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신생흰쥐의 알콜성 뇌손상 후 환경강화가 BDNF 발현 및 운동수행력에 미치는 영향
이선민,구현모,김진상,Lee Sun-Min,Koo Hyun-Mo,Kim Jin-Sang 대한물리치료학회 2003 대한물리치료학회지 Vol.15 No.3
Alcohol exposure during development leads to significant long-term neurobehavior dysfunction and central nervous system alteration. The purpose of this study was to determine the effects of enriched enviroment in developmental period through motor behavior test and expression of BDNF. Neonatal rat exposed to alcohol on postnatal days 4 through 10 were studied. Female Sprague-Dawley pups were assigned to two groups. Experimental group(EG) via 4.5 g kg-1day-1 of ethanol was housed in enriched enviornment for 9 weeks. The main result of this study were as follows: 1. There was significant difference in the mean of weight change between control and experimental group. 2. In motor behavior test, there was significant difference in the mean of weight change between control and experimental group. 3. Regarding the immunoreactivity of BDNF were higher appeared experimental group than control group. In conclusion, the present results reveals that enriched enviroment in developmental period is to be extremely useful in neuronal reprganization and motor behavior improvement after alcohol exposure.
흰쥐의 피부화상 후 저강도 레이저 조사가 표피성장인자의 발현에 미치는 영향
이선민,구현모,남기원,김석범,김진상,Lee Sun-Min,Koo Hyun-Mo,Nam Ki-Won,Kim Souk-Boum,Kim Jin-Sang 대한물리치료학회 2002 대한물리치료학회지 Vol.14 No.3
This study was performed to investigate the effect of low power laser irradiation on epidermal growth factor(EGF) expression in the burned skin of the rats. Burns of about 3cm in diameter were created with 75'c water on the back of the rats, and the lesion of experimental group were irradiated on days 1, 2, and 3 postwounding. Control tensions were not irradiated. After burns, low power laser irradiation was applied by using 1000Hz, 830nm GaAlAs (Gallium-aluminum- arsenide) semiconductor diode laser. The expression of epidermal growth factor evaluated immunohistochemistry on mouse anti-EGF. The results of this study were as follows 1. In expression of EGF, the lesion of experimental group made EGF to more induce significantly than control tensions. 2. EGF immunoreactivity in burned skin were increased markedly 3 days after burns, and increased gradually from 1 day to 2 days in burns which is laser irradiation These data suggest that low power laser have wound healing effect in the burned skin of the rats.
이선민,최병숙,Lee, Sunmin,Choi, Byungsook 한국주거학회 2014 한국주거학회 논문집 Vol.25 No.3
The purpose of this study is to identify the relationship between the physical environment and mental health of the adolescents in urban and rural areas. This study was performed using the questionnaire survey method. The research subjects were high school students in Seoul and Jeollabuk-do rural areas. The questionnaire inquired about the housing, neighborhood, and school environments, and these contents were depended on previous studies. The survey was conducted from August 27 to September 6, 2013, and 446 data were collected. They were analyzed with the SPSS 12.0 program. The main results are as follows. 1) The urban adolescents evaluated physical environment to be better than rural adolescents. Specifically, the urban adolescents evaluated 'facility/accommodation', 'security/health', 'amenity' of the housing environment, 'disorder', 'comfortability', 'nature awareness' of the neighborhood environment, and 'noise', 'overcrowding', and 'security' of the school environment to be higher. 2) The urban adolescents' self-esteem was significantly higher than rural ones. 3) The physical environment factors, which had effects on adolescents' mental health, are different depending on the areas, and so adolescents' physical environment would be designed by the local environment conditions.
이선민,Mina Lee,Eun Ji Lee,김래온,Yong-Duk Kim,권겸일 대한파킨슨병및이상운동질환학회 2023 Journal Of Movement Disorders Vol.16 No.1
Nineteen (50%) patients with high SCOPA-AUT scores above median value (12.5) were assigned into the PD-HSAS group and others were assigned to the PD-LSAS group. Compared with the PD-LSAS group, the PD-HSAS group exhibited slower gait, shorter stride, decreased cadence, increased double support phase, decreased swing phase, and increased variability in swing time. Total SCOPA-AUT score showed significantly positive correlations with gait variability and instability but a negative correlation with gait hypokinesia. In subdomain analysis, urinary dysautonomia was highly associated with impairment of gait dynamics. All significant results were found to be more remarkable in backward gait than in forward gait.
기울기 프로파일을 이용한 일괄처리 방식 지형참조항법의 성능 개선
이선민(Sun Min Lee),유영민(Young Min Yoo),이원희(Won Hee Lee),이달호(Dal Ho Lee),박찬국(Chan Gook Park) 제어로봇시스템학회 2012 제어·로봇·시스템학회 논문지 Vol.18 No.4
In this paper, we analyzed the navigation error of TERCOM (TErrain COntour Matching), which is TRN (Terram Referenced Navigation) batch processing, caused by scale factor error of radar altimeter and proved the possibility of false position fix when we use the TERCOM’s feature matching algorithm. Based on these, we proposed the new TRN batch processing algorithm using the slope measurements of terrain. The proposed technique measures on periodic changes in the slope of the terrain elevation profile, and these measurements are used in the feature matching algorithm. By using the slope of terrain data, the impact of scale factor errors can be compensated. By simulation, we verified improved outcome using this approach compared to the result using the conventional method.
이세영(Seyoung Lee),이선민(Sunmin Lee),이용우(Yongwoo Lee),이제희(Jehee Lee) 한국컴퓨터그래픽스학회 2021 한국컴퓨터그래픽스학회 학술대회 Vol.2021 No.7
우리는 단일 모션 클립에서 매개 변수화된 모션 집단을 학습하는 새로운 알고리즘을 제시한다. 각 동작은 심층정책 네트워크로 표현되며, 연속적인 동작 공간을 탐색하여 사용자 입력 및 환경 상호 작용에 대응하여 물리 시뮬레이션 상에서 모션을 생성한다. 모션 매개 변수화와 동작 추적의 동시 학습은 학습된 모터 기술의 성능과 시각적 품질을 크게 향상시킨다. 우리는 매우 역동적인 동작들을 작업 목표, 신체 비율, 물리적 수치 및 환경 조건에 대해 매개 변수화하여서 알고리즘의 유연성을 입증했다.
고악성도 신경아교종의 수술 후 방사선 치료 성적과 예후인자 분석
이선민(Sun Min Lee),박영제(Young Je Park),윤원섭(Won Sup Yoon),이석(Suk Lee),양대식(Dae Sik Yang),정용구(Yong Gu Jeong),김철용(Chul Yong Kim) 대한방사선종양학회 1992 Radiation Oncology Journal Vol.10 No.1
Purpose: To analyze the postoperative radiotherapy results and prognostic factors in patients with WHO grade 3 and 4 gliomas. Materials and Methods: A total of 99 patients with malignant gliomas who underwent postoperative radiotherapy between 1988 and 2007 were enrolled in this study. Total resections, subtotal resections (≥50%), partial resections (<50%), and biopsies were performed in 16, 38, 22, and 23 patients, respectively. In total there were 32, 63 and 4 WHO grade 3, 4, and unspecified high grade gliomas, respectively. The biologically equivalent dose was in the range of 18.6 to 83.3 Gy10 (median dose, 72.2 Gy10). We retrospectively analyzed survival rate, patterns of failure, prognostic factors, and adverse effects. Results: The median follow-up time was 11 months and there were 54 patients (54.5%) with local failure. The one and 2-year survival rates were 56.6% and 29.3%, respectively, and the median survival duration was 13 months. The one and 2-year progression-free survival rates (PFS) were 31.3% and 18.2%, respectively, and the median PFS was 7 months. The prognostic factors for overall survival were age (p=0.0001), surgical extents (subtotal resection, p=0.023; partial resection, p=0.009; biopsy only, p=0.002), and enhancement of tumor in postoperative imaging study (p=0.049). The factors affecting PFS were age (p=0.036), tumor enhancement of the postoperative imaging study (p=0.006). There were 3 patients with grade 3 and 4 side effects during and after radiotherapy. Conclusion: In addition to age and surgical extents, tumor enhancement of the postoperative imaging study was included in the prognostic factors. The most common relapse patterns were local failures and hence, additional studies are needed to improve local control rates. 목 적: WHO 등급 3/4의 신경아교종 환자에서 수술 후 방사선 치료의 결과와 예후인자를 분석하였다. 대상 및 방법: 1988년부터 2007년까지 수술 후 고악성도 신경아교종으로 확진된 환자들 중 방사선 치료를 시행한 99명을 대상으로 하였다. 나이는 18∼77세(중앙값, 51세), 남, 여가 각각 55, 44명이었다. 수술은 완전절제, 아전절제(50% 이상 절제), 부분절제(50% 미만 절제), 조직검사만 시행한 예가 각각 16, 38, 22, 23명이었고, WHO 등급 3, 4, 기타(unspecified high grade glioma)가 각각 32, 63, 4명이었다. 방사선 치료는 1.8 또는 2 Gy 통상 분할치료 혹은 1.2 또는 1.5 Gy 하루 2회 치료 방법으로 하였고 중앙 생물학적 등가선량은 72.2 Gy10 (18.6∼83.3 Gy10)였다. 동시항암화학방사선치료나 연속화학방사선요법을 적용한 환자가 49명이었다. 환자들의 생존율 및 실패양상, 예후인자, 부작용에 대해 후향적으로 분석하였다. 결 과: 대상 환자의 중앙 추적 관찰기간은 11개월이었다. 국소치료 실패한 환자가 54명(54.5%)이었고, 이중 12명(22.2%)은 방사선치료부위 밖의 병변 진행을 동반하였다. 전체 생존율은 1년 56.6%, 2년 29.3%였고, 중앙생존기간은 13개월이었다. 무진행생존율은 1년, 2년이 각각 31.3%, 18.2%였으며, 중앙생존기간은 7개월이었다. 전체생존율에 영향을 미치는 인자로는 나이(p=0.0001), 수술 절제 정도(완전절제를 기준으로, 아전절제 p=0.023, 부분절제 p=0.009, 조직생검 p=0.002), 수술 후 영상검사에서 조영증가 여부(p=0.049)였다. 무진행생존율에 영향을 미치는 인자는 나이(p=0.036)와 수술 후 영상검사에서 조영증가 여부(p=0.006)였다. 방사선치료중과 후에 3등급 이상의 부작용이 각각 3명과 1명에서 발생하였다. 결 론: 나이, 수술절제 정도, 수술 후 영상검사에서 조영증가 여부가 생존율에 유의한 요인으로 분석되었다. 국소 치료실패가 대부분을 차지하여, 국소 제어율 향상을 위한 추가적인 연구가 필요할 것이다