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진성 적혈구 증다증 환자에서 발생한 발목뼈 결핵 1 예
고성애,정선영,손세훈,김동근,박성우,허지안,이경희,김민경,현명수 영남대학교 의과대학 2009 Yeungnam University Journal of Medicine Vol.26 No.1
Talus tuberculosis is a rare disease, even in an endemic tuberculosis area. In reviews of the worldwide literature, only 18 cases of talus tuberculosis have been reported. Recently, we experienced a case of a 70-year-old polycythemia vera patient with right metatarsopharyngeal joint pain for 2 months duration who was diagnosed with talus tuberculosis with prostate involvement. Tuberculosis should be considered as one of the causes of monoarticulitis, especially in countries, where the disease is endemic. Additionally, we highly recommend taking a biopsy of the site of suspected infection because an early diagnosis is the key to successful treatment.
방선균 WCM-9가 생산하는 Polyene 항진균성 항생물질(AF1)의 생물학적 성상
신운섭,정선호,이동희,이경호,김수기,박주영,고춘명 대한의진균학회 1996 대한의진균학회지 Vol.1 No.1
Background: Pathogenic fungi infect humans, especially immunocompromised patients, with superficial or deeply invasive pattern. In the past 20 years, fungal infections have been increased dramatically resulted by increment of organ transplantation, cancer, AIDS patients, or use of broad-spectrum antibacterial agents. Fungal infections are now important causes of morbidity and mortality of hospitalized patients. but there is no effective antifungal antibiotics as well as antibacterial antibiotics Objective: Effective new antifungal antibiotics are needed for the treatment of mycosis. So in an effort to develop effective antifungal antibiotics, we screened over 600 isolates of Streptomyces spp. from soil. Methods: Antifungal producing strain was selected using disk diffusion method, An antifungal substance (AF1) was purified with ethyl acetate extraction, silica gel column chromatography and reverse phase HPLC. MICs of AF1 were detected by agar dilition method. Results: The compound showed UV maxima of 307, 321, 340, 359 nm indicating methylpentaene. Minimum inhibitory concentrations of the AF1 were 3.7 ㎍/ml against mold, and 3.7 - 7.4 ㎍/ml against Candida species. AF1 was also active against Cryptococcus neoformans, with MIC of 0.9 ㎍/ml. The concentration of AF1 for K^+ ion release from human red blood cell and hemolysis were 5 ㎍/ml. Conclusion: The antibiotic purified from culture broth of Streptomyces sp. WCM-9 was a polyene antifungal antibiotic which have broad spectrum antifungal activity.
간편한 Sugar Butenolide의 합성에 관한 연구
고동수 同德女子大學校 1997 同大論叢 Vol.27 No.1
3,4-O-isoprophlidene-D-arabinopyranose (5), which can be prepared from D-arabinose by acetonation reaction, underwent Wittig reaction to give cis : trans (4 : 1) mixture of sugar enonate as a cis major. The cis-enonate eventually was transformed to chiral sugar lactone (11) which could be used as a chiral building block. This paper provides an facile, efficient route to chiral sugar lactones which have many functional groups with rigidity, permitting application to various chemical transformations with chirality transfer.
RuOx로 안정화된 n형 GaAs 표면의 구조적·전기적 특성
고동완,김은규,김용,정관수 慶熙大學校 材料科學技術硏究所 1998 材料科學技術硏究論集 Vol.11 No.-
We have studied RuO_(x) passivation on n-type GaAs substrates in RuCl_(3) solution by dipping methods for the purpose of investigation of device and interface characteristics such as metal-semiconductor structure. The GaAs surface morphologies before and after RuO_(x) passivation were compared by Atomic Force Microscope and depth profile of the passivated surface was measured by Auger Electrom Spectroscopy. The surface morphologies of the passivated GaAs were improved by RuO_(x) passivation with root-mean-square roughness about 2Å and the passivated layer was thermally stable. The current-voltage characteristics of metal-semiconductor structure on the passivated GaAs were improved by RuO_(x) passivation at the order of 10^(-2)Å/cm^(2) better than without passivation and were thermally stable.
최희동,이명재,고동완,곽성관,김동식,정관수 慶熙大學校 레이저 工學硏究所 2002 레이저공학 Vol.13 No.-
In this work, we examined the electrical and mechanical characteristics of TFD devices for various top electrode materials by measuring barrier height and performing ASE depth profile. It was found that the shift of current-voltage(Ⅰ-Ⅴ) characteristics of TFD device depends on the top electrode material. The main reason of the asymmetry in Ⅰ-Ⅴ curve was the differences in barrier height of top and bottom electrodes, and chemical composition at the interface region between top electrode and insulator layer also was important reason. The barrier heights(φ_B) evaluated from temperature dependence of the Ⅰ-Ⅴ relation are 0.7795(Al) 1.0287(Ti) and 1.2928(Ta) eV.
이동민,장경식,양종태,장대용,김종오,서영욱,고영엽,홍순표 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1
Background: The sigmoid septum described an anatomical variation in the contour of the left ventricular outlet. It is related to degenerative change with aging. We observed clinical significance of sigmoid septum in Korean. Methods: Echocardiographic examination was performed in 434 patients. Sigmoid septum is defined as discrete bulging of the proximal interventricular septum with that thickness is greater than 1.3cm or the thickness is grater 1.5 times than adjacent mid interventricular septum in apical 3 chamber view. Result: The incidence of patient with sigmoid septum(septum patient) is 24.8% (male 8.4%, female 16.3%) . The incidence increases with age and is more common in women. The patients with sigmoid septum were compared with targeted groups, there was no significant difference in blood pressure between them, but in height and weight, the former were lower. (p<001, p<03). In the patients with sigmoid septum, weight and the surface area of a body have an opposite correlation with increase of age (p<03, r=-0.34) (p<04, r=-0.31) , but no decrease of height was found according to age increase (p=0.47, r=-0.11) The main reason patients with sigmoid septum ask echocardiolography and its clinical symptoms were abnormal results of previous electrocardiography and/or usual chest pain. Compared with control group, interventricular septal thickness is larger in septum patients (p<001). The thickness of interventricular septum located in subaortic left ventricular outflow tract is 1.6±0.3cm. There is another web like structure that continued from interventricualr septum to anterior free wall of left ventricle and the width is 1.6±0.4cm. A sign of insignificant obstruction due to left ventricular outflow was observed from three sigmoid septum patients. Conculusion: Septum patient is largely found in older age group and the body weight and body surface area are lower than control group. The body weight and body surface area are opposite correlation with age. So sigmoid septum is considered as structural change by weight reduction with aging. It is assumed that septum patients are related with asymptomatic ischemia because they have more abnormal ECG finding such as T wave inversion on precordial leads or standard leads, nonspecific ST-T change, LBBB etc. Sigmoid septum is not only proximal interventricular septal bludging but also another web like structure continuing to anterior wall of left ventricle.