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강준,강신광,최진,김정원,서을주,이부규,유은실 대한병리학회 2007 Journal of Pathology and Translational Medicine Vol.41 No.1
We report a case of an intraneural perineurioma that developed in an unusual location, the tongue. A 16-year-old male presented with a 1 cm sized protruding submucosal mass in his tongue without any sensory or motor signs or symptoms. The mass was excised. The mucosa was intact, with an ill-defined firm mass measuring 1.0×0.8×0.6 cm in the submucosa and muscle. The cut surface of the mass was pinkish gray and fibrotic. Microscopically, the mass contained tortuous and thickened peripheral nerve bundles in the submucosa, showing onion bulb like structures. The onion bulb like structures consisted of centrally located S-100 protein positive Schwann cells surrounded by Glut-1 positive perineurial cells. The FISH study did not reveal any genetic aberrations in chromosome 22.
재왕절개를 위한 경막외마취경험 : Lidocairie 과 Marcaine 의 비교
강준구,이철우,정운혁,유건희,유제열 대한마취과학회 1981 Korean Journal of Anesthesiology Vol.14 No.3
From Sept. 1980 to Jan. 1981 twenty three cases of epidural anesthesia for cesarean section were performed at St. Mary's Hospital, Catholic Medical College, Seoul, Korea. The choice of anestheia for cesarean section is still controversial. But the popularity of epidural anesthesia for elective cesarean section continues to grow even though the technique offers no advantage in terms of the biochemical condition of the mother and child. Marcaine which is a new stable, long-acting local anesthetics, was recently introduced to our department. A comparative study between marcaine and lidocaine application to the lumbar epidural anesthesia was performed. The results were as follows: 1) All of the 0.25% marcaine group revealed inadequate anesthesia for cesarean section. 2) Muscle relaxing effect of the 0.5% Marcaine group was revealed to be inferior to that of 2% lidocaine group. 3) Average time of onset of anesthesia was 24 min with marcaine and 18 min with lidocaine respectively. 4) Duration of single epidural injection of marcaine was 279±47 min and that of lidocaine was 122±31 min which revealed the duration of epidural anesthesia with marcaine was longer than that of lidocaine―about one hour. 5) The post operative pain was controlled successfully by means of means of continuous epidural technique with either 1.0% lidocaine or 0.25% Marcaine.
고석태,김해석,유강준 한국응용약물학회 1993 Biomolecules & Therapeutics(구 응용약물학회지) Vol.1 No.1
This study was performed to elucidate the mechanism of antidiuretic action of diltiazem by infusion into the vein and carotid artery, of diuretic action into a renal artery in dog. Renal denervation caused a reversal of the effect of diltiazem from the antidiuretic to the diuretic when infused into vein or carotid artery, and potentiated the diuretic effect when infused into a renal artery. The changes of renal function in diuretic circumstances as described above included the increase in renal plasma flow, osmolar clearance, the amounts of sodium and potassium excreted in urine and the decrease in reabosrption rate of sodium and potassium in renal tubules. Above results suggest that antidiuretic action of diltiazem may be mediated by central nervous system, not by endogenous substance, diuretic action by direct renal action.
高錫太,金海石,柳康俊 조선대학교 약학연구소 1993 藥學硏究誌 Vol.15 No.1
Enalapril, angiotensin converting enzyne(ACE) inhibitor, when injected into the vein in dog, produced diuretic action accompanied with the icrease of renal plasma flow(RPF), glomerular filtration rate (GFR), osmolar substance clearace(Cosm) and excretion rates of sodium and potassium in urihne(E_Na, E_K), but in this time, reabsorption rates of sodium and potassium in renal tubules(R_Na, R_K) were not changed at all. Enalapril, when infused into carotid artery, exhibited the same aspect with changes of renal function by intravenous enalapril. Enalapril infused into a renal artery did not affect the renal function of experimental kidney as a matter of control kidney. Above resalts suggest that enalapril produced diuretic action by renal hemodynamic inprovement through the central function
고석태,윤재경,유강준 朝鮮大學校 1997 藥學硏究誌 Vol.18 No.2
Vasopression which is antidiuretic hormone in human body produced the diuretic action in dog. This atudy was investigated in order to certify the diuretic action and to search out the mechanism of the action on the vasopression. Vasopressin, when given in a dose of 10.0mU/㎏, bolus+1.0mU/㎏/min intravenously, exhibited the increase of urine flow(Vol), renal plasma flow(RPF), osmolar clearance(Cosm) and amounts of sodium and potassium excreated in urine(E_Na, E_K), the decrease of reabosorption rate of sodium and potassium in renal tubules(R_Na, R_K), and then elevated the mean arterial pressure(MAP). Vasopressin given in a increased dose to 30.0 mU/㎏,bolus+1.0mU/㎏/min intravenously elicited the same aspect with that exhibited by a small dose in changes of Vol. and all reansl fuction and potentiated the change rates, whereas this time MAP did not change at all when compared with control value. Vasopressin, when adminstered into a renal artery, but increased slightly the Vol, glomeruler filtration rate(GFR). E_Na and E_K excepted the no change of R_Na and R_K in the control (not administered)kidney. Vasopressin. when infused into carotid artery, showed the increase of Vol. GFR,E_Na, E_K and no change of R_Na and R_K in a dose of 1/5 of intravenouse dose. Diuretic action of vasopressin administewred into carotid artery was not influenced by renal denervation. Above results suggest that vasopressin produces diuretic action by hemodynamic changes in dog. These hemodynamic changes may be mediated by central endogenous substances not associated with renal nerve.
고석태(Suk Tai Ko),유강준(Kang Jun Yu),김순회(Soon Hoe Kim),이은방(Eun Bang Lee),천선아(Seon Ah Cheon),신동숙(Dong Sook Shin),이은심(Eun Shim Lee),김옥경(Ok Kyung Kim),강선영(Seon Young Kang),손문호(Moon Ho Sohn) 한국응용약물학회 1996 Biomolecules & Therapeutics(구 응용약물학회지) Vol.4 No.2
The general pharmacological properties of Artemisia extract powder (DA-9601) produced from Artemisia asiatica leaves were investigated in mice, rats, guinea pigs and rabbits. DA-9601 at the dose of 800 ㎎/㎏ po had no influences on general behaviour, barbital sleeping time and motor coordination of mice. The material at the oral dose of 800 ㎎/㎏ did exhibit neither analgesic action nor hypothermic effect. Anticonvulsant action, muscle relaxant action and the effect on intestinal propulsion were not identified at 800 ㎎/㎏ po. In the isolated ileum and trachea of guinea pig, the material did not show direct effect and inhibitory action of chemically or electrically stimulated contraction at the concentration of 2 x 10^(-5) g/㎖ The sinus rates of atria and contractility of papillary muscle of guinea pig were not influenced by DA-9601 at a dose of 2 x 10^(-5) g/ml. No influences on blood pressure and respiration were observed at 40 ㎎/㎏ iv, in rabbits. However, transient decreases in blood pressure of rabbits were observed as given 120 ㎎/㎏ in iv route with slight respiratory depression, and slight diuretic effect could be found without any changes in Na^+ and K^+ excretion.
고석태(Suk Tai Ko),유강준(Kang Jun Yu),신동숙(Dong Sook Shin),이수연(Soo Hyan Lee) 한국응용약물학회 1995 Biomolecules & Therapeutics(구 응용약물학회지) Vol.3 No.2
This study was performed in order to certify the antidiuretic action and to investigate the mechanism of antidiuretic action of debrisoquin infused into a renal artery in dog. Debrisoquin, when infused into a renal artery, exhibited the antidiuretic action accompanied the reductions of glomerular filtration rate and renal plasma flow, and the decreased amounts of sodium and potassium excreted in urine, limited only to the infused side, while control kidney function remained unchanged at all. The antidiuretic action of debrisoquin infused into a renal artery was blocked by pretreament of prazosin, α₁-adrenergic blocking agent, or reserpine, catecholamine depleting agent. These results suggest that debrisoquin infused into a renal artery elicits antidiuretic action through indirect stimulation of renal sympathetic nerves.