구강 편평세포암종에서 E-cadherin과 ${\beta}-catenin$의 발현과 임상병리학적 특징

표성운,이광배,김영실,이상화,Pyo, Sung-Woon,Lee, Kwang-Bae,Kim, Young-Sill,Lee, Sang-Hwa 대한악안면성형재건외과학회 2006 Maxillofacial Plastic Reconstructive Surgery Vol.28 No.5

Changes in cell adhesion molecules are associated with infiltration and metastatic progression of cancer. Reduced expression of E-cadherin and ${\beta}-catenin$ complex in some carcinomas has been reported. The changes in the expression in oral squamous cell carcinoma (OSCC) is not fully understood and it also remains undetermined whether the expression of these adhesion molecules in metastatic lesions differs from that in the primary lesions. In the present study, therefore, we immunohistochemically examined the expression of E-cadherin and ${\beta}-catenin$ in 45 primary OSCCs and 19 metastatic lymph nodes. We compared the expression of these molecules between primary and metastatic lesions and investigated the correlation between the expression and clinicopathologic parameters. The expression of E-cadherin and ${\beta}-catenin$ was reduced in 35/45 (78.2%), 14/45 (31.2%) of primary tumors respectively, but 18/19 (94.7%) and 17/19 (89.4%) of lymph nodes showed preserved expression. The reduced expression of the E-cadherin was associated with lymph node metastasis, invasive mode and marginal status but no significant relationship was not found with ${\beta}-catenin$. In conclusion, the loss of E-cadherin and ${\beta}-catenin$ complex function is associated with progression of OSCC and suggest that the expression of this complex will be a supplementary prognostic tool.

하악 임플란트 식립 시 발생한 골수강 내로 임플란트의 함입:증례보고

표성운,양은석,김우정,박수현,김희수,허현아,김제원,윤현중 대한통합치과학회 2019 대한통합치과학회지 Vol.8 No.2

Displacement of implants in the posterior mandible bone marrow is extremely rare but can result from age, osteopenia/osteoporosis, asymptomatic bone marrow defect due to the deficiency of an implant’s primary stability. There are some methods to avoid the complication such as obtaining a firm anchorage of the fixture within the superior surface of cortical bone and ommission of the countersinking drilling. Also, It needed to know the anatomic variations and scrutinize the patient’s medical information. The purpose of this article is to provide a report of 3 implant displacement cases and review the causes, methods which can reduce complications

당뇨쥐에서 임플란트 즉시 식립 후 조직계측학적 연구를 통한 임플란트 골유착 비교

표성운,허현아,박수현,김성민 대한통합치과학회 2016 대한통합치과학회지 Vol.5 No.2

Introduction: Dental implants are routinely used with high success rates in generally healthy individuals. By contrast, their use in patients with diabetes mellitus remains controversial as altered bone healing around implants has been reported. The present study aimed to investigate the bone healing response around immediately placed titanium implants in the rats with controlled and uncontrolled diabetes. Materials and Methods: Twenty rats were divided into the control, insulin-treated and diabetic groups. The rats received streptozotocin (60 mg/kg) to induce diabetes; animals in the insulin-treated group also received three units of subcutaneous slow-release insulin. A titanium implant (1.2×3 mm) was placed in the extraction socket of the maxillary first molar and was harvested at 2 and 4 weeks. After routine process of histologic process, section were measured for Bone-implant contact, bone density using Image analysis program. Results: After 2 weeks post-implantation, BCR (Bone contract ratio) of the control, the diabetic group and insulintreated group was 42.62%, 24.55% and 27.75%, respectively. The BCR of the control was lower than the diabetic group and insulin-treated group. After 4 weeks post-implantation, BCR (Bone contract ratio) of the control, the diabetic group and insulin-treated group was 45.32%, 39.14% and 43.84%, respectively. Also, the results of bone density was showed a similar pattern of the results of BCR. Conclusion: The immediate placement of titanium implants in the maxilla of controlled diabetic rat led to a wanted bone healing response. In conclusion, the results of this study suggest that immediate implant insertion in patients with controlled diabetes might be indicated.

악안면 부위에 발생한 섬유성 골이형성증에 대한 임상조직병리학적 연구

표성운,남일우,PYO, Sung-Woon,Nam, Il-Woo 대한악안면성형재건외과학회 1992 Maxillofacial Plastic Reconstructive Surgery Vol.14 No.1

Fibrous dysplasia is a benign pathologic condition of bone in which fibrous tissue gradually expands and replaces normal bone into fibro-osseous lesion. It is a primary developmental abnormality of bone-forming mesenchyme in origin. This study shows clinical history, radiological and histopathological feature of fibrous dysplasia with the intention of establishing correct diagnosis, treatment plan and evaluation of prognosis. This paper reviews and summarizes the materials from 57 fibrous dysplasias submitted to the Department of Oral and Maxillofacial Surgery in College of Dentistry, Seoul National University. Conclusions obtained were as following : 1. Fibrous dysplasia developed mainly in teenagers and shows female predeliction. 2. Fibrous dysplasia developed much on the maxilla 3. Monostotic fibrous dysplasia was most popular form. 4. Main symptom of fibrous dysplasia was painless swelling. 5. Radiological feature of fibrous dysplasia was ground-glass appearance, 6. Histopathological feature of fibrous dysplasia was irregular immature bony trabeculae(woven bone). 7. Treatment of fibrous dysplasia was mainly conservative contouring surgery.

구강편평세포암에서 인유두종 바이러스 16/18의 감염과 p53 종양억제 유전자의 돌연변이에 관한 연구

표성운,남일우 서울大學校 齒科大學 1997 齒大 論文集 Vol.21 No.2

당뇨쥐 상악골에서 즉시 임플란트 후 골유착에 대한 면역조직학적 연구

표성운,박수현,조창준,신현정,허현아,최재호 대한통합치과학회 2017 대한통합치과학회지 Vol.6 No.2

Purpose: Dental implants are used successfully for restoration of dental function. However, the impact of diabetes on the healing of bone associated with immediately placed dental implants is not completely understood. And little is known about the expression of biological molecules involved in bone healing around implants. The purpose of this study was to investigate the bone response around immediately placed titanium implants in the maxilla of ovariectomized rats by immunohistochemical method. Materials and methods: 36 rats were divided into the control, insulin-treated and diabetic groups. Rats received streptozotocin (60 mg/kg) to induce diabetes; animals in the insulin-treated group also received 3 units of subcutaneous slow-release insulin. Two titanium implants (1.2×3 mm) were placed in the extraction socket of maxillary first molars of animals and specimens were harvested at 3 days, 1, 2 and 4 weeks. The expression levels of bone morphogenetic protein (BMP)-4, transforming growth factor (TGF)-β and osteonectin (ON) were measured. Result: The BMP-4 expression increased immediately all groups at day 3, week 1 and week 2. However, staining intensity of diabetic group was weaker than the control and the insulin-treated group but not significant. At week 4, in all groups, the mount of BMP-4 expression decreased. The TGF-β expression instantly showed at day 3 in control group only. At week 1 and 2, TGF-β staining gradually increased in all group. But in the all group staining intensity decreased at 4 week. And we found the expression of ON in the control and the insulin-treated group were higher than that of the diabetic group at 1 weeks and 4 weeks, indicated that bone formation be active in those groups. Conclusion: In this study, insulin treatment increased expression of biologic molecules in the bone around the immediate placed titanium implants in the maxilla of diabetic rat. It is expected that insulin might reverse the reduced predictability of success of immediate implantation with the uncontrolled diabetes patients.

에스트로겐 결핍과 후방 전위된 하악 과두가 측두하악 관절 골관절염 발생에 미치는 복합적 영향

표성운,윤현중,박수현,허현아,김욱경 대한통합치과학회 2022 대한통합치과학회지 Vol.11 No.1

Osteoarthritis (OA) of the temporomandibular joint (TMJ) is known to be caused by multiple etiological factors like hormonal imbalance and excessive mechanical stress. However, it is still unknown whether these factors have a mutual effect on the degenerative process of the condyle. The aim of this study was to examine the combined effects of estrogen and posteriorly displaced occlusion on the condyle using a rat model. Total of twenty female Sprague-Dawley rats at 8 weeks old were divided into four groups; sham-operated (control) or ovariectomized (OVX) and posteriorly displaced dental occlusion (PDO) and ovariectomized and posteriorly displaced dental occlusion (OVX+PDO). Eight weeks after ovariectomy, in the experimental group, a guiding plane appliance was attached to the maxillary incisors to induce posterior displacement of the condyles in the occluded condition. Animals were sacrificed at 4 weeks, and the condyles were removed to observe the histologic findings and to measure the articular cartilage thickness and observed bone structure by micro-computed tomography. Histologic results showed that obvious degradation was found in the condylar cartilage and subchondral bone of rats with PDO procedure. Also, histomorphometric analysis showed the lowest cartilage thickness in the OVX+PDO group compared to control and OVX groups (P=0.027, P=0.039, respectively). Also, subchondral bone in the OVX+PDO group was severely destructed compared to the control and OVX groups. These results suggest that the combined effect of estrogen deficiency by OVX and excessive mechanical stress by functionally displaced occlusion on the condyle can exaggerate the TMJ OA. It is required that further investigation about the pathway of estrogen deficiency and excessive mechanical stress through molecular biologic study.

치성낭에서 c-erbB-2 종양 단백의 발현에 관한 면역조직화학적 연구

표성운,김창현,이원,김영실,Pyo, Sung-Woon,Kim, Chang-Hyen,Lee, Won,Kim, Young-Sil 대한구강악안면외과학회 2001 대한구강악안면외과학회지 Vol.27 No.1

To investigate epithelial cell proliferation reactivity in the odontogenic cysts, the expression of c-erbB-2 oncoprotein by epithelial lining was studied in odontogenic keratocyst(OKC, n=10), dentigerous cyst(DC, n=12), radicular cyst(RC, n=12) and normal dental follicle(n=7). The c-erbB-2 immunoreactivity was studied using a streptavidine- biotin- peroxidase method with polyclonal rabbit antihuman antibody to c-erbB-2 oncoprotein which is known to react with formalin fixed, paraffin-embedded sections and the intensity of staining was determined by manually. In all of 10(100%) OKCs, showed positive expression for c-erbB-2 oncoprotein compared with 10/12(83.3%) in DCs, 11/12(91.7%) in RCs and 5/7(71.4%) in normal dental follicles. The expression within OKC was higher than that of DC, RC and dental follicle but statistically not significant(p>0.05) and but may reflects underlying genetic defect. These results demonstrate differences in c-erbB-2 expression between the epithelial linings of the three major odontogenic cyst types, indicating differences in proliferation activity and differentiation processes within these lesions. And, in particular, these results are able to explain the peculiar aggressive growth pattern of OKC.

구강 및 구인두종양수술시 구순-하악골이단 접근법의 이용에 관한 임상적 연구

표성운,Pyo, Sung-woon 대한악안면성형재건외과학회 1999 Maxillofacial Plastic Reconstructive Surgery Vol.21 No.2

The labiomandibulotomy approch to the oral cavity and oropharygeal region was first described by Roux in 1836 and become popular for oral and oropharyngeal tumors in cases where there are no clinical and radiological signs of mandible invasion. Anterior labiomandibulotomy and swing procedure provides excellent access and facilitate a mandibular resection and subsequent repair. In last two years, 8 cases of oral and oropharyngeal tumors were treated by this approach at the Dept. of Oral & Maxillofacial Surgery, Holy Family Hospital, Catholic University of Korea. And we analyzed postoperative complications as well as functional evaluations, and the results were as follows; In 4 cases, marginal mandibulectomy were combined with labiomandibulotomy and in case of malignancies, neck dissection was performed simultaneously. In almost case, plate and miniscrew fixation was used for osteotomy sites. Histologic evaluation of the resection margins of the specimens revealed tumor free in all cases. The postoperative complications were occured in 3 cases, one case of nonunion, one case of orocutaneous fistula, and one case of wound dehisence. Occlusal stability, jaw movement and swallowing function were acceptable postoperatively in 3 months. From above results, we concluded that, this approach not only provides wide exposure, permitting radical removal of benign and malignant lesions but also preserves function with minimal complications.

Two Metastatic Carcinoma to the Mandible: Case Report and Literature Review

표성운,박수현,허현아,윤현중 대한통합치과학회 2023 대한통합치과학회지 Vol.12 No.3

Cancers have the ability to spread to the oral cavity and invade the mandible. Metastatic malignant lesions are relatively uncommon, accounting for approximately 1% of all oral malignancies. Due to their unusual clinical and radiographic characteristics, diagnosing metastatic lesions presents a challenge. The objective of this report is to present two cases of metastatic breast carcinoma and follicular thyroid carcinoma in the mandible. These cases emphasize the significance of obtaining a comprehensive medical history and conducting a thorough clinical examination to enable early detection of metastatic carcinomas in the mandible.