한방 이화주의 미백 및 피부 주름 개선 효과

이상진(Sang-Jin Lee),권이영(Yi-Young Kwon),조성원(Sung-Won Cho),권희숙(Hee-Suk Kwon),신우창(Woo-Chang Shin) 한국식품영양과학회 2013 한국식품영양과학회지 Vol.42 No.4

본 연구에서는 한방이화주의 피부 생리기능 활성을 알아보기 위해 70% EtOH 추출물의 피부 미백, 주름 개선 및 항염증 효과를 조사하였다. HEE은 tyrosinase 활성 억제 및 tyrosine을 기질로 melanin이 형성되는 pathway에 관여하는 주요한 인자인 TRP-1과 TRP-2를 저해하는 작용 기전을 통해 피부 색소침착의 주요 원인 물질인 melanin 생합성을 농도 의존적으로 저해하는 것을 확인하였다. HEE은 피부진피 내 피부 탄력을 유지하는 elastin을 분해하는 효소인 elastase의 활성을 저해하였고, 피부의 keratinocyte가 생성분비하는 MMP-2와 MMP-9의 단백질 발현과 proteolytic 활성을 억제하여 노화에 따른 피부 주름 생성 억제할 수 있는 가능성을 확인하였다. 또한 세포 독성 없이 LPS에 의해 유도된 염증 반응을 50% 저해하는 HEE의 농도(IC50)는 24.9 μg/mL이며, 50 μg/mL 농도로 처리하였을 때 염증 반응 저해 효과가 70%로 높은 효과를 가지는 것을 확인하였다. 이상의 결과를 종합하면 HEE의 피부 미백, 주름 개선 및 항염증에 우수한 효과를 나타내고 있으므로 기능성 화장품의 주요한 소재로 이용 가치가 높을 것으로 사료된다. Extrinsic skin aging is characterized by the loss of skin tone and resilience, irregular pigmentation, and deep wrinkles. The aim of this study was to investigate the effects of Ehwa Makgeolli containing oriental herbs (Glycyrrhiza uralensis Fisch., Lycium chinense MILL., Morus alba L., and Saururus chinensis Baill) on skin whitening and wrinkling in human skin cells. We prepared Makgeolli extracts (HEE) with 70% ethanol. HEE significantly inhibited in vitro mushroom tyrosinase activity and reduced the cellular and secreted melanin content of mouse melanoma melanocytes (B16F1 cells). HEE down-regulated the protein expression of tyrosinase related protein (TRP)-1/-2, a key player in melanogenesis. Treatment with HEE in human keratinoctyes (HaCaT cells) inhibited the proteolytic activities of matrix metalloproteinase (MMP)-2/-9 in a dose-dependent manner and dramatically reduced the expression of MMP-2/-9. In addition, HEE attenuated lipopolysaccharide (LPS)- induced nitric oxide production in murine macrophages (RAW264.7 cells). These results indicate that HEE may be a great cosmeceutical ingredient for its whitening, anti-wrinkle, and anti-inflammatory effects.

유해화학물질 운송 파이프의 안정성 진단 센서 개발을 위한 기초연구

신상희(Shin, Sang_Hee) 대한토목학회 2019 대한토목학회 학술대회 Vol.2019 No.10

자성체 가스관에서 복수의 결함에 의한 원격장와전류 신호특성 조사

신영길,이윤태,송성철,정희성 국립7개대학공동논문집간행위원회 2004 공업기술연구 Vol.4 No.-

Remote field eddy current testing signals have unique signal characteristics such as the equal sensitivity to ID and OD defects and the linear relationship between defect depth and phase signal strength. In this paper, those and new signal characteristics are studied by carefully prepared experiments with gas pipes. Many kinds of defects are designed and fabricated, such as ID and OD defects, axial and circumferential defects, and multiple defects on the same circumference. Multiple defects on the indirect paths and very long defects reveal the linear relationship between defect depth and phase signal strength. Equal sensitivity to ID and OD defects is also demonstrated. It is found that the phase signal is more sensitive to axial defects and the phase signals from circumferential defects tend to underestimate the total defect length.

Bowling 투구 動作分析

신성휴,위승두,손명성,구희성 조선대학교 스포츠과학연구소 1998 스포츠科學硏究 Vol.9 No.-

The Purpose of this study is the provide basic data for bowlers by analyzing the kinematical variables of throwing motion to the male pro bowler using 3-dimensional image analysis method. This researcher took the pictures with a video camera, analyzed them using the Kwon 3D program. 1×4×2m control object installed to get a 3 dimensional space coordinates. Results were as follows. 1. It was indicated that the trunk angle did not change left and right. Back and forth from stance to release motions of three subjects, and the average angle of trunk angle at the stance and that at the tabular side were 19.5˚ and 14.6˚ respectively, which showed they did not deviated from well-known range of forward direction, 15-20˚ and lateral direction 10-15˚. Also the trunk angle of release motion was average 17.1˚ for thalamus side, 41.3˚ for tabular side. 2. It was indicated that the knee angle repeated the increase and decrease to a small degree from the first to the fourth phase, the average angle of left knee at the release motion, the sixth phase was 110.8˚, which was higher than generally known 90˚.

분해성 폴리에틸렌 필름의 생분해 및 광분해성에 관한 연구

신부영,장상희,정병욱 嶺南大學校 工業技術硏究所 1997 工業技術硏究所論文集 Vol.25 No.2

Photo-biodegradable master batch was prepared by using mechanical and thermal oxidation that in general occur during polymer processing operation. Master batches were prepared by melt mixing in air circumstance, respectively. High density polyethylene(HDPE) sheets containing 20 wt.% photo-biodegradable M/Bs were prepared by compression molding and we observed the photodegradability under the mercury-vapor lamp. The sheet of containing M/B prepared above 95% of its original elongation and very brittle within 120 hours irradiation, however, pure HDPE sheet still retained about 80% original elongation for 120 hours irradiation. Under the natural sunlight, photo-biodegradable HDPE films lost about 98% of its original elongation at break for 8weeks outdoor exposure in summer. The common film still retained 75% of its original elongation at the same period. Surface morphology of the films was examined by using scanning electron microscopy(SEM). The effects of water on the mechanical properties and morphology of film were examined during the irradiation. In the case of biodegradation test, incubator test were performed simultaneously. Microorganism (fungi) growth in photo-biodegradable film surface was augmented by exposed time increasingly.

간호사의 목표관리[MBO]에 대한 인식과 간호조직의 유효성

신을숙,안성희 대한간호행정학회 2008 간호행정학회지 Vol.14 No.3

Purpose: It is a descriptive study to analyze correlation between the perception of management by objectives(MBO) and organizational effectiveness among clinical nurses. Methods: The subjects were 315 nurses at two hospitals (A and B) of C university, who have had more than 3.5 years of nursing experience. The survey instrument included two major concepts, Perception of MBO (29 items) and organizational effectiveness, which has three sub-concepts, job satisfaction (18 items), organizational commitment (12 items), and motivation (20 items). The data analyses included t-test, ANOVA, Scheffe' test, Pearson's correlation coefficients, and Stepwise multiple regression. Result: The mean score of the perception of MBO was 3.13 out of 5. In organizational effectiveness, job satisfaction was 3.09, organizational commitment 3.25, and motivation 3.38. The perception of MBO had significantly positive correlation with job satisfaction(r=.71), organizational commitment(r=.65) and motivation(r=.61). The perception of MBO explained 50.4%, 42.4%, and 37.1% for job satisfaction, organizational commitment, and motivation respectively. Conclusions: The results show that the MBO affected the organizational effectiveness, and the MBO serves as a useful system to improve the organizational effectiveness in a nursing department.

급성 림프구성 백혈병 환자에서 발생한 침습성 국균 심내막염 2예

신성철,백경란,정재홍,송봉근,김동희,전경만,채제욱,손준성,정숙인,오원섭,송재훈 대한감염학회 2003 감염과 화학요법 Vol.35 No.5

국균은 호흡기를 통해 유입되며 심한 면역기능저하 환자에서 기회감염을 일으키는 진균이며 주로 혈관을 따라 폐를 침범하고 심장과 골침범은 매우 드문 것으로 알려져 있다. 저자들은 급성 림프구성 백혈병 환자에서 발생한 침습성 국균 심내막염을 2예을 경험하였다. 19세 남자환자로 동종 조혈모세포이식 후 발생한 고열과 요통의 원인으로 감염성 심내막염 진단하에 수술결과 국균에 의한 감염으로 확증되어 수술적 절제술과 liposomal amphotericin B로 치료하였으나 국균 심내막염의 재발과 국균 척추염의 악화, 뇌 출혈로 사망하였다. 23세 남자환자로 관해요법 후 발생한 고열과 요통의 원인으로 국균 심내막염과 국균 척추염 진단하에 수술적 절제술과 amphotericin B로 치료하여 1년 2개월 동안 국균 심내막염의 재발은 없었으나 지속적인 백혈병의 재발과 국균 척추염의 악화, 침습성 폐 국균증으로 사망하였다. Although Aspergillus endocarditis has rarely been reported, it can cause fatal complications in hematologic malignancy patients and allogeneic stem cell transplant recipients. We experienced two cases of aspergillus endocarditis developed in acute lymphoblastic leukemia patients. Case; A 19-year-old patient developed Aspergillus endocarditis after allogenic hemopoietic stem cell transplantation. He was treated with surgical intervention and liposomal amphotericin B. He died of recurred Aspergillus endocarditis and cerebral hemorrhage probably related with aspergillosis of central nervous system. Case 2; A 23-year-old patient developed invasive Aspergillus endocarditis after induction chemotherapy. Aspergillus endocarditis was successfully treated by surgical intervention and amphotericin B. He died of refractory neutropenic fever and sepsis after the third relapse of leukemia and repetitive chemotherapy. He probably had invasive pulmonary aspergillosis without evidence of endocarditis recurrence. Because the mortality of Aspergillus endocarditis is very high, early diagnosis and surgical intervention are very important for better outcome.

분자내 고리화반응에 의한 <Benz-[f]-Indole>-4,9-Dione 유도체 합성

신상희,서명은 梨花女子大學校 藥學硏究所 1991 藥學硏究論文集 Vol.- No.1

Compound of the structure of <benz-[f]-indole>-4.9-dione are known to have an antibacterial activity against Gram-positive bacteria. New kinds of 2-amino-<benz-[f]-indole>-4.9-diones are prepared via intramolecular cyclization. 2-Chloro-3-(α-cyano-α-ethoxycarbonyl-methyl)-1.4-naphthoquinone was reacted with some alkylamines (methylamine, ethylamine, ethanolamine, isopropylamine, cyclohexylamine, benzylamine) to yield 2-amino-3-ethoxycarbonyl-N-alcyl-<benz-[f]-indole>-4.9-diones.

녹차 건분이 고지방식이 급여에 의한 흰쥐의 지질 농도에 미치는 영향

신미경,김덕희,한성희 한국식생활문화학회 2003 韓國食生活文化學會誌 Vol.18 No.3

The effects of dried green tea leaf powders on serum lipid concentrations were evaluated in rats. Sixty male Sprague-Dawley rats weighing 100±10g were divided into six groups and fed high fat diets for six weeks. Experimental groups were administered with following diets: Normal fat diet and normal and high fat diets with 1% dried green tea leaf powders. Tissue weights of live, lung, stomach, heart, kidney and spleen of high fat diet exposed rats were reduced by dried green tea leaf powders groups. The concentrations of serum triglyceride in rats fed the dried green tea leaf powers were lower than those in other groups. The concentrations of total cholesterol in green tea leaf powders the were lower powders green tea were significantly higher than those of other groups. The levels of LDL-cholesterol in serum of the dried green tea leaf powders groups were tended to be lower than those of other groups. GPT and GPT were decreased in dried green tea leaf powders groups and than in the high fat groups. LDHase was lower in the dried green tea leaf powders groups than in the high fat group. These results suggest that dried leaf powders green tea groups may reduce elevated levels of serum lipid concentrations in rats fed high fat diets.

인체 체액내 황색포도상구균의 증식과 철 획득 기전

신성희,이강길,이명희,양남웅,임용,김진호 대한감염학회 2000 감염 Vol.32 No.5