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Ursodeoxycholic acid 의 무정형 초미립자제제들의 CCI4 유도 간손상 생쥐에 대한 보호 효과
정한영(Han Young Chung),김애라(Ae Ra Kim),정해영(Hae Young Chung),곽신성(Sin Seung Kwak),최우식(Woo Sik Choi),이지현(Ji Hyoen Lee),박태현(Tae Hyun Park),김유정(You Jung Kim),김현일(Hyun Il Kim) 한국응용약물학회 2002 Biomolecules & Therapeutics(구 응용약물학회지) Vol.10 No.1
N/A The particle size of medicinal materials is an important physical property that affects the pharmaceutical behaviors such as dissolution, chemical stability, and bioavailability of solid dosage forms. The size reduction of raw medicinal powder is needed to formulate insoluble drugs or slightly soluble medicines and to improve the pharmaceutical properties such as the solubility, the pharmaceutical mixing, and the dispersion. The objective of the present study is to evaluate physiological activity of amorphous and nano-particle preparations of insoluble drug, ursodeoxycholic acid (UDCA), which were made by three types of fine grinding mills. The change of physical properties of ground UDCA was conformed by Mastersiger microplus and X-ray diffraction. We have investigated hepatoprotective effects of the nano-particle preparations of UDCA by planetary mill, vibration rod mill and jet mill in CCl_4-induced oxidatively injured mouse liver. The results showed that nano-particle preparations of UDCA all decreased reactive oxygen sepecies generation and lipid peroxidation in CCl_4-induced oxidative stress mice. Among them, nano-particle preparations by vibration rod mill and jet mill showed more significantly hepatoprotective effects compared to intact UDCA and planetary millground UDCA. These results suggest that ground UDCA with vibration rod mill and jet mill shows a high amorphous state and the improved dissolution.