone defect, autogenous or allogenic bone grafting remains the standard. However, these methods have numerous disadvantages including limited amount, donor site morbidity and spread of diseases. Tissue engineering technique by culturing stem cells may allow for a smart solution for this problem. Adipose tissue contains mesenchymal stem cells that can be differentiate into bone, cartilage, fat or muscle by exposing them to specific growth conditions. In this study, the authors procured the stem cell from buccal fat pad and differentiate them into osteoblast and are to examine the bone induction capacity. Buccal fat-derived cells (BFDC) were obtained from human buccal fat pad and cultured. BFDC were analyzed for presence of stem cell by immunofluorescent staining against CD-34, CD-105 and STRO-1. After BFDC were differentiated in osteogenic medium for three passages, their ability to differentiate into osteogenic pathway were checked by alkaline phosphatase (ALP) staining, Alizarin red staining and RT-PCR for osteocalcin (OC) gene expression. Immunofluorescent and biochemical assays demonstrated that BFDC might be a distinguished stem cells and mineralization was accompanied by increased activity or expression of ALP and OC. And calcium phosphate deposition was also detected in their extracelluar matrix. The current study supports the presence of stem cells within the buccal fat pad and the potential implications for human bone tissue engineering for maxillofacial reconstruction.
표성운(Sung woon Pyo),민성기(Sung ki Min),정무혁(Moo hyuk Chung),김창현(Chang hyun Kim) 대한구강악안면외과학회 1997 대한구강악안면외과학회지 Vol.23 No.4
Pain from cancer is a major problem of managing the oral cancer patients in terminal stage. Overall, pain is reported by about 50% of patients at all stages of cancer and by over 70% with advanced neoplasms. Unrelieved pain can be incapaciting and preclude a satisfying quality of life. But, pain is often poorly assessed, and many clinicians lack sufficient knowledge to optimize cancer pain treatment. There are three basic approaches to the control of pain : modifying the source of pain, altering the central perception of pain, and blocking the transmission of pain to the central nervous system. The optimal use of these approaches and an individualized plan for pain control can maximize both quality and duration of life in dying patients. Opioid analgesics are are the mainstay of pharmacologic treatment. Practical opioid therapy include selection of both drug and route, dose titration, and management of side effects. We present our experienced pharmacologic treatment protocol for cancer pain management that collaborated by Dept. of Hospice, Catholic Medical Center. It will acts as a guideline for our colleague to facilitate the translation of current knowlegde into the clinical practice.
구강 편평세포암에서 E-cadherin 유전자의 과메틸화
표성운(Sung-Woon Pyo),김영실(Young-Sill Kim),박지영(Ji-Young Park),김창현(Chang-Hyen Kim),이원(Won Lee),박민규(Min-Kyu Park) 대한구강악안면외과학회 2009 대한구강악안면외과학회지 Vol.34 No.2
Loss of E-cadherin (E-cad) expression has been found in multiple cancers and is postulated to facilitate tumor cell dissociation and metastais. Promotor methylation may provides an alternative pathway for loss of gene function. This study evaluated the role of hypermethylation in the downregulation of E-cad in oral squamous cell carcinoma (OSCC). We examined the E-cad expression by immunohistochemical staining and detected methylation status by methylation-specific polymerase chain reaction (MSP) in 20 OSCC tissues. Overally, 12 (60%) cases of hypermethylation of Ecad were detected and we found there were no correlation between methylation and age, histologic grade, lympn node metastasis, tumor size and clinical stage. However, Eleven (73.3%) of 15 samples which was negative for E-cad staining showed hypermethylation of E-cad promotor region. On the other hand, only one (20%) of 5 E-cad positive sample was observed with methylated status. The underexpression of E-cad was found to be related to promotor hypermethylation (p=0.035). In conclusion, we suggest that hypermethylation play a role in inactivation of E-cad gene and may be a appreciable biomarker for diagnosis and treatment of OSCC.
Circum-mandibular wiring for pediatric mandibular fracture : Case report
표성운(Sung Woon Pyo) 대한구강악안면외과학회 1995 대한구강악안면외과학회지 Vol.21 No.4
소아와 악골골절은 성인에 비하여 매우 드물다. 상대적으로 적은 발생 빈도는 골의 연성, 두부 전체의 크기에 비하여 작은 안면, 그리고 위험한 환경에 노출되는 기회가 적은 이유로 이해될 수 있다. 그러나 연령의 증가 및 성장 과정에 따라 하악골의 위치가 안면 구조에서 돌출된 위치를 차지하게 됨에 따라 그 발생 빈도가 증가하는 경향이 있다. 소아 하악골절의 처치는 잘못된 치료후 심각한 후유증을 유발할 가능성과 치료시 환아의 협조를 얻기 힘드는 등의 치료 자체의 어려움으로 매우 중요한 의미를 갖는다. 처치 방법은 연령과 골절 위치에 따라 다르나, 대개의 경우 비관혈적 정복 및 악간고정으로 충분하다. 최근에는 미세 금속판등을 이용한 관혈적 정복술 및 내고정술도 널리 시행되고 있는 형편이나, 아직 악골 성장에 대한 영향의 유무가 확립되지 않았고 제거 여부에 대한 논란의 여지가 있으며, Rowe등은 소아 안면골의 높은 재개조 성향으로 과도한 정복과 처치가 요구되지는 않는다고 주장한 바 있다. 가장 효과적인 방법은 적절한 골절 정복과 치유기간중 안정성을 제공하는 가장 보존적인 방법을 사용하는 것이다. 이에 저자는 소아 하악골절 환자에게 아크릴릭 레진 상부자와 환악걸찰술올 이용하여 양호한 결과를 얻었기에 이에 보고하는 바이다. Pediatric mandibular fractures are generally regarded as uncommon. The relative low incidence has been explained by the resilent nature of the bones, the bones, the small facial size in relation to head size, and the fact that children are not as frequently exposed to major trauma. But, correlated to the maturational growth pattern of the pediatric facial skeleton, and entities that are placed in a more prominent position, the frequency of a mandibular fracture increases with increasing age during childhood. The treatment of mandibular fractures in chidren has great significance owing to the serious deformities consquent to poor treatment and the problems of therapy that are peculiar to children. At present, management of a fracture by means of open reduction using mini-or microplate and screw was frequently reported, however, most often consisted of closed reduction and intermaxillary fixation. The idal management of a mandibular fracture in chidren is the simplest method which will produce adequate reduction and stabilization. So, the author presents two cases of treatment of the pediatric mandibular fractures using an acrylic resin splint and circummandibular wiring with satisfactory results.