교육과정 개혁과 학습문화

서경혜,이주연,현성혜,이자연,심수원,김지혜 한국교육과정학회 2007 교육과정연구 Vol.25 No.3

성견에서 교정적 고정원으로서의 티타늄 미니스크류에 대한 연구 : An experimental investigation in dogs

윤병수,최병호,이원유,김경남,심형보,박진형 대한치과교정학회 2001 대한치과교정학회지 Vol.31 No.5

교정치료에서 원하는 치아이동을 위해서는 안정된 고정원이 필요한데 티타늄 미니스크류가 매식과 제거가 쉽고, 구강 내 여러 부위에서 적용이 가능하고, 환자가 느끼는 불편감이나 비용적인 부담이 적고, 제거 후에 치유가 빠르게 진행될 수 있는 등의 장점이 있어 최근에 교정적 고정원으로 사용되기 시작하였다. 티타늄 미니스크류를 교정적 고정원으로 사용한 임상 예들이 여러 편 발표되었는데 미니스크류의 이완이 가장 큰 실패의 원인으로 보고되고 있다. 그러나 지금까지 보고된 논문들에서 교정적 고정원으로 안정성을 줄 수 있는 스크류의 식립 길이에 관한 연구가 없는 상태이다. 교정적 고정원으로 미니스크류를 효과적으로 사용하기 위해서는 식립 부위에 따른 골구조와 골밀도 차이를 고려한 식립 길이에 관한 기준이 필요하다. 이에 본 연구에서는 성견의 상악골과 하악골에서 직경 2mm 티타늄 미니스크류를 다양한 길이로 식립하고 교정력을 적용한 후 그 안정성을 평가하여 교정적 고정원으로 사용될 수 있는 미니스크류의 식립 길이를 결정하고자 하였다. 미니스크류가 상악에서는 6mm이상, 하악에서는 4mm 이상이 골 내에 식립될 때 8주 동안 200g의 교정력에 동요도나 위치변화를 보이지 않았다. 식립 부위로는 부착치은 부위 치근 사이에 식립될 때 구강청결이 유지되고 미니스크류 주변 치은조직에 자극을 주지 않아 정상적인 조직으로 유지 될 수 있었다. 또한 교정력 적용 8주 후 치근단 방사선 사진검사에서 스크류 주변 치근 흡수나 치조골 흡수, 치주 인대 손상이 관찰되지 않았다. 따라서 상 ㆍ 하악 골밀도와 골구조의 차이를 고려하여 미니스크류의 골내 식립 길이를 적절히 조절함으로써 교정적 고정원으로 티타늄 미니스크류가 효과적으로 사용될 수 있다고 생각된다. Titanium miniscrews are being used increasingly as an anchorage for tooth movement, because they are easy to place and to remove, increase the number of sites available, give minimum strain to patients regarding surgical procedures, and offer uneventful healing after removal. The use of titanium miniscrews as an orthodontic anchorage has been reported in clinical case reports, but clinicians hove experienced screw loosening when using such screws. To our knowledge, there are no published reports evaluating the stability of miniscrews. Information about the length of miniscrews used in relation to the location is of some importance, as stability will vary depending on bone quality. The purpose of this study was to evaluate a variety of lengths of miniscrews (diameter: 2mm) which were inserted in maxilla or mandible and to demonstrate in a dog moedl which miniscrew provides fundamental stability in the jaws. 10 mm long miniscrews in the maxilla and 8mm long miniscrews in the mandible showed no clinical mobility and retained their position throughout an 8 weeks force (200g) application. The mucosal condition around the screws was healthy in cases in which miniscrews were inserted in the alveolar bone between the roots and the head of the screws emerged into the attached gingiva. When the force application was terminated, radiographic analysis revealed neither root resorption nor periodontal pathology around the miniscrews that remained stable during the entire treatment period. This study suggests that if titanium miniscrews with adequate length are properly used depending on the location, they provide sufficient stability for orthodontic anchorage.

Cunninghamella elegans에 의한 폐 mucormycosis

박경실,서광수,조무자,김춘식,심상인,김선무 대한임상병리사협회 2001 대한임상병리사회지 Vol.21 No.1

Scrub Typhus : 확진된 76예의 임상 소견에 대한 전향적 연구

김동민,김현리,박치영,윤성호,송현제,심수경 대한감염학회 2006 감염과 화학요법 Vol.38 No.4

배경 : Orientia tsutsugamushi에 의한 인체 감염은 혈액과 임파선을 타고 전신에 퍼져 혈관 염을 일으켜, 전신 장기의 침범 소견을 보인다. 그러나 아직 까지 전신장기 침범에 대한 임상 소견 및 검사 결과의 전향적인 추적 관찰에 대한 연구는 거의 없는 실정이다. 재료 및 방법 : 조선대학교병원에 내원한 환자 중 확진법(gold standard)인 간접형광항체법(IFA)으로. 확인된 76명의 환자를 대상으로 내원시 임상 양상 및 검사 결과의 평가 및 치료 후 검사 결과의 변화에 대한 전향적인 연구를 수행하였다. 결과 : 대부분의 환자에서 발열, 갈증, 전신 쇠약감, 두통을 호소하였으며, 특이 할만한 소견으로 현재까지 보고되지 않았지만, 대부분의 환자가 갈증을 심하게 호소한다는 것이다. 3명의 젊은 건강한 환자를 제외한 대부분의 환자에서 이러한 갈증 증상을 호소하였으며, 이러한 갈증은 발열이 호전되어도 지속되었으며, 퇴원 이후에 까지 지속되는 양상을 보였다. 혈액검사상 scrub typhus 초기에 나타날 수 있는 신기능 장애 및 간 기능 장애는 대부분 가역적으로 적절한 항생제 투여 후 모두 정상으로 회복됨을 확인할 수 있었다. 혈액 검사상 CRP, LDH, AST가 대부분의 환자에서 상승하였고, 특히 LDH의 상승이100% 환자에서 관찰된 것은 특이할 만 한데 적절한 치료후 CRP는 신속히 호전을 보이나, LDH는 서서히 호전됨을 확인하였다. DIC 검사상 DIC는 입원환자의 95.5%에서 확인되었으나, 비교적 일부의 환자에서 출혈 및 경색이 초래되는 것으로 생각된다. 결론 : Scrub typhus 초기에 나타 날수 있는 신기능 장애, 간기능 장애 및 DIC는 대부분 가역적으로 적절한 항생제 투여 후 모두 정상으로 회복되며, 이러한 관찰이scrub typhus 환자의 진단 및 임상 경과의 이해에 도움이 되리라 사료된다. Background : Orientia tsutsugamushi spreads to the entire body through the blood and lymphatics, and it induces vasculitis that results in the patients manifesting symptoms of systemic organ involvement. Materials and Methods : We conducted a prospective study to evaluate the clinical manifestations and the change of the laboratory results after instituting treatment for scrub typhus. Results : Most patients presented with fever (100%), malaise (96.1%) and thirst (96.1%). It was remarkable that most patients presented with severe thirst, except for 3 healthy, young patients. This thirst was persistent even after the resolution of fever. The renal and hepatic dysfunction were reversible after the administration of appropriate antibiotics. For the blood testing, it was deteded that the CRP, and LDH were elevated in most patients (95.9% and 100% respectively). DIC could be diagnosed in 95.5% of the patients at the time of admission Conclusion : Most patients presented with fever, malaise and severe thirst, and the renal and hepatic dysfunction were reversible after the administration of appropriate antibiotics. DIC was observed in most of our patients, but hemorrhage and infarction were not present. CRP showed a rapid improvement, nonetheless, the LDH and DIC test results improved slowly.

Bombesin stimulates colonic motility via muscarinic cholinergic pathway in isolated, vascularly perfused rat colon

Sei Jin Youn , Kyoung Soo Lee, Young Shim Cho, Joung Ho Han, Soon Man Yoon, Hee Bok Chae, Seon Mee Park 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.4

Although bombesin (BN) regulates colonic motility, the associated mechanism of action remains unclear. The objective of this study was to investigate the effect of BN on colonic motility using isolated rat colon. An isolated rat colon was perfused with Krebs solution via the superior mesenteric artery. Intraluminal pressure was measured via microtip catheter pressure transducers at both proximal and distal portions of the isolated colon. After a control period, BN was administered intraarterially in concentrations of 13, 26, 130, and 260 pM. After pretreatment with hexamethonium (10-3 M), atropine (10-5 M), or tetrodotoxin (10-6 M), BN was administered at a concentration of 260 pM (proximal colon) or 130 pM (distal colon); intraluminal pressure was then monitored. Changes in motility were expressed as the percentage change of motility index (MI) over the basal period. As a result, BN increased colonic motility and a dose-dependent increase in proximal colonic motility was observed. The stimulant effect of BN was almost completely abolished by atropine and tetrodotoxin at both the proximal and distal colon. However, BN was not inhibited by hexamethonium at both the proximal and distal colon. Therefore, the stimulant action of BN may be mediated by local cholinergic muscarinic receptors

Effects of cigarette smoking on blood lipids in Korean men: Cardiovascular and Metabolic Diseases Etiology Research Center cohort

( Soo Kyoung Kim ),( Hyeon Chang Kim ),( Jee-seon Shim ),( Dae Jung Kim ) 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.2

Background/Aims: Cigarette smoking and abnormal blood lipids are major risk factors for cardiovascular disease. The results of previous studies on the relationship between cigarette smoking and dyslipidemia are controversial. In the present study, we investigated the independent association between cigarette smoking and blood lipid levels in a male Korean population. Methods: A total of 1,932 men aged from 30 to 64 years old participated in the Cardiovascular and Metabolic Diseases Etiology Research Center cohort study. Smoking history was obtained by in-person interviews. In all regression models, measurements of triglyceride levels were log-transformed. Results: Triglyceride levels were higher in current smokers than in never-smokers (median: 149 mg/dL vs. 115 mg/dL, p < 0.001) even after adjusting age, body mass index, alcohol intake, systolic blood pressure, fasting glucose, physical activity, and nutrition intake (β = 0.14, p < 0.001). We further divided people into heavy and light smokers using 20 pack-years as the cut-off. Higher triglyceride were found in current heavy smokers (β = 0.18, p < 0.001), current light smokers (β = 0.13, p < 0.001), as well as in past heavy smokers (β = 0.08, p = 0.037), as compared to never-smokers. Moreover, significantly lower high-density lipoprotein cholesterol (HDL-C) were observed in current heavy smokers (β = -2.27 mg/dL, p = 0.009). Conclusions: Cigarette smoking is associated with higher triglyceride in Korean men, with the most dramatic effect seen in current smokers with a smoking history of more than 20 pack-years. HDL-C were also lower in current smokers with more than 20 pack-years.

방광이행상피세포암진단에 있어서 요중 NMP22와 BTA검사의 유용성

이수연,강은숙,홍기숙,심봉석,김옥경,구혜수,이정수,장석흔 대한임상병리학회 2000 대한임상병리학회지 Vol.20 No.4

배 경 : 방광암의 진단은 방광경조직검사 및 요세포검사를 통해 이루어졌으나 최근 nuclear matrix protein22 (NMP22)나 bladder tumor antigen (BTA) 검사 등의 비침습적이고 신속한 검사법이 개발되었다. 이에 저자들은 방광암 환자에서 요중 NMP22와 BTA 검사를 시행하여 요세포검사와 비교하였고 그 유용성을 평가하였다. 방 법 : 방광경 조직검사에서 방광암으로 진단된 27명과 정상대조군 23명을 대상으로 하였다. NMP22는 자연 배뇨 검체를 요채집병(Matritech , USA)에 모아 효소면역법으로 측정하였다. BTA 검사는 자연 배뇨검체를 라텍스 입자가 부착된 검사용지(Bard, USA)에 묻혀 노란색이 나타날 때 양성으로 판정하였다. 방광암 환자는 요세포검사를 병행하였다. 결 과 : 방광암 환자의 NMP22의 평균값은 144.6 U/㎖로 건강 대조군의 2.9 U/㎖와 유의한 차이가 있었다(P<0.01). NMP22 검사와 BTA 검사의 민감도는 각각 89%와 74%로서 요세포검사의 민감도인 41%보다 높았다. NMP22 검사의 분화도에 따른 민감도는 grade 1 (G1)은 88%, G2는 82%, G3는 100%였으며(P<0.01) BTA 검사는 각각 63%, 73%, 88%였다(P<0.580). NMP22 검사의 종양 병기에 따른 민감도는 표재성 암은 79%, 침윤성 암은 100%였으며(P=0.110) BTA 검사는 79%, 69%였다(P=0.678). NMP22 검사와 요세포검사를 동시에 시행시의 양성률과, BTA 검사와 요세포검사를 동시에 시행시의 양성률은 각각 96%이었다. 방광암 치료 후 추적검사시 요세포검사와 BTA 검사 결과의 일치율은 75% (24/32)이었다. 방광암이 아닌 비뇨기계 질환 환자에서 BTA 검사의 위양성률은 17% (8/47)이었다. 결 론 : NMP22와 BTA 검사는 방광암의 세포 분화도 및 병기와 무관하게 높은 민감도를 보여 요 검체를 이용하여 비침습적이고 신속하게 시행할 수 있는 유용한 선별 검사로 생각된다. Background : Urinary bladder cancer has been diagnosed by urine cytology and cystoscopy with biopsy. Recently, in vitro noninvasive diagnostic tests, measuring urinary nuclear matrix protein22 (NMP22) and bladder tumor antigen (BTA), were introduced. We analyzed the usefulness of the NMP22 and BTA tests for diagnosing bladder cancer and compared those with voided urine cytology. Methods : Single voided urine specimens were obtained from 27 patients with bladder cancer and 23 healthy volunteers. The urine specimens were assayed by enzyme immunoassay (NMP22, Matrietech , Newton, MA.) and latex immunoassay (BTA, Bard, USA). Urine cytology was performed in patients with bladder cancer. Results : Mean urinary NMP22 level of patients with bladder cancer (144.6 U/㎖) was significantly higher than those of normal controls (2.9 U/㎖, P<0.01). The sensitivities were 89% and 74% for NMP22 and BTA tests, respectively, compared with 41% for voided urine cytology. The sensitivities of NMP22 and BTA tests were 88%, 63% at grade 1 (G1), 82%, 73% at G2, and 100%, 88% at G3, respectively (P<0.01; NMP22, P=0.580; BTA). According to tumor stage, the sensitivities of NMP22 and BTA tests were both 79% at superficial, and 10% and 69% at invasive cancer, respectively (P=0.110; NMP22, P=0.678; BTA). The sensitivities of urine NMP22 and BTA tests combined with urine cytology were both 96%. In following of transitional cell carcinoma patients, agreement between urine cytology and BTA test was 75% (24/32). Among the various urologic disease, false positive rate for BTA test was 17% (8/47). Conclusions : Urinary NMP22 and BTA tests were more sensitive than voided urine cytology regardless of tumor grade and stage, so these noninvasive and simple tests can be used as screening tests for urinary bladder transitional cell carcinoma.

S-237 : Hemoglobin is associated with diastolic blood pressure in patients with ABPM

( Soo Young Kim ),( In Kyoung Shim ),( Jung Ho Heo ),( Kyoung Im Cho ),( Hyun Su Kim ),( Jae Woo Lee ),( Tae Joon Cha ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1

Background: It has been hypothesized that an increased hemoglobin level elevates blood pressure (BP). This study investigated the association between hemoglobin level and BP in patients with ambulatory BP monitoring (ABPM). Methods: The study included 465 consecutive patients from January 2008 to May 2013. All patients underwent ambulatory BP monitoring and hemoglobin level was measured. Results: In the study population, 57.9% were men and the mean age was 50.4 years (±13.6 years). In baseline characteristics, hemoglobin was associated with age (p<0.001 [r=-0.206]), hs-CRP (p=<0.001 [r=-0.191]), uric acid (p<0.001 [r=0.347]). In ABPM parameters, it was associated with 24hr diastolic BP (DBP) (p=0.001 [r=0.160]), 24hr mean BP (p=0.002 [r=0.145]), daytime DBP (p<0.001 [r=0.206]), Daytime mean BP(p=0.001 [r=0.158]), and nighttime DBP(p=0.001 [r=0.126]). Also It was related with 24hr SBP standard deviation (SD) (p=0.028 [r=-0.102]), 24hr heart rate SD (p<0.001 [r=0.194]), daytime SBP SD (p=0.002 [r=-0.144]), daytime heart rate (p=0.003 [r=0.136]), nighttime heart rate SD (p<0.001 [r=0.191]). Conclusion: The results show that hemoglobin level is positively associated with diastolic blood pressures. The underlying biological mechanism for the reported associations are not yet elucidated, but it may be possible by increased blood viscosity, vasoconstriction by erythropoietin, some effect of rennin-angiotensin-aldosterone system.

Synthesis of Numerous Edge Sites in MoS₂ via SiO₂ Nanorods Platform for Highly Sensitive Gas Sensor

Shim, Young-Seok,Kwon, Ki Chang,Suh, Jun Min,Choi, Kyoung Soon,Song, Young Geun,Sohn, Woonbae,Choi, Seokhoon,Hong, Kootak,Jeon, Jong-Myeong,Hong, Seung-Pyo,Kim, Sangtae,Kim, Soo Young,Kang, Chong-Yun American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.37

<P>The utilization of edge sites in two-dimensional materials including transition-metal dichalcogenides (TMDs) is an effective strategy to realize high-performance gas sensors because of their high catalytic activity. Herein, we demonstrate a facile strategy to synthesize the numerous edge sites of vertically aligned MoS<SUB>2</SUB> and larger surface area via SiO<SUB>2</SUB> nanorod (NRs) platforms for highly sensitive NO<SUB>2</SUB> gas sensor. The SiO<SUB>2</SUB> NRs encapsulated by MoS<SUB>2</SUB> film with numerous edge sites and partially vertical-aligned regions synthesized using simple thermolysis process of [(NH<SUB>4</SUB>)<SUB>2</SUB>MoS<SUB>4</SUB>]. Especially, the vertically aligned MoS<SUB>2</SUB> prepared on 500 nm thick SiO<SUB>2</SUB> NRs (500MoS<SUB>2</SUB>) shows approximately 90 times higher gas-sensing response to 50 ppm NO<SUB>2</SUB> at room temperature than the MoS<SUB>2</SUB> film prepared on flat SiO<SUB>2</SUB>, and the theoretical detection limit is as low as ∼2.3 ppb. Additionally, it shows reliable operation with reversible response to NO<SUB>2</SUB> gas without degradation at an operating temperature of 100 °C. The use of the proposed facile approach to synthesize vertically aligned TMDs using nanostructured platform can be extended for various TMD-based devices including sensors, water splitting catalysts, and batteries.</P> [FIG OMISSION]</BR>

Anti-oomycete Activity of Furanocoumarins from Seeds of Psoralea corylifolia against Phytophthora infestans

Shim, Sang-Hee,Kim, Jin-Cheol,Jang, Kyoung-Soo,Choi, Gyung-Ja The Korean Society of Plant Pathology 2009 Plant Pathology Journal Vol.25 No.1

In the course of a searching natural antifungal compounds from plant seeds, we found that the methanol extract of Psoralea corylifolia seeds showed potent control efficacy against tomato late blight caused by Phytophthora infestans and wheat leaf rust Puccinia recondita. Under bioassay-guided purification, we isolated two furanocoumarins, psoralen and isopsoralen, with anti-oomycete activity against P. infestans. By 1-day protective application, both compounds strongly reduced the disease development of P. infestans on tomato seedlings, but hardly controlled development of leaf rust on wheat seedlings. This is the first report on the anti-oomycete activity of P. corylifolia as well as that of psoralen and isopsoralen.