당뇨병에 병발한 신모균증 1 예

이상종 ( Sang Jong Lee ),정을순 ( Eul Soon Chung ),김녕중 ( Young Choong Kim ),이시원 ( Si Won Lee ),이원경 ( Won Kyung Lee ),이충식 ( Chung Sik Lee ),이중달 ( Jung Dal Lee ) 대한내과학회 1980 대한내과학회지 Vol.23 No.9

흰쥐에서 Treadmill 훈련에 따른 심근의 적응과 cytochrome oxidase 활성에 관한 세포화학적 연구

최정목,이충식,Choi, Jeung-Mok,Lee, Choong-Sik 한국현미경학회 2001 Applied microscopy Vol.31 No.1

흰쥐를 실험 대상으로 하여 Treadmill 운동을 실시하여 운동에 의한 심근의 적응과 cytochrome oxidase 활성에 관한 세포화학적 연구 알아보고자 실험을 실시하였다. 실험동물은 SD계 웅성 흰쥐를 이용하여 출생 3개월 정도의 체중 $150{\pm}10g$정도로 실험을 시작하였다. 실험군은 일상 대조군과 운동군 2개군으로 나누고, 각각 1일, 3일, 1주일, 4주일, 8주일 및 12주일 동안 각각 4마리씩 운동시켜 실험에 이용하였다. 형태 계측학적 방법으로 심장의 무게변화, 심근섬유와 모세혈관의 비, 그리고 CO 활성정도를 측정하였다. 광학및 전자현미경을 이용하여 관찰한 결과 다음과 같은 결론을 얻었다. 심장무게 변화는 모든 실험군에서 실험기간에 비례하여 증가하였다. 일상 대조군에 비해 운동군에서 유의한 증가를 보였다. 모세혈관과 근섬유 비율은 일상 대조군에서는 유의한 변화가 없었고, 운동군에서는 운동 4주일 이후부터 유의한 증가를 보였다. Cytochrome oxidase C 활성율은 일상 대조군에서는 유의한 변화가 없었고, 운동군에서는 운동 1주일 이후부터 유의한 증가를 보였다. 사립체에 CO활성 형태는 일상 대조군에서는 I형과 III형이, 운동군에서는 실험기간에 비례해서는 II형과 III형이 많이 관찰되었다. 이상과 같은 실험결과들을 미루어볼 때 Treadmill 운동결과 CO의 활성과 심근섬유와 모세혈관의 비율이 운동에 의해 변화를 보여, 흰쥐의 심근에서는 treadmill 운동은 약 4주 정도에서 심장의 적응성이 어느 정도 이루어지는 것으로 사료된다. The present study was to elucidate the cytochemical study on the cytochrome oxidase (CO) activity and myocardial adaptation to treadmill exercise in rat. The three month Sprague-Dowley male $(150{\pm}10g)$ were used in experimental animal. The experimental groups were divided into 2 groups: the normal sedentary group and the treadmill exercise group. On each 1st and 3rd day, 1st, 4th, 8th, and 12th experimental week four rats of each group were sacrificed for tests. The morphometrical measurements were used to evalute the change of heart weight, rate of myocardial fibers to capillaries, and cytochemical study of CO activities, using light and electron microscopy. The results were as follows: The heart weights were more increased in the treadmill exercise group than those of their sedentary group. The rate of myocardial fibers to capillaries were not changed in sedentary group, but those were significantly from 4th weeks in the treadmill exercise group. The CO activity was not changed in sedentary group, but increased in treadmill exercise group after 1 st week. I and III types of CO activity were increased In sedentary group, in contast to II and III types in treadmill exercise group on electron micrographic study. These results suggest that, the treadmill exercise-induced changes in CO activity and rate of myocardial fibers to capillaries appear to be related to exercise, and the adaptive response seems to occurs from 4th week of treadmill exercise.

상부 위장관의 (胃腸管) 위내시경 (胃內視鏡) 검사 2470에 대한 고찰

김인숙,이원경,이충식,이은기,정을순,최용직 ( In Sook Kim,Won Kyung Lee,Choong Sik Lee,Eun Ki Lee,Eul Soon Chung,Yong Gik Choi ) 대한소화기학회 1981 대한소화기학회지 Vol.13 No.2

The endoscopic findings were compared with the radiologic findings and the following results were obtained. 1) In the gastrofiberscopic findings, the main stomach diseases were gastritis, benign ulcer, stomach cancer in order of frequency, and duodenal ulcer, esophageal diseases k bezoars were also noted. In gastritis, chronic superficial gastritis was the most common with 47. 9%. 2) In normal group on gastrofiberscopy, the sex ratio was nearly same and the most fre- quent age group was 6th decade with the incidence of 28. 5%. In gastritis, male to female ratio also was same, and the most common age group was 5 th decade, In gastric ulcer, the sex ratio was 1. G:1 with male preponderance and in age distribution, 5 th was common, while stomach cancer heing 1.3:1 R 6 th decade was the most frequent occurrence. 3) In the advanced stomach cancer, endoscopic gross finding by Bormann's classification was as follows; type g (32.9%), type p (23.1po), type ]I (18.1%), type I (14. 0%). So called early cancer was 4. 5%. 4) In gastric ulcer, the site of lesion revealed that the antrum was the highest frequency (43. 3%), the next was angle (33. 3%), and the body (23. 7%) in order, while in gastric cancer, a e antrum was 40. 7%, the body was 32. 1% and the angle was 27. 2%, 5) In relationship between radiologic and endoscopic findings equality was noted in 79, 3% of gastritis, in 89. 5% of gastric ulcer and in 98. 7%of gastric cancer. 6) Of the total 2470 cases, 1303 cases were associated with other diseases, as follows; liver diseases(24. 7%), anemia(16. 2%), helminthiasis(14%), neurosis(6. S%), pulmonary tuberculosis (6. 7%), 6-U tractinfection (8. 2%), and so on.

실험적인 간암 유발과정에서 Butylated Hydroxytoluene이, 미치는 영향 I : 미세구조적인 연구

최정목,강대영,서광선,이충식,송규상,김진만,박원학,Choi, Jeung-Mok,Kang, Dae-Young,Suh, Kwang-Sun,Lee, Choong-Sik,Song, Kyu-Sang,Kim, Jin-Man,Park, Won-Hark 한국현미경학회 1997 Applied microscopy Vol.27 No.2

A morphologic study on the effect of butylated hydroxytoluene (BHT) on experimental hepatocarcinogenesis induced by 3'-methyl-4-dimethyl aminoazobenzene (3'-MeDAB) was investigated. A total of 110 Sprague-Dowley male rats weighting about 200 g each were used for the experiment, and divided into 4 groups; the 3'-MeDAB, BHT, 3'-MeDAB/BHT treated group, and the control group. Four to eight rats of each group were sacrified on the 4th, 8th, 14th and 16th experimental weeks, with continuous pelletized feeding containing 0.09% 3'-MeDAB and 0.5% BHT. The liver was examined by transmission and scanning electron microscopy. The results were as follows; Electron microscopically, the fine structure of the hepatocytes remained consistently abnormal up to 16 weeks after the 3'-MeDAB treatment. There was no significant difference in the groups observed earlier than in the ones observed later. Many subcellular changes were observed : nuclear change, decreased glycogen, mitochondrial abnormalities, disaggregated rough endoplasmic reticulum, marked proliferation of smooth endoplasmic reticulum, dilatation and distortion of bile canaliculi, increased lysosomes, apoptotic bodies, migration of bile ductule cell. In the BHT treated group, the ultrastructural changes of hepatocytes were not significant, except for the lipid droplets and proliferated smooth endoplasmic reticulum among hepatocytes depending on the experimental duration. The various subcellular changes of 3'-MeDAB/BHT treated groups were simillar to those of the 3'-MeDAB treated group, but the degree of changes in the 3'-MeDAB/ BHT treated group decreased compared with those of the 3'-MeDAB treated group. These results suggest that dietary butylated hydroxytoluene has a protective/inhibitory effect on the hepatocarcinogenesis induced by 3'-methyl-4-dimethyl -aminoazobenzene.

Transferrin Receptors in the Liver Cell Membrane of Carcinogen (3-methyl-4-dimethyl-arninoazobenzene) Treated Rat

이재흔,노의선,허강민,이충식,석정호,Lee, Jae-Heun,Ro, Eu-Sun,Hur, Gang-Min,Lee, Choong-Sik,Seok, Jeong-Ho The Korean Society of Pharmacology 1993 대한약리학잡지 Vol.29 No.1

화학물질에 의한 간암 유발과정에서 transferrin receptor (TfR)의 변동을 밝히기 위해 간을 부분절제한 정상백서의 재생간과 발암물질로 3-Me-DAB를 8주간 투여한 백서 또는 약물 투여 후 부분 간절제 수술을 행하여 세포분열을 유도시킨 백서 간조직으로부터 parenchymal cell (PC)과 nonparenchymal cell (NPC)를 분리하고 각각의 세포막을 제조하여 $^{125}I-transferrin$ 결합실험을 실시한 바 다음과 같은 성적을 얻었다. 1. 3-Me-DAB 투여에 의하여 간조직에서 oval cell의 증식, 재생성 변화, 결절형성, 담관의 증식 및 담관세포암 등의 현저한 조직학적 변화가 동반되었다. 그러나 간세포증식을 더욱 촉진시키기 위하여 부분간절제 수술을 하였을 때 수술 후 경과에 따른 형태학적 변동은 큰 차이가 없었다. 2. 정상 재생간의 PC 및 NPC homogenate에서 transferrin 결합량은 부분간 절제 수술 후 1일 및 3일에 증가되었으며 수술 후 7일에 정상으로 회복되었다. 3-Me-DAB 투여에 의해 두세포군에서 모두 정상세포보다 높게 나타났으며 재생기간에 따라 계속 증가되었다. 3. 정상간의 NPC 세포막에서 transferrin 최대 결합량 (Bmax)은 PC 세포막에서 보다 많이 분포되어 있었으며, Kd는 양세포막에서 5.05 또는 6.3nM로 비슷하였다. 4. 재생간의 NPC 및 PC 세포막에서 transferrin 결합량은 부분 간절제 수술 후 1일 및 3일에 $40{\sim}50%$ 증가되었고 수술 후 7일에 정상치로 회복되었다. 5. 3-Me-DAB 처치에 의하여 NPC 및 PC 세포막의 transferrin 결합량은 정상 간세포막에서 보다 약 3배 증가되었고, 3-Me-DAB 투여후 재생간의 NPC 세포막에서는 부분 간절제 수술 후 3일까지 증가된 후 감소되는 양상인데 반해 PC 세포막에서는 수술 후 7일까지 계속 증가되었다. 6. 3-Me-DAB 투여 후 NPC 및 PC 세포막 transferrin binding site에서 Kd치가 $3.1{\sim}4.1\;nM$과 $25.4{\sim}54.1\;nM$인 두 종류가 존재하는 것으로 나타났다. 이상의 실험성적으로 TfR는 1) 간조직의 PC 및 NPC 세포에 모두 분포되어 있으며, 2) 정상 재생간 및 3-Me-DAB의 처리 후 간세포에서의 세포막 TfR의 증가는 세포내 합성량의 증가에 의하여 일어나며, 3) 정상 재생간의 세포막 TfR는 한 종류의 high affinity site $(Kd,\;<3.1{\sim}7.5\;nM)$에 의하여 증가되나, 3-Me-DAB 처리 후 간세포막에서는 정상에서와 같은 high affinity형 이외에 affinty가 낮은 다른 형태의 TfR $(Kd,\;25.4{\sim}54.1\;nM)$가 세포막으로 출현됨으로써 크게 증가되는 것으로 사료된다. To investigate the alteration of transferrin receptor (TfR) in the proliferating or transformed liver cells, $^{125}I-transferrin$ binding experiment was carried out in the isolated parenchymal cells (PC) or nonparenchymal cells (NPC) from normal regenerated rat liver after partial hepatectomy and from the liver of 3-methyl-4-dimethyl-aminoazobenzene (3-Me-DAB) treated rat. With the administration of 3-Me-DAB for 8 weeks, the liver tissue showed marked morphologic changes of oval cell proliferation, regenerations of hepatocytes, and atypical proliferations of bile ducts, but these changes were little affected by partial hepatectomy. Transferrin binding values in PC or NPC homogenate from the regenerated liver of normal rat, were increased by 3rd day and diminished to control level at 7th day after partial hepatectomy. With the treatement of 3-Me-DAB for 8 weeks, transferrin binding sites in homogenates were higher than those of normal rat liver and increased by 7th day after partial hepatectomy. Transferrin binding sites (Bmax) in the cell membrane of NPC were higher than those of PC of normal rat liver, but there was no significant difference in Kd values between both groups (5.05, 6.3 nM). In the normal resenerated rat liver, transferrin binding sites in the PC or NPC plasma membrane, were increased by 3rd day and diminished to control level at 7th day after partial hepatectomy. With 3-Me-DAB tratment, transferrin binding sites in both liver NPC and PC plasma membrane were increased about 3 folds, compared to those in each plasma membrane of normal rat liver. And after partial hepatectomy of 3-Me-DAB trated rat, transferrin binding sites were increased by the 3rd day in the NPC plasma membrane but increased by the 7th day in the PC plasma membrane. In the transferrin binding sites of the PC or NPC plasma membrane of 3-Me-DAB treated liver, two kinds of Kd values $(3.1{\sim}4.7\;nM,\;25.4{\sim}54.1\;nM)$ were detected. The present results suggest that 1) TfRs are distributed in the liver PC as well as NPC; 2) Increased TfRs in PC or NPC plasma membrane of normal regenerated liver after partial hepatectomy and 3-Me-DAB treated rat liver, may be due to increased intracellular synthesis; 3) Increased TfRs in normal regenerated liver after partial hepatectomy might be related to the expression of a single type of high affinity site $(Kd,\;3.1{\sim}7.5\;nM)$, but in 3-Me-DAB treated rat liver might be related to the expression of high and low affinity types of receptors $(Kd,\;25.4{\sim}54.1\;nm)$.

유제한성 병기의 소세포 폐암에서 3주 간격으로 시행된 irinotecan과 cisplatin을 이용한 과다분할 방사선 동시 요법

이정은 ( Jeong Eun Lee ),박희선 ( Hee Sun Park ),정성수 ( Sung Soo Jung ),김주옥 ( Ju Ock Kim ),조문준 ( Moon June Cho ),김진환 ( Jin Hwan Kim ),이충식 ( Choong Sik Lee ),김선영 ( Sun Young Kim ) 대한결핵 및 호흡기학회 2007 Tuberculosis and Respiratory Diseases Vol.63 No.2

배경: Irinotecan hydrochloride는 topoisomerase I inhibitor로서 소세포 폐암에 효과적인 약제로 알려져 있다. Irinotecan은 cisplatin과 더불어 방사선감작물질로 작용하기도 한다. 본 연구는 이전에 치료받은 경험이 없는 제한성 병기의 소세포 폐암 환자에서 irinotecan과 cisplatin(IP)의 방사선 동시화학요법의 효과를 평가하기 위하여 시행되었다. 방법: 2002년 12월부터 2004년 11월까지 충남대학교 병원에서 새로이 제한성 병기의 소세포 폐암으로 진단된 24명의 환자들을 대상으로 하였다. Irinotecan 60 mg/m2을 제 1일과 제 8일째 투여하였고 cisplatin 60 mg/m2을 제 1일째 투여하였으며 매 3주 간격으로 시행되었다. 제 3차 항암화학요법을 시작하는 날과 동시에 과다 분할방사선 치료(twice-daily thoracic irradiation; 45 Gy total)을 시작하였다. 예방적 전 뇌 방사선 조사(Prophylactic cranial irradiation)가 방사선 동시화학요법이 끝난 후 완전반응(complete response)을 나타낸 환자에서 시행되었다. 제 2차 항암요법과 제 6차 항암요법이 끝난 후에 흉부 전산화 단층촬영과 기관지경 등을 통한 병기의 재평가가 이루어졌다. 결과: 병기의 재평가는 19명의 환자에게 이루어졌다. 중앙 추적관찰기간은 12.5개월이고 전체 99회의 항암치료가 시행되었다. 평균 한 환자당 5.2회의 항암치료가 시행되었다. 실제 용량강도는 cisplatin 19.6 mg/m2/week과 irinotecan 38.2 mg/m2/week이었다. 9명의 환자가 완전반응을 보였고 10명의 환자가 부분반응(partial response)을 보여서 전체 반응률은 95%였다. 3에서 4도의 혈액학적 독성은 백혈구 감소증(35% of cycles), 빈혈(7% of cycles), 혈소판 감소증(7% of cycles) 등으로 나타났다. 3에서 4도의 비 혈액학적 독성은 설사(5% of cycles)였다. 3에서 4도의 방사선 식도염(10% of patients)을 제외하고는 과다 분할 방사선 치료를 이용한 방사선 동시 화학요법의 기존의 방법과 독성 면에서는 큰 차이가 없었다. 치료와 관련된 사망은 관찰되지 않았다. 평가가 가능한 환자들에서 1년 생존율과 2년 생존율은 각각 89% (16/18)와 47% (9/18)였다. 결론: 3주 간격으로 시행된 irinotecan과 cisplatin을 이용한 과다분할 방사선 동시 요법은 제한성 병기의 소세포 폐암 환자에서 부작용은 높지 않으면서 효과적인 치료법으로 고려될 수 있을 것이다. (Tuberc Respir Dis 2007; 63: 154-164) Background: Irinotecan hydrochloride, a topoisomerase I inhibitor, is effective against small-cell lung cancer. Irinotecan also can act as a potential radiation sensitizer along with cisplatin. To evaluate efficacy and toxicity of irinotecan plus cisplatin (IP) with concurrent thoracic radiotherapy, we conducted a phase II study of IP followed by concurrent IP plus hyperfractionated thoracic radiotherapy in patients with previously untreated limited-stage small-cell lung cancer. Methods: Twenty-four patients with previously untreated small-cell lung cancer were enrolled onto the study since November 2004. Irinotecan 60 mg/m2 was administered intravenously on days 1 and 8 in combination with cisplatin 60 mg/m2 on day1 every 21 days. From the first day of third cycle, twice-daily thoracic irradiation (total 45 Gy) was given. Prophylactic cranial irradiation was given to the patients who showed complete remission after concurrent chemoradiotherapy. Restaging was done after second and sixth cycle with chest CT and/or bronchosocpy. Results: Up to November 2004, 19 patients were assessable. The median follow-up time was 12.5 months. A total of 99 cycles (median 5.2 cycles per patient) were administered. The actual dose intensity values were cisplatin 19.6 mg/m2/week and irinotecan 38.2 mg/m2/week. Among the 19 patients, the objective response rate was 95% (19 patients), with 9 patients (47%) having a complete response (CR). The major grade 3/4 hematological toxicities were neutropenia (35% of cycles), anemia (7% of cycles), thrombocytopenia (7% of cycles). Febrile neutropenia was 4% of cycles. The predominant grade 3/4 non-hematological toxicities was diarrhea (5% of cycles). Toxicities was not significantly different with concurrent administration of irinotecan and cisplatin with radiotherapy, except grade 3/4 radiation esophagitis (10% of patients). No treatment-related deaths were observed. The 1-year and 2-year survival rate of eligible patients was 89% (16/18) and 47% (9/18), respectively. Conclusion: Three-week schedule of irinotecan plus cisplatin followed by concurrent IP plus hyperfractionated thoracic radiotherapy is an effective treatment for limited disease small-cell lung cancer, with acceptable toxicity.

가토 동맥에서의 Endothelial Nitric Oxide Synthase

성갑규(Gap Kue Sung),이충식(Choong Sik Lee),유재현(Jae Hyeon Yu),김재(Jei Kim),전병화(Byeong Hwa Jeon) 한국지질동맥경화학회(구 한국지질학회) 2000 韓國脂質學會誌 Vol.10 No.2

N/A N/A

Phase II Study of Induction Irinotecan + Cisplatin Chemotherapy Followed by Concurrent Irinotecan + Cisplatin Plus Twice-Daily Thoracic Radiotherapy

이정은,박희선,정성수,김주옥,조문준,김진환,이충식,김선영,Lee, Jeong Eun,Park, Hee Sun,Jung, Sung Soo,Kim, Ju Ock,Cho, Moon June,Kim, Jin Hwan,Lee, Choong Sik,Kim, Sun Young The Korean Academy of Tuberculosis and Respiratory 2007 Tuberculosis and Respiratory Diseases Vol.63 No.2

배경: Irinotecan hydrochloride는 topoisomerase I inhibitor로서 소세포 폐암에 효과적인 약제로 알려져 있다. Irinotecan은 cisplatin과 더불어 방사선감작물질로 작용하기도 한다. 본 연구는 이전에 치료받은 경험이 없는 제한성 병기의 소세포 폐암 환자에서 irinotecan과 cisplatin(IP)의 방사선 동시화학요법의 효과를 평가하기 위하여 시행되었다. 방법: 2002년 12월부터 2004년 11월까지 충남대학교 병원에서 새로이 제한성 병기의 소세포 폐암으로 진단된 24명의 환자들을 대상으로 하였다. Irinotecan $60mg/m^2$을 제 1일과 제 8일째 투여하였고 cisplatin $60mg/m^2$을 제 1일째 투여하였으며 매 3주 간격으로 시행되었다. 제 3차 항암화학요법을 시작하는 날과 동시에 과다 분할방사선 치료(twice-daily thoracic irradiation; 45 Gy total)을 시작하였다. 예방적 전 뇌 방사선 조사(Prophylactic cranial irradiation)가 방사선 동시화학요법이 끝난 후 완전반응(complete response)을 나타낸 환자에서 시행되었다. 제 2차 항암요법과 제 6차 항암요법이 끝난 후에 흉부 전산화 단층촬영과 기관지경 등을 통한 병기의 재평가가 이루어졌다. 결과: 병기의 재평가는 19명의 환자에게 이루어졌다. 중앙 추적관찰기간은 12.5개월이고 전체 99회의 항암치료가 시행되었다. 평균 한 환자당 5.2회의 항암치료가 시행되었다. 실제 용량강도는 cisplatin $19.6mg/m^2$/week과 irinotecan $38.2mg/m^2$/week이었다. 9명의 환자가 완전반응을 보였고 10명의 환자가 부분반응(partial response)을 보여서 전체 반응률은 95%였다. 3에서 4도의 혈액학적 독성은 백혈구 감소증(35% of cycles), 빈혈(7% of cycles), 혈소판 감소증(7% of cycles) 등으로 나타났다. 3에서 4도의 비 혈액학적 독성은 설사(5% of cycles)였다. 3에서 4도의 방사선 식도염(10% of patients)을 제외하고는 과다 분할 방사선 치료를 이용한 방사선 동시 화학요법의 기존의 방법과 독성 면에서는 큰 차이가 없었다. 치료와 관련된 사망은 관찰되지 않았다. 평가가 가능한 환자들에서 1년 생존율과 2년 생존율은 각각 89% (16/18)와 47% (9/18)였다. 결론: 3주 간격으로 시행된 irinotecan과 cisplatin을 이용한 과다분할 방사선 동시 요법은 제한성 병기의 소세포 폐암 환자에서 부작용은 높지 않으면서 효과적인 치료법으로 고려될 수 있을 것이다. Background: Irinotecan hydrochloride, a topoisomerase I inhibitor, is effective against small-cell lung cancer. Irinotecan also can act as a potential radiation sensitizer along with cisplatin. To evaluate efficacy and toxicity of irinotecan plus cisplatin (IP) with concurrent thoracic radiotherapy, we conducted a phase II study of IP followed by concurrent IP plus hyperfractionated thoracic radiotherapy in patients with previously untreated limited-stage small-cell lung cancer. Methods: Twenty-four patients with previously untreated small-cell lung cancer were enrolled onto the study since November 2004. Irinotecan $60mg/m^2$ was administered intravenously on days 1 and 8 in combination with cisplatin $60mg/m^2$ on day1 every 21 days. From the first day of third cycle, twice-daily thoracic irradiation (total 45 Gy) was given. Prophylactic cranial irradiation was given to the patients who showed complete remission after concurrent chemoradiotherapy. Restaging was done after second and sixth cycle with chest CT and/or bronchosocpy. Results: Up to November 2004, 19 patients were assessable. The median follow-up time was 12.5 months. A total of 99 cycles (median 5.2 cycles per patient) were administered. The actual dose intensity values were cisplatin $19.6mg/m^2$/week and irinotecan $38.2mg/m^2$/week. Among the 19 patients, the objective response rate was 95% (19 patients), with 9 patients (47%) having a complete response (CR). The major grade 3/4 hematological toxicities were neutropenia (35% of cycles), anemia (7% of cycles), thrombocytopenia (7% of cycles). Febrile neutropenia was 4% of cycles. The predominant grade 3/4 non-hematological toxicities was diarrhea (5% of cycles). Toxicities was not significantly different with concurrent administration of irinotecan and cisplatin with radiotherapy, except grade 3/4 radiation esophagitis (10% of patients). No treatment-related deaths were observed. The 1-year and 2-year survival rate of eligible patients was 89% (16/18) and 47% (9/18), respectively. Conclusion: Three-week schedule of irinotecan plus cisplatin followed by concurrent IP plus hyperfractionated thoracic radiotherapy is an effective treatment for limited disease small-cell lung cancer, with acceptable toxicity.

차량 내비게이션 표본자료를 이용한 통행수요 패턴 분석

박경선(Park, Kyoung Seon),남대식(Nam, Dai Sik),이충식(Lee, Choong Shik),천승훈(Cheon, Seung Hoon),김현명(Kim, Hyun Myung) 대한교통학회 2015 대한교통학회 학술대회지 Vol.73 No.-

현재 교통 계획 및 수요 분석에서 기종점간 통행량 자료(OD matrix)는 필수 요소이다. OD의 추정은 가구통행 실태조사 등의 샘플 조사를 통해 이루어지는데, 비용제약으로 많은 샘플을 확보하기 어려운 단점이 있다. 이에 분석데이터의 정확도에 대한 많은 논쟁이 있어왔다. 이러한 자료상 문제를 극복하기 위해 다양한 연구가 계속되고 있으나 통행자들의 실제 통행수요 패턴을 정확히 반영하지 못하고 있다. 하지만 최근 정보통신 기술이 발전하면서 교통계획 연구에서 활용할 수 있는 차량 내비게이션 자료가 장기간 반복적 으로 수집되고 이를 통해 신뢰성 있는 통행수요의 패턴 분석이 가능해지게 되었다. 따라서 본 연구에서는 차량 내비게이션 표본자 료를 이용하여 국가교통데이터베이스 OD의 정확도 평가 및 표본 OD 전수화 기법을 개발하고 통행 수요량 및 통행수요 패턴 분석 을 실시하였다. 본 연구를 시작으로 차량 내비게이션 자료는 향후 교통수요 OD 구축 및 검증 등 다양한 교통계획 분야에서 활용도 가 높아질 것으로 기대된다.

위선종과 위암에서 면역조직화학적 염색을 이용한 p53 단백 발현율의 비교

김진희(Jin Hee Kim),서광식(Kwang Sik Seo),김성걸(Seong Gul Kim),임의혁(Euyi Hyeog Im),육은주(Eun Ju Yook),정현용(Hyun Yong Jeong),이헌영(Houn Young Lee),김영건(Young Kun Kim),이충식(Choong Sik Lee) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.5

N/A Backgrounds: The mutation of p53 gene and p53 protein accumulation is discovered in dysplasia of stomach and gastric cancer. We compared p53 protein expression rate with gastric adenoma and gastric cancer using the immunohistochemical stain and tried to know the correlation of the malig- nant potential of gastric adenoma with p53 protein expression. Methods: We obtained 52 tissues from 22 gastric cancers and 30 gastric adenomas. Accumulation of p53 protein was detected by immunohistochemistry using Anti-Human p53 monoclonal antibody(Pab 1801; Pharmingen). Results: p53 immunoreactivity was detected in 33.3% of gastric adenomas and in 59.l% of gastric cancers. But, threre was no significant difference between two groups(p=0.065). The rate of p53 expression according to various stages, differentiations, cell types in gastric cancers was not significantly different. Also, p53 expression rate according to cell types, size in gastric adenomas showed no significant difference. Conclusions: We suggest that mutation of the p53 gene is an early event in stomach tumorigenesis. But there is to be required more research about the correlation of the malignant potential of gastric adenoma with p53 protein expression. (Korean J Gastroenterol 1995;27: 509 - 516)