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Ursodeoxycholic acid 의 무정형 초미립자제제들의 CCI4 유도 간손상 생쥐에 대한 보호 효과
정한영(Han Young Chung),김애라(Ae Ra Kim),정해영(Hae Young Chung),곽신성(Sin Seung Kwak),최우식(Woo Sik Choi),이지현(Ji Hyoen Lee),박태현(Tae Hyun Park),김유정(You Jung Kim),김현일(Hyun Il Kim) 한국응용약물학회 2002 Biomolecules & Therapeutics(구 응용약물학회지) Vol.10 No.1
N/A The particle size of medicinal materials is an important physical property that affects the pharmaceutical behaviors such as dissolution, chemical stability, and bioavailability of solid dosage forms. The size reduction of raw medicinal powder is needed to formulate insoluble drugs or slightly soluble medicines and to improve the pharmaceutical properties such as the solubility, the pharmaceutical mixing, and the dispersion. The objective of the present study is to evaluate physiological activity of amorphous and nano-particle preparations of insoluble drug, ursodeoxycholic acid (UDCA), which were made by three types of fine grinding mills. The change of physical properties of ground UDCA was conformed by Mastersiger microplus and X-ray diffraction. We have investigated hepatoprotective effects of the nano-particle preparations of UDCA by planetary mill, vibration rod mill and jet mill in CCl_4-induced oxidatively injured mouse liver. The results showed that nano-particle preparations of UDCA all decreased reactive oxygen sepecies generation and lipid peroxidation in CCl_4-induced oxidative stress mice. Among them, nano-particle preparations by vibration rod mill and jet mill showed more significantly hepatoprotective effects compared to intact UDCA and planetary millground UDCA. These results suggest that ground UDCA with vibration rod mill and jet mill shows a high amorphous state and the improved dissolution.
Kwak, Youn-Sig,Han, Ki-Soo,Lee, Jung-Han,Lee, Kyung-Hee,Chung, Woo-Sik,Mysore, Kirankumar S.,Kwon, Young-Sang,Kim, Hee-Kyu,Bae, Dong-Won The Korean Society of Plant Biotechnology 2009 식물생명공학회지 Vol.36 No.3
The hypersensitive reaction (HR) is the most common plant defense reaction against pathogens. HR is produced during both host- and nonhost-incompatible interactions. Several reports suggest that similarities exist between host and nonhost resistances. We assayed the pattern of generation of reactive oxygen species (ROS) and scavenging enzyme activities during nonhost pathogen-plant interactions (Xanthomonas campestris pv. campestris/Capsicum annuum L.) and incompatible host pathogen-plant interactions (Xanthomonas campestris pv. vesicatoria race1/Capsicum annuum L.). Both ${O_2}^-\;and\;H_2O_2 $ accumulated much faster during nonhost resistance when compared to the host resistance. The scavenging enzyme activities of superoxide dismutase (SOD), catalase (CAT) and peroxidase (POX) were also different during the host- and nonhost-incompatible interactions. CAT activity was much higher during nonhost resistance, and several new isozymes of SOD and POX were detected during nonhost resistance when compared to the host resistance. Lipoxygenase (LOX) activity was higher in host resistance than nonhost resistance during the early stages of infection. Interestingly, the nitric oxide (NO) radical accumulated equal amounts during both host and nonhost resistance at early stages of infection. Further studies are needed to determine the specific pathways underlying these differences between host and nonhost resistance responses.
곽효성,한영민,임영수,전수빈,이상용,정경호,김종수,손명희,최기철 의과학연구소 1998 全北醫大論文集 Vol.22 No.1
1. Purpose : To evaluate of the effectiveness of bronchial arterial embolization acdording to the causess of hemoptysis. 2. Materials and methods : This study included 39 patients who had undertaken arterial embolization for the control of hemyptysis. The patinets were classified 1. Purpose: To evaluate of the effectiveness of bronchial arterial embolization according to the causes of hemoptysis. 2. Materials and methods: This study included 39 patients who had undertaken arterial embolization for the control of hemoptysis. The patinets were classified into the three groups: pulmonary tuberculosis (n=22), idiopathic bronchiectasis (n=10), lung cancer (n=7). Gelfoam particle were used as embolized material for all patients. And only for two patients, embolization coil was interpolated. The period of follow-u[ was from 1 to 66 months after arterial embolization. Immediate results were assessed based on careful observation of patients for 1 month after arterial embolization: success, indicating complete cessation of hemoptysis for 1 month: and fail, indicating continued hemoptysis or recurrent hemoptysis within 1 month. Long-term results were evaluated in patients with immediate success who could be followed for at least 1 month. Patients were classified into the three categories: complete remission, indicating complete cessation of bleeding during the observation period : partial remission, indicating complete cessation of hemoptysis with recurrent bloody sputum during the observation period : and recurrence, indicating recurrent hemoptysis. 3. Results : immediate success rate was 76.9%(30/39), and as classified into the causes, idiopathic bronchiectasis 90.0% (9/10), pulmonary tuberculosis 81.8% (18/22), lung cancer 42.9%(3/7). Long-term results in the causes of idiopathic bronchiectasis showed a high remission rate (77.8%), a low recurrence rate (22.2%). In pulmonary tuberculosis, remission rate was 70.8%m recurrence rate was 29.4%. No recurrence was observed in the cases of success of the lung cancer. During and after embolization, the complications were mild chest pain 1 or fever, which relieved spontaneously within a few days. 4. Conclusion : The benign diseases such as pulmonary tuberculosis and idiopathic bronchiectasis showed a high immediate success rate and a high long-term remission rate. The lung cancer showed a low immediate success rate. But during observation period, lung cancer showed no recurrence. (Key Words : Lung, hemorrhage, therapeutic, blockade)
Carotidynia presenting with acute ischemic stroke after carotid sinus massage
Kwak, Hyo Sung,Chung, Gyung Ho,Lee, Chan-Hyuk,Jeong, Seul-Ki,Ryu, Han Uk The Korean Society of Clinical Neurophysiology 2017 Annals of Clinical Neurophysiology Vol.19 No.1
Carotidynia is characterized by unilateral neck pain around the carotid artery. We describe a 50-year-old woman who presented with transient left-side weakness and right-side neck pain. She frequently massaged the uncomfortable neck area during the symptomatic course of the condition. Magnetic resonance imaging revealed multifocal cerebral infarctions and a carotid intramural thrombus ipsilateral to the carotidynia.Long-term carotidynia might result in the involvement of an intramural thrombus and intimal disruption, and ischemic stroke after carotidynia may be provoked by carotid sinus massage.
기니픽 유두근 및 백서 심실 단일세포에서 신약, KR-30818 이 활동전위 및 ATP-sensitive potassium channel에 미치는 효과
정진욱,장미경,정일성,곽용근,채수완,한홍주,김용기,조규박 의과학연구소 1995 全北醫大論文集 Vol.19 No.1
백서 심근세포에서 새로 개발된 혈관 이완제인 KR-30818이 유두근의 활동전위 및 심실근의 단일통로전류에 미치는 영향을 관찰하여 다음과 같은 결과를 얻었다. 1. KR-30818dms 유두근의 활동전위를 농도에 비례하여 단축시켰으며, 이러한 KR-30818의 효과는 glibenclamide 3*10^-^6 M에 의해 거의 차단되었다. 2. Excised inside-out patch에서 run-down 발생전 세포내 ATP 1mM존재시 세포내 KR-30818은 농도에 비례하여 단일통로활성을 증가시켰다. 3. Run-down 발생전 KR-30818은 세포내 ATP농도와 K_A_T_P통로활성간의 용량 반응곡선을 우측으로 평행하게 이동시켰다. 4. Run-down후 KR-30818은 UDP 존재여부에 관계없이 K_A_T_P 통로활성에 영향을 주지 못하였다. 이상의 실험성적으로, 새로 개발된 K_A_T_P통로개구제인 KR-30818은 심근의 ATP-sensitive potassium channel에 대하여 ATP의 억제효과를 경쟁적으로 길항하여 K_A_T_P통로를 개구시키는 것으로 사료된다. Effects of KR-30818((-)-2-hydroxymethyl-2-methyl-4-(2'-oxo-1'-pyrrolidinyl)-6-nitro-2H-1-benzopyran), a newly synthesized vasorelaxant, onaction potential of papillary muscles of guinea pig and ATP-sensitive potassium channel current(I_K_A_T_P) of single ventricular muscle cells of rats were examined. Patch clamp technique was used in excised inside-out patch configuration. 1. KR-30818 casued the shortening of action potential duration in dose-dependent manner, which was inhibited by glibenclamide(3uM). 2. In excised inside-out configurationand 1mM ATP-containing intracellular condition before rundown, KR-30818 dose-dependently activated the cardiac ATP-sensitive K^+ channel. 3. Before run-down, KR-30818 shifted the dose-response relation curve between [ATP] and the K_A_T_P channel activity to th right in parallel. 4. After run-down, KR-30818 did not affect the K_A_T_P channel activity either in the absence or in the presence of 3mM UDP. From the above results, we conclude that KR-30818 antagonized the inhibitory effect of ATP on the K_A_T_P channel in a competitive manner, thereby enhancing the channel openings.
Chung Jun Seong,Kwak Han Deok,Ju Jae Kyun 대한대장항문학회 2022 Annals of Coloproctolgy Vol.38 No.6
Congenital factor V (FV) deficiency is a rare hemorrhagic disorder that can cause excessive bleeding during and after surgery in the affected patient. This report is the case of a patient who had FV deficiency with recurrent posthemorrhoidectomy bleeding treated with the hemostatic procedure and fresh frozen plasma (FFP) transfusions. A 45-year-old male patient had previously undergone hemorrhoidectomy for multiple hemorrhoids at a local hospital. Hemorrhoidectomy was successful; however, he was transferred to our hospital for evaluation of the origin of the recurrent posthemorrhoidectomy bleeding and underwent a hemostatic procedure. This bleeding was treated with coagulation using electrocautery, multiple sutures, and FFP transfusion (1,600 mL/day) for 7 consecutive days. The patient’s plasma FV activity was 23%. Early detection of clotting factor deficiency in patients with hemorrhagic events after surgical treatments may prevent unnecessary procedures such as reoperations and minimize the cost of replacement therapy such as large-volume FFP transfusion.