65세 이상 외래 방문환자를 대상으로 한 심전도 소견

하원철,성낙일,김강,이경미,박준형,배준호,나득영 동국대학교 의학연구소 2008 東國醫學 Vol.15 No.1

The electrocardiogram is one of the most widely used diagnostic tools. Especially it is useful to the patients who have cardiovascular disease. Because elderly population are the fastest growing component of national population, I analyzed the frequencies of specific electrocardiogram findings in patients aged 65 years and older living in Gyeong-ju to collecting ECG data. Sinus bradycardia (17.0%) and Left ventricular hypertrophy (25.2%), QT prolongation (30.9%) were the most common abnormalities found in the population as a whole. Left-axis deviation (11.6% vs. 3.1%, p = 0.001) and right bundle branch block (11.9% vs. 4.1%, p= 0.001) were more common in men than women. First-atrioventricular block (2.2% vs. 5.5%, p = 0.025) and T wave abnormalities (4.1% vs. 13.2%, p = 0.001), left ventricular hypertrophy (21.6% vs. 28.0%, p = 0.049) were more common in women. QT prolongation were more common in 75 years and older (26.7% vs. 38.1%, p = 0.001). Left-axis deviation (9.4% vs. 3.9%, p = 0.024) and Right bundle branch blocks (9.8% vs. 3.0%, p = 0.003) were more common in men aged 65~74 years. Left ventricular hypertrophy (20.9% vs. 30.0%, p = 0.025) and T wave abnormalities (4.3% vs. 12.2%, p = 0.002) were more common in women aged 65~74 years. Atrial fibrillation (7.1% vs. 1.1%, p = 0.013) and left-axis deviation 17.6% vs. 2.1%, p = 0.001), Right bundle branch block (17.6% vs. 5.3%, p = 0.001) were more common in men aged 75 years and older. First-atrioventricular block (0% vs. 5.9%, p = 0.020) and T wave abnormalities (3.5% vs. 14.4%, p = 0.008) were more common in women aged 75 years and older. In conclusion, Left ventricular hypertrophy and sinus bradycardia, QT prolongation were most common electrocardiographic findings in as a whole. Left-axis deviation and right bundle branch block, fist-atrioventricular block, T wave abnormalities, QT prolongation were significantly different in age and gender. 심전도는 전 세계적으로 가장 널리 사용되는 진단적 도구로서, 특히 심혈관계 질환이 있는 환자에게 그 유용성이 크다. 현대 사회는 고령화 사회로 노인 인구에 대한 사회적, 의학적 관심이 높다. 이에 본 연구자는 노인 인구에 대한 심전도 자료를 수집하기 위해 동국대 경주 병원 외래 진료실을 방문한 65세 이상 노인 환자 737명을 대상으로 심전도 검사를 시행하였다. 좌심실 비대(25.2%), QT 간격 연장(30.9%)과 동성 서맥(17.0%)을 보인 경우가 가장 많았고, 좌축 편위 (11.6% vs. 3.1%, p = 0.001), 우각 차단(11.9% vs. 4.1%, p = 0.001)의 경우 여자 환자보다 남자 환자에서 빈도가 높았고, 1도 방실 차단(2.2% vs. 5.5%, p = 0.025)과 비정상적인 T파 양상(4.1% vs. 13.2%, p = 0.001), 좌심실 비대(21.6% vs. 28.0%, p = 0.049)의 경우 남자 환자보다 여자 환자에서 빈도가 높았다. 75세 이상 환자 군에서 QT 간격 연장(26.7% vs. 38.1%, p = 0.001)이 65세에서 74세 사이 환자 군에 비해 빈도가 높은 것 외에 유의한 차이는 없었다. 결론적으로 고령 환자에서 비정상적인 심전도 소견으로 좌심실 비대와 QT 간격 연장, 동성 서맥의 빈도가 높았으며 좌축 편위, 우각 차단, 1도 방실 차단 등은 성별, 연령대별로 유의한 차이가 있었다.

외과계 집중치료실에서 입원한 환자에서 APACHE II score의 의의

이영재,이영준,박순태,하우송,정민화,권수인,조영현,권진용,최상경,손신 대한외상학회 1997 大韓外傷學會誌 Vol.10 No.1

This study attempts to evaluate the prognostic value of the APACHE II scoring system in patients of surgical intensive care unit(SICU) and to examine its usefullness in stratifying these patients according to their surgical risk and as a potential aid in making rational and objective treatment decision. The records of 161 patients admitted to the Department of Surgery, Gyeong-Sang National University Hospital between Jan. 1991 and Dec. l995 were reviewed. 1) Of a total of 161 patients, 87 were male, 74 were female, and male to female ratio was 1.71: 1. 2) This group was seen most commonly in the age group of 55-64 which occupied 30.3% of entire group. 3) The distribution of patients according to the etiology were 74 patients(46%) in trauma, 61 patients(37%) iin postop-complication, 26 patients(9%) in others. 4) The distribution of patients according to the APACHE II scores was 9 to 29 point in adm. Day and the most patients was located between 10 and 14 of 62 patient(39%). 5) The length of hospitalization was 9 days in survived patients and 8 days in non-survived patients. The length of hospitalization of 77% of patients in this study was below 10 days. 6) The death rate was 45.45%(73 patient), this patients according to APACHE II scores was 13 to 29, median 19.2 in adm. Day, the most patients was located 20 to 24(20%). Non of the survived patients had the APACHE II score of above 20 points, but all recovered patients were below 13 points. 7) The median APACHE II score in survived patients was 10.52 point at adm. Day and 6.55 point at 5 days after admission. And non-survived patients was 20.25 point at adm. Day and 30.48 point 5 days after admission(p$lt;0.001). 8) Among the patients with low APACHE II score (below 14 points), there was no mortality. But, there was mortality with APACHE II score of above l5 points. We conclude that APACHE II scoring system is useful in measuring the severity of acute disease and predicting the outcome.

In vitro induction effects of Commiphora molmo (Myrrh) extracts on cell migration through anti-inflammatory activity

Hyun Joo Ha(Hyun Joo Ha),Seung-Jae Lee(Seung-Jae Lee),Seon Gyeong Bak(Seon Gyeong Bak),Seung Woong Lee(Seung Woong Lee),Sun Hee Cheong(Sun Hee Cheong) 한국축산식품학회 2020 Food and Life Vol.2020 No.1

Commiphora molmo (Myrrh) contains various biological activities. However, the underlying molecular mechanisms in cells remain unknown. The purpose of this study was to confirm the efficacy of inhibiting nitric oxide (NO) production induced by lipopolysaccharides (LPS) on J774 macrophage cells of myrrh, and additionally regulatory effects of perform wound healing. Further, vascular endothelial growth factor (VEGF), phosphorylation of signal transducer and activator of transcription3 (p-STAT3) and Janus kinase 2 (p-JAK2) levels in macrophage cells were regulated in the presence of myrrh extract. Based on the above results, myrrh is thought to provide basic data on anti-inflammatory properties through interleukin 6 (IL-6) inhibitory activity and regulatory effects of cell migration.

Patient satisfaction before and after occlusal adjustment using a visual analog scale

Ha-Rim Lee,Sun-Haeng Lee,Gyeong-Je Lee 조선대학교 치의학연구원 2023 Oral Biology Research (Oral Biol Res) Vol.47 No.1

This study aimed to identify the most desirable method of occlusal adjustment in patients with occlusal trauma due to occlusal interference by their natural teeth and propose further considerations for occlusal adjustment. Among patients with occlusal interference of natural teeth and resulting occlusal trauma, occlusal adjustment was performed for 71 patients, and a questionnaire was administered to assess the discomfort experienced by the patients before and during treatment. Informed consent was obtained from the patients. The patient’s discomfort before treatment was first examined, and satisfaction after treatment was investigated using the same survey. The questionnaire survey revealed that patients were concerned about the noise and process of the treatment before occlusal adjustment; however, following the treatment, noise was the primary discomfort. Before treatment, women exhibited higher treatment-related anxiety than men; however, no such sex-related difference was observed after treatment. Furthermore, both sexes considered the noise associated with the treatment to cause maximum discomfort, and patients in both the treatment groups assigned high scores for the necessity of occlusal adjustment, sufficient relevant information should be provided to patients to minimize treatment-related anxiety. Moreover, noise management can help improve patient satisfaction with the treatment.

2009 Historical Consideration of Hanji Used as Art Materials

Lee, Ji-Young,Kim, Chul-Hwan,Lee, Young-Rok,Baek, Gyeong-Gil,Lee, Hee-Jin,Gwak, Hye-Jung,Kim, Sung-Ho,Gang, Ha-Ryun Korea Furniture Society 2009 한국가구학회지 Vol.20 No.3

Traditional Korean paper called Hanji using bast fibers from mulberry tree is made through complicated handmade works. This made Hanji very strong and exceedingly durable. Therefore it is said to last a thousand years. Such incomparable features of Hanji come from the unique sheet forming method called ouibalttugi using a bamboo screen. Excellent physical properties of Hanji reflect the wide variety of use, all central to everyday life. Despite its Excellency, the papermaking practice of traditional handmade paper, Hanji, from Korea is little known outside its country. This might be due to public apathy on Hanji in modern times. Without future apprentices dedicated to the craft, the Korean tradition able to make its soul is in danger of extinction in its homeland. Therefore more concern and more affection on Hanji is required immediately. It must be kept in mind that Hanji is our cultural heritage in pride over time.

Evaluation of the zoonotic potential of multiple subgroups of clade 2.3.4.4 influenza A (H5N8) virus

Lee, Yu-Na,Lee, Eun-Kyoung,Song, Byung-Min,Heo, Gyeong-Beom,Woo, Sang-Hee,Cheon, Sun-Ha,Lee, Youn-Jeong 3M Company 2018 Virology Vol.516 No.-

<P><B>Abstract</B></P> <P>Clade 2.3.4.4 H5N8 highly pathogenic avian influenza viruses (HPAIVs) have spread worldwide. Phylogenetic analysis identified two genetic groups of the H5N8 HPAIVs in South Korea; group A evolved further into four subgroups. Here, we examined the zoonotic potential, both in vivo and in vitro, of genetically distinct subgroups of H5N8 HPAIVs isolated in South Korea. When compared with other subgroups, A/mallard/Korea/H2102/2015 (H2102) virus caused relatively severe disease in mice at high doses. In ferrets, all H5N8 viruses replicated restrictively in the respiratory tract and did not induce significant clinical signs of influenza infection. <I>In vitro</I> studies, all viruses displayed a hemagglutinin phenotype that was poorly adapted for infection of mammals, although the H2102 virus exhibited higher replication kinetics at 33°C than the others. Although H5N8 HPAIVs have not yet acquired all the characteristics required for adaptation to mammals, their ability to evolve continuously underscores the need for timely risk assessment.</P> <P><B>Highlights</B></P> <P> <UL> <LI> H2102 HPAIV (H5N8) caused relatively severe disease in mice at high doses. </LI> <LI> All H5N8 viruses replicated restrictively in the respiratory tract of ferrets. </LI> <LI> All H5N8 viruses displayed a HA phenotype that was poorly adapted to mammals. </LI> <LI> H2102 HPAIV (H5N8) showed higher replication kinetics at 33°C than other strains. </LI> <LI> H5N8 HPAIVs have not yet acquired all features required for mammalian adaptation. </LI> </UL> </P>

Tellimoside, a Flavonol Glycoside from Brasenia schreberi, Inhibits the Growth of Cyanobacterium (Microcystis aeruginosa LB 2385)

Lee, Min-Kyung,Park, Hee-Jung,Kwon, Sung-Ho,Jung, Ye-Jin,Lyu, Ha-Na,Lee, Do-Gyeong,Song, Na-Young,Choi, Hong-Keun,Park, Sangkyu,Baek, Nam-In,Lee, Youn-Hyung 한국응용생명화학회 2013 Applied Biological Chemistry (Appl Biol Chem) Vol.56 No.1

Principal components of aquatic plants responsible for inhibiting the growth of Microcystis aeruginosa, a blue-green alga (cyanobacterium) were determined. Methanol extracts of Brasenia schreberi showed strong inhibitory activity against the growth of the cyanobacterium. Two purified flavonoids were afforded through repeated column chromatographies. The compounds were determined as quercetin (1) and quercetin 3-O-(6"-galloyl)-${\beta}$-D-glucopyranoside, tellimoside (2) by the interpretation of spectroscopic data including NMR, MS, and IR. Compounds 1 and 2 were first isolated from Brasenia schreberi. In addition, compound 2 showed very strong inhibitory activity against the growth of M. aeruginosa.

Evidence of Intercontinental Transfer of Avian Influenza Viruses Carrying Nonstructural Allele B Gene Belonged to North American Lineage into Republic of Korea

Sun Ha Cheon,Yu Na Lee,Eun Kyeong Lee,Gyeong Beom Heo,Youn Jeong Lee 대한수의학회 2017 대한수의학회 학술대회발표집 Vol.2017 No.-

블루투스를 이용한 이중링크 음악 전송시스템 개발

이경구(Gyeong-Gu Lee),하동경(Dong-Gyeong Ha),유강주(Grang-Ju Yu),신옥근(Ok-Keun Shin) 한국정보과학회 영남지부 2007 한국정보과학회 영남지부 학술발표논문집 Vol.1 No.1

블루투스 기술에 기반한 무선헤드폰 장치는 음악을 전송하는 송신장치가 근거리에 위치한 단일의 수신측 무선헤드폰 장치에 음악을 전송하는 단일링크 구조로 구성되어 있다. 음악 재생 서비스를 제공하기 위해서는 데이터 전송의 동시성과 연속성이 보장되어야 끊기지 않고 신뢰성이 보장된 서비스를 제공할 수 있다. 따라서 장치들 간의 링크구조가 1:1 단일 구조의 한계성을 가지게 된다. 본 논문에서는 단일의 송신장치가 두 개의 수신장치에 각각의 개별 링크를 설정하여 동일한 음악을 동시에 전송하기 위한 시스템의 구성 방법을 제안하였다. 제안한 방법에서는 시스템의 전송효율을 높이기 위하여 멀티 스레드 처리 기법을 사용하였으며, 블루투스스택 클래스를 구현하였다. 제안한 이중링크 음악전송 시스템의 전송효율을 분석하기 위한 데이터 전송 실험을 통하여 다중링크 음악 전송의 가능성을 확인하였다.

포터블 뇌파 바이오피드백 시스템을 위한 전치증폭기 및 DSP 하드웨어의 설계

이경일 ( Lee Gyeong Il ),안보섭 ( An Bo Seob ),박정제 ( Park Jeong Je ),이승하 ( Lee Seung Ha ),조진호 ( Jo Jin Ho ),김명남 ( Kim Myeong Nam ) 한국센서학회 2003 센서학회지 Vol.12 No.3

본 논문에서는 포터블 뇌파 바이오피드백시스템을 위한 전치증폭부 및 디지털 신호처리부의 하드웨어 구현에 대한 연구를 수행하였다. 뇌파의 특성을 고려하여 외부 잡음을 제거할 수 있는 뇌파 획득용 전치증폭부를 구현하였다. 측정된 뇌파에는 안전도, 근전도, 심전도 등의 신호들이 포함되어 있으며 이들은 뇌파 분석에 방해가 된다. 따라서 이러한 신호들을 제거하기 위하여 적응여파기 알고리듬을 수행하고 전치증폭부를 실시간으로 구동하는 디지털신호처리부를 구현하였다. 시뮬레이션 파형과 실제 뇌파를 적용한 실험결과를 통하여 개발된 시스템의 성능을 확인할 수 있었으며 휴대형 뇌파 바이오피드백 시스템에 적용 가능함을 확인하였다. In this study, we carried out a study for implementation of the pre-amplifier and the digital signal processing part for the potable EEG biofeedback system. As we consider characteristics of the EEG signal, we designed the pre-amplifier to obtain the EEG signal to be reduced noise signal. Because the EEG signal include EOG, EMG, ECG signals etc, it is difficult to analyze of the EEG signal. Therefore, we developed DSP board and operation program which was embed the LMS adaptive filter algorithm and operate with the pre-amplifier in the real time. The simulation signal and pure EEG signal is used in the experiment. As the result, we confirmed good efficiency of developed system and possibility of application to the portable EEG biofeedback system.