Value of Additional von Kossa Staining in Thyroid Nodules with “Suspicious for Malignancy” on Cytology

권형주,김은경,곽진영 대한갑상선학회 2015 International Journal of Thyroidology Vol.8 No.1

Background and Objectives: We investigated the clinical value of additional von Kossa staining in thyroid nodules with “suspicious for malignancy” on cytology. Materials and Methods: From March 2010 to November 2010, 55 patients with 55 nodules which were diagnosed as “suspicious for malignancy” on cytology and had microcalcifications on ultrasound (US) underwent surgery and made up our final study population. We evaluated the role of the von Kossa stain as a preoperative diagnostic factor for thyroid cancer using histopathology as the “gold standard”. Diagnostic performances were calculated of the presence of psammoma bodies on both cytology and the von Kossa staining and of US in predicting thyroid cancers. Results: Of 55 nodules with microcalcifications on US and “suspicious for malignancy” on cytology, 53 (96.4%) were malignant and 2 (3.6%) were benign on histopathology. All pathologically benign nodules were negative on the von Kossa stain. The sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) of the von Kossa stain were 28.3%, 100%, 30.9%, 100%, and 5% for diagnosis, respectively. Conclusion: Von Kossa staining can be a valuable diagnostic tool in a thyroid nodule with “suspicious for malignancy” on cytology and microcalcifications on US, objectively.

전통세라믹고도화

권형주,김형준,이준영 한국세라믹학회 2016 세라미스트 Vol.19 No.2

골수기질세포에서 방사선 반응 유전자로서의 Plasminoge Activator Inhibitor-1

권형주,조덕연,박찬규,이영희,송지연 한국발생생물학회 2005 발생과 생식 Vol.9 No.1

조혈세포의 주요 서식지가 되는 골수기질세포는 줄기세포의 운명을 결정하는 다양한 인자들을 제공한다. 방사선요법은 항암치료법으로 널리 활용되고 있으나, 조혈세포의 파괴로 인한 부작용이 심각한 문제로서 조혈세포에 의한 혈액세포가 빠른 시간 내에 회복되는 것이 필수적이다. 본 연구에서는 방사선을 조사했을 때의 줄기세포 서식지를 구성하는 세포인 골수기질세포에서 발현되는 유전자를 탐색하여 그 기능과 조절 및 혈액 형성을 이해하는 기초를 마련하고자 하였다. 방법론적으로는 polymerase chain reaction(PCR) 및 agarose 전기영동 방법을 활용한 differential display를 활용하였으며, 결과로서 여러 후보 유전자가 선별되었으나, plasminogen activator inhibitor-1(PAI-1) 유전자만이 감마선에 의해 유도됨이 반복 확인되었다. PAI-1 유전자 유도의 의미는 향후에 더 연구해야 할 것이다.

The Role and Future of Endoscopic Spine Surgery: A Narrative Review

권형주,박정윤 대한척추신경외과학회 2023 Neurospine Vol.20 No.1

Many types of surgeries are changing from conventional to minimally invasive techniques. Techniques in spine surgery have also changed, with endoscopic spine surgery (ESS) becoming a major surgical technique. Although ESS has advantages such as less soft tissue dissection and normal structure damage, reduced blood loss, less epidural scarring, reduced hospital stay, and earlier functional recovery, it is not possible to replace all spine surgery techniques with ESS. ESS was first used for discectomy in the lumbar spine, but the range of ESS has expanded to cover the entire spine, including the cervical and thoracic spine. With improvements in ESS instruments (optics, endoscope, endoscopic drill and shaver, irrigation pump, and multiportal endoscopic), limitations of ESS have gradually decreased, and it is possible to apply ESS to more spine pathologies. ESS currently incorporates new technologies, such as navigation, augmented and virtual reality, robotics, and 3-dimentional and ultraresolution visualization, to innovate and improve outcomes. In this article, we review the history and current status of ESS, and discuss future goals and possibilities for ESS through comparisons with conventional surgical techniques.

소아 간 혈관내피종 : 17년간의 치료경험

권형주,문석배,박귀원,정성은,Kwon, Hyung-Joo,Moon, Suk-Bae,Park, Kwi-Won,Jung, Sung-Eun 대한소아외과학회 2008 소아외과 Vol.14 No.2

Infantile hepatic hemangioendothelioma (IHHE) is the most common benign vascular hepatic tumor in children. We analyzed the 17-year experience of IHHE. The medical records of 16 patients (M:F=8:8) treated at the Department of Pediatric Surgery and the Department of Pediatrics Seoul National University Children's Hospital between January 1991 and January 2008 were reviewed retrospectively. Mean age at presentation was 87 days (1 day - 551 days). Seventy five percent of patients were diagnosed with imaging study and 25 % with biopsy. Major symptoms were hepatomegaly (N=5), palpable abdominal mass (N=4) and congestive heart failure (N=3). Six patients had no symptoms. Kasabach-Merritt syndrome was combined in one patient. Nine patients (56.3 %) underwent operation and 2 patients (12.5 %) underwent only medical treatment. Clinical observation was tried on 5 patients (31.3 %) without any treatment. Operation was performed on the patient with clinical symptoms or on patients where the differentiation between begin and malignant could not be determined. Patients who had clinical symptoms but tumor was unreresectabile were treated medically. Among the 5 patients who had been observed for their clinical course, 2 patients showed complete regression and the tumors of the remaining 3 patients were regressing. Clinical symptoms, the age at presentation, the size of tumor and ${\alpha}$-FP, all had no significant statistical relationship with the time required for complete tumor regression. There was no relationship between the size change of the tumor and the change of ${\alpha}$-FP level. Only the size of tumor was related with clinical symptoms. One patient died of post-operatvie bleeding. Treatment plan was determined by the extent of the tumor and the presence of clinical symptoms. Observation was enough for the patients without clinical symptoms and complete resection was curative for patients with clinical symptoms. Medical treatment is an alternative for the patient whose tumor is unresectable.

체계적 문헌 고찰 및 메타분석 결과의 해석

권형주 대한외과학회 2022 대한외과학회 학술대회 초록집 Vol.2022 No.5

UWB MB-OFDM 시스템에서 TOA 성능향상을 위한 동기화 기법

권형주,이준호,정영석,조상호,Kwon, Hyung-Ju,Lee, Joon-Ho,Jeong, Yeong-Suk,Jo, Sang-Ho 한국통신학회 2007 韓國通信學會論文誌 Vol.32 No.5c

We propose how to improve the performance of TOA estimation in UWB MB-OFDM systems. The scheme is based on the correlation between the OFDM preamble and the template signal. The validity of the proposed scheme is shown using the simulation results, where it is shown that the performance of the proposed scheme outperforms that of the existing schemes IEEE 802.15.3a task group에서 채택한 4가지의 UWB 채널 모델과 AWGN 채널 모델에 대해서, MB-OFDEM 시스템의 preamble 신호를 이용한 TOA 성능 향상기법을 제안한다. 제안되는 방법은 수신 신호와 template 신호 사이의 correlation에 의한 타이밍 동기화 지점을 이용하여 TOA를 추정한다. 제안한 방법의 성능이 기존의 방법에 비하여 우수한 성능을 나타냄을 전산모의실험을 통하여 확인한다.

2종의 Ferrite가 혼합된 복합 Ferrite 전파흡수체의 정합주파수 제어

권형주,신재영,오재희 한국세라믹학회 1993 한국세라믹학회지 Vol.30 No.10

The performance of ferrite composite microwave absorber has been evaluated as the matching frequency, the matching thickness and the band width. Especially, matching frequency is very important in application of microwave absorber because it determines operating frequency range. In this study, the ferrite composite microwave absorbers consisted Ni-Zn ferrite and Zn2Y ferroxplana were prepared in order to control matching frequency. Then, the variation of the material constants and microwave absorbing characteristics were investigated with various ferrite mixing ratio. The material constants of ferrite composite microwave absorber could be controlled by variation ferrite mixing ratio. Therefore, it was confirm that matching frequency of microwave absorber could be shifted by control of material constants.

세라믹 중소기업의 중기와 단기 성장에 미치는 영향 요인의 탐색적 연구 : 자원기반이론 관점으로

권형주,이종원,박지형 피터드러커 소사이어티 2019 창조와 혁신 Vol.12 No.3

Contrary to the general perception that ceramic industry is traditional industries such as pottery and electrical appliance manufacturing, the ceramic industry is a high-tech industry that makes electronic, communication, energy, environment and consumer goods as core material of the fourth industrial revolution. 99 percent of the total ceramic manufacture companies are small and medium-sized manufacturing. There are few studies on the success factors of the management strategic point of view due to the perception that the ceramic industry is a traditional industry. We apply the internal resource-based theory, which is the management strategy theory, to analyze the field data of 289 small-and medium-sized ceramic manufacturers in 2013-2015 by analyzing short-term growth factors through the logistic regression analysis and mid-term growth factors through the panel data analysis. As a result of analysis, it is found that the facility investment of the company is the most important growth factor in the short term and the R&D investment and human resources investment are the main growth factors in the medium term in the ceramic industry. In this study, we have found that short-term and long-term growth factors can be different in academic terms. In practice, it can be useful for application of growth strategies of ceramic industry companies. 세라믹산업은 도자기, 전기기구 제조 등의 전통산업이라는 일반적인 인식과는달리 4차 산업혁명의 핵심소재로 전자, 통신, 에너지·환경, 소비재 등을 만드는 첨단 산업이고 전체 기업의 99%가 중소 제조기업으로 구성되어 있어 있다. 세라믹산업이 전통산업이라는 인식 때문에 경영 전략적 관점의 성공요인에 대한 연구는거의 없다. 본 연구는 경영전략이론인 내부자원 이론을 적용하여 2013~2015년 3 개년 첨단세라믹산업 중소제조기업 289개사 기업 필드 데이터를 로지스틱회귀분석을 통해서는 단기적 성장요인 분석하였고, 패널분석을 통해서는 중기 성장요인을 분석하였다. 분석결과 세라믹산업의 중소 제조기업은 단기적으로는 기업의 설비투자가 가장 중요한 성장요인이며, 중기적으로는 연구투자, 인력투자가 주요한성장 요인임을 발견하였다. 본 연구는 필드데이터를 분석하여 기업성장요인이 단기와 장기가 다를 수 있다는 사실을 발견하였다는 점에서 의의가 있다. 또한 본 연구의 결과를 세라믹 산업 기업의 성장 전략의 적용에 유용하게 활용될 수 있을 것이라고 생각된다.

친환경차 유냉식 모터오일쿨러 옵셋핀(Offset Fin) 설계인자에 따른 구조 및 특성 연구

권형주,권혁주,이상민 한국신뢰성학회 2023 한국신뢰성학회 학술대회논문집 Vol.2023 No.6