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( Christoph Sarrazin ),( Mark S. Sulkowski ),( Preethi Krishnan ),( Rakesh Tripathi ),( Gretja Schnell ),( Yan Xie ),( Daniel E. Cohen ),( Roger Trinh ),( Lino Rodrigues-jr. ),( Yan Luo3,Nancy S. Shul 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: The 3 direct-acting antiviral (3-DAA) regimen of ombitasvir, ritonavir-boosted paritaprevir and dasabuvir ± RBV is approved in the US and EU for treatment of hepatitis C virus (HCV) genotype (GT) 1 infection. Baseline resistance associated variants (RAVs) in HCV NS3 or NS5A can impact response to other DAA regimens; we assessed the prevalence and impact of RAVs on response to the 3-DAA regimen. Methods: Next-generation sequencing (Illumina MiSeq) assessed baseline samples from treatment-naive (PEARL-IV), -experienced (SAPPHIRE- II), or cirrhotic (TURQUOISE-II) GT1a patients who received 3-DAA + RBV, and treatment-experienced (PEARL-II) or cirrhotic (TURQUOISE-III) GT1b patients who received 3-DAA alone. Thresholds of 1 and 15%, respectively, detected the prevalence and impact of baseline RAVs; impact of RAVs conferring ≥ 5-fold resistance to components of the 3-DAA regimen on response was determined by com- paring SVR rates in patients with or without RAVs. Results: SVR rates were 96% and 100% in patients with GT1a and GT1b, respectively. One or more NS5A RAVs were present in 11% of treatment-experienced or cirrhotic GT1a patients, whereas NS5A RAVs were found in 19% of GT1b patients (15% threshold). Similar SVR rates were seen in GT1a patients with or without NS5A RAVs. All GT1b patients with NS5A RAVs, including at position Y93, achieved SVR. NS3 RAVs were uncommon (≤2%). NS3 RAVs were not seen in any of the 14 virologic failures and an NS5B RAV was seen in 1 virologic failure. The presence of the GT1a NS3 Q80K polymorphism had no impact on SVR. Conclusions: Understanding impact of baseline NS5A RAVs on treatment outcomes is important for relevant HCV therapies. Patients with HCV GT1a-infection treated with the 3-DAA regimen + RBV achieved high SVR rates, regardless of the presence of baseline RAVs. All GT1b patients treated with the 3-DAA regimen alone achieved SVR.
문정순,최경혜 외3명 國軍看護士官學校 2000 국군간호사관학교논문집 Vol.19 No.-
The aims of this study is 1) to identify how many senior nursing students would volunteer to be a nursing officer 2) to know what is their most desired job and which factors are considered to choose a job the most 3) to investigate their recognition level of nursing officers 4) to study how differently the military nursing cadet would cope with the war situation from the nursing students who did not volunteer to be a nursing officer, and the nursing students who volunteered 5) to investigate what are the differences in value view showed by cadets, non-volunteers and volunteers. The subjects were 1157 senior nursing students attending at 4-tear nursing schools and 82 senior cadets of the AFNA. The data were collected form May 24, 2000 to June 24, 2000. The questionnaire was composed of 5 factors of value, which are G.D. Spindler's value view scale. The data were analyzed with the descriptive statistics, χ² test and ANOVA by means of SPSS/WIN 8.0. The results were as follows; 1) 14 respondents (1.21%) reported that they would apply to be a nursing officer. 2) there was a significant difference in general characteristics such as high school records and college credits. In their high school records, mean score for nursing cadets was 4.66, non-volunteer 3.63 and volunteer 3.07. In their college credits, mean score for nursing cadets was 4.07, non-volunteer 4.02 and volunteer 3.64. Interestingly, nursing cadets demonstrate significantly higher mean high school records than the others(p<009.). 3) Eighty percent(860 persons) considered the most desired job as a clinical field while 7.9% considered community health, 4.3% graduate school and 2.2% another job respectively. 4) Non-volunteered reported that the first consideration for a job was prospectiveness in 45.1%, payment in 17.5%, and occupational stability in 16.3%. Volunteered respondents reported that the most consideration for a job was occupational stability in 28.6%, prospectiveness and social reputation in 21.4%.
논문 : 2011년 아프리카 민족들에 대한 유럽과 북미 정부들의 합의된 공격이 이루어지는 동안 유럽과 북미의 인텔리겐치아에게 고함
쿰마엔둠베3 ( Kumaa Ndumbe3 ),정지은 한국정치평론학회 2011 정치와 평론 Vol.9 No.-
1884년 유럽의 제국주의 열강들이 베를린에 모여 아프리카에 대한 영향권 분배를 합의했듯이, 2011년 현재 다시 베를린에서 북대서양조약기구(Nato)는 아프리카에 대한 서구의 공격을 결정한다. 유럽-북미의 아프리카에 대한 착취의 열망은 식민주의 이후에도 끊임없이 자행되고 있으며, 윤리, 도덕, 진리에 대립되는 이들의 폭력은 서구의 인텔리겐치아들에 의해 다시 각색되고 있다. 유럽의 인텔리겐치아들이 아프리카인들을 ``야만의 민족``으로, 또 아프리카를 신이 내려준 유럽의 소유물로 간주하고 식민화를 정당화 한 것처럼, 이제 서구는 자신들의 탐욕을 ``민주주의,`` ``자유``와 ``발전``라는 용어를 빌어 타민족에 대한 학살과 지배를 정당화하고 있다. 서구 언론은 자원 확보와 세계패권을 위한 아프리카 공격의 진실은 함구한 채 세계여론을 주도하며 세계시민의 눈과 귀를 막고 있으며, 아프리카인들의 목소리는 세계로 전달되지 않는다. 이제 유럽-북미는 휴머니티라는 공공의 운명을 실현시키는데 실패하고 말았다. 서구의 아프리카 침탈은 더 이상 참을 수 없는 지경에 와있음을 아프리카인인 필자는 서구의 언어로 경고하며, 유럽과 북미의 지성인들에게 이 글을 통해 책임을 다할 것을 촉구하고 있다. L`OTAN, en cette annee de 2011, decide avec les pays occidentaux l`agression des pays africains de meme qu`en 1884 les grandes puissances imperieuses de l`europe se sont reunies pour la concertation du partage de leurs droits sur le continent africain. L`ambition d`exploitation de la ressource africaine continue meme apres la fin de la colonisation et la violence des pays occidents qui trahit l`ethique, la morale et la verite est deformee encore par l`intelligentsia occidental. Les occidentaux justifient en ce moment la tuerie et la domination sur les autres peuples au nom de la "democratie," de la "liberte" et du "progres" de meme qu,en passe, les intelligentsias europeens ont justifie la colonisation en appelant les peuples africains "peuples barbares" ou en considerant l`afrique comme propriete donnee a eux par Dieu. Les medias occidentaux dirigent les medias mondiaux en dissimulant la verite de l`agression occidentale de l`afrique qui n`est d`autre que l`assurance de la ressource afraicaine et la suprematie sur ces pays. Ils voilent les yeux et bouchent les oreilles des citoyens mondiaux. La voix des peuples africains ne sont pas transmis au monde. Desormais il est en effet inevitable que l`Europe et l`Amerique du Nord echoue a sauvegarder le destin commun de l`humanite. Moi, l`ecrivain africain avertis en langue occidental que la pillage occidentale faite aux peuples africains a abouti a etre insupportable et appelle les intelligentsia d`Europe et d`Amerique du Nord d`assumer leur responsabilite par cet article.
이영현(Younghyun Lee),정영만(Youngman Jeong),정찬세(Chanse Jeong),양순용(Soonyong Yang3) 한국자동차공학회 2013 한국자동차공학회 지부 학술대회 논문집 Vol.2013 No.4
This paper describes a production process of unmanned 3-wheel vehicle. We selected EV’s components and specification for the manufacturing of electric vehicles. and We made electric vehicle directly. Typical feature of our EV is method of motor drive. One motor is installed to rear wheel. we need to control at rear wheels. we measured steering angle, motor rpm. and We made program that control wheel operation dependent on vehicle speed and steering angle
김정태 외 3인 한밭대학교 적정기술연구소 2014 적정기술 Vol.6 No.2
개발협력 분야에서 적정기술의 활용에 대한 관심이 늘어나면서 지속가능한 접근과 방법론이 무엇인지에 대한 논의가 활발해지고 있다. 또한 개발협력의 출구전략으로 협동조합과 사회적 기업 등 사업화의 관점에서 적정기술을 연계하는 접근도 시도되면서‘적정기술 비즈니스’라는 방법론이 주목받고 있다. 이번 원고에서는 적정기술 비즈니스의 가장 기본이 되는 원칙으로서 적정기술의 구루인 폴 폴락(Paul Polak)이 제시하는‘제로베이스 설계’(Zero-based Design)의 의미와 원칙을 통해 적정기술 비즈니스를 기획하는 데 필요한 관점이 무엇인지를 살펴보고자 한다.