닭의 신장기능에 미치는 Oxytocin의 영향

고석태 한국약제학회 1971 Journal of Pharmaceutical Investigation Vol.1 No.1

The existence of oxytocin in the pituitary gland of chicken has been ascertained, but its physiological roles are still obscure. In this study the action of oxytocin on renal function of the chicken was investigated during water diuresis, utilizing clearance and the Sperber technique. The results obtained are summarized as follows: Oxytocin, like in many species of mammals, elicited a profound diuretic response in the chicken. Urine flow, excretion of electrolytes, as well as glomerular filteration rate increased, with intravenous infusion of 3∼10 mμ/㎏/min. Oxtocin, infused into the renal portal circulation via hindleg vein in a dose of 3∼13 mμ/㎏/min. elicited marked increase in urine flow, glomerular filteration rate and sodium excreted in the urine. The diuretic effect was more pronounced in the infused side. It is suggested that diuretic response to oxytocin in the chicken results from dual action of oxytocin: increase of GFR and inhibition of sodium reabsorption on the renal tubule. The possibility that oxytocin might act through some endogenous substances could be ruled out.

黃蓍엑기스의 개 腎臟機能에 미치는 影饗

高錫太,林東潤 조선대학교 약학연구소 1982 藥學硏究誌 Vol.4 No.1

This study is an attempt to investigate the effects of Astragali Radix on renal function in dogs, making use of its water extract(ARWE) and methanol extract (ARME). ARWE and ARME, when administered into a cephalic vein of dog, produced diuretic effects, respectively. Intravenous ARME exhibited the increase in amounts of sodium and potassium excreted in urine, osmolar clearance and free water clearance with the enlargement of urine flow, and then the reabsorption rates of sodium and potassium in renal tubules were significantly diminished. ARME given intravenously elicited not only increase in amounts of sodium and potassium excreted in urine, but also enlargements of renal plasma flow and glomerular filtration rate with increase of urine flow, at the same time reabsorption rates of sodium and potassium in renal tubules were significantly reduced. ARWE, when infused directly into a renal artery, exerted diuresis and significant increases in excretion of sodium and potassium by reducing the reabsorption rates in renal tubules. From the above results it is concluded that both water and methanol extract of Astragali Radix cause diuretic action in dog, in that a) ARWE inhibits reabsorption of electrolytes in renal tubles and b) ARME changes the renal hemodynamics with inhibition of reabsorption of electrolytes in renal tubules, and the action of ARWE on the kidney is due to direct action.

商陸 Extract의 血壓反應에 미치는 影響

高錫太,丁榮獄,李玟宰 朝鮮大學校 1988 藥學硏究誌 Vol.10 No.1

This study was performed in order to investigate the effect of Phytolaccae Radix on blood pressure reponse in dog and rabbit using Phytolaccae Radix water and methanol extract. Phytolaccae Radix water and methanol extract(PWE and PME), when given intravenously, produced hypotensive action in normal dog and rabbit, but hypertensive action in vagotminized rabbit. In vagotminized rabbits, hypertensive action of PWE was not influenced by phentolamine(sympathetic α-blocking agent), bethanidine(neuronal blockade), rearepine(catecholamine depleting agent) and atropine(antimuscarinic agent(, whereas potentiated by pretreatment with chlorisondamine(autonomic ganglionic blocking agent). PWE, when given intracerbroventricularly, did not elicite the hypertensive action in vagotminized rabbit. Above results suggest that PWE and PME produces hypotensive action in normal dog and rabbit. The hypotensive actions of PWE and PME in normal rabbit is induced by stimulation of vagus nerves, the hypertensive action of PWE in vagotominized rabbit is produced by direct vasoconstriction.

商陸 Extract의 家兎 腸運動에 미치는 影響

高錫太,李尙休,李玟宰 朝鮮大學校 1988 藥學硏究誌 Vol.10 No.1

Author attempted to observe the effect of phytolaccae Radix water(PWE) and methanol extract(PME) on the movement of intestinal strips of rabbit in this paper. Both PWE and PME elicited the contractions in longitudinal muscle strips of ilum and in longitudinal or circular muscle strips of colon. The contractions of longitudinal muscle strips of ilum and colon induced by PWE and PME were blocked by atropine(anticholinergics) diphenhydramine(antihiatamines) and cyproheptadine(antiserotonins). The contraction of longitudinal strips of colon by PWE or PME was not produced in Ca^2+ free bath solution. Above results suggest that the intestinal contraction by PWE and PME is induced by stimulition of choline, histamine and serotonin receptors being mediated by Ca^2+.

AngiotensinⅡ 遮斷劑의 賢欌機能에 미치는 影響

高錫太 조선대학교 약학연구소 1990 藥學硏究誌 Vol.12 No.1

This study was attempted to investigate the effect of angiotensin Ⅱ inhibitors, (Sar^1, Val^5, Ala^8)-angiotensin Ⅱ(VAⅡ) and (Sar^1, Thr^8)-angiotensin Ⅱ (TAⅡ), on renal function, making use of dog. VAⅡ(100.0㎍/㎏) and TAⅡ(100.0㎍/㎏, 5.0㎍/㎏/min), when given intravenously in dog, produced the decrease of urine flow, at this time renal plasma flow(RPF) and osmolar clearance(Cosm) were reduced, but glomerular filtration rate(GFR), free water clearance(??) were not changed, and then the decreased excretion in urine and the increased reabsorption in renal tubules of Na^+ and K^+ were exhibited. When VAⅡ and TAⅡ were administered into a renal artery, VAⅡ(1.0㎍/㎏/min and 1.0㎍/㎏/min+10.0㎍/㎏) did not affect on renal function, wherease TAⅡ (10.0㎍/㎏, 30.0㎍/㎏ and 3.0㎍/㎏/min) exhibited antidiuretic action along with the same mechanism as shown in intravenous TAⅡ in not only experimental but also control kidney. When VAⅡ and TAⅡ were injected into a carotid artery, VAⅡ(30.0㎍/㎏) did not influence on renal function, but TAⅡ, in small doses of 3.0㎍/㎏ and 10.0㎍/㎏ which did not affect when given intravenously, exhibited the same aspect as shown in intravenous TAⅡ. Above results suggest that angiotensinⅡ inhibitors produce antidiuretic action by facilitation of Na^+ reabsorption in distal tubule through central action.

商陸 Extract가 개의 腎臟機能에 미치는 影響

高錫太,李熙淑,李相鉉 조선대학교 약학연구소 1986 藥學硏究誌 Vol.8 No.1

Effect of Phytolaccae Radix on renal function was investigated in dog using it's water and methanol extracts. Phytolaccae Radix water extract (PWE), when injected intravenously, produced significant diuresis accompanied with the increased glomerular filtration rate and renal plasma flow and also exhibited the increased urinary sodium and potassium excretion and the decreased reabsorption rate of sodium and potassium in tubles, as well as osmolar clearance was increased, but free water clearance was increased only in a small dose and decreased in a large dose of PWE. Phytolaccae Radix methanol extract (PME) given intravenously produced antidiuresis associated with the decrease of all renal function. PWE, when administered into a renal artery, produced diuresis with the increase of amounts of sodium and potassium excreted in urine and with the increase of osmolar and free water clearances, with no significant changes of glomerular filtration rate and renal plasma flow, these with no confined only infused kidney. PME given into a renal artery elicited antidiuresis along with the decreased all renal function only in experimental kidney. Above results suggest that PWE produces diuresis through indirect improvement of hemodynamics and direct inhibition of elecrolyte reabsorption in tubules, and that PME, elicite antidiuresis by direct suppression of renal hemodynamics.

새로운 항암성 백금착제의 일반약리작용(Ⅰ)

고석태,강선영,최홍석 朝鮮大學校 1996 藥學硏究誌 Vol.18 No.1

The general pharmacological effects of new platinum(Ⅱ) coordinated anticancer agents, SA〔Pt(trans-1-dach)(DPPE)〕, SB(〔pt(cis-dach)(DPPP)〕2NO_3 and SC〔Pt(en)(DPPE) 2NO_3)were investigated in rats. The new platinum(Ⅱ) anticancer agents decreased pain threshold and analgesic index in rats, and these compounds produced a transient increase of blood pressure in anesthized rats. SB enhanced the gastric ulcer induced by serotonin and the transport rate of meal in small intestine in rats, however SA and SC had effevt. These platinum comppunds had no effect on inflammation, explorat-ory behavior and the thiopental induced sleeping time in rats.

Sulfadiazine의 擔汁中 排泄에 關한 硏究

高錫太 조선대학교 약학연구소 1978 藥學硏究誌 Vol.1 No.1

This study on the biliary excretion of sulfadiazine has been established in the rats. 1. Sulfadiazine, administered intravenously to rats with ligated renal pedicles and a cannulated bile duct rapidly appeared in the bile in high concentration. 2. Bettween 0-30 min and 30-60 min after administration, the bile-to-plasma concentration ratios(B/P) of the sulfadiazine were 1.02-2.67, 1.14-3.79 for 1㎎/㎏, 1.48-3.89, 1.30-3.81 for 10㎎/㎏, 1.97.-4.27, 2.11 -4.07 for 50㎎/㎏, and 1.70-4.21, 1.71-5.34 for 100㎎/㎏. Thus,B/P ratios at any doses of sulfadiazine greatly exceeded 1.0 at all experimental periods. 3. Furthermore, the biliary excretion of sulfadiazine was inhibited by probenecid significantly. 4. Hepatic clearance of sulfadiazine in the rats was increased from 0.515 to 1.780㎖/60 min when the does was raised from 1.0㎎/㎏ to 50.0 ㎎/㎏ of sulfadiazine, but at 100㎎/㎏ more than 50㎎/㎏ , decreased to 1.250 ㎖/60 min. All these results indicate that sulfadiazine is excreted into the bile by active transport process in the rats with ligated renal pedicles and a cannulated bile duct.

초록집 ( 1992 . 5 . 6 ) : 제 2 분과 ( 약효검색 , 약리대사 ) ; 흰쥐 적출 관류부신을 이용한 Catecholamine 분비작용의 검색방법

고석태,임동윤 한국응용약물학회 1992 학술대회 Vol.1992 No.1

Norepinephrine과 AngiotensinⅡ의 혈압 상승작용에 대한 Diltiazem의 영향

高錫太,姜璟遠 조선대학교 약학연구소 1995 藥學硏究誌 Vol.17 No.1

This study was performed in order to investigated the effects of diltiazem, Ca^-2 channel blocker of benzothiazepine derivates, on the pressor actions of norepinephrine and angiotensinⅡ in rabbit Diltiazem inhibited the pressor actions of norepinephrine and angiotensinⅡ, but inhibition time by diltiazem was not continuous. In some other way, potentiated appearance of the pressor action of norepinephrine was exhibited 30∼40min after administration of diltiazem. Diltiazem inhibited both the pressor action of angiotensinⅡ and the potentiated pressor action of norepinephrine in rabbit pretreated with bethanidine, adrenergic neuronal blocking agent, and diltiazem diminished both the potentiated pressor action of norepinephrine and angiotensinⅡ in rabbit pretreated with chlorisondamine, ganglionic blocking agent.