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( Myung Jin Lee ),( Kye Hyung Kim ),( Jong Youn Yi ),( Su Jin Choi ),( Chung Jong Kim ),( Nak Hyun Kim ),( Kyoung Ho Song ),( Pyoeng Gyun Choi ),( Ji Hwan Bang ),( Wan Beom Park ),( Eu Suk Kim ),( San 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus Myung Jin LEE1, Kye-Hyung KIM1, Jongyoun YI2, SuJin CHOI1, Chung-Jong KIM1, Nak- Hyun KIM1, Kyoung-Ho SONG1, Pyoeng Gyun CHOI1, Ji-Hwan BANG1, Wan Beom PARK1, Eu Suk KIM1, Sang-Won PARK1, Hong Bin KIM1, Nam Joong KIM1, Myoung- Don OH1 Seoul National University College of Medicine, Korea1, Pusan National University School of Medicine, Korea2 Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel Bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV). No effective antiviral therapy is proven yet, but clinical use of ribavirin (RBV) has been tried. We investigated the antiviral effect of RBV against SFTSV in vitro. Methods: To test for cytotoxicity of RBV, Vero cells were treated with different concentrations of RBV (3.90 to 500 μg/mL, two-fold dilution) and analyzed by cell viability MTS assay 48h post-infection. To determine antiviral activity of RBV against SFTSV, Vero cells were infected with SFTSV strain Gangwon/Korea/2012 at 100 TCID50 (50% tissue culture infective dose) per well in a 96-well plate, and RBV was added at the concentrations showing no or minimal cytotoxicity. Viral RNAs were extracted from the culture supernatants and quantifi ed using one-step real-time reverse transcription- PCR to amplify the partial large segment of SFTSV. Statistical analysis was done by one-way ANOVA with Tukey`s post hoc test. Results: Cytotoxicity due to RBV was not observed at RBV concentration =31.3 μg/ mL. Viral RNAs at 24h post-RBV treatment were reduced with increasing RBV concentrations (1-32 μg/mL), compared with those of mock-treated cells (P <0.01, Figure). Half maximal inhibitory concentration (IC50) of RBV was 3.69 μg/mL at 24h post-RBV treatment. Conclusions: Our study shows that RBV has antiviral effect against SFTSV in a dose-dependent manner. Further studies are required to evaluate the effi cacy of RBV in SFTS.
근대 실내 공간 구성원리의 한국적 변형에 관한 연구 : 김수근과 김중업 작품의 실내공간 분석을 중심으로
김은홍;남경숙 한양대학교 2007 韓國 生活 科學 硏究 Vol.27 No.1
Modernism Architecture in international style has made new spatial paradigm using steel and glass until 1900s. This paradigm influenced in indoor space was shown to Works of four great masters, Mies van der rohe, Le Corbusier, Aalvar alto, Frank L. Wright, and some characteristics are found in four great masters' works in common. These characteristics are simplicity of spatial form, usefulness and functionality of design, openness of indoor space, Total design, internal and external interpenetration. These are shown in interior space of Korea modern architecture as changing their conditions. This study drives at what major characteristics changes the way of proper transformation and adaption in two modern architect of Korea, Kim Swoogeun and Kim Chungup as according to modern architecture principals. Some controlling principles are found out in their works, and the ways of transformation and adaption are analogy with its special occasion of Korea.
김석동,김광겸,김동일,김우성 호서대학교 반도체제조장비국산화연구센터 2000 반도체 장비기술 논문집 Vol.2000 No.-
본연구에서는 FPD 스토커 유틸리티 데이타 베이스부분과 이와 관련한 Registry system을 집중적으로 분석하여 FPD 스토커 유틸리티 설계에 관한 여구를 수행하였다. GUI를 통해 윈도우 환경에서 구성하기 위해 MFC(Microsoft Foundation Class)의 멀티플(Mutiple) 다큐멘트(Document)/뷰(View), 즉 MDI 구조를 사용하였다. 어플리케이션에서 사용되는 데이터를 관리하는 다큐멘트와 다큐멘트의 내용을 사용자에게 보여주는 역할과 사용자로부터 발생된 이벤트를 처리하는 부분으로 구성하였다. GUI가 실행되어 메인 쓰레드(Main Thread)가 만들어 지면 모든 데이터베이스 조작들과 모든 다큐멘트/뷰 상호작용을 처리되며다음과 같이 수행하였다. 1) 데스크탑(Desktop)매니저 생성 2) 메시지 버스를 담당하는 메시지 버스 쓰레드를 생성 3) 레지스트리(Registry)의 데이터를 이용하여 설정 4) 데이터베이스 초기화 스토커(Stocker) 그래픽 사용자 인터페이스(GUI)는 기계 조작자가 쉽고 편하게 Material의 저장과 검색을 할 수 있도록 엔진(Engine)르 가지고 통신하는 어플리케이션을 개발하였다.
노치 형상 및 냉각속도에 따른 Zr-2.5Nb 압력관의 DHC거동
김상재,김영석,임경수,김성수,정용무 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.1
The objective of this study is to investigate the delayed hydride cracking (DHC) velocity and the incubation time for the water-quenched and furnace-cooled Zr-2.5Nb tube with the different radius of a notch tip. DHC tests were carried out at constant K_1 of 20 MPa√m and 250℃ on the cantilever beam (CB) specimens subjected to furnace cooling or water quenching after electrolytic charging with 57 or 72 ppm hydrogen, respectively. An acoustic emission sensor was attached to the CB specimens to detect the incubation time before the start of DHC. The shape of the notch tip changed from the fatigue crack to the dull crack with its radius ranging from 0.1 to 0.15 mm. The DHC incubation time increased remarkably with the increasing radius of the notch tip, which appeared more strikingly on the furnace-cooled CB specimens than on the water-quenched ones. However, both furnace-cooled and water-quenched CB specimens indicated little change in the DHC velocity with the radius of the notch tip unless their notch tip exceeded 0.125mm. These results demonstrate that the uncleation rate of hydrides at the notch tip determines the incubation time and the DHC velocity becomes constant after the concentration of hydrogen at the notch tip reaches the terminal solid solubility for dissolution (TSSD). This observation agrees well with Kim's DHC model. A difference in the incubation time and the DHC velocity between the furnace-cooled and water-quenched specimens is discussed in terms of the uncleation rate of hydrides at the notch tip and the hysteresis of hydrogen solubility.
모터링 壓縮壓力 分析을 통한 스파크 點火機關의 動力損失에 관한 硏究
김인태,박경석 경희대학교 산학협력기술연구원 2002 산학협력기술연구논문집 Vol.8 No.-
This study deals with the optimum motor torque that is analyzed ower required starter motor's consumption power and cranking it, with normal compressed condition of engine, compared to measuring compressed pressure by using wattage and pressure sensor consuming which is cranking engine. Compressed pressure measuring method by pressure sensor is able to apply comfortable and quickly mechanical abrasion, or internal performance than its method by existing mechanical type compression pressure gauge, and it can analyze motor's battery condition and starter motor's performance through voltage decent, electric current consumption its cranking. Also, it can find valve airtight badness and valve open-close timing badness through vacuum section wave measurement with cranking. In brief, the objects of this thesis are following. 1. It studies consumption power by compressed pressure resistance of enginecranking. 2. It studies starter motor's consumption power according to decrease of compressed pressure performance. 3. It analyzes and studies compressed pressure manageability of analysis method and internal performance of engine by pression sensor. 4. For cranking, measuring and analyzing requiring voltage and electric current, it analyzes battery condition and starter motor's performance.
김보경,이석훈 충남대학교 1991 忠南科學硏究誌 Vol.18 No.1
This paper studies the schemes to apply the Simulated Annealing algorithm that is used as an optimization stchnique for neural Network as a technique for finding the optimal design of experiments and compares this implemented results with those of Branch and Bound algorithm which completely gurarantees the optimality in order to evaluate their performance. In this comparison, D-optimality is used as a criterion for optimization.
김경남,이서영,석주경 大韓齒科器材學會 1993 대한치과재료학회지 Vol.20 No.2
A primary goal of successful endodontic therapy is the complete obturation of the root canal. The root canal sealer is an extremely important component of the root canal filling in order to achieve three-dimensional obturation of the canal space. All root canal sealers are required to possess certain physical and biological properties included biocompatibility, antimicrobial effect, strength, sealing ability, adequate working and setting times, solubility, and various other characteristics for clinical use. The physical properties of four commercial root canal sealers - AH 26, Nogenol, Sealapex and Tubli-seal-were evaluated in this study. Solubility, dimensional change, fluidity and film thickness were tested according to American Dental Association Specification No. 57 for endodontic filling materials. The results were as follows : 1. Dimensional change of AH 26 was higher than specification. The other tested properties were acceptable. 2. Nogenol showed 17.8mm of fluidity and 60.6㎛ of film thickness. Solubility and dimensional change were not able to evaluate since this material does not set. It seems that this material is not suitable for multiple canal and needs higher skill of manipulation. 3. Sealapex showed suitable fluidity and film thickness. Solubility and dimensional change were not able to evaluate since this material does not set like Nogenol. 4. Tubli-seal showed good properties except solubility. In this study, all materials showed different physical properties. It is important that dentist have to understand all characteristics of paticular root canal sealing materials to achieve better result. Reevaluation of specification for root canal sealer may be recommended from the result of this study.
자일리톨과 탄수화물의 Streptococcus mutans에 대한 효과
김경희,정병초,양규호,오종석 전남대학교 치의학연구소 2002 구강과학 Vol.14 No.1
Xylitol is a 5-carbons carbohydrate, which can be replacedwith sucrose for preventing caries. The replication of Streptococcus mutans and its formation of artificial plaque were studied in the media containing xylitol. The combined effect of xylitol and other carbohydrates on Streptococcus mutans wasalso studied. The replication of Streptococcus mutans was inhibited according to the increased concentration of xylitol.Streptococcus mutans replicated at the initial stage ofincubation in the media containing glucose. fructose of loctose, while replicating from the beginning of incubation in the media containing fructose as combining with xylitol. The formation of artificial plaque by Streptococcus mutans was significantly reduced in the media containing with xylitol and fructose. These results indicated that the replication of Streptococcus mutans was inhibited according to the increased concentration of xylitol, and the formation fo artificial plaque by Streptococcus mutans was significantly inhibited in the media containing xylitol and fructose.