http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Mun, Se Hwan,Kim, Jie Wan,Nah, Seong Su,Ko, Na Young,Lee, Jun Ho,Kim, Ju Dong,Kim, Do Kyun,Kim, Hyuk Soon,Choi, Ji Da,Kim, Soo Hyun,Lee, Chang Keun,Park, Seung Hwa,Kim, Bo Kyung,Kim, Hyung Sik,Kim, Yo Wiley Subscription Services, Inc., A Wiley Company 2009 Vol.60 No.3
<B>Objective</B><P>Interleukin-32 (IL-32) is a recently discovered cytokine that appears to play a critical role in human rheumatoid arthritis (RA). It is highly expressed in synovium and fibroblast-like synoviocytes (FLS) from RA patients, but not in patients with osteoarthritis (OA). This study was undertaken to assess IL-32 levels in RA synovial fluid (SF) and to investigate the secretion and regulation of IL-32 in RA FLS.</P><B>Methods</B><P>FLS and SF were obtained from the joints of RA patients. The secretion and expression of IL-32 and activation of signaling molecules were examined by enzyme-linked immunosorbent assay, immunoblotting, immunoprecipitation, reverse transcriptase–polymerase chain reaction, and small interfering RNA (siRNA) transfection.</P><B>Results</B><P>IL-32 levels were high in RA SF compared with OA SF. Furthermore, RA FLS expressed and secreted IL-32 when stimulated with tumor necrosis factor α (TNFα). TNFα-induced expression of IL-32 was significantly suppressed, in a dose-dependent manner, by inhibitors of Syk, protein kinase Cδ (PKCδ), and JNK and by knockdown of these kinases and c-Jun with siRNA. We also observed that PKCδ mediated the activation of JNK and c-Jun, and experiments using specific inhibitors and siRNA demonstrated that Syk was the upstream kinase for the activation of PKCδ.</P><B>Conclusion</B><P>The present findings suggest that IL-32 may be a newly identified prognostic biomarker in RA, thereby adding valuable knowledge to the understanding of this disease. The results also demonstrate that the production of IL-32 in RA FLS is regulated by Syk/PKCδ-mediated signaling events.</P>
Mun, Se Hwan,Kim, Hyuk Soon,Kim, Jie Wan,Ko, Na Young,Kim, Do Kyun,Lee, Beob Yi,Kim, Bokyung,Won, Hyung Sik,Shin, Hwa-Sup,Han, Jeung-Whan,Lee, Hoi Young,Kim, Young Mi,Choi, Wahn Soo The Japanese Pharmacological Society 2009 Journal of pharmacological sciences Vol.111 No.1
<P>We investigated whether oral administration of curcumin suppressed type II collagen–induced arthritis (CIA) in mice and its effect and mechanism on matrix metalloproteinase (MMP)-1 and MMP-3 production in CIA mice, RA fibroblast-like synoviocytes (FLS), and chondrocytes. CIA in mice was suppressed by oral administration of curcumin in a dose-dependent manner. Macroscopic observations were confirmed by histological examinations. Histological changes including infiltration of immune cells, synovial hyperplasia, cartilage destruction, and bone erosion in the hind paw sections were extensively suppressed by curcumin. The histological scores were consistent with clinical arthritis indexes. Production of MMP-1 and MMP-3 were inhibited by curcumin in CIA hind paw sections and tumor necrosis factor (TNF)-α–stimulated FLS and chondrocytes in a dose-dependent manner. As for the mechanism, curcumin inhibited activating phosphorylation of protein kinase Cδ (PKCδ) in CIA, FLS, and chondrocytes. Curcumin also suppressed the JNK and c-Jun activation in those cells. This study suggests that the suppression of MMP-1 and MMP-3 production by curcumin in CIA is mediated through the inhibition of PKCδ and the JNK/c-Jun signaling pathway.</P>
Interleukin-33 stimulates formation of functional osteoclasts from human CD14(+) monocytes.
Mun, Se Hwan,Ko, Na Young,Kim, Hyuk Soon,Kim, Jie Wan,Kim, Do Kyun,Kim, A-Ram,Lee, Seung Hyun,Kim, Yong-Gil,Lee, Chang Keun,Lee, Seoung Hoon,Kim, Bo Kyung,Beaven, Michael A,Kim, Young Mi,Choi, Wahn So Birkhäuser ; Springer 2010 Cellular and molecular life sciences Vol.67 No.22
<P>Interleukin (IL)-33 is a recently described pro-inflammatory cytokine. Here we demonstrate IL-33 as a regulator of functional osteoclasts (OCs) from human CD14(+) monocytes. IL-33 stimulates formation of tartrate-resistant acid phosphatase (TRAP)(+) multinuclear OCs from monocytes. This action was suppressed by anti-ST2 antibody, suggesting that IL-33 acts through its receptor ST2, but not by the receptor activator of NF-κB ligand (RANKL) decoy, osteoprotegerin, or anti-RANKL antibody. IL-33 stimulated activating phosphorylations of signaling molecules in monocytes that are critical for OC development. These included Syk, phospholipase Cγ2, Gab2, MAP kinases, TAK-1, and NF-κB. IL-33 also enhanced expression of OC differentiation factors including TNF-α receptor-associated factor 6 (TRAF6), nuclear factor of activated T cells cytoplasmic 1, c-Fos, c-Src, cathepsin K, and calcitonin receptor. IL-33 eventually induced bone resorption. This study suggests that the osteoclastogenic property of IL-33 is mediated through TRAF6 as well as the immunoreceptor tyrosine-based activation motif-dependent Syk/PLCγ pathway in human CD14(+) monocytes.</P>
관동맥 질환에서 혈중 Lipoprotein(a)의 농도
한세환 ( Han Se Hwan ),정일권 ( Jeong Il Gwon ),김기업 ( Kim Gi Eob ),문종호 ( Mun Jong Ho ),박찬욱 ( Park Chan Ug ),신승호 ( Sin Seung Ho ),양동호 ( Yang Dong Ho ),김순길 ( Kim Sun Gil ),홍세용 ( Hong Se Yong ) 대한내과학회 1993 대한내과학회지 Vol.44 No.4
연구배경 : 최근 관동맥질환에서 고콜레스테롤혈증과 함께 Lipoprotein(a){Lp(a)}의 증가가 중요한 위험인자로 알려졌다. 저자들은 Lp(a)가 혈전유발인자인 동시에 한국인의 관동맥질환에서 위험인자가 될수 있음을 알아보기 위하여 본연구를 시행하게 되었다. 방법 : 관동맥 질환 환자 26명(급성 심근경색증 12명, 협심증 14명), 고혈압 환자 16명, 건강이 50명을 대상으로 혈중 Lp(a)를 ELISA법으로 측정하고, 관동맥질환 및 고혈압 환자의 혈중 총콜레스테롤치와 혈중 Lp(a)치와의 관계를 비교하여 보았다. 결과 : 혈중 Lp(a)는 관동맥 질환군에서 358±155mg/L, 고혈압군에서 207±110mg/L, 정상군에서 166±33mg/L로 관동맥 질환군에서 고혈압 및 정상 대조군보다 현저하게 증가되어 있었다(p<0.005). 관동맥 질환 환자중 혈중 총콜레스테롤이 200mg/dl 이하인 16례를 다시 분석해보면 혈중 Lp(a)는 294±129mg/L로 역시 고혈압군 및 정상대조군보다 의미있게 증가되어 있었다.(p<0.05). 각 군에서 혈중 Lp(a)의 성별, 연령별 유의한 차이는 없었으며 콜레스테롤이나 중성지방의 농도에도 통계학적으로 유의한 차이는 없었다. 결론 : 관동맥 질환 환자에서 높은 혈중 Lp(a)는 관동맥 질환에 대한 하나의 위험인자가 됨을 시사한다. 또한 혈중 총콜레스테롤이 200mg/dl 이하인 관동맥질환군에서 높은 Lp(a)농도는 콜레스테롤과는 무관하게 하나의 독립적이 위험인자가 되는 것으로 사료된다. Background: Since its description in the early 1960s by Berg, Lp(a) has been shown to be associated with coronary artery disease(CAD). Lp(a) is composed of one LDL particle, to which one molecule of apolipoprotein(a) is covalently linked. Lp(a) excess is considered to have not only ahterogenic but also antifibrinolytic activities by complex mechanisms. The purpose of this study was to evaluate Lp(a) as a risk factor of CAD, and to study the relations between Lp(a) and cholesterol level in patients with CAD. Methods: We determined plasma levels of Lp(a) in 26 patients with CAD including AMI and AP(11 men and 15 women, median age 60 years), in 16 patients with HT(6 men and 10 women, median age 61 years), and in 50 control subjects (25 men and 25 women, median age 57 years) clinically free of cardiovascular disease. We measured plasma Lp(a) level in CAD and HT group with ELISA method and compared the result with that of control group. We also measured serum cholestreol and TG with autoanalyzer in CAD and HT groups. Results: Plasma Lp(a) levels were 358±155mg/L in CAD group, 207±110mg/L in HT group and 166±33mg/L in control group. Patients with CAD had higher Lp(a) levels than HT and control subjects(p<0.005). No gender differences in Lp(a) levels were observed between men and women(patients or control subjects). No statistically significant differences were seen for total cholesterol and TG in each group. We analyzed again plasma Lp(a) levels of 16 patients with CAD whose cholesterol levels are below 200 mg/dl. It was 294±129mg/L, also higher in CAD compared with HT and control groups(p<0.05). Conclusion: The Lp(a) levels of the CAD groups were significantly higher than those of HT and control groups, this suggest that Lp(a) excess is a risk factor for the development of CAD. The high Lp(a) levles in patients who has serum total cholesterol below 200 mg/dl is considered that is a risk factor, independent of high cholesterol level.
고선환 ( Go Seon Hwan ),송은섭 ( Song Eun Seob ),김세련 ( Kim Se Lyeon ),이문희 ( Lee Mun Hui ),김우철 ( Kim U Cheol ),송윤섭 ( Song Yun Seob ),박지현 ( Park Ji Hyeon ),임문환 ( Im Mun Hwan ),이병익 ( Lee Byeong Ig ),이우영 ( Lee 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.4
Endometrial stromal sarcomas (ESS) of the myometrium compose just 0.2% of uterine malignant tumors. In terms of their cellular mitotic activities, they are named as low grade or high grade ESS. As low grade ESS are very rare, we would like to report our 3
Terahertz Time Domain Spectroscopy, T-Ray Imaging and Wireless Data Transfer Technologies
Mun Cheol Paek,Min Hwan Kwak,Seung Beom Kang,Sungil Kim,Han-Cheol Ryu,Sang Kuk Choi,Se Young Jeong,Dae Won Kang,Dong Suk Jun,Kwang Yong Kang 한국전자파학회JEES 2010 Journal of Electromagnetic Engineering and Science Vol.10 No.3
This study reviewed terahertz technologies of time domain spectroscopy, T-ray imaging, and high rate wireless data transfer. The main topics of the terahertz research area were investigation of materials and package modules for terahertz wave generation and detection, and setup of the terahertz system for time domain spectroscopy(TDS), T-ray imaging and sub-㎔ wireless communication. In addition to Poly-GaAs film as a photoconductive switching antenna material, a table-top scale for the ㎔-TDS/imaging system and terahertz continuous wave(CW) generation systems for sub-㎔ data transfer and narrow band T-ray imaging were designed. Dielectric properties of ferroelectric BSTO(BaxSr1-x TiO₃) films and chalcogenide glass systems were characterized with the ㎔-TDS system at the ㎔ frequency range. Package modules for terahertz wave transmitter/receiver(Tx/Rx) photoconductive antenna were developed.