비지의 영양학적 품질특성

김군자,류호경,이영근,김동섭 밀양대학교 농업기술개발연구소 2000 農業技術開發硏究所報 Vol.4 No.1

This study was carried out to examine the qualities of soybean curd residue for utilizing as foodstuff. The content of moisture, crude protein, crude fat and ash were 80.98, 3.32, 0.94 and 0.82%, respectively. The major fatty acids were linoleic acid, oleic acid, linolenic acid and stearic acid. The hydrolysate of protein of sobean curd residue was composed chiefly of aspartic acid, glutamic acid, glycine, alanine, arginine and threonine, but the major free amino acids of soybean curd residue were arginine(234.1), ethanolamine (91.6), γ -amino-n-butyric acid(60.2), glutamic acid(55.8), valine(49.8), asparagine(47.3) and Iycine(48.3μ mol/100g). Key words : Soybean curd residue, Fatty acid, Amino acid

Discrepant Bowel Perforation from a Primary Lesion after Chemotherapy of Diffuse Large B Cell Lymphoma

Ho Goon Kim,Mi Ran Jung,Hyo Kang,Oh Cheong,Jae Kyun Ju,Young Kyu Park,Seong Yeob Ryu,Dong Yi Kim,Young Jin Kim,Shin Kon Kim 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.76 No.1

Diffuse large B cell lymphoma is the most common type of non-Hodgkin’s lymphoma, representing approximately one-third of all cases and involving the gastrointestinal tract in about 18%. With the development of modern chemotherapeutic regimens and advances in medical care, the prognosis for malignant lymphoma can be excellent. However, because of the aggressive adjuvant therapy required, complications such as bowel perforation may be fatal. In cases of chemotherapy for malignant lymphoma, we should keep in mind the possibility of perforation of the bowel after chemotherapy. Early detection is important to save patients.

Preoperative predictors of malignant gastric submucosal tumor

Ho Goon Kim,Seong Yeob Ryu,Sang Kwon Yun,Jae Kyoon Joo,Jae Hyuk Lee,Dong Yi Kim 대한외과학회 2012 Annals of Surgical Treatment and Research(ASRT) Vol.83 No.2

Purpose: The preoperative prediction of malignant potential in patients with gastric submucosal tumors (SMTs) plays an important role in decisions regarding their surgical management. Methods: We evaluated the predictors of malignant gastric SMTs in 314 patients with gastric SMTs who underwent surgery in Chonnam National University Hospital. Results: The malignant SMTs were significantly associated with age (odds ratio [OR], 1.067; 95% confidence interval [CI], 1.042 to 1.091; P < 0.0001), presence of central ulceration (OR, 2.690; 95% CI, 1.224 to 5.909; P = 0.014), and tumor size (OR, 1.791; 95% CI, 1.483 to 2.164; P < 0.0001). Receiver operating characteristic curve analysis showed that tumor size was a good predictor of malignant potential. The most relevant predictor of malignant gastric SMT was tumor size with cut-offs of 4.05 and 6.40 cm. Conclusion: Our findings indicated that age, central ulceration, and tumor size were significant preoperative predictors of malignant SMTs. We suggest that 4 cm be selected as a threshold value for malignant gastric SMTs. In patients with a gastric SMT larger than 4 cm with ulceration, wide resection of the full thickness of the gastric wall or gastrectomy with adequate margins should be performed because of its malignant potential.

Gastric Outlet Obstruction due to Eosinophilic Gastroenteritis

Ho Goon Kim,Mi Ran Jung,Hyo Kang,Oh Cheong,Jae Kyun Ju,Young Kyu Park,Seong Yeob Ryu,Dong Yi Kim,Young Jin,Shin Kon Kim 대한외과학회 2008 Annals of Surgical Treatment and Research(ASRT) Vol.75 No.6

Despite of its rarity, eosinophilic gastroenteritis (EG) needs to be recognized by the clinician because this disease can masquerade as irritable bowel syndrome and it may be misdiagnosed in clinical practice. We report here on a female patient with gastric outlet obstruction that was due to EG, and we review the relevant literature for either an association or a causality of EG.

Intraperitoneal Bronchogenic Cyst Misidentified as Gastric Submucosal Tumor

Ho Goon Kim,Mi Ran Jeong,Hyo Kang,Oh Cheong,Jae Kyun Ju,Young Kyu Park,Seong Yeob Ryu,Dong Yi Kim,Young Jin Kim 대한외과학회 2010 Annals of Surgical Treatment and Research(ASRT) Vol.79 No.2

Most bronchogenic cysts originate in the mediastinum, while 15% to 20% occur in the lung parenchyma. According to the literature, most intrapulmonary cysts occur in the lower lobes. But, they are rarely located in an extrathoracic site, such as subdiaphragmatic retroperitoneal area. We describe a paraesophageal intra-abdominal bronchogenic cyst, first considered as gastric submucosal tumor. Resection was successfully realized by laparoscopy. A 20-year-old female was admitted to our hospital with incidentally detected gastric submucosal tumor. At operation, there was a 2.5×2 ㎝ sized cystic tumor that was isolated from the gastric wall. We performed tumor resection laparoscopically. The postoperative course was uneventful and the patient was discharged on the second postoperative day. Histological examination reported a bronchogenic cyst. We, herein, report this case.

Upregulation of the serine palmitoyltransferase subunit SPTLC2 by endoplasmic reticulum stress inhibits the hepatic insulin response

Kim Goon-Tae,Devi Shivani,Sharma Amitesh,Cho Kyung-Hee,Kim Su-Jung,Kim Bo-Rahm,Kwon Sang-Ho,Park Tae-Sik 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

Endoplasmic reticulum (ER) stress is induced by various conditions, such as inflammation and the presence of excess nutrients. Abnormal accumulation of unfolded proteins leads to the activation of a collective signaling cascade, termed the unfolded protein response (UPR). ER stress is reported to perturb hepatic insulin response metabolism while promoting insulin resistance. Here, we report that ER stress regulates the de novo biosynthesis of sphingolipids via the activation of serine palmitoyltransferase (SPT), a rate-limiting enzyme involved in the de novo biosynthesis of ceramides. We found that the expression levels of Sptlc1 and Sptlc2, the major SPT subunits, were upregulated and that the cellular concentrations of ceramide and dihydroceramide were elevated by acute ER stress inducers in primary hepatocytes and HepG2 cells. Sptlc2 was upregulated and ceramide levels were elevated by tunicamycin in the livers of C57BL/6J wild-type mice. Analysis of the Sptlc2 promoter demonstrated that the transcriptional activation of Sptlc2 was mediated by the spliced form of X-box binding protein 1 (sXBP1). Liver-specific Sptlc2 transgenic mice exhibited increased ceramide levels in the liver and elevated fasting glucose levels. The insulin response was reduced by the inhibition of the phosphorylation of insulin receptor β (IRβ). Collectively, these results demonstrate that ER stress induces activation of the de novo biosynthesis of ceramide and contributes to the progression of hepatic insulin resistance via the reduced phosphorylation of IRβ in hepatocytes.

대장 선종성 용종의 악성화에 영향을 미치는 인자

김영호,이화영,김선우,박형석,손희정,김재준,배상수,최규완,백승운,고광철,이풍렬,이종철,박정호,박상종,천정학,심상군,김창섭 대한소화기학회 1999 대한소화기학회지 Vol.34 No.6

Background/Aims: The aim of this study was to investigate predictive factors for malignant transformation of colorectal adenomatous polyps in Korea. Methods: One thousand five hundred and eighty- nine sessions of colonoscopic polypectomy were performed from November 1994 to September 1998 for 1,375 patients with adenomatous polyps at Samsung Medical Center. We analyzed the 2,179 adenomatous polyps including 55 (2.5%) polyps with malignant transformation, retrospectively. Results: Six parameters showed significant differences in univariate (p$lt;0.01) and multivariate analysis. For each parameter, the proportions of malignant polyps were as follows: for number of polyps, 1.3% in cases of single polyp and 10.3% in cases of multiple polyps; for size, 1.4% of polyps less than 1 cm and 15.5% of polyps larger than 1 cm; for location, 4.6% of the polyps located in rectum or sigmoid colon and 1.1% of the polyps located in descending to ascending colon; for morphology, 0.9% in polyps of Yamada type I/II and 7.6% in polyps of Yamada type III/IV; for underlying histology, 1.4% in cases of tubular adenoma and 8.1% in cases of tubulovillous or villous adenoma; for degree of dysplasia, 1.2% in cases accompanied with low-grade dysplasia and 8.9% in cases accompanied with high-grade dysplasia. Conclusions: The malignant potential of colorectal adenomatous polyps in Korea is correlated with multiplicity, distal location, pedunculated shape as well as well-known factors like size, histologic type and degree of dysplasia.

Quantitative analysis of COX-2 promoter methylation in gastric carcinoma

Ho Goon Kim,Seong Yeob Ryu,Kyung Hwa Lee,Jae Hyuk Lee,Dong Yi Kim 대한외과학회 2018 Annals of Surgical Treatment and Research(ASRT) Vol.95 No.2

Purpose: To determine the occurrence of COX-2 methylation in gastric carcinoma (GC), the status and level of CpG methylation in the promoter region of cyclooxygenase-2 (COX-2) were analyzed in early and advanced GCs, as well as in normal gastric tissues. Methods: The extent of promoter methylation of the COX-2 gene was assessed quantitatively using pyrosequencing in 60 early and 60 advanced GCs samples harvested upon gastrectomy, and 40 normal gastric mucosa samples from patients with benign gastric diseases as controls. Results: The methylation frequency for the COX-2 gene was significantly higher in early than in advanced GCs (40.0% vs. 20.0%, P < 0.05). A significant difference was found in COX-2 methylation between GCs and normal gastric tissues (30.0% vs. 10.0%, by PS; P < 0.05). COX-2 gene methylation was significantly associated with the depth of invasion (P = 0.003), lymph node metastasis (P = 0.009), distant metastasis (P = 0.036), and TNM staging (P = 0.007). The overall survival of patients with COX-2 methylation was significantly lower than that of patients without COX-2 methylation (P = 0.005). Conclusion: These results demonstrated that COX-2 promoter methylation was significantly higher in tumor tissues, and was an early event for GC, thus, COX-2 gene methylation may be important in the initial development of gastric carcinogenesis. Thus, GCs with methylation in COX-2 may not be good candidates for treatment with COX-2 inhibitors. Furthermore, COX-2 methylation could be a significant prognostic factor predicting a favorable effect on GC patient outcome when downregulated.

기능성 소화불량증에서 Helicobacter pylori 감염이 위근위부 운동기능에 미치는 영향

김영호,박정미,손희정,최준영,김재준,최규완,백승운,고광철,이풍렬,이종철,김병태,심상군,김창섭 대한소화기학회 1999 대한소화기학회지 Vol.34 No.2

Background/Aims: Little is known about the effect of Helicobacter pylori (HP) infection on proximal gastric motor function in functional dyspepsia (FD). We evaluated total gastric emptying, initial proximal gastric distribution of meal (IPGD), proximal gastric emptying, basal tone, compliance and postprandial accommodation in the patients with FD relating to HP status. Methods: Of 25 subjects, 18 were HP positive and 7 were HP negative by the result of 13C urea breath test. A solid-phase scintigraphic gastric emptying and gastric barostat were performed. Results: In both HP-positive and HP-negative patients, sex, age, symptom score and body mass index were not different. Total gastric half-emptying time (101±13.9 min vs. 107±25.9 min), retention rate at 30 min (80.4±1.2% vs. 81.6±3.2%) and at 120 min (47.3±4.1% vs. 49.9±7.7%) were similar between the two groups. IPGD (69.4±4.1% vs. 64.6±11.1%) and proximal half-emptying time (37.9±5.2 min vs. 48.4±13.2 min) were not different between the two groups. basal tone (60.8±3.4 ml vs. 65.0±7.0 ml), compliance (49.2±2.4 ml/mmHg vs. 37.6±5.7 ml/mmHg), and accommodation (207±46% vs. 137±75%) were not different between the two groups. Conclusions: There was no association between HP infection and proximal gastric motor function in FD.

Clinicopathological Features of Female Gastric Carcinoma Patients with Curative Resection: Comparison with Male Patients

Ho Goon Kim,Hoi Dong Ghu,Sang Kwon Yun,류성엽,Dong Yi Kim 전남대학교 의과학연구소 2012 전남의대학술지 Vol.48 No.2

Little is known about the clinicopathological features of female gastric carcinoma (FGC) patients. We compared the clinicopathologic features and outcomes of FGC patients with curative resection with those of male gastric carcinoma (MGC) patients. We reviewed the hospital records of 940 FGC patients between 1986 and 2005 at Chonnam National University Hospital. Multivariate analysis showed that presence of serosal invasion, lymph node metastasis, and operative type were significant prognostic factors for survival of FGC patients with curative resection. Furthermore, the overall 5-year survival rate of FGC patients with curative resection (53.4%) was higher than that of MGC patients (47.6%, p<0.05). In advanced cases, no significant difference was observed in the overall 5-year survival rate between the FGC and MGC patients (41.6% vs 37.4%, p>0.05). Therefore, serosal invasion, lymph node metastasis, and type of operation were statistically significant parameters associated with survival. Early detection is more important for improving the prognosis of female patients with gastric cancer than for male patients.