Sulfonylurea Herbicide Resistance Mechanism of Some Acetohydroxy Acid Synthase Mutants and New Designed Herbicides Specific to the Mutants

Mun Myong Choe,Hun Chol Kang,In Chul Kim,Hai Su Li,Ming Gen Wu,Im Shik Lee 한국잔디학회 2017 Weed & Turfgrass Science Vol.6 No.1

The mutation rate of proline in the position 197 (Pro197) in acetohydroxy acid synthase (AHAS) is highest among sulfonylurea (SU) herbicide-resistance mutants. Therefore, it is significant to investigate the resistance mechanism for the mutation and to develop the herbicides specific to the mutants. SU herbicide resistance mechanism of the mutants, 197Ser, 197Thr and 197Ala, in AHAS were targeted for designing new SU-herbicide. We did molecular dynamics (MD) simulation for understanding SU herbicide-resistance mechanisms of AHAS mutants and designed new herbicides with docking and MD evaluations. We have found that mutation to 197Ala and 197Ser enlarged the entrance of the active site, while 197Thr contracted. Map of the root mean square derivation (RMSD) and radius gyrations (Rg) revealed the domain indicating the conformations for herbicide resistant. Based on the enlarging-contracting mechanism of active site entrance, we designed new herbicides with substitution at the heterocyclic moiety of a SU herbicide for the complementary binding to the changed active site entrances of mutants, and designed new herbicides. We confirmed that our screened new herbicides bonded to both AHAS wild type and mutants with higher affinity, showing more stable binding conformation than the existing herbicides.

Sulfonylurea Herbicide Resistance Mechanism of Some Acetohydroxy Acid Synthase Mutants and New Designed Herbicides Specific to the Mutants

Choe, Mun Myong,Kang, Hun Chol,Kim, In Chul,Li, Hai Su,Wu, Ming Gen,Lee, Im Shik The Korean Society of Weed ScienceThe Turfgrass So 2017 Weed & Turfgrass Science Vol.6 No.1

The mutation rate of proline in the position 197 (Pro197) in acetohydroxy acid synthase (AHAS) is highest among sulfonylurea (SU) herbicide-resistance mutants. Therefore, it is significant to investigate the resistance mechanism for the mutation and to develop the herbicides specific to the mutants. SU herbicide resistance mechanism of the mutants, 197Ser, 197Thr and 197Ala, in AHAS were targeted for designing new SU-herbicide. We did molecular dynamics (MD) simulation for understanding SU herbicide-resistance mechanisms of AHAS mutants and designed new herbicides with docking and MD evaluations. We have found that mutation to 197Ala and 197Ser enlarged the entrance of the active site, while 197Thr contracted. Map of the root mean square derivation (RMSD) and radius gyrations (Rg) revealed the domain indicating the conformations for herbicide resistant. Based on the enlarging-contracting mechanism of active site entrance, we designed new herbicides with substitution at the heterocyclic moiety of a SU herbicide for the complementary binding to the changed active site entrances of mutants, and designed new herbicides. We confirmed that our screened new herbicides bonded to both AHAS wild type and mutants with higher affinity, showing more stable binding conformation than the existing herbicides.

What Did They Mean by “Calculation Principles”?: Revisiting Argumentative Styles in Late Ming to Mid-Qing Chinese Mathematics

( Su Jim-hong ),( Ying Jia-ming ) 한국과학사학회 2016 한국과학사학회지 Vol.38 No.2

This article discusses the influence that two versions of the Elements had in Ming and Qing China as well as Chinese scholars` efforts to “integrate” (huitong 會通) Western and Chinese mathematics into a unified system in terms of argumentative styles in mathematics. Although much high praise was given to the axiomatic-de-ductive system of Euclid`s Elements, numerical arguments and problem-solving re-main important traits in the works of Chinese scholars. The compilation of the Shuli jingyun 數理精蘊 and the inclusion of another version of the Elements in it again prompted East Asian mathematicians to reflect more upon their methods of argu-mentation, and later scholars began to write texts whose arguments are more abstract than numerical. This paper presents examples taken from the works of several rep-resentative scholars from the late Ming to the mid-Qing periods to argue that their efforts of huitong produced argumentative styles that are a combination of both Chi-nese and Western approaches, and that there was a trend of moving from concrete calculations to general arguments in mathematical texts throughout the course of history. Finally, the authors conclude that what 17^th and 18^th century Chinese math-ematicians meant by “calculation principles” (suanli 算理) was never the kind of pure deduction in the Euclidean manner, but a combination of induction and deduc-tion, with the help of intuition, for the purpose of problem-solving.

Letters to the Editor : Delayed Granulomatous Reaction after Oral Piercing during Thaipusam

( Su Ming Wong ),( Jyh Jong Tang ),( Suganthi Thevarajah ),( Roshidah Baba ) 대한피부과학회 2012 Annals of Dermatology Vol.24 No.3

MRI Features of Spinal Epidural Angiolipomas

Su Hu,Chun-hong Hu,Xiao-yun Hu,Xi-ming Wang,Hui Dai,Xiang-ming Fang,Lei Cui 대한영상의학회 2013 Korean Journal of Radiology Vol.14 No.5

Objective: To describe the MRI findings in ten patients of spinal epidural angiolipoma for differentiated diagnosis presurgery. Materials and Methods: Ten surgically proved cases of spinal epidural angiolipomas were retrospectively reviewed, and the lesion was classified according to the MR findings. Results: Ten tumors were located in the superior (n = 4), middle (n = 2), or inferior (n = 4) thoracic level. The mass, with the spindle shape, was located in the posterior epidural space and extended parallel to the long axis of the spine. All lesions contained a fat and vascular element. The vascular content, correlating with the presence of hypointense regions on T1-weighted imaging (T1WI) and hyperintense signals on T2-weighted imaging, had marked enhancement. However, there were no flow void signs on MR images. All tumors were divided into two types based on the MR features. In type 1 (n = 3), the mass was predominantly composed of lipomatous tissue (> 50%) and contained only a few small angiomatous regions, which had a trabeculated or mottled appear. In type 2 (n = 7), the mass, however, was predominantly composed of vascular components (> 50%), which presented as large foci in the center of the mass. Conclusion: Most spinal epidural angiolipomas exhibit hyperintensity on T1WI while the hypointense region on the noncontrast T1WI indicates to be vascular, which manifests an obvious enhancement with gadolinium administration.

An Online Response System for Anomaly Traffic by Incremental Mining with Genetic Optimization

Ming-Yang Su,Sheng-Cheng Yeh 한국통신학회 2010 Journal of communications and networks Vol.12 No.4

A flooding attack, such as DoS or Worm, can be easily created or even downloaded from the Internet, thus, it is one of the main threats to servers on the Internet. This paper presents an online real-time network response system, which can determine whether a LAN is suffering from a flooding attack within a very short time unit. The detection engine of the system is based on the incremental mining of fuzzy association rules from network packets,in which membership functions of fuzzy variables are optimized by a genetic algorithm. The incremental mining approach makes the system suitable for detecting, and thus, responding to an attack in real-time. This system is evaluated by 47 flooding attacks,only one of which is missed, with no false positives occurring. The proposed online system belongs to anomaly detection, not misuse detection. Moreover, a mechanism for dynamic firewall updating is embedded in the proposed system for the function of eliminating suspicious connections when necessary.

AN ALLOCATION ALGORITHM FOR DATA PATH SYNTHESIS

Su,Ming,Xue,Hongxi 대한전자공학회 1995 ICVC : International Conference on VLSI and CAD Vol.4 No.1

A novel approach, called clustering allocation algorithm for data path synthesis of digital system, is presented The algorithm introduce equivalent set to allocate the mutually exclusive operations or variables, and globally considers the minimum cost of data path under the minimum number of functional units and registers. The algorithm has been implemented and tested by the benchmarks for data path synthesis. The experimental results show that the algorithm gets the better results than other published algorithms in less CPU time.

An Online Response System for Anomaly Traffic by Incremental Mining with Genetic Optimization

Su, Ming-Yang,Yeh, Sheng-Cheng The Korea Institute of Information and Commucation 2010 Journal of communications and networks Vol.12 No.4

A flooding attack, such as DoS or Worm, can be easily created or even downloaded from the Internet, thus, it is one of the main threats to servers on the Internet. This paper presents an online real-time network response system, which can determine whether a LAN is suffering from a flooding attack within a very short time unit. The detection engine of the system is based on the incremental mining of fuzzy association rules from network packets, in which membership functions of fuzzy variables are optimized by a genetic algorithm. The incremental mining approach makes the system suitable for detecting, and thus, responding to an attack in real-time. This system is evaluated by 47 flooding attacks, only one of which is missed, with no false positives occurring. The proposed online system belongs to anomaly detection, not misuse detection. Moreover, a mechanism for dynamic firewall updating is embedded in the proposed system for the function of eliminating suspicious connections when necessary.

마약범죄의 경제적 분석

소명월(Su, Ming-yue),유원도(Liu, Yuan-tao) 경희법학연구소 2010 경희법학 Vol.45 No.2

본 논문의 연구대상은 마약범죄이며, 기본방법은 경제학의 법학영역에서의 최신 연구성과를 참조하여 마약범죄 및 그에 대한 징벌에 대하여 경제학적 분석을 하는 것으로 그 목적은 경제학적 분석의 시각에서 출발하여 형법이외에서 형법의 이론과 적용을 인식하려는 데 있다. 본 논문은 4개 부분으로 구성된다. 첫 번째 부분에서는 경제학의 기본적 이론특징으로부터 출발하여 경제학법칙을 법학영역에서 적용하는 보편성과 합리성을 검토하였다. 두 번째 부분에서는 일반대중들이 숙지하고 있는 공급과 소요라는 가장 간단한 경제학원리로부터 출발하여 현행 법률의 마약범죄에 대한 규제와 형사정책을 분석하였다. 세 번째 부분에서는 마약의 상품성 속성을 분석하는 것으로부터 출발하여 마약은 일종의 수요가 격탄성이 비교적 작은 상품으로서 이에 대하여 그 경제적 속성에 적합하는 형사정책을 취하여야 한다고 분석하였다. 네 번째 부분에서는 경제학적 분석의 방법 을 완전히 형법영역에 도입하기 위하여 학문, 입법, 사법 등 면에서 노력하여야 부분을 검토하였다. This article is focused on drug crimes, the authors make use of the latest results of economic research in economics to analyze the drug crimes and the punishments imposed upon such crimes. The purpose of this article is further understanding the theory and practice of criminal law from a different point of view. This article is divided into four parts. In the first part, the authors explain basic theoretical premises of economics, they held such a view that the social phenomena are economic phenomena, and the theory of economics can also be used in other area of social science. So it is reasonable to apply economic theory in the research of law. In the second part, the authors utilize the most fundamental law of economics, “the law of demand and supply” to explain the drug crimes and criminal policy. In the third part, the authors regard the drug as a kind of commodities. By analyzing the tributes of such a special commodity the authors want to explain that proper criminal policy must be applied to the drug as a commodity of low elasticity of demand. In the fourth part, the authors give some advices on the fields of the academic, the legislative and the judiciary to fulfill the economic approach to criminal law.

해양레저장비 산업 용어 표준화 방안 연구

강민수(Ming-Su Kang),임장곤(Jang-Gon Im),김헌우(Hyen-Woo Kim) 한국항해항만학회 2021 한국항해항만학회 학술대회논문집 Vol.2021 No.11