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HIV 감염자에 대한 달팽이 엑기스의 혈액면역학적 효과
조영걸,이희정,오원일,강은숙,김은순,김영봉,조양자,조군제 大韓免疫學會 1996 大韓免疫學會誌 Vol.18 No.2
A unique sialic-acid-binding lectin from giant African snail Achatina fulica(AF) has a T cell mitogenicity. It was also noted that acetone extracts of AF have a anti-HIV effect in vitro. Thirty HIV-infected individuals(HIV+) were treated with AF extract(40% Chunho extract) for average 5. 5 months. Peripheral blood sampling and questionnaire were done every month after take. There was a significant decrease of WBC from 4 months after take. As a result, lymphocyte counts also decreased(P<0.01). However, there was a significant increase of CD4+T cell percentage from 1 month(P<0.01). The mean increase of CD4+T cell count was significant for first one month(39/pl)(P<0.05). Body weight also increased significantly(P<0.05). Over 90% HIV+ ex-pressed symptomatic improvement and wanted to be treated with AF extract continuously after the end of this study. In one HIV+ treated with AF for 19 months, the increases of CD4+T cell percentage and counts over 11 times after AF extract take were mean 67% and 85%, respectively, compared to baseline value. These data strongly suggest that aqueous AF extract has a immune enhancing effect on HN+.
Bioactive Sphingolipids as Major Regulators of Coronary Artery Disease
( Jae-hwi Song ),( Goon-tae Kim ),( Kyung-ho Park ),( Woo-jae Park ),( Tae-sik Park ) 한국응용약물학회 2021 Biomolecules & Therapeutics(구 응용약물학회지) Vol.29 No.4
Atherosclerosis is the deposition of plaque in the main arteries. It is an inflammatory condition involving the accumulation of macrophages and various lipids (low-density lipoprotein [LDL] cholesterol, ceramide, S1P). Moreover, endothelial cells, macrophages, leukocytes, and smooth muscle cells are the major players in the atherogenic process. Sphingolipids are now emerging as important regulators in various pathophysiological processes, including the atherogenic process. Various sphingolipids exist, such as the ceramides, ceramide-1-phosphate, sphingosine, sphinganine, sphingosine-1-phosphate (S1P), sphingomyelin, and hundreds of glycosphingolipids. Among these, ceramides, glycosphingolipids, and S1P play important roles in the atherogenic processes. The atherosclerotic plaque consists of higher amounts of ceramide, glycosphingolipids, and sphingomyelin. The inhibition of the de novo ceramide biosynthesis reduces the development of atherosclerosis. S1P regulates atherogenesis via binding to the S1P receptor (S1PR). Among the five S1PRs (S1PR1-5), S1PR1 and S1PR3 mainly exert anti-atherosclerotic properties. This review mainly focuses on the effects of ceramide and S1P via the S1PR in the development of atherosclerosis. Moreover, it discusses the recent findings and potential therapeutic implications in atherosclerosis.
Preoperative predictors of malignant gastric submucosal tumor
Ho Goon Kim,Seong Yeob Ryu,Sang Kwon Yun,Jae Kyoon Joo,Jae Hyuk Lee,Dong Yi Kim 대한외과학회 2012 Annals of Surgical Treatment and Research(ASRT) Vol.83 No.2
Purpose: The preoperative prediction of malignant potential in patients with gastric submucosal tumors (SMTs) plays an important role in decisions regarding their surgical management. Methods: We evaluated the predictors of malignant gastric SMTs in 314 patients with gastric SMTs who underwent surgery in Chonnam National University Hospital. Results: The malignant SMTs were significantly associated with age (odds ratio [OR], 1.067; 95% confidence interval [CI], 1.042 to 1.091; P < 0.0001), presence of central ulceration (OR, 2.690; 95% CI, 1.224 to 5.909; P = 0.014), and tumor size (OR, 1.791; 95% CI, 1.483 to 2.164; P < 0.0001). Receiver operating characteristic curve analysis showed that tumor size was a good predictor of malignant potential. The most relevant predictor of malignant gastric SMT was tumor size with cut-offs of 4.05 and 6.40 cm. Conclusion: Our findings indicated that age, central ulceration, and tumor size were significant preoperative predictors of malignant SMTs. We suggest that 4 cm be selected as a threshold value for malignant gastric SMTs. In patients with a gastric SMT larger than 4 cm with ulceration, wide resection of the full thickness of the gastric wall or gastrectomy with adequate margins should be performed because of its malignant potential.
성인 급성 골수성 백혈병의 염색체 이상과 면역 표현형의 임상적 중요성
조군제(Goon Jae Cho),공옥녀(Ok Nyu Kong),정종윤(Jong Yun Cheong),이경우(Kyung Woo Lee),이정현(Jung Hyun Lee),정주섭(Joo Seop Chung),이은엽(Eun Yup Lee) 대한내과학회 2002 대한내과학회지 Vol.62 No.6
목적 : 저자들은 급성 골수성 백혈병에 있어 염색체 이상의 빈도 및 예후와 면역표현형의 임상적 중요성을 알아보고자 본 연구를 시행하였다. 방법 : 1996년 1월부터 2000년 12월까지 부산대학교병원 내과를 방문하여 급성 골수성 백혈병으로 진단 받은 68예를 대상으로 염색체 및 면역표현형 분석과 혈액학적, 임상적 양상을 비교하였다. 이중 47예에서 관해유도 치료를 시행하였으며 염색체 예후군에 따라 치료 성적을 비교하였다. 결과 : 염색체 이상은 핵형의 유형에 따라 t (8;21), t (15;17) 및 inv (16)을 예후양호군 (n=19, 28%), -5, del (5q), -7, der (1;7), 3q 이상 및 3개 이상의 클론성 이상이 갖는 복합성 핵형 (complex karyotype)을 예후불량군 (n=11, 16%), 정상 염색체 및 기타 염색체 이상을 중간위험군 (n=38, 56%)의 세 군으로 구분하였다. 염색체 이상의 빈도는 56% (38/68)였으며 관해유도 치료군에 있어 전체 완전 관해율은 64%였다. 예후양호군, 중간위험군 및 예후불량군의 완전 관해율은 각각 88%, 59% 및 44%였다 (p=0.021). 생존기간의 중앙값은 7개월이었으며 예후불량군 및 중간위험군의 생존기간의 중앙값은 2개월 및 6개월이었다. 예후양호군에서는 생존기간 중앙값에 아직 도달하지 않았다 (p=0.008). 또한 5년 생존율은 38%였으며 예후양호군, 중간위험군 및 예후불량군의 5년 생존율은 각각 68%, 31% 및 9%였다 (p=0.009). CD7, CD14, CD33, CD34 및 terminal deoxynucleotidyl transferase의 표현 여부는 완전 관해율 및 생존율에 통계적으로 의미 있는 차이가 없었다. 다변수 분석에서 연령 및 염색체 이상이 통계적으로 의미가 있었다. 결론 : 급성 골수성 백혈병 환자에 있어 염색체 분석은 치료 성적을 예측하는데 중요하다. 따라서 본 연구와 같은 염색체 결과를 고려하여 치료 방향을 정해야 하겠다. Background : This study was performed to identify the incidence and prognostic significance of chromosomal abnormalities as well as clinical significance of immuno phenotype in patients with acute myelogenous leukemia (AML). Methods : The chromosomal abnormalities, immunophenotype and their hematologic/clinical correlations were studied in 68 patients with de novo AML admitted to Pusan National University Hospital between January 1996 and December 2000. 47 of 68 patients had received induction chemotherapy and we analysed the response of treatment according to the karyotype pattern and immunophenotype. Results : The karyotypic patterns were divided into three groups; favorable (t (8;21), t (15;17) and inv (16); n=19,28%), poor (-5, del (5q), -7, der (1;7), abn (3q) and complex karyotypes; n=11, 16%) and intermediate group (other abnormalities or normal karyotype; n=38, 56%). The incidence of chromosomal abnormalities was 56% (38/68) and overall complete remission (CR) rate of 47 evaluable patients was 64%. The CR rates of favorable, intermediate and poor groups were 88%, 59% and 44%, respectively (p=0.021). The median survival time of all patients was 7 months, those of poor and intermediate groups being 2 months and 6 months. The median survival time of favorable group was not reached (p=0.008). The overall 5 year survival rate was 38% and those of favorable, intermediate and poor groups were 68%, 31% and 9%, respectively (p=0.009). Expression of CD7, CD14, CD33, CD34 and terminal deoxynucleotidyl transferase had no impact on CR rate and overall survival. In multivariate analysis, both age and chromosomal abnormalities influence significantly on prognosis. Conclusion : Cytogenetic study is important in predicting the outcome of patients with AML. And the treatment must be tailored according to the result of cytogenetics such as this study.(Korean J Med 62:608-616, 2002)