완전 기저 동맥 중복과 동반된 모야모야병(Moyamoya disease) 1예

권준범,양현덕,한범기,이지용,문준식,이성수 대한신경과학회 1999 대한신경과학회지 Vol.17 No.2

수근관 증후군에서의 무증상성 척골신경병증

문준식,이성수,이지용,한범기,권준범,양현덕,이성익 대한신경과학회 1999 대한신경과학회지 Vol.17 No.2

충남대학교 연습림의 산책로 훼손에 관한 연구

이준우,박범진,최윤호 충남대학교 농업과학연구소 1998 농업과학연구 Vol.25 No.1

Three major trails of campus forest in Chungnam National University were selected to investigate the use impacts on environmental deterioration of trail according to the different amount of use. Rook-exposed, root-exposed, deepening, widening, diverged points as the deterioration types of trail which were surveyed at total of 92 points in major trail of campus forest in Chungnam National University. Major deterioration types of trail were widening, rock-exposure, root-exposure, in order of frequency. And trail conditions(trail slope and maximum depth) of deteriorated points were significantly different from those of non-deteriorated points.

수소 자기 공명 분광 영상으로 확인된 후두엽성 중첩성 복합 부분 간질에 의한 뇌신경 세포의 손상

서범천,김옥준,김현숙,최철희,김서현,이병인 대한신경과학회 1999 대한신경과학회지 Vol.17 No.1

제주도 북부연안역의 생물생태학적 기초연구 : 함덕해역의 식물플랑크톤 동태와 일차생산력

이준백,고형범,고유봉,최영찬 제주대학교 해양연구소 1995 해양자원연구소연구보고 Vol.19 No.-

한국산 생열귀나무 (Rosa davurica Pall.) 잎의 생리활성 기능 검색에 관한 연구

김준범,최승필,이득식,함승시 한국식품저장유통학회 ( 구 한국농산물저장유통학회 ) 2004 한국식품저장유통학회지 Vol.11 No.1

생열귀나무의 잎을 시료로 생리활성 기능을 검색하기 위해 메탄올, 에탄올, 클로르포름 및 물 추출물을 조제 하였다. 얻어진 추출물에 대하여 DPPH 자유라디칼 소거법에 의한 항산화성 효과와 S. thphimurium TA98과 TA100을 이용한 항돌연변이원성 효과를 검토하여 다음과 같은 결론을 얻었다. 생열귀나무 잎의 용매별 추출수율은 물 추출물이 24.8%로 가장 높았으며, 그 다음으로는 메탄올 추출물 (21.3%), 에탄올 추출물 (17.0%) 및 클로로포름 추출물 (5.6%) 순으로 높은 수율을 나타내었다. 생열귀나무 잎의 각 추출물의 수소전자공여능 IC_(50)(Inhibition comcentration)을 측정한 결과 물, 메탄올, 에탄올 추출물의 경우 대조구인 butyl-hydroxytoluence, 비타민 C, 알파토코페놀과 유사하게 나타나 항산화 억제효과가 우수한 것으로 나타났다. 생열귀나무 잎의 메탄올 추출물의 항돌연변이 효과는 TA98 균주에 대하여 세 종류의 변이원 물질 모두 농도 증가에 따라 억제율이 증가함을 나타내었으며, 생열귀나무 잎의 클로르포름 추출물 결과는 TA98균주에 대하여 3가지 변이원 물질 모두 농도 증가에 따라 억제율이 증가함을 나타내었다. 생열귀나무 잎의 에탄올 추출물의 경우 TA98 균주에 대하여 200 μg/plate의 농도를 첨가하였을 때 B(α)P에 대해 79.8%의 억제율로 가장 높은 수치를 나타내었고, 생열귀나무 잎의 물 추출물은 TA98 균주에 대하여 200 μg/plate의 농도 첨가에서 B(α)P에 대해 67.2%의 억제율을 보였다. The objective of this study was carried out to investigate biological activities effects of Korean leaf from Rosa davurica Pall, in vitro. They were extracted with methanol, ethanol, chloroform and water. Methods of the antimutagenic used in this experiment were well-known bacterial short term tests which include Ames test and the antigenotoxic used in this experiment was DPPH radical scavenge. All extracts (ethanol, methanol, water) except chloroform extract exhibited 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity with IC_(50) of 11.5 μg/mL, 6.4 μg/mL, 4.8 μg/mL. In Ames test, most of extracts had strong antimutagenic effects against the mutagenesis induced by 4-nitroquinoline-1-oxide (4NQO), N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), 3-amino-1, 4-dimethyl-5H-pyrido[4,3-b]indol(Trp-P-1) and benzo(α)pyrene(b(α)P). The extracts of leaves (200 μg/plate) showed approximately 60~80% inhibitory effect on the mutagenesis induced by 4NQO, Trp-P-1 and B(α)P against TA98 strain, whereas 60~80% inhibition were observed on the mutagenesis induced by MNNG, 4NQO, Trp-P-1 and B(α)P against TA100 strain, respectively.

일부 지역 주민에서 초기 신기능 저하의 지표로서 혈청 Cystatin C 농도의 유용성

원기범,김준섭,박준형,강혁주,이정호 동국대학교 의학연구소 2009 東國醫學 Vol.15 No.2

혈청 cystatin C농도는 혈청 creatinine농도에 비해 신기능을 정확히 반영한다고 알려져 있지만, 대규모 연구 자료가 제한적이었다. 따라서 저자는 다수의 일부 지역 주민을 대상으로 cystatin C를 creatinine과 비교하여 신기능의 지표로서 cystatin C의 유용성을 알아보고자 하였다. 2008년 7월부터 9월까지 포항지역의 건강 검진자 999명 (남자: 324명, 여자: 657명)을 대상으로 혈청 cystatin C, 혈청 creatmine, 나이, 체중을 측정하고, Cockcroft-Gault식으로 사구체 여과율을 계산하였다. 계산된 사구체 여과율을 National Kidney Foundation의 Kidney Disease Outcomes Quality Initiative (KDOQI)에서 제시한 만성 신장병 분류 기준에 따라 5단계로 분류하였지만 4단계 (중증의 사구체 여과율 저하) 및 5단계 (신부전 또는 투석) 에 포함되는 대상자들의 숫자가 적어 (4단계: 4명, 5단계: 1명) 연구 대상에서 제외하였다. 대상자들의 평균 나이는 52.1 ± 17.1 세, 평균 체중은 59.7 ± 11.3 Kg,평균 혈청 cystatin C농도는 0.9 ± 0.2 mg, 평균 creatinine 농도는 1.0 ± 0.2 mg/dL이었다. 사구체 여과율을 각 단계별로 비교해 본 결과는 다음과 같이 혈청 cystatin C농도는 1 단계 (정상 신기능)는 0.8 ± 0.1 mg, 2단계 (경도의 신기능 저하)는 0.9 U 0.1 mg, 3단계 (중등도의 신기능 저하)는 1.0 d=0.1mg로 각각 유의한 차이를 보였다 (p<0.05).혈청 creatinine농도는 1단계는 0.9 ± 0.2 mg/dL, 2단계는 0.9 ± 0.1 mg/dL, 3단계는 1.0 ± 0.1 mg/dL로 l단계와 2단계 간에 차이가 없었으나 (p>0.05), 2단계와 3단계 간에는 유의한 차이를 보였다 (p<0.05).혈청 cystatin C농도와 혈청 creatinine농도는 나이 (cystatin C: r=0.275, p<0.05; creatinine: r=0.300, p<0.05) 및 체중 (cystatin C: r=0.075, P<0.05; creatinine: r=0.162, p<0.05) 과 양의 상관 관계를 보였다. 혈청 cystatin C 농도는 성별 간의 차이가 없었고, 혈청 creatinine농도는 남성에서 유의하게 높았다. 혈청 cystatin C농도는 혈청 creatinine농도에 비해 초기 신기능 저하를 반영하는 유용한 지표라고 생각된다. Although serum cystatin C has been suggested to be a better alternative marker than serum creatinine for estimating renal function, there have been limited data about its superiority over creatinine in a large number of populations. The aim of this study was to evaluate cystatin C as a renal marker compared to creatinine in a large population of the local community. We measured serum cystatin C, creatinine, age, body weight from 999 volunteers (Male; 324, Female; 657) of a single local cohort, Phohang, from July to September, 2008, and then calculated the GFR according to Cockcroft Gault(CG) formula. The population was divided into five stages followed by the chronic renal disease classification presented by KDOQI. The numbers in stage 4 (severe renal impairment), and 5 (renal failure) were too small (4 in stage 4, 1 in stage 5) to perform statistical analysis, so we excluded them. The mean age was 52.1 ± 17.1, and body weight 59.7 ± 11.3 Kg; serum cystatin C 0.9 ± 0.2 mg/L; serum creatmine 1.0 ± 0.2 mg/dL; CG GFR 70.6 ± 19.1 ml/min/1.73 m^(2). The tests completed for the comparison among each stage suggested the following results; serum cystatin C levels in stage 1 (normal renal function), stage 2 (mild deterioration of renal function), and stage 3 (moderate deterioration of renal function) showed the significant differences (stage 1 vs 2: 0.8 ± 0.1 vs 0.9 ± 0.1, p<0.05; stage 2 vs 3: 0.9 ± 0.1 vs 1.0 ± 0.1, p<0.05). Serum creatinine levels showed no significant differences between stage 1 and stage 2 (stage 1 vs 2: 0.9 ± 0.2 vs 0.9 ± 0.1, p>0.05), but showed significant differences between stage 2 and stage 3 (stage 2 vs 3: 0.9 ± 0.1 vs 1.0 ± 0.1, p<0.05). Serum cystatin C and creatinine presented positive correlation between age (cystatin C: r=0.275, p<0.05; creatinine: r=0.300, p<0.05) and body weight (cystatin C: r=0.075, p<0.05; creatinine: r=0.162, P<0.05). Serum cystatin C levels showed no significant difference in sex, but serum creatinine levels were significantly higher in men than women. Serum cystatin C level is suggested to be more useful parameter than serum creatinine level to evaluate early renal impairment.

9.5/65/35 PLZT를 이용한 Color filtering 특성에 관한 연구

宋埈泰,余東勳,李範熙 成均館大學校 科學技術硏究所 1992 論文集 Vol.43 No.1

In this study 9.5/65/35 PLZT was selected which has the excellent quadratic electro-optic property and slim-loop. It was fabricated by the methods of vacuum hot-pressing and sintering. The electrode of color filter was evaporated using the interdigital type masks. They had the ratio of electrode gaps and the specimen thickness which were 1 : 1, 1.5 : 1, 2 : 1, and 2.5 : 1. Its color filtering characteristics were measured in the range of wavelength 380 to 780[nm] and electric field 0 to 15[kV/cm]. The results shows the relationship between the thickness of specimen, the electrode gap and the maximum RGB transmittance.

무등산 도립공원의 개발에 관한 연구

권준오,신광철,이덕범 조선대학교 국토개발연구소 1994 국토개발연구 Vol.14 No.2

Mt. Mudeung is considered as one of the important tourist attractions to satisfy Kwangju citizens as well as tourists so this study on provincial parks shows following suggestions to help the development of tourist resources and the preparation of recreation space. The conclusions are : First, in developing tourist resources, native and available resources should be considered in relation to local characteristics. And then tourist route, space for receation, and paths up the mountain should be provided, in connection with tourist attractions. Second, the landscape ought to be designed in harmony with surrounding natural forests, so that it can show both its unity and variety coming out of characteristics of the space. Third, after grasping functions and characteristics of Mt. Mudeung, the strategy for development should be made. Fourth, experts are required to take care of cultural resources. Firth, as the silent pattern of tour and recreation have changed into active one, resources to developed. Besides, convenience facilities should be repaired and newly made. Sixth, visitors' purpose and motivation show that Mt. Mudeung, provincial park, is being used as a nearby park. Seventh, it is to destory nature and the scenery that Mt. MuDeung provincial park is exploit the openspace of tourism and leisure. Consequently the development of openspace for social tourism and leisure is enough considered with natural environment and it is well planned to don't destory the ecosystem in order to play the important role of developed space and citizen's park.

음이온 리빙중합에 의한 방향족 아민 양말단변성 폴리부타디엔의 합성

전준표,이범재,박상호 忠南大學校 産業技術硏究所 2002 산업기술연구논문집 Vol.17 No.2

Functionalization reaction of poly(butadienyl)lithium with 4,4'-bis(dimethylamino)-benzophenone, 4,4'-bis(diethylamino)benzophenone, 1,1'-bis[(4-dimethylamino)phenyl]ethylene, and 1,1'-bis[(4-diethylamino)phenyl]ethylene in n-heptane provide the corresponding ω-amine chain-end funstionalized polymers in 90∼95% yields. α-Functionalized polybutadienes were prepared by the polymerization using amine functional initiator, which was obtained by the stoichiometric reaction of sec-butyllithium and 1,1'-bis[(4-dimethylamino)phenyl]ethylene, or 1,1'-bis[(4-diethylamino)phenyl]ethylene. Utilizing these two reaction technologies, well-known α,ω-difunctionalized polybutadienes could be synthesized by the polymerization using amine functional initiator followed by chain-end functionalization.